Gels
·
2021
·Vol. 7
·期 1
·21
·
IF 4.702
Xingxia Xu,Weihong Lu,Jian Zhu,Xiangqiang Pan,Xiulin Zhu
A new kind of on-demand dissolution hydrogel is successfully synthesized by modification of chitosan using γ-selenobutyrolactone. The chitosan hydrogel with different selenium contents is formed by ring opening of γ-selenobutyrolactone with the amines of D-glucosamine units on the chitosan backbone. The structure of the hydrogel was confirmed by1H NMR, XRD and XPS. Its physical and biological properties were evaluated by rheology characterization, degradation tests and cytotoxicity test. The hydrogel showed excellent biocompatibility and good degradation properties under oxidation or reduction conditions. All the evidence demonstrated that this type of material has good prospects for dressing applications.Keywords:chitosan;hydrogel;diselenide;on-demand dissolution
研究领域:
生物材料学
·
组织工程学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2018
·Vol. 56
·期 10
·1067-1077
·
IF 2.588
Yuanfeng Gao,Chang-Ming Dong
Stimuli-responsive polypeptides are receiving much attention for drug delivery systems and tissue engineering scaffolds; however, it is challenging to construct multiple-responsive polypeptides and one-component polymeric hydrogels. Herein, a novel type of triple redox/temperature-responsive diselenide-containing poly(methoxydiethylene glycol- l -glutamate) homopolypeptide was facilely synthesized by selenocystamine-initiated ring-opening polymerization in DMF at 30 °C, and their chemical structures and physical properties were fully characterized by means of 1 H NMR, GPC, FT-IR, WAXD, and CD. They self-assembled into spherical micelles in aqueous solution, which possess a lower critical solution temperature, redox-responsiveness inherited from diselenide bond, and the triple stimuli-sensitive self-assembly behaviors, as characterized by means of turbidity, DLS, TEM, and zeta potential measurements. The diselenide-containing homopolypeptides formed supramolecular hydrogels at room temperature, exhibiting a thermal gel–sol transition. The rheological tests evidence that the mechanical modulus of the hydrogel is independent of angular frequency within 100 rad/s and at 25 °C, in which the storage modulus of G′ is order of magnitude greater than the loss modulus of G″, displaying a solid-like elastic behavior. Moreover, the mechanical modulus of the hydrogel can be tuned by changing the chain length of the homopolypeptide, the 10-mM 1,4-dithiothreitol (DTT) reduction, and 1 mM H 2 O 2 oxidation, respectively. Consequently, this work provides a simple strategy to fabricate triple-stimuli responsive polypeptide micelles and one-component hydrogels. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018 , 56 , 1067–1077
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2019
·Vol. 297
·期 2
·225-238
·
IF 1.906
Zhang Longshuai,Liu Yuancheng,Zhang Kui,Chen Yuanwei,Luo Xianglin
Redox-responsive block copolymer micelles have been studied extensively as drug carriers. In this study, tri-block copolymers, methoxyl poly(ethylene glycol)-b-poly(ε-caprolactone)-SeSe-b-poly(ε-caprolactone)-b-methoxyl-poly(ethylene glycol) (mPEG-PCL-SeSe-PCL-mPEG) and methoxyl poly(ethyleneglyco)-b-poly(ε-caprolactone)-SS-b- poly(ε-caprolactone)-b-methoxyl-poly(ethylene glycol) (mPEG-PCL-SS-PCL-mPEG), were synthesized to investigate the redox sensitivity differences between diselenide and disulfide micelles. The changes of micelles in size and structure were investigated under conditions with glutathione (GSH) or H 2 O 2 . The results showed that the size and PDI of (mPEG-PCL-Se) 2 micelles presented more significant variations under redox condition in comparison with (mPEG-PCL-S) 2 micelles. The DOX released faster and more from diselenide micelles than disulfide micelles. The half maximal inhibitory concentration (IC 50 ) of (mPEG-PCL-Se) 2 /DOX micelles was lower than that of (mPEG-PCL-S) 2 /DOX micelles against 4T1 and Hela cells. The amount of intracellular drug release from diselenide micelles was higher than from disulfide micelles in Hela cells with GSH 4.6 mM. Therefore, the (mPEG-PCL-Se) 2 micelles similar to (mPEG-PCL-S) 2 micelles are stimuli-responsive and may be more sensitive drug carriers.
