Communications Biology
·
2024
·Vol. 7
·期 1
·1-11
·
IF 5.2
Qin Danhui,Song Hui,Wang Caiwei,Ma Xiaojie,Fu Yu,Zhao Chunyuan,Zhao Wei,Zhang Lei,Zhang Weifang
Stimulator of interferon genes (STING) is vital in the cytosolic DNA-sensing process and critical for initiating the innate immune response, which has important functions in host defense and contributes to the pathogenesis of inflammatory diseases. Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) specifically binds the CpG dinucleotides in the viral RNAs of multiple viruses and promotes their degradation. ZAPS (ZC3HAV1 short isoform) is a potent stimulator of retinoid acid-inducible gene I (RIG-I) signaling during the antiviral response. However, how ZC3HAV1 controls STING signaling is unclear. Here, we show that ZC3HAV1 specifically potentiates STING activation by associating with STING to promote its oligomerization and translocation from the endoplasmic reticulum (ER) to the Golgi, which facilitates activation of IRF3 and NF-κB pathway. Accordingly, Zc3hav1 deficiency protects mice against herpes simplex virus-1 (HSV-1) infection- or 5,6-dimethylxanthenone-4-acetic acid (DMXAA)-induced inflammation in a STING-dependent manner. These results indicate that ZC3HAV1 is a key regulator of STING signaling, which suggests its possible use as a therapeutic target for STING-dependent inflammation.
研究领域:
免疫学
·
病毒学
·
炎症性疾病
✓ 已验证
DOI
PubMed
高影响因子
FUEL
·
2018
·
IF 4.908
Youan Ji,Yucui Hou,Shuhang Ren,Congfei Yao,Weize Wu
Phenolic compounds, which are widely used in producing synthetic fibers, engineering plastics, and other industrial organic chemicals, can be obtained from oil mixtures before further processing or applications by separation. Based on Lewis/Brønsted acid-base theory, we proposed the separation of phenolic compounds from oil mixtures using some environmentally benign biological reagents (BRs, including 1,3-dimethylxanthine-DMX, isonicotinamide-INA, and L-lysine-LYS). The effects of stirring time, temperature, initial phenol concentration, and BR:phenol mole ratio on phenol removal were studied in detail. LYS, INA and DMX show phenol removal efficiencies of 98.4%, 82.2%, and 66.6% from toluene at BR:phenol mole ratios of 1.6, 1.4, and 0.4, respectively, and those of 99.1%, 91.8%, and 74.6% from n -hexane at BR:phenol mole ratios of 2.20, 1.60, and 0.80, respectively, at room temperature. The BRs were regenerated with an anti-extraction method for four cycles without significant changes in separation efficiency and their properties. In addition, it is found that there is little toluene entrained in the biological reagents, which is as low as 2.3 wt% of separated phenol, indicating high purities of products. These BRs show the advantages of easy biodegradation, no corrosion to the equipment and containers, and no pollution to the environment.
研究领域:
化学工程
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Materials Chemistry Frontiers
·
2019
·Vol. 3
·期 5
·922-930
·
IF 0
Guang Wu,Lingling Zhao,Hongze Liang,Yinghua Yan,Hui Tan
Polymeric hairy microspheres with a Janus hollow structure were prepared via cationic polymerization using SiO2 nanoparticles as interface protection cores and sacrificial templates. Sulfonic acid groups (–SO3H) were introduced onto the surface of the microspheres by sulfonation and facilitated the further loading of titania. The Janus hollow polymeric hairy microspheres (HSPHS) could be applied as efficient adsorbents to remove both hydrophilic dye rhodamine B (RB) and hydrophobic dye dimethyl yellow (DMY) from the surrounding solution, and the results showed that >98% of RB or/and DMY could be removed within several minutes. The maximum adsorption amount on the Janus HSPHS was 3.48 and 0.14 mol g−1 for RB and DMY, respectively. In addition, the HSPHS can also serve as catalyst scaffolds to load anatase titania for the photocatalytic degradation of RB. Janus hollow microspheres coated with anatase titania (HSPHS@TiO2-An) demonstrated a remarkable photocatalytic efficiency and recyclability. High photocatalytic activity was observed for HSPHS@TiO2-An and the catalytic efficiency remained with almost no loss of the photocatalytic activity even after five catalytic cycles. Thus, the Janus hollow polymeric hairy microspheres have promising applications in water treatment as efficient adsorbents and catalyst scaffolds.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yanmei Li,Junmei Nie,Xinyu Li,Ni Yan,Renjiang Kong,Jiaqi Huang,Yeyang Wu,Zhuofeng Li,Yingtao Zhong,Xin Chen,Hong Cheng
