Nanomaterials
·
2022
·Vol. 12
·期 13
·2207
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IF 5.719
Xin Li,Xiaobin Wang,Wei Guo,Feng Luan,Chunyuan Tian,Xuming Zhuang,Lijun Zhao
In this paper, the SQDs@MnO2NS as the probe was applied to construct a novel “turn-on” fluorescent sensor for sensitive and selective detection of hydrazine (N2H4). Sulfur quantum dots (SQDs) and MnO2nanosheets (MnO2NS) were simply mixed, through the process of adsorption to prepare the architectures of SQDs@MnO2NS. The fluorescent emissions of SQDs@MnO2NS play a key role to indicate the state of the sensor. According to the inner filter effect (IFE) mechanism, the state of the sensor at the “off” position, or low emission, under the presence of MnO2NS, is which the ultraviolet and visible spectrum overlaps with the fluorescence emission spectrum of SQDs. Under the optimal conditions, the emission was gradually recovered with the addition of the N2H4, since the N2H4as a strong reductant could make the MnO2NS converted into Mn2+, the state of the sensor at the “on”. Meanwhile, the fluorescent sensor possesses good selectivity and high sensitivity, and the detection concentration of N2H4with a wide range from 0.1 µM to 10 mM with a detection limit of 0.072 µM. Furthermore, actual samples were successful in detecting certain implications, indicating that the fluorescent sensor possesses the potential application ability to monitor the N2H4in the water.Keywords:sulfur quantum dots;MnO2nanosheet;hydrazine;fluorescence probe
研究领域:
分析化学
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环境科学
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2015
·
IF 4.097
Yi He,Wei Huang,Yun Liang,Haili Yu
A novel, label-free, and low-cost colorimetric assay is developed for the detection of hydrazine with high-selectivity and excellent sensitivity using MnO 2 nanosheets as probes. It is first time demonstrated that MnO 2 nanosheets can be used as colorimetric probes for environmental analysis. In the absence of hydrazine, MnO 2 nanosheets exhibit a strong ultraviolet–visible (UV–vis) absorption peak at 370 nm due to the d-d transition. Once hydrazine is introduced, MnO 2 nanosheets will be reduced to Mn(OH) 2 nanoparticles, and the absorbance at 370 nm decreases remarkably. In this case, a distinct color change from yellow to colorless can be observed, which is dependent on the concentration of hydrazine. The signal change can allow colorimetric detection of hydrazine. The assay offers a good linear range from 0.5 μM to 20 μM and a detection limit of 0.4 μM for hydrazine. The lowest detection concentration by the naked eye is as low as 11 μM. Additionally, the developed assay was successfully applied for the colorimetric detection of hydrazine in environmental water samples.
研究领域:
分析化学
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环境科学
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DOI
高影响因子
Results in Surfaces and Interfaces
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2024
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IF 0
Xiaohan Jiang,Junjie Zhang,Zitong Zhou,Zihao Zhou,Xinyi Cheng,Shaojun Shi,Jiexia Chen,Yunyun Ling
Blue fluorescent carbon dots with high purity were synthesized through a one-step hydrothermal method using citric acid and ethylenediamine as raw materials and then purification by column chromatography. In-situ controllable synthesis was used to prepare carbon dots-manganese dioxide (CDs-MnO 2 ) nanosheets, with carbon dots as the seed, potassium permanganate as the manganese source and sodium citrate as the reducing agent. The as-prepared nanosheets were characterized by transmission electron microscopy, absorption spectroscopy, and fluorescence spectroscopy. It was found that MnO 2 can be degraded by Glutathione (GSH) through a redox reaction, which restores the fluorescence of CDs. A new method for determining GSH was constructed using CDs-MnO 2 fluorescence sensing. The method is simple and sensitive, with linear ranges of 0.1–5 μM and 10–60 μM, respectively, and a lowest detection limit of 0.034 μM. The method was successfully used for the determination of GSH in human serum, with satisfactory recoveries in the range of 98.9–100.1%.