The polymer micelles containing diselenide or disulfide with similar molecular structure are prepared to investigate the redox sensitivity differences. Both micelles have redox sensitivity and capability to enter into 4T1 cells and Hela cells. (mPEG-PCL-Se) 2 micelles present more significant sensitivity and lower IC 50 against cancer cells than disulfide micelles. The diselenide micelles may be more sensitive platforms and be suit to tumor cells in which GSH is less than 10 mM.
研究领域:
药学
·
生物化学
·
材料科学
✓ 已验证
DOI
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 8
·1709
·
IF 4.2
Yanru Hu,Peng Liu
The diselenide bond has attracted intense interest in redox-responsive drug delivery systems (DDSs) in tumor chemotherapy, due to its higher sensitivity than the most investigated bond, namely the disulfide bond. Here, a diselenide-bridged doxorubicin dimeric prodrug (D-DOXSeSe) was designed by coupling two doxorubicin molecules with a diselenodiacetic acid (DSeDAA) molecule via α-amidation, as a redox-triggered drug self-delivery system (DSDS) for tumor-specific chemotherapy. The drug release profiles indicated that the D-DOXSeSecould be cleaved to release the derivatives selenol (DOX-SeH) and seleninic acid (DOX-SeOOH) with the triggering of high GSH and H2O2, respectively, indicating the double-edged sword effect of the lower electronegativity of the selenide atom. The resultant solubility-controlled slow drug release performance makes it a promising candidate as a long-acting DSDS in future tumor chemotherapy. Moreover, the interaction between the conjugations in the design of self-immolation traceless linkers was also proposed for the first time as another key factor for a desired precise tumor-specific chemotherapy, besides the conjugations themselves.
研究领域:
药物化学
·
肿瘤学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2021
·
IF 5.161
Ruitong Liu,Shouhai Li,Na Yao,Jianling Xia,Mei Li,Haiyang Ding,Lina Xu,Xiaohua Yang
Multifunctional coating materials from bio-renewable resources have attracted significant attention in recent years. In this study, a series of multifunctional castor oil-based polyurethane (PU) networks with different hard segments containing diselenide bonds are prepared. The characteristics of PU networks such as self-healing, shape memory, mechanical behavior , and recyclable properties are investigated. All PU networks containing diselenide bonds exhibited self-healing properties under heating due to the metathesis of diselenide. PU network with a hard segment of asymmetric alicyclic structure heals entirely within 2 h under a moderate temperature (70 °C). The shape fixation and recovery ratio are kept above 99.3% and 60.6% after three cycles, respectively. Furthermore, the PU network exhibited high tensile strength (6.9 MPa), superior elongation at break up to 468%, and excellent recyclability. This work would be helpful to the development of research on functional bio-based polymer coatings containing materials dynamic covalent bonds of diselenide.
