JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
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2022
·
IF 6.76
Weibin Cai,Haihan Wang,Q. Gary Yang,Tiankun Liu,Yujun Wang
Methyl isobutyl ketone (MIBK) and diisopropyl ether (DIPE) are two commonly used extractants in industry, but their efficiency in extracting phenols , especially polyhydroxyphenols, is low. In the work, a highly-efficient extractant was proposed to extract phenolic compounds, including polyhydroxyphenols. The interactions between three extractants, cyclohexanone (CYC), MIBK and DIPE, and phenols were analyzed by the COSMO-RS method and CYC shows stronger interactions with phenols than MIBK and DIPE. The results of Fourier-transform infrared spectroscopy (FTIR) show that strong hydrogen bonds are formed between CYC and phenolic compounds, in agreement with the results of the COSMO-RS method. The effects of concentration, temperature and pH values on the extractant performance were studied. Results showed that the performance of CYC is the best, followed by MIBK and DIPE, whose performance is the worst. As CYC was used as the extractant, the distribution coefficients of the three phenolic compounds, phenol, resorcinol and phloroglucinol, are 96.7, 47.8, 13.0, respectively. These values are 35%, 263%, and 160% larger than those of phenol, resorcinol and phloroglucinol, respectively, corresponding to MIBK. CYC is a highly-efficient extractant for the extraction of phenolic compounds, including polyhydroxyphenol.
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COMBUSTION AND FLAME
·
2021
·
IF 4.185
Zhanjun Cheng,Hui Wang,Wenhao Yin,Jinglan Wang,Wei Li,Zhandong Wang,Lili Xing,Xuezhi Gao,Bowen Mei,Yan Zhang,Jiuzhong Yang,Lixia Wei,Xin Zhong,Hu Wang,Yuyang Li,Beibei Yan,Guanyi Chen
To explore the fuel isomeric effect on ether combustion characteristics, pyrolysis , and laminar flame propagation of di-n-propyl ether (DPE) and diisopropyl ether (DIPE) were investigated. A new kinetic model of DIPE was developed based on our recent DPE model [Fuel 298 (2021) 120797]. The pyrolysis experiments were carried out in two jet-stirred reactors at near-atmospheric pressure with good agreement on the measurements using synchrotron vacuum ultraviolet photoionization mass spectrometry and gas chromatography/mass spectrometry. The decomposition profile of DIPE showed a faster trend than that of DPE, which can be attributed to the faster alcohol elimination reaction of DIPE. The dominant roles of alcohol elimination reaction and H-abstraction reactions in fuel consumption explain the production of fuel-specific oxygenated species, i.e. n -propanol and propanal in DPE and i -propanol, acetaldehyde and acetone in DIPE. The laminar burning velocities of DPE and DIPE were also measured in a high-pressure constant-volume cylindrical combustion vessel at the initial temperature of 373 K and pressures of 1–10 atm. It was found that the linear DPE propagated faster than DIPE with the branched structure under all investigated conditions. Rate of production analysis and sensitivity analysis were also performed to elucidate the key radicals and reactions responsible for the remarkable reactivity of isomeric fuels. Fuel structures have a great influence on the distribution of radical pools, resulting in the easy formation of active radicals in DPE flames such as vinyl and ethyl and stable radicals in DIPE flames like methyl and allyl. The successive decomposition reactions of these dominant radicals promote the DPE flame and inhibit the DIPE flame propagation respectively, which explains the higher laminar burning velocities and reactivity of DPE than that of DIPE. Furthermore, the present model was also examined against the literature data, including pyrolysis and oxidation in the jet-stirred reactor and flow reactor.
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JOURNAL OF MOLECULAR LIQUIDS
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2021
·
IF 6.165
Qingsong Li,Hongyue Guo,Song Lin,Yicong Zhao,Hui Li
To separate and purify diethoxymethane (DEM) from water, in 101.3 kPa and at 303.2 K, the liquid-liquid equilibria (LLE) data of water + DEM + solvents (p-xylene, isopropyl ether, ethyl acetate and isooctyl alcohol) were obtained. The ability to extract DEM from water was evaluated by distribution coefficient (D) and separation coefficient (S). The LLE data were tested by the Bachman and Hand equations with the linear coefficient was greater than 0.99. As well as correlated by the NRTL and UNIQUAC thermodynamic models with the RMSD are no greater than 0.70%.
