ENERGY & FUELS
·
2026
·Vol. 40
·期 33
·18043-18052
·
IF 6
Pang Bo,Pu Baian,Peng Hao,Xue Kang,Shi Chengxiang,Gao Ruijie,Ai Minhua,Huang Zhen-Feng,Zhang Xiangwen,Zou Ji-Jun,Pan Lun
Conventional
high-energy-density hydrocarbon fuels face an intrinsic
trade-off between increasing ring number and decreasing net heat of
combustion. To address this limitation, we propose a synthetic strategy
based on tandem [4 + 2]/[2 + 1] cycloaddition. Norbornadiene and methyl
dicyclopentadiene were employed as feedstocks to develop a coupled
synthetic approach that combines Diels–Alder [4 + 2] cycloaddition
for constructing a polycyclic framework with Simmons–Smith
[2 + 1] cyclopropanation for energy enhancement. By optimizing the
reaction parameters, the Diels–Alder and Simmons–Smith
reactions achieved optimal conversions of 77.89% and 90.96%, respectively,
with selectivities of 43.54% and 85.82%. The resulting fuel fraction
exhibits a high density of 1.060 g cm –3 , a volumetric
net heat of combustion of 44.85 MJ L –1 , and a freezing
point below −60 ° C. This study demonstrates an effective
strategy for simultaneously achieving high density, high volumetric
energy content, and excellent low-temperature performance, providing
useful guidance for the molecular design and synthesis of next-generation
high-energy-density fuels.
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ACS Applied Bio Materials
·
2026
·
IF 4.7
Fuyuan Tan,Jie Lyu,Guofeng Qu,Wenliang Li,Haiyue Peng,Yiwei Liu,Jiali Liao,Yuanyou Yang,Shuqiong Peng,Ning Liu,Feize Li
Nanoscale metal–organic frameworks have great potential in constructing a high-performance anticancer nanodrug delivery system (NDDS) for combining phototherapy and chemotherapy. However, their practical applications are still challenged by a limited antitumor effect and complex component. In this study, we proposed constructing a multifunctional NDDS via simply integrating positron-emitting radionuclide 89Zr and chemotherapeutic doxorubicin (DOX) into the porous coordination network-222 (PCN-222) featuring intrinsic photoactivity and good guest accommodation ability. It has been demonstrated that the synthesized DOX@89Zr-PCN-222 exhibits good stability, favorable nanoscale dimensions, and excellent biocompatibility. More importantly, the prepared DOX@89Zr-PCN-222 can provide bioinformation on the constructed nanoformulation from the living cells to the whole body, able to achieve controlled release of cytotoxin as a response to low pH and reductive glutathione (GSH). The excellent tumor binding ability of DOX@89Zr-PCN-222 has been confirmed by both fluorescence and nuclear imaging, particularly in vivo positron-emission tomography over 7 days. As a result, the prepared NDDS has exhibited remarkable anticancer efficacy to suppress tumor growth and prolong the median survival of a murine breast cancer model, highlighting its great potential for tumor chemo-PDT therapy.
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MACROMOLECULAR BIOSCIENCE
·
2025
·
IF 4.1
Wanyi Zhao,Haoran Chen,Man Zhang,Zhongbing Huang,Changsheng Zhao
Vascular restenosis, a significant complication after stent implantation, originates from the migration of vascular smooth muscle cells to the intima and the excessive extracellular matrix deposition, resulting in intimal hyperplasia. Thus, enhancing endothelial cell adhesion and reducing smooth muscle cell adhesion capacity are crucial to address this issue. Heparin, a naturally derived glycosaminoglycan, exhibits excellent anticoagulant activity and endothelial cell promoting effects, yet its clinical utility is constrained by bleeding risks, supply instability, immunogenicity, and demanding storage conditions. In this study, sulfonated carboxymethyl chitosan (SCCS) is employed as a heparin-mimicking polymer, immobilized on a glass substrate via dopamine-mediated adhesion. Compared with carboxymethyl chitosan, the SCCS-coated substrate significantly promotes endothelial cell adhesion while effectively inhibiting smooth muscle cell attachment. Additionally, the whole blood cell analysis and complement activation results exhibit that the SCCS coating has excellent blood compatibility. These findings suggest that the SCCS coating has the potential to be applied on various vascular stents to prevent restenosis, offering a nobel strategy for improving vascular interventional therapy.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xingxing Huang,Xiaojiang Huang,Muyu Feng,Haocheng Yang,Xuan Wang,Zhiqiang Zhang,Jinsuo Lu