研究领域:
材料科学
·
生物基材料
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产品关联
DOI
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2021
·
IF 6.141
Lei Lyu,Dong Li,Yuxian Chen,Yefei Tian,Jianzhong Pei
Asphalt with self-healing property prevents the formation and propagation of cracks in asphalt pavements, while rejuvenation encapsulation and induction heating suffer from unsustainable nature and energy consumption. Herein, dynamic covalent chemistry was used to endow asphalt binder with self-healing property via modifying the asphalt with diselenide-crosslinked polyurethane elastomer . Fourier-transform infrared spectrometer and thermal-gravimetry results indicate that diselenide-bonds were stably introduced into the asphalt binder. The results from healing tests illustrated that diselenide bonds enhance the self-healing capability of polyurethane elastomer and asphalt binder, especially at the early stage after a fracture. This study opens up novel perspectives for preparing asphalt with self-healing property attributed to dynamic covalent chemistry.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry B
·
2016
·Vol. 4
·期 29
·5059-5067
·
IF 4.872
Chao Wei,Yan Zhang,Heng Xu,Ying Xu,Yue Xu,Meidong Lang
Well-defined diselenide-centered biodegradable tri-block copolymers methoxyl poly(ethylene glycol)-b-poly(ε-caprolactone)-b-methoxyl poly(ethylene glycol) (mPEG–PCL–Se)2 were precisely synthesized by the combination of ring opening polymerization using di(1-hydroxyethylene) diselenide as a new initiator and a facile coupling reaction. The amphiphilic block copolymers enabled the formation of self-assembled micelles which revealed an excellent reductive response to glutathione (GSH) due to the unique reduction-responsive cleavage of the diselenide bond. Such GSH response ensured an enhanced release of anticancer drugs (DOX) from the micelles in simulative tumor microenvironments; moreover, the drug release could be changed to some extent through fine-tuning the chemical composition of the copolymers. Flow cytometry and confocal laser scanning microscopy (CLSM) measurements confirmed that the DOX-loaded micelles could be efficiently taken up by oral squamous carcinoma (HN30) cells and DOX was released into the nuclei of cancer cells following 4 h of incubation. The cell viability assays showed the diselenide-containing polymers were nontoxic up to a tested concentration (400 μg mL−1), while the DOX-loaded micelles exhibited an evident inhibition toward HN30 cells. Therefore, the reduction-labile biodegradable (mPEG–PCL–Se)2 may offer an alternative platform for tumor-targeting therapy.
研究领域:
材料科学
·
药学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Congling Yang,Qianying Guo,Xinchun Wang,Hongmei Chen,Huan Tan,Bo Feng,Jie Weng
Multi-responsive drug-delivery systems have been widely explored to enable specific delivery to target sites. Here, interleukin-4 (IL-4), an anti-inflammatory cytokine, is first encapsulated in situ inside a zeolitic imidazolate framework (ZIF-8) to form IL-4@ZIF-8, which is subsequently coated with a diselenide block copolymer to obtain IL-4@ZIF-8@Se-Se-polymer. This delivery system enables redox-responsive release of IL-4 by the diselenide copolymer and a pH-triggered release by ZIF-8. Moreover, IL-4 release is precisely controlled stepwise by the stimuli response, with the dissociation of the diselenide copolymer, and breakdown of the ZIF-8 structure. The targeted release property of the IL-4@ZIF-8@Se-Se-polymer endows the materials with efficient macrophage immune regulation, as systematically demonstrated in vitro. This study provides an effective example of the delivery and on-demand release of IL-4, and may find promising applications in tissue engineering for the management of inflammation.
研究领域:
生物材料学
·
免疫学
·
药物递送系统
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2017
·Vol. 5
·期 4
·669-677
·
IF 4.21
Chao Wei,Yan Zhang,Zhongchen Song,Yiru Xia,Heng Xu,Meidong Lang
Stimuli-responsive nanocarriers have been limited for bench-to-bedside translation mainly because the stimuli sensitivity and responsive rate are not high enough to ensure sufficient drug concentration at the target sites for superior therapeutic benefits. Herein, we reported an enhanced bioreduction-responsive and biodegradable nanocarrier based on the amphiphilic poly(ester urethane) copolymers (PAUR-SeSe) bearing multiple diselenide groups on the backbone. The copolymer could spontaneously self-assemble into stable micelles in aqueous medium with an average diameter of 68 nm, which could be rapidly disassembled in a reductive environment as a result of the reduction-triggered cleavage of diselenide groups. Furthermore, the PAUR-SeSe micelles showed an enhanced drug release profile and cellular uptake compared with the disulfide-containing analogue (PAUR-SS). CCK8 assays revealed that the antitumor activity of DOX-loaded PAUR-SeSe micelles was much higher than that of DOX-loaded PAUR-SS micelles. Besides, the blank micelles and degradation products were nontoxic up to a tested concentration of 50 μg mL−1. Therefore, the enhanced therapeutic efficacy and good biocompatibility demonstrated that this drug nanocarrier had great potential for smart antitumor drug delivery applications.