Stimulator of interferon genes (STING) plays an essential role in initiating the innate anti-tumor immunity, which could be activated by the cytosolic DNA but suppressed by the immunosuppressive cells. In this work, a self-delivery ternary immunostimulant (designated as ImmSt) is fabricated for colorectal cancer therapy with the immunological cascades of photodynamic DNA damage and T regulatory cell inhibition. Among which, the photosensitizer of Chlorin e6 (Ce6), the STING agonist of 5,6-dimethylxanthine-4-acetic acid (DMXAA) and the phosphatidylinositol 3-kinases (PI3Ks) inhibitor of ZSTK474 could self-assemble into uniform nanomedicine without drug excipient, which enhances the drug stability, bioavailability and pharmacological activities. Importantly, the photodynamic therapy (PDT) effect of ImmSt produces enormous reactive oxygen species to ablate tumor cells, and also triggers the release of cytosolic DNA to amplify the STING signal in combination with the STING agonist. Moreover, ImmSt is able to induce a systemic anti-tumor immunity by the cascade activation of T cells and the decrease of T regulatory cells. In vitro and in vivo results confirm that ImmSt can efficiently eradicate colorectal cancer without severe side effects, which may provide a sophisticated mechanism for immunotherapy in consideration of the immune activation and immunosuppressive factors.
研究领域:
肿瘤学
·
免疫疗法
·
药理学
·
纳米技术
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Rongrong Dai,Bingyan Zhou,Jingwen Zeng,Pengle Qian,Yadong Sun,Yingtang Zhou,Zheng Guo
A dual-phase copper-doped iron oxide nanozyme (Cu-α/γFO) was synthesized via a facile hydrothermal method for efficient organic pollutant degradation. The as-prepared Cu-α/γFO exhibits excellent peroxidase-like activity, degrading 99.5% rhodamine B (RhB) under optimal conditions (pH 4, 40°C) while retaining 40.73% of its initial activity after three cycles. Critically, it demonstrates broad-spectrum catalytic efficacy, efficiently degrading diverse organic dyes (e.g., cresol red, methyl violet, methylene blue), and retains high catalytic activity even in complex environments containing coexisting cations (K⁺, Ca²⁺, Mg²⁺), anions (H₂PO₄⁻, HCO₃⁻, NO₃⁻), or organic solvents (acetone, ethyl acetate). X-ray diffraction (XRD) and Raman spectroscopy confirmed the Cu-doping-induced α/γ-Fe₂O₃ phase crystal structure, while minimal copper leaching after 21-day aqueous storage validated structural integrity. The mechanism of enhanced peroxidase-like activity of Cu-α/γFO was proposed based on integrated characterization, including electron spin resonance (ESR), electrochemical impedance spectroscopy (EIS), X-ray photoelectron spectroscopy (XPS), and density of states calculations. Degradation pathways were elucidated using high-performance liquid chromatography-mass spectrometry (HPLC-MS) identification of intermediates and theoretical calculations. This work presents a dual-phase engineering strategy through targeted metal doping, advancing high-performance nanozymes for sustainable environmental remediation.
研究领域:
环境催化
·
纳米材料
·
纳米酶
·
水处理
·
材料化学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Chen Liu,Yutang Kang,Yuanyuan Rao,Shasha Feng,Feng Zhang,Zhaoxiang Zhong,Weihong Xing
In this study, a polyacrylonitrile (PAN) nanofibrous membrane demonstrating both high particulate matter filtration efficiency and formaldehyde visual detection capabilities was obtained by electrospinning. The additive polyvinylpyrrolidone (PVP) was introduced to adjust the structural characteristics and hydrophilicity of the membrane, while methyl yellow (MY) was added as a colorimetric indicator. Sulfamic acid was then loaded on the membrane to obtain the sensing property. The obtained nanofibrous membrane exhibits excellent PM0.3 filtration efficiency (99.88%) with low filtration pressure drop (159.3 Pa). The sensing accuracy for formaldehyde can reach below 50 ppb (World Health Organization, safety concentration <80 ppb), and it can identify formaldehyde at a concentration of 1 ppm within 10 min. Owing to the specific reaction between sulfamic acid and formaldehyde, the membrane exhibited excellent anti-interference performance against other volatile organic compounds. This nanofiber colorimetric sensing membrane holds great potential for application in respiratory protective equipment.