研究领域:
分析化学
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生物传感
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纳米材料
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DOI
Analytical Methods
·
2017
·Vol. 9
·期 38
·5653-5658
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IF 1.9
Yalei Hu,Lin Zhang,Xin Geng,Jia Ge,Haifang Liu,Zhaohui Li
Ascorbic acid (AA) is a significant small biomolecule and plays a key role in many biochemical processes. In this work, a rapid turn-on fluorescent probe was developed for sensitive and selective sensing of AA based on carbon dots–MnO2 nanocomposites. The nanocomposites were constructed by in situ synthesis of MnO2 nanosheets in carbon dot (C-dot) solution, and the fluorescence of C-dots was quenched with the formation of the nanocomposites due to the fluorescence resonance energy transfer (FRET) from C-dots to the generated MnO2 nanosheets. Once AA was introduced into the system, MnO2 nanosheets were reduced to Mn2+ and the fluorescence of C-dots would be recovered. Under the optimized conditions, this method shows rapid and sensitive response toward AA, the assay time is 2 min and the limit of detection is 68 nM. Moreover, the carbon dots–MnO2 nanocomposite based fluorescence sensing system was successfully employed to determine AA in commercial tablets with satisfactory results. Taking full advantage of C-dots and MnO2 nanosheets, this probe shows remarkable properties including easy operation, low cost and good biocompatibility, and has great potential to be used in biological and clinical diagnostic applications.
研究领域:
分析化学
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生物医学
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材料科学
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DOI
高影响因子
Analytical Methods
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2019
·Vol. 11
·期 11
·1469-1474
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IF 2.378
Ping Chen,Hui Zhong,Xiang Wang,Changdong Shao,Sanjun Zhi,Xiao-Rong Li,Changmei Wei
Ascorbic acid (AA), as a key coenzyme in human metabolic pathways, plays an important role in various physiological reactions. An abnormal level of AA is found to be associated with several diseases. In this paper, we developed a label-free colorimetric method for the determination of AA by using manganese dioxide (MnO2) nanosheets. Once AA was introduced, MnO2 was reduced to Mn2+, which resulted in a remarkable color fading of MnO2 nanosheet solution. Thus, AA can be quantified by photometry in a linear range from 0.1 to 20 μM with a detection limit of 98 nM. The detection strategy possesses the advantages of versatility and low cost and shows great potential for AA detection in clinical medicine and food safety.
研究领域:
分析化学
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医学检验
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食品安全
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DOI
高影响因子
Analytical Methods
·
2023
·Vol. 15
·期 33
·4059-4065
·
IF 3.1
Hao Liang,Danliang Li,Xuebing Zhang,Deshuai Zhen,Yunfei Li,Yuchen Luo,Yuyun Zhang,Dongyun Xu,Lili Chen
A simple dual-signal assay that combined colorimetric and fluorometric strategy for uric acid (UA) rapid detection was designed based on the versatility of facile synthesized MnO2 nanosheet. The oxidization of 3,3′,5,5′-tetramethylbenzidine (TMB) and the fluorescence quenching of quantum dots (QDs) occurred simultaneously in the presence of MnO2 nanosheet. UA could decompose MnO2 nanosheet into Mn2+, resulting in the fluorescence recovery of QDs, along with the fading of the blue color of ox TMB. Based on the principles above, the detection of UA could be realized by the change of the dual signals (colorimetric and fluorometric). The linear range of the colorimetric mode was 5–60 μmol L−1, and the limit of detection (LOD) was 2.65 μmol L−1; the linear range of the fluorescence mode was wide at 5–120 μmol L−1, and the LOD could be as low as 1.33 μmol L−1. The method was successfully used for analyzing UA levels in human serum samples, indicating that this new dual-signal method could be applied in clinical diagnosis.
