JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2021
·
IF 2.694
Tiantian Tao,Yumin Liu,Jiayin Zhang,Yu Zhou,Yanbo Liu,Zhenguo Gao
Experimental solubility data of dibenzoylmethane (DBM) in three pure solvents (ethyl acetate, acetonitrile, methylbenzene) and three binary solvents (methanol + water, ethanol + water, and isopropyl alcohol + water) were measured by the gravimetric method from 278.15 to 318.15 K under atmospheric pressure. The experimental results showed that the solubility of DBM increased with the increase of temperature. Moreover, the solubility of DBM was temperature-dependent when the type and composition of solvents remained unchanged. The solubility of DBM decreased with the increase of solvent polarity because the molecular structure of DBM was not conducive to the formation of hydrogen bonds between solute and solvent molecules. The solubilities of DBM were correlated by the modified Apelblat equation, the van’t Hoff equation, the λh equation, and the NRTL equation. The modified Apelblat model produced the best fitting results among these models.
研究领域:
物理化学
·
热力学
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DOI
高影响因子
Polymers
·
2019
·Vol. 11
·期 2
·194
·
IF 3.164
Feng Ye,Qiufeng Ye,Haihua Zhan,Yeqian Ge,Xiaotao Ma,Yingying Xu,Xu Wang
Zinc orotate (ZnOr2), which is a new kind of poly(vinyl chloride) (PVC) stabilizer, is prepared in this work through the precipitation method, and its impact on the thermal stability of PVC is measured by thermogravimetric analysis (TG), Congo red test, and discoloration test. The results exhibit that the thermal stability of PVC is positively enhanced after the addition of ZnOr2. In contrast with a commercial thermal stabilizer, zinc stearate (ZnSt2), a noteworthy improvement was observed that ZnOr2could postpone the “zinc burning” of PVC. This is principally ascribed to the Or anion in the structure of ZnOr2being able to absorb the HCl released by PVC, and to supersede unstable chlorine atoms in the structure of PVC. In addition, blending ZnOr2with calcium stearate (CaSt2) in diverse mass ratios can significantly accelerate the thermal stability of PVC. Optimum performance was achieved with a CaSt2:ZnOr2ratio of 1.8:1.2. Moreover, an outstanding synergistic effect can be observed when CaSt2/ZnOr2is coupled with other commercial auxiliary stabilizers. The initial color and long-term stability of PVC including CaSt2/ZnOr2is significantly increased when pentaerythritol (PER) is added, while dibenzoylmethane (DBM) can only improve its long-term thermal stability.Keywords:poly(vinyl chloride);zinc orotate;dibenzoylmethane;thermal stabilizer;pentaerythritol;synergistic effect
研究领域:
材料科学
·
化学工程
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产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2020
·Vol. 25
·期 3
·468
·
IF 3.267
Xiu E Feng,Ke Meng Cui,Qing Shan Li,Zi Cheng Wu,Fei Lei
Based on a foregoing gram-scale laboratory process, an efficient scale-up preparation process of 5,2′-dibromo-2,4′,5′-trihydroxydiphenylmethanone (LM49-API), a new acute pyelonephritis candidate drug, was developed and validated aiming to reduce by-products and achieve better impurity profiles. Meanwhile, the polymorph ofLM49-APIand process-related impurities were also investigated. Ultimately, the optimal reaction conditions were verified by evaluating the impurity profiles and their formation during the synthesis. Six process-related impurities were synthesized and identified, being useful for the quality control ofLM49-API. Its finalized preparation process was further validated at 329–410 g scale-up production in 53.4–57.1% overall yield with 99.95–99.98% high-performance liquid chromatography (HPLC) purity, and it is currently viable for commercial production.LM49-API-imCandLM49-API-imXwere identified as the main single impurities inLM49-API, with the content controlled to be less than 0.03%.Keywords:5,2′-dibromo-2,4′,5′-trihydroxydiphenylmethanone;process development;process-related impurity;acute pyelonephritis;polymorph
研究领域:
药物化学
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有机合成
·
药物开发
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产品关联
DOI
PubMed
高影响因子
TOXICOLOGY AND APPLIED PHARMACOLOGY
·
2022
·
IF 4.46
Yuan-Lin Zhang,Hong-Xia Yuan,Jian Sun,Xiu-E Feng,Jin-Hong Ren,Yuan-Biao Qiao,Qing-Shan Li
Directly targeting caveolar caveolin-1 is a potential mechanism to regulate endothelial permeability, especially during oxidative stress , but little evidence on the topic limits therapeutics discoveries. In this study, we investigated the pharmacological effect of an antioxidant LM49 (5,2′-dibromo-2,4′,5′-trihydroxydiphenylmethanoe) and its five diphenylmethanone derivatives on endothelial permeability and establish two distinct mechanisms of action. Multiplex molecular assays with theoretical modeling indicate that diphenylmethanone molecules, including LM49, directly bind the caveolin-1 steric pocket of ASN53/ARG54, ILE49/ASP50, ILE18, LEU59, ASN60, GLU48 and ARG19 residues. They also indicated dynamic binding-affinity for diphenylmethanone derivatives. First, this molecular interaction at caveolin-1 pocket inhibits its phosphorylation at TYR14 residue in H 2 O 2 -injured endothelial cell. A positive correlation was established between diphenylmethanone derivative binding-affinity and caveolin-1 phosphorylation inhibition. Inhibition of caveolin-1 phosphorylation, however, was independent of the LM49-mediated variation of protein tyrosine kinase activity, suggesting a direct blockage of adenosine triphosphate substrate diffusion into cavelion-1 structure. Second, LM49 increases the expression of cellular adhesive and tight junction proteins , VE-cadherin and occludin , in H 2 O 2 -injured cell, in a dose dependent manner. A leakage assay of fluorescein isothiocyanate-labeled dextran 40 across cell monolayer suggested improvement in endothelial barrier integrity with diphenylmethanone treatments. Our results demonstrate a direct targeting effect of caveolin-1 on endothelial permeability, and should guide the diphenylmethanone therapy against oxidative stress-induced junction dysfunction, especially at caveolar membrane invagination.