研究领域:
材料科学
·
环境健康
·
呼吸防护
·
纳米技术
·
分析化学
·
功能材料
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Guangyou Jia,Hongyue Yu,Xirui Huang,Yating Zhan,Qianqian Lu,Mengmeng Hou,Jia Jia,Minchao Liu,Yufang Kou,Wenxing Wang,Tiancong Zhao,Xiaomin Li,Wei Luo
Surface structural modification is critical for regulating the physicochemical stability of nanomaterials. Cassie-model, which describes a phenomenon where an air layer exists between the superhydrophobic surface and liquid, has been widely applied in the design of surface structures to directly avoid the contact between the material and the liquid, thereby improving corrosion resistance. Although the construction of superhydrophobic interfaces to realize Cassie-model has achieved remarkable results, current researches mainly focus on macro-substrates. Whether this approach is viable for protecting particles at the nano-scale remains underexplored. Here, we report the fabrication of Fe 3 O 4 @rSiO 2 core@shell nanoparticles with a rough silica shell (rSiO 2 ) that exhibit exceptional acid resistance. We demonstrate that the nanoscale array structure on the surface of the rSiO 2 shell (height: 20 nm, diameter: 6 nm) can generate an air layer between the Fe 3 O 4 inner core and corrosive media. Due to the presence of the air protective layer induced by the Cassie-model surface structure, the Fe 3 O 4 nanoparticles retain their structure and function under highly acidic conditions (12 M HCl), and maintain their magnetothermal properties. Additionally, the unique surface roughness of the Fe 3 O 4 @rSiO 2 core@shell nanoparticles significantly enhances their bacterial adhesion capabilities, enabling drug-free structural-antibacterial performance even after exposure to strong acidic conditions. These findings open up new possibilities for the applications of nanomaterials in harsh environments.
研究领域:
材料科学
·
纳米技术
·
表面工程
·
腐蚀防护
·
生物医学应用
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2025
·
IF 16
Ping Fu,Jia-Hui Xin,Wan-Long Li,Wan-Ting Lin,Zi-Lu Zhang,Xiao-Wei Luo,Chang Liu,Jaslyn Ru Ting Chen,Runkai Su,Si-Yuan Zhang,Zi-Jun Zhang,Qi-Zhi Zhong,Zhi-Kang Xu,Ling-Shu Wan
Polymer membranes are essential in separation processes such as desalination and organic solvent nanofiltration. However, simultaneously manipulating subnanometer pore size, homogeneity, and chemistry remains challenging due to the coupled diffusion–reaction of building blocks in membrane formation, resulting in the trade-off between permeance and selectivity. Here, we report a versatile enzyme-mediated strategy that kinetically decouples diffusion and reaction, enabling multidimensional pore engineering with tunable pore sizes (0.43–0.84 nm), improved homogeneity, and modular surface chemistry across eight polyamine–phenolic combinations. Phenolics with desired moieties diffuse uniformly into polyamine branch voids and create enzyme-regulated pores, forming highly homogenized and chemically tailored selective layers with ultraselectivity of ∼30 toward solutes with molecular weights below 350 Da, outperforming state-of-the-art membranes (selectivity <10). In high-value pharmaceutical separation, these membranes further achieve 1 order of magnitude higher selectivity, a 7.3-fold increase in solvent permeance, and a 6.8-fold improvement in enrichment efficiency compared to commercial membranes. By highlighting the importance of multidimensional pore engineering in improving membrane selectivity and permeability, our work suggests a pathway for unlocking the potential of polymer nanofiltration membranes for accurate molecular sieving applications.
研究领域:
膜科学
·
高分子科学
·
分离技术
·
酶催化
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Huanyu Zhou,Xiaodong Wang,Yuting Zhou,Niandong Jiao
Miniature robots have important applications in fields such as cargo transportation, environmental detection, and energy exploration. In particular, miniature robots that can swim in oil water systems have great potential for droplet manipulation or cargo assembly. However, the need to impart high antiwetting and low oil adhesion properties to these robots still severely hinders their movement in oil water systems. In this work, we prepared underwater-superoleophobic miniature robots using an ultrafast oxygen plasma treatment, which requires only 8 s of surface modification. Owing to their underwater superoleophobicity, the robots can swim at the oil water interface and perform cargo transport, assembly, and rotation, as well as transport oil droplets underwater. In addition, under magnetic fields (20–60 mT), the strider robot can swim and jump at the oil water interface, demonstrating flexible, responsive motion. These findings demonstrate that our rapidly fabricated, multifunctional miniature robots possess excellent interfacial mobility and controllability, suggesting promising applications in oil–water systems.
