Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 16
·2657-2666
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IF 5.047
Maowen Chen,Yan Hu,Yanhua Hou,Menghuan Li,Maohua Chen,Caiyun Mu,Bailong Tao,Wei Zhu,Zhong Luo,Kaiyong Cai
Autophagy is associated with the proliferation and differentiation of mesenchymal stem cells (MSCs). In this study, we investigated the biological impact of silica-based nanobiomateiral-induced autophagy on the differentiation of MSCs, in which the nanoparticulate cues include solid silica nanoparticles (SSN), mesoporous silica nanoparticles (MSN) and biodegradable mesoporous silica nanoparticles (DMSN). The treatment with SSN significantly up-regulated the LC3-II expression via ERK1/2 and AKT/mTOR signaling pathways compared to DMSN and MSN, leading to a higher autophagic activity in MSCs. The enhanced protein adsorption of DMSN and MSN could prevent the direct interaction between cells and nanoparticles, which consequently reduces the autophagic stimulation of MSCs. It should be noted that MSCs exhibited increased differentiation potential when the autophagic activity was enhanced by the treatment with different nanoparticles. In comparison, no difference in the cell differentiation potential was found when an autophagy inhibitor (chloroquine, CQ) was incorporated in all groups. The study may contribute to the development of silica-based nanobiomaterials in the future.
研究领域:
纳米生物技术
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干细胞生物学
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材料科学
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细胞与分子生物学
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DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2018
·
IF 5.08
Long Huang,Saijiao Yang,Junyu Chen,Jianwen Tian,Qiang Huang,Hongye Huang,Yuanqing Wen,Fengjie Deng,Xiaoyong Zhang,Yen Wei
Fluorescent silica nanoparticles (FSNPs) have attracted great interest for potential applications in biological and biomedical fields because they possess higher fluorescence quantum yield and better fluorescence stability as comparison with small organic fluorescent molecules. The encapsulation of covalent linkage with fluorescent organic dyes or fluorescent metal complexes has demonstrated to be the commonly adopted strategies for fabrication of FSNPs previously. However, it is still challengeable to obtain FSNPs based polymer composites with intensive fluorescence and good water dispersibility through a one-pot surface modification strategy. In this paper, we developed a facile method to fabricate novel FSNPs based polymer composites (PhE@MSNs-PEtOx) through introducing the aggregation-induced emission (AIE) dye (PhE-OH) and poly(2-ethyl-2-oxazoline) (PEtOx) onto mesoporous silica nanoparticles (MSNs) based on cationic ring opening polymerization (CROP). The resulting PhE@MSNs-PEtOx composites possess strong fluorescence emission, excellent hydrophilicity and biocompatibility. These features make the final FSNPs based polymer composites great potential for biomedical applications. Taken together, we have developed for the first time that FSNPs based polymer composites can be facilely prepared through the one-pot introduction of AIE dyes and hydrophilic PEtOx on MSNs. Moreover, the novel FSNPs based composites could also be utilized for other biomedical applications considered their properties.
研究领域:
材料科学
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生物医学工程
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化学
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DOI
PubMed
高影响因子
DRUG DELIVERY
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2018
·
IF 3.095
Bin Ma,Lizhen He,Yuanyuan You,Jianbin Mo,Tianfeng Chen
Nanomaterials-based drug delivery systems display potent applications in cancer therapy, owing to the enhanced permeability and retention effect and diversified chemical modification. In this study, we have tailored and synthesized different sized mesoporous silica nanoparticles (MSNs) through reactant control to investigate the relevancy of nanoparticle size toward anticancer efficacy and suppressing cancer multidrug resistance. The different sized MSNs loaded with anticancer ruthenium complex (RuPOP) and conjugated with folate acid (FA) to enhance the selectivity between cancer and normal cells. The nanosystem (Ru@MSNs) can specifically recognize HepG2 hepatocellular carcinoma cells, thus enhance accumulation and selective cellular uptake. The smaller sized (20 nm) Ru@MSNs exhibit higher anticancer activity against HepG2 cells, while the larger sized (80 nm) Ru@MSNs exhibit higher inhibitory effect against DOX-resistant hepatocellular carcinoma cells (R-HepG2). Moreover, Ru@MSNs induced ROS overproduction in cancer cells, leading to DNA damage and p53 phosphorylation, consequently promoting cancer cells apoptosis. Ru@MSNs (80 nm) also inhibited ABCB1 and ABCG2 expression in R-HepG2 cells to prevent drug efflux, thus overcome multidrug resistance. Ru@MSNs also inhibited tumor growth in vivo without obvious toxicity in major organs of tumor-bearing nude mice. Taken together, these results verify the size effects of MSNs nanosystem for precise cancer therapy.
