SENSORS AND ACTUATORS B-CHEMICAL
·
2014
·
IF 3.84
Huihui Chen,Zhiqiang Liu,Duxia Cao,Shanshan Lu,Jingzhong Pang,Yunhui Sun
Two new fluorescence turn-on chemosensors for cyanide based on dipyridylamine substituted aurone moiety have been synthesized. The strong yellow-green fluorescence of the compounds were completely quenched after the addition of Cu(II) ions because of the complexation between the compounds and Cu(II) ions and were almost recovered after the addition of cyanide owing to the strong bonding ability between cyanide and Cu(II) ions, which lead to the removal of copper ions from the complexes. The chemosensors exhibit good repeatability.
研究领域:
分析化学
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2024
·
IF 4
Dongxu Yi,Yuhang Dong,Minghui Qi,Minghung Hong,Bin Zhu,Guobin Ren
Drug development necessitates substantial investments in both human and material resources. In the advanced stages of development, significant solubility challenges frequently emerge, critically influencing a drug's applicability and efficacy. Crystal engineering, particularly through the application of cocrystal technology, presents a novel strategy to address these solubility issues without compromising the drug's effectiveness. However, the success rate of cocrystals formation remains relatively low. This article evaluates the impact of widely used virtual cocrystal screening methods on prediction outcomes, especially in the context of conformational diversity. The study describes the effects of eight dipyridamole (DIP) conformations and 130 cocrystal formers (CCFs) using molecular complementarity and molecular electrostatic potential methods, while the hydrogen bond propensity method did not account for conformations variations. Findings indicate that different DIP conformations lead to variable prediction outcomes in virtual cocrystal screening. Thus, it is crucial consider the conformational states of APIs and CCFs in virtual screenings to enhance prediction accuracy. By comparing virtual screening results with experimental results, this study demonstrated that incorporating conformational considerations can improve cocrystal success rates, minimize experimental workload, and contribute to energy-conservation and emission-reduction. Additionally, this research provides the true positives and true negatives data of DIP's cocrystal, laying the groundwork for further studies.
研究领域:
药学
·
化学信息学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2014
·
IF 4.058
Xianfei Zeng,Yang Zhou,Wenhui Ma,Shixing Wang,Keqiang Xie,Jijun Wu,Kuixian Wei
Di(2-picolyl)amine derivates functionalized inorganic/organic hybrid magnetic network was prepared for selective detection and removal of Zn (II). A significant visual color change from colorless to pink-red was observed under the irradiation of 365 nm UV lamp. The inorganic/organic hybrid Fe 3 O 4 @SiO 2 nanoparticles were characterized by TEM, XRD, VSM, FT-IR, and TGA techniques. The fluorescence photograph showed that di(2-picolyl)amine functionalized Fe 3 O 4 @SiO 2 nanoparticles were sensitive and selective to Zn 2+ in acetonitrile solution. The di(2-picolyl)amine functionalized Fe 3 O 4 @SiO 2 nanoparticles with high saturation magnetization can conveniently separate metal ions from aqueous solution. Fluorescence spectra showed that the intensity varied obviously with the concentration of Zn 2+ . The removal efficiency of Zn 2+ can reach as high as 97.1% and the saturated adsorption amount of Zn 2+ is 161.6 mg/g. Langmuir linear fitting can illustrate the well consistent with the adsorption results.
研究领域:
化学
·
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
·
2022
·
IF 0.847
Fang-Min CHEN,Chi-Chi ZHOU,Xiong HE,Yan LI,Xiu-Qing ZHANG
ABSTRACT Two new 3-D Cd(II) coordination polymers with p -phthalic acid ( p -BDC) and 4,4΄-dipyridylamine (4,4΄-dpa), namely [Cd 2 ( p -BDC) 2 (4,4΄-dpa) 2 ] n 1 and {[Cd( p -BDC)(4,4΄-dpa) (H 2 O)]·4H 2 O} n 2 were successfully synthesized under hydrothermal conditions at 120 and 140 °C. They were characterized by single-crystal X-ray diffraction, IR, PXRD and TGA . It was further characterized by Hirshfeld surface (HS) analysis for complex 2 . The luminescent properties of the complexes have also been investigated.
研究领域:
化学
·
材料科学
✓ 已验证
DOI
高影响因子
Journal of Nanoelectronics and Optoelectronics
·
2021
·Vol. 16
·期 1
·17-22
·
IF 0.961
Gu Xiao-Yu,Lin Jie,Zhao Wen-Li,Xue Ze-Chun,Cui Chuan-Sheng,Huang Xian-Qiang
With the increasing interest in polyoxometalates (POMs) materials over the past few decades, scientific researchers have focused their attention on the fruitful utilization of POMs hybrids as efficient catalysts in many organic reactions. In this paper, dipyridine amine (dpa) organic ligand hybrid polyoxomolybdate material was solvothermally synthesized and structurally identified by elemental analysis, X-ray diffraction and infrared spectrum. Structural refinement of the hybrid polyoxomolybdate compound 1 with general formula [Hdpa]4Mo8O26 · 2DMF (DMF = N,N-dimethylformamide) shows that compound 1 presents in the space group P-1 with triclinic system, and is built up from a well-known β-[Mo8O26]4– anionic cluster, four free protonated dpa cations and two free DMF molecules. Remarkably, the β-Mo8O26-based hybrid material was further applied as the catalyst in the conversion of sulfides utilizing hydrogen peroxide (30%) as green terminal oxidant and exhibited efficient catalytic activities for selective oxidation of sulfides.
