EUROPEAN JOURNAL OF MEDICAL RESEARCH
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2025
·Vol. 30
·期 1
·1-11
·
IF 3.4
Zhang Zihao,Ren Jiayi,Tang Ke,Hu Xinyi,Liu Jinhui,Li Chunming
Background Oral cancer (OC) is one of the major types of cancer and the most common cause of cancer-related mortality in Asia. In recent years, matrix stiffness in the tumor microenvironment has been found to play an important role in regulating tumor cell behavior. However, the regulatory mechanisms associated with matrix stiffness in OC cells remain unclear. Methods In this study, polyacrylamide gels with different stiffness were prepared to simulate low versus high matrix stiffness environments in tumor tissues by adjusting the acrylamide and cross-linker concentrations. Subsequently, the effects of different stiffness on OC cell survival, migration, invasion and invadopodia formation were explored based on cell counting kit-8 (CCK-8), Transwell and confocal microscopy. Meanwhile, the levels of markers relevant to phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), apoptosis (BAX and BCL2) as well as metastasis (Cadherin-1, CDH1; Cadherin-2, and CDH2) were calculated via western blotting and real-time quantitative PCR. Results According to the results, high matrix stiffness was seen to contribute to the increased number of migrated and invaded cells as well as the enhanced viability of OC cells, along with the aggravated invadopodia formation and the up-regulation in CDH2 and BCL2 levels yet the down-regulation in CDH1 and BAX levels. Elevated PI3K/AKT phosphorylation levels were also seen in high matrix stiffness-mediated OC cells, and the intervention using LY294002 could visibly overturned the effects of high matrix stiffness on the cell migration, invasion and invadopodia formation of OC cells. Conclusions This study reveals that matrix stiffness may enhance the invasiveness and anti-apoptotic ability of OC cells by activating the PI3K/AKT pathway, which provides a new idea for exploring the microenvironmental regulation of tumor mechanics and targeted intervention strategies.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Luyang Wang,Jiahe Li,Changsheng Tang,Pengxiang Li,Yulin Yang,Debin Xia,Jian Zhang,Ping Wang,Kaifeng Lin
Aluminum–lithium (Al Li) alloy powders exhibiting the micro–explosion phenomenon are promising energetic additives for solid propellants. However, their high surface reactivity, particularly due to lithium (Li), leads to poor compatibility with binder components, thereby hindering practical application. Importantly, low−temperature reaction conditions slowed the reaction rate, helping to preserve the active components of Al 5Li powder during its modification with dichlorodimethylsilane (DCDMS) via a Li–induced low−temperature Wurtz–type reaction, which resulted in in–situ polymerization and formation of LiCl. Residual Si Cl groups reacted with surface hydroxyls, generating trace HCl that removed native passivation layers (e.g., Li₂CO₃) and produced additional LiCl, while low–temperature enhanced DCDMS adsorption and limited surface species consumption, promoting formation of a dense chlorosilane coating encapsulating part of the LiCl. The modified Al–5Li@DCDMS powders showed good compatibility with hydroxyl–terminated polybutadiene (HTPB) and, compared with conventional Al–based HTPB propellants, exhibited pronounced micro–explosion behavior, with a 6.84 % higher burning rate and a 43.90 % shorter ignition delay. This work offers a viable surface passivation strategy and demonstrates the application potential of Al Li alloy powders in advanced solid propellant systems.
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Biomimetics
·
2025
·Vol. 10
·期 6
·368
·
IF 3.9
Lei Feng,Liugen Xu,Junhao Wen,Minghai Zhao,Amjad Ali,Naushad Ahmad,Jianwei Lu,Li Guo
Developing safe and efficient cryoprotectants is critical for effective cryopreservation in biomedical applications. Inspired by natural antifreeze proteins (AFPs), a series of linear and star-shaped peptoids featuring isopropanol side chains to mimic the amphiphilic characteristics of threonine were prepared. The effects of chain length and molecular topology on antifreeze properties were systematically investigated. Both ice recrystallization inhibition (IRI) and ice crystal growth suppression improved with increasing chain length, and star-shaped peptoids exhibited superior performance. Notably, the star-shaped peptoid S-(A6)3demonstrated excellent antifreeze activity and low cytotoxicity, highlighting its promise as a novel, non-toxic alternative to conventional cryoprotectants like DMSO. These findings provide valuable insight into the structure-property relationship of peptoids for cryopreservation applications.
