OPTICAL MATERIALS
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2024
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IF 3.8
Yixiong Wu,Yanqi Xu,Cunjun Li,Hai Wang,Xinyu Wang,Aimiao Qin,Haiqing Qin,Linjiang Wang
One-step selectively photocatalytic phenol hydroxylation to produce Dihydroxybenzenes (DHB) is an attractive and challenging strategy. However, the rapid recombination of photogenerated carriers existed in single component photocatalyst seriously hinders the photocatalytic efficiency. The heterojunction strategy can optimize the band structure of the photocatalyst, and effectively improve the carriers' separation and transfer during the photocatalytic process. Herein, we successfully designed and prepared a 3D TiO 2 @Ni 3 Fe 1 -LDH core-shell heterostructure photocatalyst by coupling TiO 2 nanorods with Ni 3 Fe 1 -LDH nanosheets for the photocatalytic phenol hydroxylation to produce DHB. The results showed that the 3D TiO 2 @Ni 3 Fe 1 -LDH core-shell heterostructure had a suitable energy band structure for the photocatalytic phenol hydroxylation and the heterostructure accelerated the carriers’ separation and transfer. Meanwhile, the high porosity and abundant active sites were conducive to the adsorption of H 2 O 2 and the photogenerated carriers transfer efficiency from the photocatalyst to H 2 O 2 . The 3D TiO 2 @Ni 3 Fe 1 -LDH core-shell heterostructure showed excellent photocatalytic performance of phenol hydroxylation, where the phenol conversion was 48.6%, and the selectivity of DHB was 81.1% at 25 °C and 4 h of light illumination. Furthermore, the as-prepared photocatalysts exhibited good stability after four cycles of experiment. This work provided a convenient and efficient method for the green synthesis of DHB.
研究领域:
材料科学
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环境科学
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化学工程
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DOI
高影响因子
Crystals
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2019
·Vol. 9
·期 10
·536
·
IF 2.061
Xian-Rui Zhang,Lei Gao,Gui-Yuan He,Chao-Jie Chen
Investigation on the solid-state pharmaceutical chemistry has been known as an intriguing strategy to not only modify the physicochemical properties of drugs but also expand the solid form landscape. Vortioxetine (VOT) is an effective but poorly soluble antidepressant. To improve the solubility of vortioxetine and expand possible solid forms, in this paper, four novel solid forms of vortioxetine with dihydroxybenzoic acids (VOT-23BA, VOT-24BA-TOL, VOT-25BA, and VOT-26BA, 23BA = 2,3-dihydroxybenzoic acid, 24BA = 2,4-dihydroxybenzoic acid, 25BA = 2,5-dihydroxybenzoic acid, 26BA = 2,6-dihydroxybenzoic acid, and TOL = toluene) were synthesized first by a solvent evaporation method and then characterized by single-crystal X-ray diffraction (SCXRD), thermal, and XRD techniques. VOT-24BA-TOL, VOT-25BA, and VOT-26BA, showed similar [2+2] tetramericR44(12) hydrogen bonds by acid-piperazine heterosynthon. In the VOT-23BA-H2O salt, the VOT cation and 23BA anion interacted through protonated piperazine-hydroxyl N-H···O hydrogen bonds, not protonated piperazine-deprotonated carboxylic acid N-H···O hydrogen bonds. Solubility studies were carried out in purified water and it was found that the VOT-23BA-H2O, VOT-25BA, and VOT-26BA salts exhibited an increase in water compared to pure VOT. The solubility of the stabilized salt formations followed the order of VOT-25BA > VOT-26BA > VOT-23BA-H2O in purified water.Keywords:vortioxetine;dihydroxybenzoic acids;salt;crystal structure;solubility
研究领域:
药物化学
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固态化学
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药剂学
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DOI
高影响因子
MICROCHEMICAL JOURNAL
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2019
·
IF 3.206
Yinhui Yi,Lirong Liu,Wei Zeng,Baohe Lv,Gangbing Zhu