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Polymers
·
2020
·Vol. 12
·期 3
·632
·
IF 3.426
Jianbing Guo,Jian Wang,Yong He,Hui Sun,Xiaolang Chen,Qiang Zheng,Haibo Xie
Soybean oil is beneficial to improve the compatibility between polylactide (PLA) and succinylated lignin (SAL), which leads to the preparation of a host of biobased composites containing PLA, SAL, and epoxidized soybean oil (ESO). The introduction of SAL and ESO enables the relatively homogeneous morphology and slightly better miscibility obtained from triply PLA/SAL/ESO composites after dynamic vulcanization compared with unmodified PLA. The rigidity of the composites is found to decline gradually due to the addition of flexible molecular chains. According to the reaction between SAL and ESO, theTgof PLA/SAL/ESO composites is susceptible to the movement of flexible molecular chains. The rheological behaviors of PLA/SAL/ESO under different conditions, i.e., temperature and frequency, exhibit a competition between viscidity and elasticity. The thermal stability of the composites displays a slight decrease due to the degradation of SAL and then the deterioration of ESO. The elongation at break and notched impact strength of the composites with augmentation of ESO increase by 12% and 0.5 kJ/m2, respectively. The triply biobased PLA/SAL/ESO composite is thus deemed as a bio-renewable and environmentally friendly product that may find vast applications.Keywords:lignin;polylactide composite;epoxidized soybean oil;dynamic vulcanization
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JOURNAL OF POWER SOURCES
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2022
·
IF 9.794
Xirui Kong,Yichen Kong,Lang He,Wenna Zhang,Yi Song,Sheng Liu,Yan Zhao
A new ether-based electrolyte with tetrahydrofuran (THF) and di-isopropyl ether (DIPE) is proposed for Lithium–Sulfur battery (LSB). By employing the common ion effect and the weakly-solvating solvent (such as DIPE), the dissolution of lithium polysulfides and the self-discharge effect are effectively inhibited. Besides, the LiFSI has be used as the co-salt in the LiTFSI-based electrolyte to improve the ionic conductivity and inhibit the side reaction on Li metal anode . It is worth mentioning that, the L1L2TD-1382 electrolyte (LiTFSI: LiFSI: THF: DIPE = 1 : 3: 8 : 2, molar ratio) ensures a stable cycling for more than 500 cycles with a high Columbic efficiency (CE) of Li deposition/stripping (>99.3%). Impressively, with selenium doped sulfurized polyacrylonitrile (SeSPAN) cathode, the Li–S cell has delivered a high capacity of 626 mAh g −1 in 500th cycle with an excellent capacity retention no less than 93%. This work provides a new insight to electrolyte design strategy of advanced electrolytes for Li–S batteries .
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ONCOGENE
·
2026
·
IF 9.1
Yu Weidong,Wang Bo,Meng Fanhao,Ren Xiaojun,Zhou Danyi,Wei Huanxin,Yang Zhengquan,Sun Hongwei,Jiang Minghua,Xia Tao,Cui Wei,Fang Hezhi
Pancreatic ductal adenocarcinoma (PDAC) cells rely on fatty acid oxidation (FAO) for proliferation; however, the regulatory mechanisms governing this dependency and their clinical implications remain unclear. Here, we report that PDAC patients exhibit decreased plasma levels of propionyl-CoA intermediates, alongside accelerated propionyl-CoA catabolic activity within both human PDAC tumors and Pd x1-Cre/ Kras G12D/+ / Trp53 R 172H/+ (KPC) mouse tumors. Specifically, PDAC cells upregulate propionyl-CoA carboxylase (PCC) to accelerate propionyl-CoA catabolism, thereby establishing a metabolic signature distinct from that of healthy tissues. Mechanistically, PCC is essential for PDAC growth, not by fueling the TCA cycle, but by preventing toxic propionyl-CoA accumulation. We further demonstrate that elevated propionyl-CoA leads to the propionylation-induced inactivation of the mitochondrial fatty acid oxidation (FAO) enzyme ACAA2 at Lysine 137, thereby blocking the FAO flux required for tumor proliferation. Moreover, high PCCA expression in patient PDAC tumors is significantly associated with decreased lipid accumulation, and PDAC cells with high PCC levels are more sensitive to etomoxir-induced cell proliferation arrest. These findings establish the PCC-ACAA2 axis as a critical metabolic vulnerability and a promising target for diagnostic and therapeutic interventions in PDAC.