研究领域:
肿瘤学
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纳米医学
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药物递送
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分子生物学
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转化医学
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DOI
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
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2017
·Vol. 19
·期 2
·1-13
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IF 2.02
Hu Nan,Liu Wei,Ding Linlin,Wu Zhaoliang,Yin Hao,Huang Di,Li Hongzhen,Jin Lixue,Zheng Huijie
Dye pollution has been a severe problem faced by worldwide environmentalists. The use of nanoparticles as adsorbents has attracted widespread interests for effectively removing dyes, while the separation of them from an aqueous solution is a difficult and important subject. For achieving the simultaneous removal of methylene blue (MB) and nanoadsorbents, this work utilized a commercial hydrophobic silica nanoparticle (SNP) (200.0 ± 10.0 nm in average particle size) as a collector and then developed a novel froth flotation technology without using any surfactants. Under the suitable conditions of anhydrous ethanol dosage of 8 mL, pH of 9.0, SNP concentration of 600 mg/L, and flotation column height of 600 mm, the removal efficiencies of MB and SNPs and the volume ratio reached 91.1 ± 4.6%, 93.9 ± 4.7%, and 10.5 ± 0.5, respectively. Subsequently, the recovered MB-adsorbed SNPs in the foamate were separated by free setting due to their high concentration and massive agglomeration. After free setting, MB could be effectively separated from the recovered MB-adsorbed SNPs by using ethanol at pH 2.0 and repeating five cycles of washing-centrifugation. Additionally, the regenerated SNPs could be reused for removing MB up to five times. Overall, this work had a significant meaning for the treatment of dye-contaminated wastewaters.
研究领域:
环境科学
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纳米技术
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水污染控制
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DOI
高影响因子
Scientific Reports
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2025
·Vol. 15
·期 1
·1-12
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IF 3.9
Li Silong,Li Na,Yin Qiangqiang,Zhang Zhichen,Hu Haifeng,Hao Liguo
This project aims to construct cRGD functionalized mesoporous silica nanoparticles and cRGD modified mesoporous silica nanoparticles for the diagnosis and treatment of tumors, providing new ideas for targeted therapy of tumors. The mesoporous silica nanoparticles were doped with gadolinium in situ to provide excellent imaging; cRGD was coupled on the particle surface to confer particle targeting; and hyaluronic acid was loaded onto the particles by electrostatic adsorption, thereby improving the biocompatibility of the particles and prolonging their in vivo circulation time.Taking pancreatic cancer as a model, we studied its targeting ability to pancreatic cancer and its phagocytosis to cancer cells; Using methods such as cell growth experiments and flow cytometry, the anti-cancer effect and pro apoptotic effect of the system were studied. In vivo distribution, tumor targeting and therapeutic efficacy of nanoparticles evaluated in a mouse model of pancreatic cancer with loaded tumors.Evaluate the bioavailability and enrichment of nanoparticles in tumor tissue using MRI technology. Evaluate the therapeutic effect and safety through changes in tumor volume, histopathological examination, and prognosis. Characterization of the synthesis results proved that cRGD-HA-DOX-Gd 2 O 3 @MSN (cHDG@MSN) was successfully synthesized with a particle size of 230.83 ± 12.36 nm.In vitro drug release experiments of DOX were carried out at different pH values (5.5 and 7.4), where the release was only up to 22.65% at pH 7.4, whereas DOX release was increased up to 78.75% at pH = 5.5.The results confirm the pH responsiveness of this nanocarrier platform.The results of cytotoxicity studies showed that cHDG@MSN itself is not cytotoxic. Biosafety evaluation and hemolysis test results confirmed that the probe is highly biocompatible.Notably, Gd 3+ significantly enhanced the T 1 contrast of the system according to MR imaging results.The apoptosis rates of SW1990 cells treated with PBS, DOX and cHDG@MSN in flow cytometry were 13.97%, 18.38% and 29.02%, respectively, demonstrating the effectiveness of the nanoprobes at the cellular level. Animal experiments demonstrated the effectiveness of nanoprobes at the pathological level and imaging level.Cells and animals demonstrated that cHDG@MSN effectively inhibited the proliferation of pancreatic cancer cells. This research further verified the pH sensitivity of the constructed compound drug delivery system to achieve accurate diagnosis and treatment of pancreatic cancer tumor cells.