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COMPOSITES COMMUNICATIONS
·
2026
·
IF 7.7
Yujie Yang,Huixing Lin,Jiaqi Li,Yang Gao,Xiaogang Yao,Haiyi Peng
Efficient thermal management is a critical challenge for next-generation electronics, where conventional polymer-based materials suffer from inherently low thermal conductivity. Inspired by natural honeycomb structures, we developed a freeze-casting strategy to fabricate high-performance hexagonal boron nitride (h-BN)/polysilylaryl-enyne (PSAE) composites exhibiting enhanced thermal conductivity. By leveraging the unidirectional crystallization of tert-butyl alcohol (TBA), a highly ordered h-BN honeycomb scaffold was constructed, facilitating the formation of efficient phonon conduction pathways. The composites, with a low h-BN (10 μm) ratio of 23 vol%, exhibit an outstanding omni-directional thermal conductivity of 4.71 W/(m·K) along the z-axis and 3.44 W/(m·K) along the x-axis, significantly outperforming conventional polymer composites. Moreover, dielectric characterization confirms that the honeycomb structure enhances anisotropic dielectric behavior ( ε rz = 3.68, ε rx = 3.32, for h-BN (10 μm) at 23 vol%). The proposed bioinspired approach presents a scalable and effective route for developing lightweight, thermally conductive composites for advanced electronic applications.
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Gels
·
2026
·Vol. 12
·期 7
·594
·
IF 6.4
Xiaoxu Wu,Zhiyu Huo,Miao Liu,Qiao Wang,Yang Wang,Zhi Li
Hydrophobic silica aerogels are widely used as thermal-insulation materials, but the thermal decomposition of their organic surface groups may affect their stability and safety during high-temperature service. In this study, ambient-pressure-dried silica aerogels modified with trimethylsilyl, dimethylsilyl, and methylsilyl groups were prepared and denoted as TSA, DSA, and MSA, respectively, to clarify how the degree of methyl substitution in the surface modifier controls the pyrolysis behavior of hydrophobic silica aerogels. Thermogravimetric analysis at different heating rates was combined with TG-FTIR, a model-free kinetic analysis, a model-fitting analysis and thermodynamic calculation. With decreasing methyl substitution from TSA to MSA, the aerogel framework became denser, the specific surface area decreased, and the contribution of solid-phase heat transfer increased slightly. The main pyrolysis process occurred at 250–800 °C and involved multiple overlapping reactions. The average activation energies of TSA, DSA, and MSA were 241.4, 246.6, and 285.5 kJ/mol according to the Kissinger–Akahira–Sunose (KAS) method and 243.0, 248.2, and 289.0 kJ/mol according to the Flynn–Wall–Ozawa (FWO) method, respectively. The higher activation energy of MSA indicates that the more condensed silica-rich framework and lower organic methyl content improves its resistance to the main degradation process. The model-fitting analysis further suggested an A1/2 mechanism for TSA and A2/5 mechanisms for DSA and MSA. TG-FTIR further confirmed the evolution of CO2, H2O, CH4, and C2H4and revealed distinct gas-release behaviors among the three samples. These results demonstrate that the surface methyl-substitution structure governs the balance between hydrophobic modification, pore-structure preservation, pyrolysis resistance, and volatile-product release, providing a basis for selecting surface modifiers for thermally stable silica-aerogel insulation materials under oxygen-limited high-temperature conditions.
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JOURNAL OF CONTROLLED RELEASE
·
2023
·
IF 10.8
Qianlong Wang,Tiantian Wang,Chonkit Lio,Xina Yu,Xiaoyi Chen,Lancong Liu,Youjiao Wu,Hui Huang,Linsen Qing,Pei Luo
Macrophages, innate immune cells, are key players in the maintenance of myocardial homeostasis under normal conditions and tissue repair after injury. The infiltration of macrophages into the injured heart makes them a potentially appealing vehicle for noninvasive imaging and targeted drug delivery of myocardial infarction (MI). In this study, we demonstrated the use of surface hydrolysis-designed AuNPs-zwitterionic-glucose to label macrophages and track their infiltration into isoproterenol hydrochloride (ISO)-induced MI sites noninvasively using CT . The AuNPs-zwitterionic-glucose did not affect the viability or cytokine release of macrophages and were highly taken up by these cells. The in vivo CT images were obtained on Day 4, Day 6, Day 7, and Day 9, and the attenuation was seen to increase in the heart over time compared to the Day 4 scan. In vitro analysis also confirmed the presence of macrophages around injured cardiomyocytes. Additionally, we also addressed the concern of cell tracking or merely AuNP tracking, which is the inherent problem for any form of nanoparticle-labeled cell tracking by using zwitterionic and glucose-functionalized AuNPs. The glucose coated on the surface of AuNPs-zwit-glucose will be hydrolyzed in macrophages, forming only zwitterionic protected AuNPs that cannot be taken up again by endogenous cells in vivo. This will greatly improve the accuracy and precision of imaging and target delivery. We believe this is the first study to noninvasively visualize the infiltration of macrophages into MI hearts using CT, which could be used for imaging and evaluating the possibility of macrophage-mediated delivery in infarcted hearts.