Being awfully harmful to the environment and human health, the sensitive and selective determination of p-dihydroxybenzene (p-DHB) in environmental water is of great significance. However, the similar structures and properties of p-DHB with catechol (CC; one p-DHB isomer) make the selective and reliable determination of p-DHB from CC in environmental waters being still a formidable challenge. In this manuscript, by preparing CC stabilized silicon quantum dots (C-SiQDs) via a simple hydrothermal process and using C-SiQDs simultaneously as a catalyst and fluorescence indicator, a novel nanosensing platform was successfully developed to selectively and sensitively detect p-DHB with double signals: fluorescence and colorimetric. For detecting p-DHB, C-SiQDs could catalyze the oxidation of p-DHB to form benzoquinone (BQ), an intermediate, which lead to the color change from pale yellow to dark brown and the efficient quenching the fluorescence of C-SiQDs. While for CC in samples, it could not contact C-SiQDs surface due to the great steric hindrance effect from CC on quantum dots surface, thus restricting the oxidation of CC and production of BQ, and leading that the obtained C-SiQDs have no response towards CC. Meanwhile, the developed nanosensor could also avoid various other possible interferences. Under optimized conditions, wide linear ranges (from 0.01 μM to 50.0 μM) and low detection limits (4.0 nM) were obtained for p-DHB. The simple and reliable C-SiQDs-based double signals proposal demonstrated to be potentially applicable for the highly selective and sensitive detection of trace p-DHB in various environmental water samples.
研究领域:
环境科学
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分析化学
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DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
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2017
·Vol. 218
·期 16
·1700206
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IF 2.5
Zelin Wu,Liang Li,Youbing Mu,Xiaobo Wan
In this study, an effective way is presented to synthesize a mussel-inspired adhesive from two inexpensive commercially available materials: polyvinyl alcohol (PVA) and 3,4-dihydroxybenzoic acid via the esterification reaction and deprotection technology. This bioinspired adhesive exhibits good bonding ability on metal, glass, plastic, and wood, and the maximum bonding strength can be up to 4.0 MPa at dry conditions on glass substrate. Meanwhile, this adhesive can also be used as a wet/underwater adhesive. Such a PVA-based bioinspired adhesive may be used as a potential candidate for applications in industrial field.
研究领域:
材料科学
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生物化学
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DOI
高影响因子
IRANIAN POLYMER JOURNAL
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2024
·
IF 2.4
Qin Jisong,Cheng Zhengzai,Djouonkep Lesly Dasilva Wandji,Gauthier Mario
To meet polymeric material sustainability requirements of the modern polymer industry, a novel diphenyl-based monomer, dimethyl 2,2’-((carbonylbis(4,1-phenylene))bis(oxy))diacetate (DPBD), was prepared from 4,4'-dixydroxybenzophenone, derived from potentially bio-sourced 4-hydroxybenzoic acid. The diester monomer DPBD was polymerized with either 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, or 1,4-cyclohexanedimethanol as aliphatic diols to afford aliphatic/aromatic copolyesters (P 1 –P 4 ). The copolyesters were characterized using gel permeation chromatography, differential scanning calorimetry, thermogravimetric analysis, dynamic mechanical analysis, and tensile testing, as well as biodegradation and earthworm acute toxicity assays. The effects of diol carbon chain length and cyclic diol monomers on polyester properties were investigated. From the results, the weight-average molecular weight (M w ) of the polyesters ranged from 37.5 to 45.5 kg/mol, glass transition temperature (T g ) ranged from 65 to 78 °C, initial thermal decomposition temperature (T d,5% ) varied from 324 to 353 °C, yield strength varied from 45 to 56 MPa, and elongation-at-break ranged from 215 to 290%. The properties can be adjusted by tuning the monomer structure, which induced a degradation rate of up to 4.6% after incubation in soil for 30 weeks, in contrast to poly(ethylene terephthalate) (PET) which showed no degradation under the same conditions. The ecotoxicity of the polyesters to earthworms remained low, even at high concentration polymer concentration tested (4000 mg/kg soil), the survival rate was above 82%. Therefore, polyesters offer a good combination of structure-to-property serving as potential alternatives to petroleum-based materials. Graphical abstract