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ENZYME AND MICROBIAL TECHNOLOGY
·
2018
·
IF 2.932
Yuping Shen,Man Wang,Yufei Chen,Lili Xu,Yi Lu,Yiying Zhou,James P. Tam,Feng Han,Huan Yang,Xiaobin Jia
Sagittatoside B, a rare secondary flavonol glycoside in Epimedii Folium, has much better in vivo bioactivities than its original glycoside epimedin B. Its preparation methods, such as acidic hydrolysis, are of low efficiency, and byproducts are generated. The objective of this study was to establish a novel catalysis system for convenient preparation of this compound based on recyclable and integrated biphase enzymatic hydrolysis. β -glucanase was selected from five commercial enzymes based on the best catalysis performance. After optimization of the conditions, the biphase system was constructed with propyl acetate and HAc-NaAc buffer (pH 4.5) (1:1 , v/v ) containing β -glucanase/epimedin B (1:2, w/w ), and the hydrolysis was performed at 60 °C for 1 h. Consequently, epimedin B was completely hydrolyzed to sagittatoside B, and 95.7% of the product was transferred into the organic phase. Moreover, a high conversion ratio of 94.0% was achieved, even after the enzyme solution was used for six cycles. Additionally, the procedure was much simplified compared with conventional enzymatic hydrolysis. The newly proposed strategy is an efficient and promising approach for the preparation of sagittatoside B in industrial applications.
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TALANTA
·
2019
·
IF 4.916
Wei Si,Yanfang Liu,Yuansheng Xiao,Zhimou Guo,Gaowa Jin,Jingyu Yan,Aijin Shen,Han Zhou,Fan Yang,Xinmiao Liang
Gangliosides , widely distributed in tissues and body fluid, have been connected to the therapy of cancer and brain related diseases. The complexity of the gangliosides structures with different polar moieties coexisting, a carbohydrate moiety and a ceramide chain, make it a great challenge in separation and analysis science. This study aimed to develop a strategy on the basis of high-accuracy data collected by an offline two-dimensional (2D) supercritical fluid chromatography (SFC) × reversed phase liquid chromatography (RPLC)/quadrupole time-of-flight (Q-ToF) system, and to integrate an in-house library with self-developed software for fast screening and identification of gangliosides from a complex sample (swine brain extract). Subsequent positive-mode MS/MS was used to validate the identified gangliosides. Finally, 153 gangliosides were separated and 79 of them were identified by the in-house library and self-developed software, 4-fold more than those by manual identification (18 gangliosides). Among the identified ones, 20 were detected in swine brain for the first time. This study established an offline 2D SFC × RPLC system and provided a new method for fast screening and automatic identification of gangliosides in complex mixtures. It will be conducive to further study of biological functions of gangliosides.
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INORGANICA CHIMICA ACTA
·
2018
·
IF 2.264
Feng He,Dan Wang,Baiyu Jiang,Zhen Zhang,Zhenmei Cheng,Zhisheng Fu,Qisheng Zhang,Zhiqiang Fan
A novel α-diimine nickel pre-catalyst Cat.1 with two electron-donating methyl substituents on the ligand backbone was synthesized and investigated for ethylene polymerization using methylaluminoxane as cocatalyst. Cat.1 exhibited higher polymerization activity and produced highly branched polyethylene with slightly higher molecular weight than that of the typical Brookhart catalyst ( B-Cat ) at elevated temperature. By tracing the changes of active center number in the polymerization process, Cat.1 was found to have higher ratio of activated nickel ([C ∗ ]/[Ni]), longer catalyst lifetime and larger chain propagation rate constant ( k p ) as compared with B-Cat . The computational studies demonstrated the electron-donating methyl substituents can make a more electron-rich ligand to influence the catalytic properties of Cat.1 . Stronger interactions between the electron-rich ligand and the nickel center should be the main reasons for longer catalyst lifetime and enhanced thermal stability of Cat.1 . The production of polyethylene with higher molecular weight by Cat.1 can be explained by its larger k p value and more stable transition state for ethylene insertion than for chain transfer reaction due to the electron-donating ligand. Overall, the results of this work clearly support the importance of ligand electronic effects on the thermal stability and intrinsic reactivity of active centers in α-diimine Ni(II) catalysts.
