ACS Applied Polymer Materials
·
2024
·
IF 4.4
Huan Xing,Yuxin Song,Liang Ma,Fengxia Wang,Mingfang Zhang,Zhonghao Li,Zherui Wan,Xiaoxu Cui,Guang Yang
The fabrication of stimulus-responsive polydiacetylene (PDA) materials with thermochromic reversibility is highly valuable for displays, optoelectronic devices, and sensors. Herein, a type of bis-diacetylene monomer (bis-DA) covalently linked by 1,4-phenylene diisocyanate was synthesized. Owing to the strong hydrogen-bonding interactions, a reversible color transition can be realized for the polymerized bis-diacetylene (bis-PDA) film in the temperature range from 30 to 150 °C. The excellent linear relationship between the colorimetric response values and temperature (from 90 to 150 °C) with an R2 value of 0.992 demonstrated that the as-prepared bis-PDA sensor can be used for the quantitative analysis of temperature. Meanwhile, the bis-PDA film displayed a reversible thermochromic property upon exposure to 980 nm near-infrared light at a relatively high power density. In addition, hybrid PDA vesicles that consist of DA and bis-DA monomers with a molar ratio of 1:1 can be utilized as sensitive, specific, and visual sensors for the detection of Pb2+ ions, with a satisfactory limit of detection of 0.15 μM. This work not only offers a fundamental understanding of the mechanism of the thermochromic property of PDA but also may broaden the applications of PDA-based sensors.
研究领域:
材料科学
·
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2014
·Vol. 6
·期 24
·14772-14783
·
IF 6.739
Danling Yang,Rongfeng Zou,Yu Zhu,Ben Liu,Defan Yao,Juanjuan Jiang,Junchen Wu,He Tian
Polydiacetylene (PDA) micelles have been widely used to deliver anticancer drugs in the treatment of a variety of tumours and for imaging living cells. In this study, we developed an effective strategy to directly conjugate magainin II (MGN-II) to the surface of PDA micelles using a fluorescent dye. These stable and well-defined PDA micelles had high cytotoxicity in cancer cell lines, and were able to reduce the tumour size in mice. The modified PDA micelles improved the anticancer effects of MGN-II in the A549 cell line only at a concentration of 16.0 μg mL−1 (IC50). In addition, following irradiation with UV light at 254 nm, the PDA micelles gave rise to an energy transfer from the fluorescent dye to the backbone of PDA micelles to enhance the imaging of living cells. Our results demonstrate that modified PDA micelles can not only be used in the treatment of tumors in vitro and in vivo in a simple and directed way, but also offer a new platform for designing functional liposomes to act as anticancer agents.
研究领域:
癌症研究
·
生物医学工程
·
药物递送系统
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Chemistry
·
2019
·
IF 3.782
Gu Shiwei,Guo Chang,Wang Hui,Tian Guangjun,Xu Suying,Wang Leyu
The flourishing advancements in nanotechnology significantly boost their application in biomedical fields. Whereas, inorganic nanomaterials are normally prepared and capped with hydrophobic ligands, which require essential surface modification to increase their biocompatibility and endow extra functions. Phenylboronic acid derivatives have long been known for its capacity for selective recognition of saccharides. Herein, we demonstrated a versatile surface modification strategy to directly convert hydrophobic inorganic nanocrystals into water-dispersible and targeting nanocomposites by employing boronic acid modified photo-polymerizable 10,12-pentacosadiynoicacid and further explore its potentials in selective cancer cell imaging.