研究领域:
机器人学
·
材料科学
·
界面工程
·
环境技术
·
微流体学
✓ 已验证
产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Qikai Si,Yang Yu,Wenjie Xu,Zhenglong Yang,Hongwu Zhang,Ting Su,Christophe Len,Deyang Zhao
Five biomass-based materials: sesame straw (SS), corn cobs (CC), bamboo powder (BP), wheat straw (WS), and furfural residue (FR), were sulfonated using sulfuric acid, as well as some commercial sulfonated catalysts, like Amberlyst, Nafion were compared for the production of ethyl levulinate (EL) from furfuryl alcohol (FAL). Remarkably, under optimum conditions (50 mg of 8% SO3H-FR at 170 °C for 5 h), 100% FAL conversion and 90% EL yield were achieved, along with stable recyclability in continuous flow. Dynamic evolution of GC in the function of reaction time under different temperatures was performed, indicating that FAL conversion to ethoxymethylfuran (EMF) occurs under a lower temperature (150 °C) and short time (45 min). On the contrary, the intermediates 5, 6, and 7 required a higher temperature for EL formation with the concomitant release of diethyl ether (DEE). Comprehensive characterizations demonstrated significant changes in the chemical composition of sulfur- or nitrogen-containing functional groups after sulfonation. In particular, the −S–O types (especially −SO3H) play a more critical role in EL production than the sulfur content alone. The adsorption energies and charge density differences of FAL (Eads) on pristine FR and the sites of −SO3H, −SO4, pyrrolic N, pyridinic N, and their complexes were compared. The FAL adsorption energy followed the order: Eads (complex) > Eads (−SO4) > Eads (−SO3H) > Eads (pyrrolic N) > Eads (pyridinic N)>Eads (pristine), indicating a synergistic adsorption effect among these functional groups in FR. Additionally, the electron transfer capacity was significantly enhanced after −SO3H doping.
研究领域:
化学工程
·
生物质能源
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 3
·1-9
·
IF 5.3
Guo Dongying,Yang Hailiang,Zhang Longyue,Dai Ruoyu,Huang Yuankui,Hu Yaoping
Specific assay for methylene blue (MB) in aquaculture is critically required to assess the safety of ecosystems and aquatic products. In this work, a facile method is demonstrated for ratiometric fluorescence determination of MB based on blue/red dual emissive carbon dots (b/r-CDs). b/r-CDs, derived from the leaves of Impatiens balsamina, show weak and strong emission peaks at 432 and 672 nm, respectively, and possess a high photoluminescence quantum yield of 35.7%. The red fluorescence of b/r-CDs at 672 nm, serving as the response signal, can be significantly quenched by MB due to the mechanism of inner filter effect, while the blue fluorescence at 432 nm is insensitive to MB, thus acting as the background reference. With addition of an increased amount of MB, the fluorescence color of b/r-CDs gradually changes from red to blue, which realizes the visual detection. The linear range and limit of detection are measured to be 0.05–10 μM and 15 nM, respectively. Notably, a portable smartphone sensing platform is built for quantitative detection of MB by analyzing the RGB values. Moreover, the practical applications of b/r-CDs for monitoring MB in real water and aquatic products using both fluorescence spectrophotometer and smartphone achieve satisfactory results. Graphical
研究领域:
环境科学
·
分析化学
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2024
·Vol. 16
·期 16
·2328
·
IF 4.7
Jiachen Ding,Tingting Li,Xiangyi Wang,Mengyang Li,Tianyu Li,Zhiming Zhang
A functionalized ethylene–vinyl-alcohol (EVOH) nanofibrous membrane (NFM) was fabricated via co-electrospinning H4SiW12O40(SiW12) and EVOH first, and then grafting citric acid (CCA) on the electrospun SiW12@EVOH NFM. Characterization with FT-IR, EDX, and XPS confirmed that CCA was introduced to the surface of SiW12@EVOH NFM and the Keggin structure of SiW12was maintained well in the composite fibers. Due to a number of carboxyl groups introduced by CCA, the as-prepared SiW12@EVOH-CCA NFM can form a high number of hydrogen bonds with CR, and thus can be used to selectively absorb congo red (CR) in aqueous solutions. More importantly, the CR enriched in the NFM can be rapidly degraded via photocatalysis. SiW12in the NFM acted as a photocatalyst, and the hydroxyl groups in the NFM acted as an electron donor to accelerate the photodegradation rate of CR. Meanwhile, the SiW12@EVOH-CCA NFM was regenerated and then exhibited a relatively stable adsorption capacity in five cycles of filtration–regeneration. The bifunctional nanofibrous membrane filter showed potential for use in the thorough purification of dye wastewater.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）