研究领域:
材料科学
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环境科学
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Shuying Gao,Fu Yang,Changjian Song,Qiong Cai,Ruyi Wang,Shijian Zhou,Yan Kong
As an energy-efficient and environmental friendliness method, solar sunlight-driven photo-oxidation catalysis process for organic chemicals synthesis has gained enormous attention, but still faces huge challenge in developing highly-efficient photocatalysts material. Two-dimensional materials engineering and surface defect engineering of photocatalysts both provide an effective strategy to improve the catalytic activity. Inspired by this pathway, we design and synthesize ultrathin porous ZnO nanosheets featuring abundant oxygen vacancies specific to producing dihydroxybenzenes based on a photocatalytic oxidation process. Several valid characterizations had been employed to discern the structural character of the obtained model catalyst, revealing that the resultant ZnO sheets afford an average thickness of 3 nm, and abundant surface porosity, thereby contributing to the rich oxygen vacancies. Such a structure could generate a synergistic effect to enhance the optical absorption and improve the transportation rate of photogenerated charge carriers from the materials design. As expected, the specific ultrathin ZnO nanosheets exhibited a greatly-improved photocatalytic activity for oxidation of phenol to dihydroxybenzenes (31.5% conversion & almost 76.7% selectivity of DHB), near 3 and 4 times higher, respectively than its counterparts that one with few oxygen vacancies and Bulk-ZnO. Impressively, the obtained catalyst showed durable catalytic activity without any activity loss during the five recycling. Finally, the feasible oxidation mechanism was proposed and testified by the controlled scavenger experiments. This study provides a novel reference on how to design high-performance photocatalytic material.
研究领域:
材料科学
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环境科学
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化学工程
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DOI
高影响因子
CRYSTAL GROWTH & DESIGN
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2024
·
IF 3.2
Yanan Mao,Kairu Wang,Mengge Liu,Chenyue Lu,Xinghua Zhao,Xin He
Highly soluble cocrystals can improve the bioavailability of poorly soluble drugs by inducing supersaturation when absorption is limited by drug dissolution. Enrofloxacin (ENR) is a concentration-dependent fluoroquinolone antibacterial with poor solubility. In this study, two new ENR salts, 3,5-dihydroxybenzoic acid (ENR-3,5-DHBA) and 2,6-dihydroxybenzoic acid (ENR-2,6-DHBA·1/2H2O), were prepared, and their physicochemical properties were evaluated for suitability in formulation development. Results showed that the solubility of the two new salts enhanced. Although ENR-3,5-DHBA had a much higher solubility than ENR, it underwent rapid precipitation during dissolution, forming the poorly soluble ENR·6H2O in aqueous form. This negated the potential high-solubility advantage of the new salt, which might have enhanced its dissolution rate and in vivo bioavailability. To solve this problem, we systematically evaluated suitable crystallization inhibitors that could maintain the supersaturation generated by cocrystal/salt dissolution for a prolonged period. At 37 °C, the solubility and mean AUC0–24h of ENR-3,5-DHBA increased by about 4.7 and 1.5 times, respectively (compared with ENR), when ENR-3,5-DHBA was dosed with 2.0 mg/mL methacrylic acid-ethyl acrylate copolymer (ME) solution instead of an active pharmaceutical ingredient. This study demonstrates that using a highly soluble salt and an appropriate crystallization inhibitor is a potentially effective formulation strategy for improving the oral bioavailability of poorly soluble drugs.