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PROGRESS IN ORGANIC COATINGS
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2023
·
IF 6.6
Yan Cheng,Shanchi Wang,Zhiguang Xu,Lianyi Jiang,Yan Zhao
Oil-repellency of fabric is essentially based on perfluoroalkyl substances (PFAS, or called perfluorochemicals (PFCs)). However, plans to phase out the use of these chemicals, even those short-chain ones (C4-C6), have been announced because they accumulate in the human body and are extremely persistent in the environment. It is urgent to develop non-fluorine surface chemistry for oil-repellent fabric finishing. Here, we report the non-fluorine oil repellency of brush-like polydimethylsiloxane (PDMS) coating (g-PDMS), and the comparison of its oil repellency with that of a common PFAS crosslink polysiloxane coating (C 4 -PFAS). A catalyst-free, solvent-free chemical vapor deposition (CVD) process was used to prepare the g-PDMS coating. For smooth glass, g-PDMS coating exhibits ultralow contact angle hysteresis (∆ θ ) for various oils (1.3–7.3°), while the ∆ θ of C 4 -PFAS coating is much higher (30.7–49.7°). For fabrics, g-PDMS and C 4 -PFAS achieved almost the same contact angles to castor oil (~134°). According to GB/T 19977-2014 standard, the oil repellency of coated fabrics was rated Grade 5 for both g-PDMS and C 4 -PFAS. Therefore, the non-fluorine oil repellency of g-PDMS is able to meet the basic requirement of oil-repellent fabric finishing, and it is expected that the oil repellency can be further improved by the rational design on surface topography .
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Journal of the Korean Ceramic Society
·
2023
·Vol. 60
·期 5
·830-839
·
IF 2.5
Li Xiaohong,Luo Xiaoyu,Li Jing,Li Jinxia,Yang Jiahao,Ahmad Zahoor,Bao Zhihao,Zhang Xiao,Chen Jianjun
An appropriate infusible method plays a vital role as one of the key processes of the fabrication of polymer-derived ceramic fibers. In this work, ozone curing, a novel room temperature controllable curing strategy was used to prepare SiCN ceramic fibers. Some circular pores were observed on the surface of the obtained SiCN ceramic fibers. The tensile strength of the fibers was also investigated. To reveal the ozone-curing mechanisms of the PSZ fibers and the formation process of the circular pores, the FT-IR, SEM, OM, XRD and TG were characterized. The results showed that the Si–H bonds and Si-CH 3 groups in the PSZ molecule were oxidized gradually to form oxygen-containing groups such as Si–OH, Si–O-Si and C = O in the ozone curing process, which contributed to the curing and weight gain of the PSZ fibers. Moreover, a hydrolysis reaction between Si-NH-Si and H 2 O might further accelerate the curing of the PSZ fibers. An unexpected result of the hydrolysis reaction is the formation of some circular pores on the surface layer of the PSZ fibers. This strategy provides a method to design, adjust and control the microstructure and composition of silicon-based ceramic fibers, and the obtained SiCN fibers may be used as catalyst support, bacterial culture and other fields.