Accelerated urbanisation has raised serious concerns on the quality of drinking water. In particular, the disinfection byproducts (DBPs) present in tap water have emerged as a potential health hazard. As hot water is routinely consumed and electrochemically assisted ultraviolet ( E -UV) technology is commonly adopted under various conditions and in aquatic environments, this study comprehensively evaluates whether E -UV boiling (E-UV/BO) technology can eliminate DBPs from drinking water. Results indicated that BO enhanced the E-UV efficacy of haloacetic acid (HAA) and aromatic DBP degradation by 1.0–1.2 times and the total organic carbon removal by 1.0–1.7 times relative to those for the ambient conditions. Trihalomethanes (THMs) were primarily eliminated through volatilisation during the BO process. The COMSOL simulation findings validated the substantial role of BO in THM elimination and demonstrated that modifying the hydrodynamic conditions of the solution can further improve the E -UV removal ability of HAAs and aromatic DBPs. After E-UV/BO treatment, the acutely toxic levels of HAAs and aromatic DBPs were reduced to ‘not harmful’ and the expressions of lipid synthesis–related genes in TCM were reduced by 50 %–80 %, confirming that the system effectively reduced ecological risks. Furthermore, experimental validation using actual water samples collected from diverse sources demonstrates the applicability of the technology under realistic environmental conditions. Incorporating E -UV devices into traditional electric kettles notably enhances drinking water quality while minimally increasing the energy usage (by approximately 5 %–10 %). E -UV/BO technology presents as a practical approach for eliminating DBPs from potable water, considerably improving the safety and quality of water.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Baoquan Liu,Lianchong Shao,Jiayun Yu,Feipeng Huang,Chengpu Chu,Shaoping Tong,Laiquan Li,Huan Wu,Yinghua Xu,Bin Liu
Halogenated disinfection byproducts (DBPs) pose significant health risks owing to their widespread occurrence and high toxicity in drinking water. Traditional water treatment technologies often fail to remove these toxic compounds without generating secondary pollutants. Herein, we report a sustainable and highly efficient electrochemical hydrogenation (ECH) strategy using a delicately designed ruthenium nanoparticle-modified electrochemical‑hydrogen-membrane (Ru NPs-EHM) reactor, which enables the complete conversion of halogenated DBPs into non-toxic products without the need for supporting electrolyte. The reactor achieves >99.9% conversion of 12 representative halogenated DBPs, with minimal formation of hazardous intermediates. The exceptional catalytic performance is attributed to the strong adsorption capability of Ru nanoparticles and the unique EHM configuration, which enhances both ECH selectivity and efficiency. This work presents a breakthrough in water treatment technology, offering a cost-effective, environmentally friendly, and scalable solution for the safe purification of drinking water.
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POLYMER
·
2026
·
IF 4.5
Jian Guan,Mengsen Niu,Zhangming Wang,Wujian Zhang,Zongjian Liu,Aiming Chen,Shengjie Xia,Panpan Zhang,Haodong Tang
Ultrahigh molecular weight (UHMW) polymers, as high-performance materials, have great potential applications in many aspects. However, the synthesis of UHMW poly (vinylidene fluoride) (PVDF) remains challenging. To achieve the synthesis of UHMW polymers, we developed a novel route to synthesize UHMW PVDF successfully and then investigated the effects of varying conditions and reactants on molecular weight and dispersity ( Đ ). The combination of Ag nanoparticles (Ag NPs) and trichloroacetic acid (TCA) represented a highly effective system for initiating the emulsion polymerization of vinylidene fluoride (VDF). Under pressures up to 70 bar, the PVDF with a number-average molecular weight up to 1.72 × 10 6 Da ( Ð = 1.62) was obtained in the presence of 28.5 ppm Ag NPs at 50 °C. Systematic investigation revealed that the molecular weight and distribution were significantly influenced by the composition of the initiating system, reaction temperature, and surfactant concentration. Preliminary investigation of the mechanism revealed that emulsion polymerization of VDF was initiated by carbon radicals generated from the reaction of Ag NPs and TCA. Furthermore, the separation of radicals in different polymer particles decreases the probability of bimolecular termination, thereby leading to an increase in the molecular weight of polymers. The synthesis of UHMW PVDF using metal nanoparticles and halogenated acids provides significant insights for future development of high-performance fluorinated polymers.