研究领域:
生物化学
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医学诊断
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纳米技术
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DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2020
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IF 3.232
Kuanxia Ma,Lushan Liang,Xie Zhou,Weiguo Tan,Ou Hu,Zuanguang Chen
We develop a simple hydrothermal method to prepare a novel nitrogen-doped carbon dots (N-CDs) originated from green carbon source Liu-bao tea and ethylene diamine. The N-CDs emits strong and stable blue fluorescence (E m = 440 nm) under the excitation wavelength of 350 nm with a quantum yield of 35%. And it is used as an excellent fluorescent output for the sensitive and visual dual-mode determination of isoniazid. The fluorescence of N-CDs is “turned off” first by manganese dioxide (MnO 2 ) nanosheets due to inner filter effect, MnO 2 nanosheets can also oxidize TMB (3,3',5,5'- tetramethylbenzidine) to blue oxTMB. Isoniazid, however, can reduce MnO 2 nanosheets to Mn 2+ , turning on the fluorescence again. The color of the solution fades from blue to colorless because less TMB can be oxidized. Under the optimal conditions, the dual-mode method has a satisfying linear relationship ranging from 2.0 to 120.0 μM with a limit of detection of 0.7 μM (S/N = 3). And it has been applied successfully to colorimetric and fluorescent determination of isoniazid in tablets and clinical plasma samples, with recoveries ranging from 94.0% to 102.4%. The properties of N-CDs and MnO 2 nanosheets were thoroughly characterized using TEM, FT-IR, XPS, AFM and fluorescence spectrophotometer, the quenching mechanism was also discussed.
研究领域:
分析化学
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药物分析
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生物医学
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2016
·
IF 4.758
Zhong-Ming Huang,Qi-Yong Cai,De-Cai Ding,Jia Ge,Ya-Lei Hu,Jie Yang,Lin Zhang,Zhao-Hui Li
Glutathione (GSH) provides essential functions towards metabolism process in biological systems and is related to many diseases such as human immunodeficiency virus, Parkinson, cardiovascular diseases, etc. In this work, a very simple, fast and label-free colorimetric method for highly sensitive GSH quantification is proposed. This strategy is based on the color change of MnO 2 nanosheets solution from yellowish-brown to colorless. Without GSH, MnO 2 nanosheets exhibit a strong ultraviolet–visible (UV–vis) absorption peak at 376 nm with the color showing as yellowish-brown. Once GSH is introduced, MnO 2 nanosheets are reduced to Mn 2+ ions rapidly, which leads to a yellowish-brown color fading and a remarkable decrease of the absorbance at 376 nm. Based on the distinct color change, a method for highly sensitive and selective detection of GSH was realized with bare eyes and UV–vis spectroscopy, respectively. This method has a wide dynamic range from 0.5 μM to 100 μΜ and shows a good linear relationship from 0.5 μM to 10 μΜ with a detection limit of 0.1 μM. More importantly, this procedure is very simple and the whole assay can be accomplished quickly within 5 min. Additionally, this developed assay has also been successfully applied to the detection of GSH in biological fluids with satisfactory results.
研究领域:
分析化学
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生物医学
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纳米材料科学
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 18
·15121-15126
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IF 3.201
Jie Yang,Zhongming Huang,Yalei Hu,Jia Ge,Jianjun Li,Zhaohui Li
Uric acid (UA) is an important biological molecule in human pathology and is related to many critical diseases. Designing a simple and rapid method for sensitive UA determination is of great significance. Herein, we report a novel turn-on fluorescence assay for UA detection, based on fluorescence resonance energy transfer (FRET) between carbon dots (C-dots) and MnO2 nanosheets. MnO2 nanosheets can adsorb C-dots to form nanocomposites, where the fluorescence of C-dots is quenched via FRET. Fluorescence recovered when UA was introduced into the sensing system due to the decomposition of MnO2 nanosheets to Mn2+. Under optimized conditions, the fluorescence signal was linearly related to UA concentration in the range of 0.1–200 μM and the detection limit was as low as 45 nM. Moreover, this developed assay was successfully applied for human urine sample analysis, which indicated that this strategy could be an efficient tool for clinical disease diagnosis.