研究领域:
药剂学
·
生物材料
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Chemistry
·
2017
·
IF 0
Yan Zhang,Ying Xu,Chao Wei,Yuanying Zhang,Liu Yang,Zhongchen Song,Meidong Lang
Herein, novel multi-responsive injectable polyester hydrogels were reported based on the diselenide-containing poly(ε-caprolactone) copolymers ((mPEG-PCL-Se) 2 ). The (mPEG-PCL-Se) 2 solution remained a free-flowing state at ambient temperature but spontaneously turned into a semisolid hydrogel upon heating to physiologic temperature. The phase transition temperature was examined to be dependent on the composition and aqueous concentration of the copolymers. More importantly, the thermo-responsive hydrogels were endowed with oxidation and reduction-triggered degradation by the incorporation of diselenide groups. Accordingly, the degradation of poly(ε-caprolactone)-based hydrogels was greatly improved and the rate of degradation was well regulated by the concentration of hydrogen peroxide (H 2 O 2 ) or glutathione (GSH). This superior stimuli-responsive degradation could lead to an enhanced drug release of encapsulated drug (Doxorubicin, DOX). Thus the oxidation and reduction-triggered degradable diselenide-containing poly(ε-caprolactone) hydrogels would offer great potential for the controlled drug delivery.
研究领域:
生物材料
·
药剂学
✓ 已验证
产品关联
DOI
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Xiang Shang,Yong Jin,Weining Du,Long Bai,Rong Zhou,Wenhua Zeng,Kunyan Lin
Waterborne polyurethane has drawn extensive attention due to its environmental friendliness and is widely used in many areas. However, it is still a great challenge to synthesize waterborne polyurethanes with flame retardancy and fast room-temperature self-healing ability, along with excellent mechanical performance and emulsion stability due to the mutually contradictory nature of these properties. Herein, waterborne polyurethanes containing organic selenium (SWPU-x) from 0.67 to 3.28 wt % were synthesized, which could simultaneously realize flame retardancy and self-healing ability based on the ability to scavenge active free radicals at high temperature and the dynamic switch of diselenide. All these SWPU-x films self-extinguished within 1 s after the ignition in the vertical combustion tests. The limiting oxygen index of SWPU-4 was improved to 28.5% with excellent UL-94 level (V-0) and self-healing efficiency (91.25%, after being healed in the photoreactor for 30 min at room temperature), together with high mechanical properties (tensile strength was 18.5 MPa and elongation at break was 869.63%), and the total heat release (THR) for SWPU-4 (49.28 MJ/m2) could decrease to 23.80% of the THR for the original waterborne polyurethane WPU (64.67 MJ/m2). This work discovered a new flame-retardant element (organic selenium) and studied its flame-retardant behaviors and self-healing function simultaneously, which would extremely extend the application of waterborne polyurethanes.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 16
·3837
·
IF 4.2
Yanru Hu,Peng Liu
The diselenide bond has attracted intense interest for drug delivery systems (DDSs) for tumor chemotherapy, owing to it possessing higher redox sensitivity than the disulfide one. Various redox-responsive diselenide-containing carriers have been developed for chemotherapeutics delivery. However, the premature drug leakage from these DDSs was significant enough to cause toxic side effects on normal cells. Here, a pH/redox co-triggered degradable polyprodrug was designed as a drug self-delivery system (DSDS) by incorporating drug molecules as structural units in the polymer main chains, using a facile one-pot two-step approach. The proposed PDOX could only degrade and release drugs by breaking both the neighboring acid-labile acylhydrazone and the redox-cleavable diselenide conjugations in the drug’s structural units, triggered by the higher acidity and glutathione (GSH) or reactive oxygen species (ROS) levels in the tumor cells. Therefore, a slow solubility-controlled drug release was achieved for tumor-specific chemotherapy, indicating promising potential as a safe and efficient long-acting DSDS for future tumor treatment.
研究领域:
生物医学工程
·
药剂学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）