研究领域:
药学
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药物制剂
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药物递送
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DOI
高影响因子
JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY
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2013
·
IF 0.9
Yihang Lv,Hui Ma,Dongdong Gao,Yi Zhong,Hong Xu,Zhiping Mao
Adhesive polymers, which contain an unusual amino acid, 3,4-dihydroxyphenylalanine (DOPA), can bind strongly to all organic or inorganic surfaces. However, due to DOPA’s poor solubility in organic solvents, it is difficult for us to get desired adhesive polymers. In this paper, poly(N-benzyloxycarbonyl-3,4-dihydroxyphenylalanine) (PNBD) was synthesized based on the modified L-DOPA. Gel Permeation Chromatography was used to analyze the molecular weight of PNBD. The structure of PNBD was characterized by Fourier Transform Infrared Spectroscopy and Hydrogen-1 Nuclear Magnetic Resonance. The adhesive properties of PNBD were determined by lap shear tensile strength tests. The results indicated that PNBD was prepared successfully and had formidable adhesive performance on the various substrates.
研究领域:
材料科学
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生物化学
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DOI
高影响因子
CRYSTAL GROWTH & DESIGN
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2019
·
IF 4.153
Qian Tao,Qian-Qian Hao,Alexander P. Voronin,Xia-Lin Dai,Yu Huang,German L. Perlovich,Tong-Bu Lu,Jia-Mei Chen
The polymorphism of multicomponent crystals has not been studied as widely as that of single-component crystals. In this work, two polymorphic forms of a pharmaceutical salt of phenazopyridine with 3,5-dihydroxybenzoic acid in a 1:1 stoichiometry were successfully obtained and fully characterized by X-ray diffraction, thermal analysis, and dynamic vapor sorption measurement. The crystal structure study exhibited similarities and differences in H-bonding synthons, molecular conformations, and packing arrangements across two polymorphs. The solid-state density functional theory computations complemented by Bader analysis of the periodic electron density and Hirshfeld surface analysis were carried out to quantify the patterns of intermolecular interactions and the energies of crystal lattices for both forms. The combined experimental and theoretical method suggests that these two polymorphs are enantiotropically related. They exhibit different but significantly improved aqueous solubility.
研究领域:
药物化学
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晶体学
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理论计算
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DOI
高影响因子
Chemistry-An Asian Journal
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2015
·Vol. 10
·期 5
·1177-1183
·
IF 4.587
Shuai Zhao,Haining Wang,Lanxia Xin,Jian Cui,Yehai Yan
Graphical Easy as 2, 3, 4 : 2-(3,4-Dihydroxyphenyl) pyrrolidine grafted graphene was developed as a competent platform for covalent functionalization of graphene, from which four typical but not exclusive graphene-derived materials of magnetic graphene-FeCl 3 complex, phenolic-, epoxide-, and methacryloyl-functionalized graphenes were successfully prepared. Covalent functionalization has proven an effective solution for graphene to realize its revolutionary potential in real applications, whereas the platform strategy (a reactive graphene-based material acting as the platform to undergo post-reactions for generation of various graphene-derived materials) is an attractive option to execute efficiently such a task. This contribution demonstrates that 2-(3,4-dihydroxyphenyl) pyrrolidine (DHPP) grafted graphene, G-OH, is a competent platform. Four typical but not exclusive graphene-derived materials have been prepared from G-OH by using the chemical virtue of each DHPP unit having three categories totaling six reactive sites. The controlled feature of 1,3-dipolar cycloaddition for the synthesis of G-OH ensures that the electronic structure and properties of pristine graphene are succeeded largely by G-OH and thus its derivatives. A promising alternative to graphene oxide, which has been widely used as a platform to prepare the graphene-derived materials but suffers from some intrinsic disadvantages, is thus developed.