研究领域:
材料科学
·
催化化学
·
有机化学
✓ 已验证
DOI
高影响因子
Acta Biomaterialia
·
2024
·
IF 9.4
Xinqi Zeng,Yanhao Li,Gang Zhao,Xiaoer Wei,Rongpu Wu,Sa Pang,Yuange Li,Zaijing Tao,Shuo Wang,Jixian Yue,Xu Chen,Yajun Xu,Yongjun Rui,Jingyi Mi,Yang Liu,Jinglei Wu,Jian Tian
Post-traumatic tendon adhesions significantly affect patient prognosis and quality of life, primarily stemming from the absence of effective preventive and curative measures in clinical practice. Current treatment modalities, including surgical excision and non-steroidal anti-inflammatory drugs, frequently exhibit limited efficacy or result in severe side effects. Consequently, the use of anti-adhesive barriers for drug delivery and implantation at the injury site to address peritendinous adhesion (PA) has attracted considerable attention. Electrospun nanofiber membranes (ENMs) have been extensively employed as drug-delivery platforms. In this study, we fabricated a polylactic acid (PLA)–dipyridamole (DP)-graft copolymer ENM called PLC-DP. This membrane exhibits enzyme-sensitive features, allowing more controlled and sustained drug release compared with conventional drug-loaded ENMs. In experiments, PLC-DP implantation reduced tissue adhesion by 47 % relative to the control group while not adversely affecting tendon healing. Mechanistically, PLC-DP effectively activates the FXYD domain containing ion-transport regulator 2 (FXYD2) protein, thereby downregulating the fibroblast-transforming growth factor beta (TGF-β)/Smad3 signaling pathway. PLC-DP leverages the anti-adhesive properties of DP and the enzyme-sensitive characteristics of graft copolymers, providing a promising approach for the future clinical treatment and prevention of PA. Statement of significance Peritendinous adhesions (PA) are a common and disabling condition that seriously affects the prognosis and quality of life of post-trauma patients. Current treatments often have limited efficacy or severe side effects, leaving a serious gap in clinical practice. We developed a significant biomaterial, poly(lactic acid)-dipyridamole graft copolymer electrospun nanofibrous membrane (PLC-DP), specifically for PA inhibition. In addition, this study uniquely combines dipyridamole, an anti-adhesive agent, and enzyme-sensitive copolymers in electrospun nanofibrous membrane. Unlike conventional drug-loaded electrospun nanofibrous membranes, PLC-DPs have enzyme-sensitive drug properties that allow for sustained drug release on demand. Our experiments showed that implantation of PLC-DP was effective in reducing tissue adhesions by 47 % without affecting tendon healing. We elucidated the mechanism behind this phenomenon, suggesting that PCD activates FXYD2 to inhibit TGF-β-induced expression of Col III, which is a key factor in PA development.
研究领域:
生物材料学
·
医学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2021
·Vol. 21
·期 6
·2100048
·
IF 4.979
Huiting Jia,Xindong Wang,Zhaoming Chen,Shuai Liu,Tongtong Zhou,Hao Zhou,Tianying Guo
Zinc ion complexes of dipicolylamine analogs, due to the strong synergistic effect between the Zn 2+ complex of containing polypyridine derivatives and polycations in each key step of pDNA transport, have been used as the third component to mediate polyethyleneimine with molecular weight 1.8 kDa (PEI1.8k)/DNA gene delivery system. And the effects of different structural characteristics, such as the number of pyridinamine ligands, the hydrophilic-hydrophobicity of the adjacent groups, on the in vitro transfection performance of the ternary complex are systematically investigated. This ternary hybrid system provides an effective strategy to improve the gene delivery of cationic polymers.
研究领域:
生物化学
·
分子生物学
·
基因治疗
✓ 已验证
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Zhirong Li,Lulu Zhang,Zhanzhong Wang,Xiongli Kang,Huiying Jin,Wenjie Zhao,Jun Zhang,Haiquan Su
Identification of the phosphatidylserine (PS) discrepancies occurring on the cellular membrane during apoptotic processes is of the utmost importance. However, monitoring the quantity of PS molecules in real-time at a single-cell level currently remains a challenging task. Here, we demonstrate this objective by leveraging the specific binding and reversible interaction exhibited by the zinc(II) dipyridinamine complex (ZnDPA) with PS. Lipoic acid-functionalized ZnDPA (LP-ZnDPA) was subsequently immobilized onto the surface of an atomic force microscopy cantilever to form a force probe, ALP–ZnDPA, enabling a PS-specific dynamic imaging and detection mode. By utilizing this technique, we can not only create a heat map of the expression level of PS with submicron resolution but also quantify the number of molecules present on a single cell’s surface with a detection limit of 1.86 × 104 molecules. The feasibility of the proposed method is demonstrated through the analysis of PS expression levels in different cancer cell lines and at various stages of paclitaxel-induced apoptosis. This study represents the first application of a force probe to quantify PS molecules on the surface of individual cells, providing insight into dynamic changes in PS content during apoptosis at the molecular level and introducing a novel dimension to current detection methodologies.
研究领域:
生物物理学
·
分子生物学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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