研究领域:
肿瘤学
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纳米医学
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影像医学
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产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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2017
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IF 3.756
Guirong Zheng,Ruirui Zhao,Aixiao Xu,Zhichun Shen,Xian Chen,Jingwei Shao
Combination with chemotherapeutic drug and gene therapy has been proven highly effective in suppressing tumor progression. Hence, an asialoglycoprotein receptor (ASGPR)-targeting nanodrug delivery system based on mesoporous silica (MSN) nanocarrier for co-delivery of sorafenib (SO) and vascular endothelial growth factor (VEGF) targeted siRNA (siVEGF) to hepatocellular carcinoma (HCC) was successfully designed and synthesized. The structure of nanoparticles was characterized by IR, particle size, zeta potential and N2 adsorption-desorption. The nanoparticles were further evaluated for drug release, cellular uptake, transfection, cell cytotoxicity and cell cycle against HepG2 and Huh7 cells. In vitro testing demonstrated that MSN-LA delivery system could not only induce S cell cycle arrest, enhance the cytotoxicity and improve the tumor target of SO and siVEGF, but also enhance the siVEGF transfection efficiency in ASGPR-overexpressing Huh7 cells. Overall, the MSN-LA delivery system can be a promising drug carrier which could further enhance the anti-cancer efficacy of SO and siVEGF via the active targeting property of LA .
研究领域:
药剂学
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肿瘤学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2019
·Vol. 7
·期 9
·4941-4949
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IF 10.733
Weifeng Zhang,Xiangyu Li,Ruixiang Qu,Yanan Liu,Yen Wei,Lin Feng
Janus membranes with opposite wetting behavior on each side are of great significance in the oil/water separation field. However, most of the reported work only focuses on the separation of immiscible oil/water mixtures instead of emulsions. In addition, almost no previous work pays attention to whether the filtrate after the separation process can meet industrial emission standards. In order to achieve controllable stabilized emulsion separation with high efficiency, a polyaniline–silica nanoparticle (PANI–SiNP)-modified Janus membrane is prepared through a facile immersion-spray coating method. PANI polymer and SiNPs are modified on two sides of the substrate, just like Yin and Yang in Chinese Tai Chi, and have opposite but complementary properties. The PANI-coated surface is superhydrophilic with underwater superoleophobic wettability, which can separate oil-in-water emulsions (including different ionic types and crude oil-in-sea water emulsion) when it is facing up. Conversely, the SiNP-coated surface exhibits opposite wettability with superhydrophobicity and superoleophilicity, which can separate water-in-oil emulsions when this side is facing up. More importantly, this Janus material has high efficiency for both oil-in-water and water-in-oil emulsions, meeting the industrial emission and purification standards. The membrane shows excellent stability and recyclability, which means it can be applied in practical wastewater treatment.
研究领域:
材料科学
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环境工程
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
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2013
·Vol. 48
·期 17
·5718-5726
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IF 2.163
Han Linbo,Zhou Ying,He Ting,Song Guosheng,Wu Fan,Jiang Feiran,Hu Junqing
A simple synthetic method has been developed for synthesis of mesoporous silica nanoparticles with versatile morphologies by adopting CTAB and C 12 –OH as dual soft templates. In such a simple method, only by regulating the dose of C 12 –OH and temperature, we can well-realize the silica nanoparticle morphological transformation from sphere to shell-like, rugby-like, peanut-like, hollow, and complex yolk–shell structures. These as-fabricated silica nanoparticles were characterized by scanning electron microscopy, transmission electron microscopy, Brunauer–Emmett–Teller (BET), and small-angle powder X-ray diffraction. The as-prepared mesoporous silica nanoparticles with versatile morphologies possessing varying BET surface areas, pore diameter, and pore distributions have some potential applications in separation, sensing, and heterogeneous catalysis.
研究领域:
材料科学
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纳米技术
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DOI
高影响因子
Soft Matter
·
2019
·Vol. 16
·期 2
·383-389
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IF 3.399
Yaping Zhang,Bin Zhen,Yue Hu,Guohong Liang,Yaqing Feng
Reverse micellar systems possess a characteristic nanoscale water-in-oil (w/o) structure and can offer mild conditions as a unique and versatile reaction medium. Reverse microemulsions containing water/TX-100 + hexanol/hexane are studied in this work through experimental techniques and simulation methods. Surfactant dosages and water amount affect the micellar structure profoundly, and the polydispersity of the surfactant molecules affects the micellar structure remarkably. TX-100 with 9–10 EO units can form micelles in a simply piling way, while TX-100 with 5–10 EO units endows the micelles with a hierarchical micellar interface and a more compact structure, leading to monodisperse micelles with a smaller diameter. Water in the polar cores has three states. In the reverse micellar system using TX-100 with 9–10 EO units, hydrolysis of tetraethoxysilane happens rapidly and the formed silica gels are apt to aggregate, resulting in polydisperse silica nanoparticles. For the micellar system using TX-100 with 5–10 EO units, the micellar hierarchical distributed interface facilitates the material exchange of tetraethoxysilane and limits the hydrolysis of tetraethoxysilane inside the micelles, providing monodisperse silica nanoparticles.