研究领域:
材料科学
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化学
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DOI
PubMed
高影响因子
Nanoscale
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2019
·Vol. 11
·期 18
·8950-8958
·
IF 6.97
Hui Yang,Shunxing Li,Huiwu Yu,Fengying Zheng,Luxiu Lin,Jie Chen,Yuehai Li,Ye Lin
Control of the active sites/centers plays an important role in the design of novel electrode materials with unusual properties and achievement of sensors with high performance. In this study, three-dimensional (3D) freestanding multi-doped hollow carbon spheres (N–Co–Fe–HCS) with a layer thickness of 30 nm, which contained multiple active sites of the heteroatom N and transition metals (Co and Fe), were synthesized via a simple template method (with SiO2 as the template) and cost-efficient in situ self-polymerization, self-adsorption/reduction and carbonization strategies. Moreover, a series of hollow carbon sphere composites of the same family (N–HCS, N–Co–HCS and N–Fe–HCS) were prepared by this sensible process using the same method and precursors but different doping elements. These differences lead to different active sites/centers from hollow carbon spheres and improved electrocatalytic activities for dihydroxybenzene isomers. Furthermore, N–Co–Fe–HCS as an electrochemical sensor exhibited excellent simultaneous qualitative and quantitative determination performance for catechol (CC) and hydroquinone (HQ). The detection limit and the linear range were 75 nmol L−1 and 0.5–500 μmol L−1 for CC and 80 nmol L−1 and 0.5–1500 μmol L−1 for HQ, respectively. The interference from the components coexisting in river water on the detection of CC and HQ was not observed. These results indicate that high-performance electrochemical sensors can be constructed by in situ multi-element doping into electrode materials to achieve multi-active sites.
研究领域:
材料科学
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分析化学
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DOI
高影响因子
Polymers
·
2024
·Vol. 16
·期 17
·2404
·
IF 4.7
Chunyuan Jiang,Xinrui Zhang,Xinyue Zhang,Xingjian Li,Shoufang Xu,Yinwen Li
For polyacrylate latex pressure-sensitive adhesives (PSAs), high peel strength is of crucial significance. It is not only a key factor for ensuring the long-lasting and effective adhesive force of polyacrylate latex PSAs but also can significantly expand their application scope in many vital fields, such as packaging, electronics, and medical high-performance composite materials. High peel strength can guarantee that the products maintain stable and reliable adhesive performance under complex and variable environmental conditions. However, at present, the peel strength capacity of polyacrylate latex PSAs is conspicuously insufficient, making it difficult to fully meet the urgent market demand for high peel strength, and severely restricting their application in many cutting-edge fields. Therefore, based on previous experimental studies, and deeply inspired by the adhesion mechanism of natural marine mussels, in this study, a traditional polyacrylate latex PSA was ingeniously graft-modified with 3,4-dihydroxybenzaldehyde (DHBA) through the method of monomer-starved seeded semi-continuous emulsion polymerization, successfully synthesizing novel high-peel-strength polyacrylate latex pressure-sensitive adhesives (HPSAs) with outstanding strong adhesion properties, and the influence of DHBA content on the properties of the HPSAs was comprehensively studied. The research results indicated that the properties of the modified HPSAs were comprehensively enhanced. Regarding the water resistance of the adhesive film, the minimum water absorption rate was 4.33%. In terms of the heat resistance of the adhesive tape, it could withstand heat at 90 °C for 1 h without leaving residue upon tape peeling. Notably, the adhesive properties were significantly improved, and when the DHBA content reached 4.0%, the loop tack and 180° peel strength of HPSA 4 significantly increased to 5.75 N and 825.4 gf/25 mm, respectively, which were 2.5 times and 2 times those of the unmodified PSA, respectively. Such superior adhesive performance of HPSAs, on the one hand, should be attributed to the introduction of the bonding functional monomer DHBA with a rich polyphenol structure; on the other hand, the acetal structure formed by the grafting reaction of DHBA with the PSA effectively enhanced the spatial network and crosslink density of the HPSAs. In summary, in this study, the natural biological adhesion phenomenon was ingeniously utilized to increase the peel strength of pressure-sensitive adhesives, providing a highly forward-looking and feasible direct strategy for the development of environmentally friendly polyacrylate latex pressure-sensitive adhesives.
研究领域:
材料科学
·
生物学
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化学工程
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）