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ACS Applied Polymer Materials
·
2023
·
IF 5
Cong Gui,Dengxu Wang,Jinfeng Cao,Shengyu Feng
Three-dimensional (3D) hierarchically porous materials are widely used owing to their unique pore structures and rich specific surface areas. Herein, we design a 3D macroporous and mesoporous silicone sponge via a one-pot efficient thiol oxidative coupling reaction between polysiloxanes and HS-modified mesoporous polymers. The diameters of the macropores and mesopores are higher and lower than 50 nm, respectively. The sponge possesses a surface area of 20.72 m2 g–1, a porosity of 61.39%, and good compression and thermal insulation properties. A dye adsorption evaluation confirmed that the sponge selectively removed cation dyes from a mixed dye solution. This synthesis method for 3D macroporous and mesoporous sponges can potentially synthesize composites of other mesoporous materials.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Zhongzheng Xu,Mingwei Zhao,Yiming Zhang,Pan Wang,Yining Wu,Lin Li,Xin Cui,Ning Sun,Caili Dai
Superhydrophobic wettability inspired by the “lotus effect” is an intriguing property in nature, but it is rarely applied in oilfield development. Superhydrophobic nanomaterials can effectively solve the problem of “high injection pressure and insufficient water injection” in low permeability oilfields by changing the properties of the core surface, which is of great significance to the development of low permeability oilfields. Herein, we report a novel type of superhydrophobic nanoparticle (SHNP) simply modified by fluorinated long chains, and a stable nanofluid is successfully prepared by compounding surfactant. The prepared SHNP nanofluid has an excellent core drag reduction effect, and the drag reduction rate is 1.35 times that of conventional NPs under the same conditions. The SHNPs assemble on the core surface to form a large number of micro/nanorough structures, which can effectively reduce the surface roughness of the core. The PIV experimental results show that compared with the injection of pure water, the center flow velocity in the subsequent water flooding center increases by 98.27% after the injection of SHNPs nanofluid (the flow velocity decreases by 53.45% after the injection of NPs). Moreover, bubble probe AFM technology has successfully shown that bubbles can be captured through the SHNPs superhydrophobic interface to form a gaseous film. By using the barrier effect of the gaseous film, the liquid–solid interface is converted to a liquid–gas-solid interface, thereby reducing the large resistance caused by the direct contact between the liquid and solid. Such SHNPs with simple modification and low cost have broad application potential in oilfield development.
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Nano Research
·
2022
·Vol. 15
·期 9
·8326-8335
·
IF 10.269
Li Xiangxia,Chen Guiyuan,Wang Yangyi,Su Lanhong,Chen Bo,Wu Kecheng,Xing Yun,Song Zechenxi,Dai Ruike,Liu Tianxin,Zhao Jiaao,Xie Zhe,Zhou Peijie,Xia Xiaoping,Min Yuanzeng
In the tumor immunosuppressive microenvironment (TIME), antigen presenting cells (APCs) usually exhibit a tumor suppressor phenotype. Toll-like receptors (TLRs) agonists could reprogram M2-type macrophages to M1-type and stimulate dendritic cells (DCs) maturation. The combination of TLR7/8 and TLR9 agonists seems to have synergistic therapeutic efficacy. Here, we designed a lipid-coated mesoporous silica nanoparticle (MSNs@Lipo) for the co-delivery of TLR7/8 agonist resiquimod (R848) and TLR9 agonist CpG oligodeoxynucleotides (ODNs) (CpG@MSNs-R@L-M). R848 was firstly conjugated onto the nanoparticle via silane chemistry, which is acidic responsive drug release. Then, CpG was loaded onto the nanoparticle through the positive charge mainly from TLR7/8 agonist R848. Our in vitro experiments further indicated that both drugs have acid-responsive release properties and could be taken up by DCs and located on the endosomes of APCs. More importantly, CpG@MSNs-R@L-M could significantly improve the antitumor efficacy in B16F10 melanoma model. The mechanistic study demonstrated that CpG@MSNs-R@L-M could remarkably modulate the TIME by promoting the maturation of DCs and repolarizing macrophages from M2 to M1 phenotype and facilitating the infiltration of tumor cytotoxic T cells. It was concluded that in comparison to single agonist, the co-delivery of dual agonists, CpG and R848, can improve anti-tumor immune responses for cancer immunotherapy.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Peng Hu,Ru Xie,Qingyi Xie,Chunfeng Ma,Guangzhao Zhang
Antifouling ability and substrate adhesion are typical trade-offs seen for a silicone coating. Furthermore, the self-healable inability limits their duration. This study reports a bioinspired self-stratifying coating composed of a polyurethane with dopamine and silane pedant groups and a bi-silanol-terminated poly(dimethylsiloxane) with fluorocarbon and poly(ethylene glycol) segments as a reactive amphiphilic polymer (RAP). During coating formation, the RAP with low surface energy can be enriched on the surface due to the self-stratifying effects, whereas the bioinspired dopamine and silane groups provide the coating with strong substrate adhesion. Besides, the multiple hydrogen bonds formed between the urethane linkages and the dopamine groups allow the coating to heal. Our study indicates such a polyurethane-based coating has excellent antifouling ability against proteins, bacteria, and diatoms, good self-healing performance at room temperature in air and water, as well as high adhesion strength on various substrates such as ceramic, steel, glass, and wood. This study provides a promising and universal strategy for the simultaneous realization of antifouling, self-healing, and strong substrate adhesion. The coatings could meet the needs of applications in marine antifouling, biomedical instruments, and other fields.
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