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Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Xiaoyan Ma,Sinong Huang,Yuhong Jin,Hang Jiang,Liangjie Tang,Yifei Wu,Yongjiong Ni,Shijun Zhu,Xueyan Li,Andrea M. Dietrich
Haloacetic acids (HAAs) are ubiquitously detected in drinking water and even persistent after boiling due to their stability and nonvolatility, which leads to risk exposure to human. To minimize the risk, HAAs removal through electrocatalytic reduction easily utilized in point-of-use household devices is proposed. Trichloroacetic acid (TCAA) as a typical target, was investigated using laboratory-prepared metal electrode modified with Vitamin B12 (VB12) by the drop coating method. The dechlorination performance and effects of influencing factors on the TCAA dechlorination by VB12/metal composite cathode were studied. Under the conditions of 10.0 mg VB12 loading and 7.0 mA/cm 2 current density, 92.9% TCAA removal efficiency was achieved within 5 h at 25 °C in neutral water solution. The degradation processes followed the first-order kinetic model. The results show that VB12/iron (Fe) electrode presented the superior electrocatalytic activity than VB12/aluminium and VB12/copper. The dechlorination efficiency of TCAA was promoted by higher VB12 loadings and current density; inhibited by alkaline condition and higher initial concentration of TCAA. The synergistic effect between atomic H* and VB12 occurred during the TCAA dechlorination process through the electron transfer . The proposed pathway elucidated that TCAA was dechlorinated to form dichloroacetic acid (DCAA) and monochloroacetic acid (MCAA), with acetic acid and chloride as ultimate products. This electrocatalysis system with VB12/Fe composite electrode exhibits high reaction efficiency, targeted dehalogenation, and environmental friendliness. This work is expected to provides a new way for the removal of halogenated DBPs at the tap and the safeguard drinking water for consumers.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
·
IF 9.8
Kaiyue Huo,Siqi Wang,Wanwan Zhao,Hongfu Guo,Weini Xiong,Ruihua Liu,Chao Yang
Currently, 1,2-dichloroethane (DCA) is frequently detected in groundwater and has been listed as a potential human carcinogen by the U.S. EPA. Owing to its toxicity and recalcitrant nature, inefficient DCA mineralization has become a bottleneck of DCA bioremediation. In this study, the first engineered DCA-mineralizing strain KTU-P8DCA was constructed by functional assembly of DCA degradation pathway and enhancing pathway expression with a strong promoter P8 in the biosafety strain Pseudomonas putida KT2440. Strain KTU-P8DCA can metabolize DCA to produce CO 2 and utilize DCA as the sole carbon source for cell growth by quantifying 13 C stable isotope ratios in collected CO 2 and in lyophilized cells. Strain KTU-P8DCA exhibited superior tolerance to high concentrations of DCA. Excellent genetic stability was also observed in continuous passage culture. Therefore, strain KTU-P8DCA has enormous potential for use in bioremediation of sites heavily contaminated with DCA. In the future, our strategy for pathway construction and optimization is expected to be developed as a standard pipeline for creating a wide variety of new contaminants-mineralizing microorganisms. The present study also highlights the power of synthetic biology in creating novel degraders for environmental remediation.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2023
·
IF 11.4
Liying Zhang,Xiaodan Ma,Qian Li,Hanlin Cui,Ke Shi,Hao Wang,Yanqing Zhang,Shuhong Gao,Zhiling Li,Ai-Jie Wang,Bin Liang
Sustainable nitrogen cycle is an essential biogeochemical process that ensures ecosystem safety and byproduct greenhouse gas nitrous oxide reduction. Antimicrobials are always co-occurring with anthropogenic reactive nitrogen sources. However, their impacts on the ecological safety of microbial nitrogen cycle remain poorly understood. Here, a denitrifying bacterial strain Paracoccus denitrificans PD1222 was exposed to a widespread broad-spectrum antimicrobial triclocarban (TCC) at environmental concentrations. The denitrification was hindered by TCC at 25 μg L–1 and was completely inhibited once the TCC concentration exceeded 50 μg L–1. Importantly, the accumulation of N2O at 25 μg L–1 of TCC was 813 times as much as the control group without TCC, which attributed to the significantly downregulated expression of nitrous oxide reductase and the genes related to electron transfer, iron, and sulfur metabolism under TCC stress. Interestingly, combining TCC-degrading denitrifying Ochrobactrum sp. TCC-2 with strain PD1222 promoted the denitrification process and mitigated N2O emission by 2 orders of magnitude. We further consolidated the importance of complementary detoxification by introducing a TCC-hydrolyzing amidase gene tccA from strain TCC-2 into strain PD1222, which successfully protected strain PD1222 against the TCC stress. This study highlights an important link between TCC detoxification and sustainable denitrification and suggests a necessity to assess the ecological risks of antimicrobials in the context of climate change and ecosystem safety.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Tianyu Zeng,Shuai Wu,Qizhi Liang,Hai Shi,Jue Gong,Ningjun Duan,Wei Li,Genxi Li,Yongmei Yin