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JOURNAL OF CHEMICAL THERMODYNAMICS
·
2018
·
IF 2.631
Qingsong Li,Bing Jia,Liping Wang,Mengmeng Yan,Hai Liu,Yingmin Yu
The liquid-liquid equilibrium (LLE) data for the water + 2,2,3,3-tetrafluoro-1-propanol + isopropyl ether/tert-butyl methyl ether ternary systems were measured at 298.2 K and 308.2 K under 101.3 kPa. The distribution coefficients and separation factors were employed to assess the capacity of solvents to extract 2,2,3,3-tetrafluoro-1-propanol from aqueous solution. Meanwhile, the reliability of the experimental data was confirmed using the Bachman and Hand equations. The NRTL and UNIQUAC models were used to correlate the experimental data and relevant binary interaction parameters were regressed. The root mean square deviations (RMSD) of the NRTL and the UNIQUAC models were less than 0.5%, which indicate that the experimental LLE data can be successfully correlated by both models.
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APPLIED ORGANOMETALLIC CHEMISTRY
·
2018
·Vol. 32
·期 12
·e4566
·
IF 3.581
Feng He,Dan Wang,Anyang Wu,Baiyu Jiang,Zhen Zhang,Zhenmei Cheng,Zhisheng Fu,Qisheng Zhang,Zhiqiang Fan
An α-diimine nickel catalyst (Cat-1) with highly conjugated acenaphthylene backbone was synthesized and used in ethylene polymerization. Compared with typical Brookhart catalyst B-Cat, Cat-1 could produce polyethylene with both higher molecular weight (up to 5.1 × 10 5 g mol −1 ) and branching density (up to 135 branches per 1000 carbons) in good polymerization activity. The polyethylene prepared using Cat-1 with higher molecular weight and branching density possessed exceptional mechanical properties (ultimate tensile strength and elongation at break could reach 12.08 MPa and 1148%) and outstanding elastomeric recovery as compared with the polymer prepared using B-Cat. Cat-1 was synthesized using a simple reaction route and the polymerization conditions were suitable for the industrial polymerization process. The novel nickel catalyst Cat-1 is promising for producing highly resilient polyethylene elastomers industrially.
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Polymers
·
2024
·Vol. 16
·期 12
·1680
·
IF 4.7
Hui Li,Changmiao Huang,Zixuan Teng,Yushu Luo,Chaocan Zhang,Lili Wu,Wenchao Huang,Tingting Zhao,Lijie Dong,Wanyu Chen
Zinc-ion batteries are promising candidates for large-scale energy storage. The side reactions of the hydrogen evolution reaction (HER) and zinc dendrite growth are major challenges for developing high-performance zinc-ion batteries. In this paper, a supramolecular gel electrolyte (BLO-ILZE) was self-assembled in an ionic liquid (EMIMBF4) with zinc tetrafluoroborate (Zn(BF4)2) on the separator in situ to obtain a gel electrolyte used in zinc-ion batteries. BLO-ILZE is demonstrated to significantly enhance conductivity over a broad temperature range between −70 and 100 °C. Interestingly, through testing and fitting, it is found that the supramolecular gel electrolyte satisfies the liquid state law over a wide temperature range, and even achieves high conductivity (2.12 mS cm−1) at −40 °C. It is equivalent to the conductivity of aqueous zinc-ion batteries (ZnSO4/H2O) at −10 °C, which is 2.33 mS cm−1. Moreover, the supramolecular gel electrolyte can effectively inhibit the HER, thus exhibiting a longer lifetime in Zn/Zn cells for 3470 h at 1 mA cm−2compared to the aqueous zinc-ion batteries with the Zn(BF4)2aqueous electrolyte (400 h at 1 mA cm−2). The assembled V2O5/BLO-ILZE/Zn full cells also showed cycling performance, with 5000 cycles at 0.5 mA g−1at room temperature, a capacity of 98%, and a coulombic efficiency of about 100%.
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