研究领域:
胶体化学
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材料科学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
Polymers
·
2018
·Vol. 10
·期 7
·726
·
IF 2.935
Qing Yin,Zhenguo Zhu,Wei Li,Maolian Guo,Yu Wang,Jianping Wang,Xingxiang Zhang
Microencapsulation of phase change materials (PCMs) could prevent the leakage of PCMs during solid–liquid phase change process. However, their applications are mainly limited by the compactness and thermal stability of the traditional polyurea shell microcapsules. To increase the thermal compactness and thermal stability of PCM microcapsules, tetraethylorthosilicate (TEOS) was employed to form polymer/SiO2composite shells to enhance the mechanical performance of polyurea and polyurethane microcapsule via interfacial polymerization and in situ polymerization. The morphology and chemical components of the microcapsules were characterized by field-emission scanning electron microscope (FE-SEM) and Fourier transform infrared (FT-IR) spectroscopy, respectively. The thermal properties of the microcapsules were investigated by differential scanning calorimetry (DSC) and thermal gravity analysis (TGA). The results showed the smoothness and compactness of both polyurea–SiO2and polyurethane–SiO2microcapsules enhanced slightly, when compared with that without TEOS addition. Moreover, the SiO2composite shell had good effect on thermal compactness, as the weight loss rate of polyurea–SiO2microcapsules and polyurethane–SiO2microcapsules decreased 3.5% and 4.1%, respectively.Keywords:phase change material;microcapsules;polyurea;SiO2nanoparticles;polyurethane
研究领域:
材料科学
·
化学工程
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产品关联
DOI
PubMed
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2022
·
IF 6.064
Zhang Hanyuan,Xu Jianxiang,Zhang Xu,Wang Teng,Zhou Dairan,Shu Wei,Zhao Tingting,Fang Weijun
Developing drug delivery nanosystems with both anticancer and antibacterial effects is of great clinical value. Herein, we report a facile approach to synthesize Ag and quaternary ammonium salt (QAS) co-decorated mesoporous silica nanoparticles (MSNs), namely, Ag/QAS-MSNs, for synergistic treatment of cancer and bacterial infections. In vitro studies demonstrated that Ag/QAS-MSNs not only had a strong antibacterial activity against the bacterial pathogens but also could efficiently induce cancer cell death through an apoptotic pathway. Moreover, in vivo combination therapy with Ag and QAS in Ag/QAS-MSNs was also tested in a nude mouse tumor model, and a significant synergistic anticancer effect, which is superior to that obtained by therapy with Ag-MSNs or QAS-MSNs alone, was achieved. Such excellent anticancer and antibacterial activity of Ag/QAS-MSNs could be attributed to the synergistic effect of Ag ions and QAS. Thus, Ag/QAS-MSNs have a promising future as potent anticancer agents with high antibacterial performance.
研究领域:
纳米医学
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肿瘤学
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微生物学
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产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2021
·
IF 7.086
Han Qiao,Xiaoxiang Wang,Peng Liao,Cheng Zhang,Chongxuan Liu
A novel Mn(II) encapsulated mesoporous silica nanoparticles (Mn-MSNs) was developed for efficiently removing antibiotic tetracycline from aqueous solutions. The material has a well-ordered, hexagonal mesopore structure with a large specific surface area (720 m 2 /g) and maximum sorption capacity (229 mg/g) that is about an order of magnitude higher than that of mesoporous silica nanoparticles without Mn-encapsulated, or encapsulated with other transition metal cations Fe 3+ and Cu 2+ . Sorption results showed that the materials can sequestrate tetracycline within a large concentration range (5 μg/L–450 mg/L). Batch sorption experiment, spectroscopic analysis and density functional theory calculation collectively indicated that Mn–O complexation was the dominant mechanism for the tetracycline sorption. Electrostatic attraction and cation-π interaction also contributed to tetracycline sorption with their contribution levels varying with pH in a synergetic way with the Mn–O complexation. The Mn(II) encapsulated MSNs exhibited a good regeneration property over five repeated sorption-desorption cycles, demonstrating its promising potential in the cost-effective applications of sequestrating tetracycline from wastewater, drinking water , and contaminated solutions.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）