The emergence of antibody-drug conjugates (ADCs) targeting trophoblast cell-surface antigen-2 (Trop-2) has reshaped the therapeutic landscape of advanced breast cancer. Accurate profiling of the Trop-2 status of tumor cells can facilitate the identification of patients who will benefit from Trop-2-targeting therapy; however limited analytical method has hindered this process. In this study, we have proposed a specific and sensitive biosensor for visual tracking of the Trop-2 status of breast cancer cells based on tetrahedral DNA nanostructure (TDN)-decorated Fe-based metal-organic framework nanoparticles (TDN-PCN-222 (Fe)). In the design, a dual-aptamer-assisted biomimetic capture strategy shows high capture efficiency while maintaining the viability and original phenotype of captured cells, ensuring the accurate profiling of the Trop-2 status. Meanwhile, by using the high intrinsic peroxidase activity and excellent targeting ability of Trop-2-specific aptamer-linked TDN-PCN-222 (Fe), specific detection of Trop-2-positive tumor cells can be achieved with a limit of detection (LOD) of 10 cells/mL, and the Trop-2 status of tumor cells can be visually tracked. Moreover, the proposed biosensor has been successfully used for tracking the Trop-2 status of tumor cells in breast cancer tissues, suggesting that our method has great promise for clinical applications.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·Vol. 140
·期 12
·e53638
·
IF 3
Yao-Shen Guo,Cheng Chen,Chun-Er Lin,Li-Ping Zhu,Hong-Xing Liu
Dichloroacetic acid (DCAA), one of the disinfection by-products in water, has showed critical harm to human health since it can cause cancer, teratogen and mutagen. Herein, a quaternized hollow fiber membrane was fabricated by ring-open reaction via a facile one-step immersion method, which could fast adsorb DCAA by flow-through adsorption. The obtained membrane with a sponge pore structure, which was quaternized at 60°C in an alkaline solution, exhibited excellent adsorption performance with removal percentage of 100%, life span up to 100 L and treating capacity of 24.8 mg m −2 . Meanwhile, the optimal membrane exhibited the exceptional performance in a neutral test solution compared with acid or alkaline test solution. It was concluded that electrostatic attraction between positively charged quaternary ammonium groups and negatively charged DCAA was responsible for the adsorption mechanism. Additionally, fitting results indicated that the adsorption of DCAA onto the membrane was mainly dominated by homogeneous monolayer adsorption. This work developed a facile approach to prepare a novel quaternized membrane with outstanding adsorption performance, which demonstrated huge potentials in the molecular separation and water purification fields.
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Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Junyan Wei,Shengnan Zhang,Ruixue Guo,Ahmed A. Allam,Jamaan S. Ajarem,Naif G. Altoom,Afzal Ahmed Dar,Ruijuan Qu,Zongli Huo,Feng Zhu
In plastic, a 2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentylphenol (UV328) ultraviolet light absorber is a common additive. When using sodium hypochlorite (NaClO) to disinfect plastic, UV328 may react with NaClO. For this work, we investigated the transformation behavior of UV328 in polyethylene (PE) plastic by NaClO. The reaction rate increased with the initial free active chlorine (OCl − ) concentration and the decrease of the initial UV328 concentration. At room temperature (25 °C) to lower temperatures (0 °C), OCl − could transform UV328, and the reaction activation energy was fitted as 31.10 kJ/mol. Replacement of the plastic carrier (change to polypropylene) had no effect on the reaction process. A total of 12 intermediates were identified, and calculations based on density functional theory (DFT) were used to assist in rationalizing the product structure. Chlorination, hydroxylation, coupling, and bond cleavage were speculated as the main transformation pathways. Dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA) were the only two measured disinfection by-products in the system, and their concentration were 18.33 and 18.19 μg/g, respectively. The toxicity prediction by Toxicity Estimation Software Tool (T.E.S.T) illustrated that the toxicity of the transformation products was higher overall than that of UV328 during the reaction. This work can help to deepen the understanding of the transformation behavior of UV328 in PE plastic in NaClO solution.
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