研究领域:
纳米技术
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBON
·
2019
·
IF 7.466
Yudi Mo,Junchen Liu,Chao Meng,Min Xiao,Shan Ren,Luyi Sun,Shuanjin Wang,Yuezhong Meng
The low electronic conductivity and poor Li + diffusion coefficient of conventional LiFePO 4 (LFP) materials severely impede its high-rate applications for lithium-ion batteries (LIBs). To break these limits, one novel poly(1,3-diethynylbenzene) (PAB) acetylenic carbon-rich polymer with extremely high-carbon content (96.75 wt%) and good solubility has been prepared by an oxidative coupling reaction. One definite advantage is that this carbon-rich PAB polymer will release, upon pyrolysis , very low amounts of gas, forming therefore uniform and dense highly conductive carbon network. Besides, the specific resistivity of continuous PAB-C layer can be as low as ∼0.01 Ω cm, which can effectively improve electrical conductivity and maintain mechanical integrity of LFP cathode. As a result, the prepared LFP@PAB-C nanocomposites with approximately 3.8 wt% carbon content and 2.5 nm carbon layer exhibit an excellent high-rate capability, e.g. even at a considerable discharge rate of 50 C, while the capacity can still be remained at 129.6 mA h g −1 . Moreover, the LFP@PAB-C nanocomposites also reveal a remarkable cycling stability with as high as 100.6% capacity retention at 20 C over 1000 cycles. This kind of LFP@PAB-C composite was demonstrated to be an ideal cathode material for high-power LIBs.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
高影响因子
Polymer Chemistry
·
2021
·Vol. 12
·期 17
·2598-2605
·
IF 5.582
Xianheng Shi,Min Liu,Lishan Li,Jiandong Zhang,Haiyan Li,Zhihao Huang,Wei Zhang,Zhengbiao Zhang,Nianchen Zhou,Xiulin Zhu
Discrete oligomers are perfect candidates for understanding the structure-dependent properties of polymers. Herein, a series of discrete conjugated oligo(fluorenediacetylene)s (D-oFDAs) with a degree of polymerization (DP) up to 10 were obtained by purification with automated flash column chromatography from polydisperse polymers. It is found that the chain length can affect not only photophysical properties but also crystalline properties. As the DP of D-oFDAs increased, the longer conjugation length caused red shifts in their optical spectra and weaker crystallinity. The effective conjugation length has been extrapolated to be as long as 9 fluorenediacetylene units. Moreover, the oligomers can form uniform films by solution casting for the fabrication of light-emitting diodes, showing that the octamer has the most efficient electroluminescence (EL) properties. When the crystal of the dimer was exposed to 254 nm UV light, only part of the sample was polymerized via a 1,4-addition reaction. Significantly, the simple, scalable and effective strategy provides opportunities to further optimize the structure with diverse blocks and side chains for precisely building macromolecular architectures.
研究领域:
材料科学
·
高分子化学
·
光电学
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Ying Bao,Ziwen Gao,Yuting Yan,Yujie Duan,Yao Zhao,Hao Wang,Chunsheng Xiao,Xuesi Chen
Bioorthogonal Raman probes offer significant advantages for multiplexed, background-free biological imaging due to their unique vibrational fingerprints and photostability. However, their widespread application is limited by the inherently weak Raman scattering signal, which creates a pressing need for high-sensitivity Raman probes. Here, chemically stable diacetylene (─C≡C─C≡C─) functionalized β-ketoenamine covalent organic frameworks (BDDA COFs) are synthesized as Raman probes for in vivo imaging of bone cracks. The BDDA COFs exhibited significantly enhanced Raman intensity at 2205 cm −1 (up to ≈10 5 fold vs 5-ethynyl-2′-deoxyuridine) compared to conventional alkyne-based probes. Moreover, polydopamine (PDA)-coated COFs (BDDA@PDA COFs) are prepared by utilizing the high affinity of PDA for calcium ions exposed at bone injury sites, thereby enabling highly sensitive and specific ex vivo and in vivo Raman imaging of bone cracks. The development of COFs containing alkyne groups as strong Raman imaging probes in the silent region provides a new paradigm for in vivo Raman imaging materials and also establishes a technical foundation for future applications in disease diagnosis and precision medicine.
研究领域:
材料科学
·
生物医学成像
·
纳米技术
·
分子探针
·
骨科
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）