研究领域:
生物化学
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医学诊断
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材料科学
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产品关联
DOI
高影响因子
TALANTA
·
2019
·
IF 4.916
Haitao Wang,Xiaokang Na,Shan Liu,Hefei Liu,Lijuan Zhang,Mingzheng Xie,Zicheng Jiang,Fei Han,Yu Li,Shasha Cheng,Mingqian Tan
Ascorbic acid (AA) is an essential vitamin and plays an irreplaceable role in humans’ daily life. Therefore, it is of profound significance to develop effective strategies for AA sensing. Herein, a novel bi-functional sensing strategy was developed by using carbon dots (CDs) and MnO 2 nanosheet as the fluorometric/magnetic signal source. When AA was absence, the fluorescence of CDs was quenched by MnO 2 nanosheet due to the inner filter effect. Neither the fluorescence nor magnetic signal of the nanoprobe can be detected. In the presence of AA, a redox reaction occurred between MnO 2 nanosheet and AA resulting in the generation of magnetic resonance imaging (MRI) response Mn 2+ and decomposing of MnO 2 nanosheet structure, thus leading to the recovery of CDs fluorescence. The detection limit of the AA was determined to be 2.89 μM with a linear range of 0–80 μM in fluorescence mode, and detection limit of 0.776 μM with a linear range of 0–80 μM in MRI mode when used transverse relaxation rate as signal. Furthermore, the developed fluorometric/magnetic bi-functional nanoprobe showed good biocompatibility, high response rate, high selectivity towards AA and could be used to analyses AA in real samples. Moreover, in vivo imaging of AA in mice was achieved in magnetic mode. The fluorometric/magnetic bi-function sensor for AA detection was introduced, which provided a novel strategy for sensor design based on CDs.
研究领域:
生物化学
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分析化学
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医学影像学
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2021
·
IF 6.057
Yue Hu,Yu-Cong Fan,Xiao-Hui Jiang,Li-Mei Zhou,Zheng-Jun Cheng
By simultaneously regulating the photoluminescence of alloy Au/Ag nanoclusters (NCs) and thiamine (VB1) through MnO 2 nanosheets (MnO 2 NS), a novel ratiometric fluorescent probe (RF-probe) was established for sensitively and selectively monitoring proanthocyanidins (PAs). The introduction of Ag (I) ions could enhance significantly the quantum yields (QYs, 11.1%) of AuNCs based on the synthetic method of UVI (UV irradiation) combined with MWH (microwave heating). MnO 2 NS could quench the fluorescence (FL) of Au/AgNCs mainly coming from Förster resonance energy transfer (FRET), while it could act as a nanozyme catalyst for directly catalyzing the oxidation of VB1 to produce highly fluorescent oxVB1. In the presence of PAs, MnO 2 was reduced to Mn 2+ , which caused that its quenching capacity and oxidase-like activity were vanished, thus the FL of oxVB1 and Au/AgNCs was reduced and recovered. The concentration of PAs could be monitored by the RF-probe with a linear range of 0.27–22.4 μmol L −1 and corresponding limit of detection (LOD) and limit of quantification (LOQ) were calculated to be 75.9 and 250.5 nmol L −1 . Furthermore, the RF-probe was successfully used for the determination of PAs in mineral water, PAs additive and PAs capsule with satisfactory results compared to the standard HPLC method.
研究领域:
分析化学
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食品科学
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生物化学
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
He Mei,Xiaolei Zhu,Ziqian Li,Jiahui Jiang,Huili Wang,Xuedong Wang,Peipei Zhou
Herein, we developed a ratiometric fluoroprobe by integrating okra-derived carbon quantum dots (CQDs) with amplex red (AR) using manganese dioxide nanosheets (MnO 2 NSs) as a medium. Fluorescence intensities (FIs) of CQDs were sharply quenched by MnO 2 NSs via an inner-filter effect processes, whereas the FIs of AR were significantly enhanced due to oxidation of AR to AR-ox by the oxidase-mimetic activity of MnO 2 NSs. Acetyrylcholinesterase hydrolyzed acetylthiocholine to produce thiocholine, and the decomposition of MnO 2 NSs to Mn 2+ by thiocholine led to the FI recovery of CQDs, but decreased FIs of AR-ox. Based on the above phenomenon and the inhibitory effect of dichlorvos (DDVP) on acetyrylcholinesterase activity, a novel ratiometric fluoroprobe for DDVP quantification was pioneered. Under optimized conditions, this fluoroprobe gave a wide linear range (4–120 μg/L), low detection limit (1.2 μg/L), and satisfactory fortification recoveries (90.0–110.0%), thereby providing good prospects for routine DDVP monitoring in foods.
研究领域:
分析化学
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食品安全
·
生物传感
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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