研究领域:
药理学
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细胞生物学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
Polymers
·
2022
·Vol. 14
·期 18
·3904
·
IF 4.967
Xin Liu,Xiaozhou Zhang,Jiawei Jiang,Hongge Jia,Xigao Jian,Jinyan Wang
Polyether ketone (PEK) plastics are linear thermoplastic polymers connected by at least one ether bond and at least one ketone bond on the aryl group. The reason for their excellent heat resistance, rigidity, and mechanical strength is that their main molecular chain contains plenty of aromatic rings and polar carbonyl groups, and their molecular chain presents a large rigidity and strong intermolecular force. In addition, the main chain contains a considerable number of ether bonds, resulting in a certain toughness. However, polyether ketone materials have the disadvantage of poor solubility because of their excellent rigidity. To improve the solubility of polyether ketone, the preparation method of a novel nitrogenous heterocyclic polyaromatic ether monomer, 2-(4-chlorophenyl)-2,3-dihydrophthalazine-1,4-dione (CDD), was proposed, and its activity of polymerization was studied. The average molecular weight of the poly(aryl ether ketone) containing a nitrogenous heterocyclic polyaromatic ether group obtained by self-polycondensation of CDD was 4.181 × 103kg/mol, and the yield was 90.5%. In order to further explore the activity of monomers, novel copolymerized poly(aryl ether ketone) (PBCD) containing a nitrogenous heterocyclic polyaromatic ether structure was prepared by ternary copolymerization with 4,4-difluorobenzophenone (DFBP) and bisphenol fluorene (BHPF) with high activity. The average molecular weight of PBCD was 72.793 × 103kg/mol, the molecular weight distribution was 2.344, and the yield was 88.1%. Fourier transform infrared spectroscopy (FT-IR) and1H NMR were used to confirm the structure of the obtained polymer. Through thermogravimetric analysis (TGA), the determined weight loss temperature of 5% under nitrogen was higher than 500 °C, indicating excellent thermal stability. Compared with the solubility of the binary copolymer containing fluorenyl poly(aryl ether ketone) (PBD), the polymer showed reasonable solubility in selective solvents such as chloroform andN,N-dimethylacetamide.Keywords:poly(aryl ether ketone);solubility;thermal properties
研究领域:
高分子科学
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材料科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
OPTICAL MATERIALS
·
2025
·
IF 4.2
Mingguang Zhu,Lihui Yang,Xinyu Ye,Meihui Chen,Yuanbin Wu,Donghong Xie,Yue Yu,Yaohui You
A series of fluorescent Schiff bases were skillfully designed and efficiently synthesized through the condensation reaction of 2-hydroxy-4-methoxybenzophenone hydrazone with various aromatic aldehydes (benzaldehyde, p -chlorobenzaldehyde, p -tolualdehyde, and p -dimethylaminobenzaldehyde). Their structures were rigorously confirmed using a combination of spectroscopic techniques, including FT-IR, HR-ESI-MS, and 1 H/ 13 C NMR spectroscopy. Notably, photophysical investigations revealed that p -dimethylaminobenzaldehyde-functionalized Schiff base featured with excited-state intramolecular proton transfer (ESIPT) upon photoexcitation in various organic solvents, whereas the other derivatives did not. In particular, this derivative demonstrated remarkable fluorescence enhancement due to synergistic effect of ESIPT and aggregation-induced emission (AIE) during aggregation process. Conversely, the emission intensities of the other Schiff bases gradually quenched in THF/H 2 O mixed solvent as the water fraction ( f w ) increased from 0 to 90 %, attributed to the typical aggregation-caused quenching (ACQ) effect. Additionally, this derivative demonstrated superior solid-state fluorescence and dyeing performance compared to its counterparts. Furthermore, this derivative showed reversible HCl/NH 3 stimuli-responsive solid fluorescence and a selective fluorescence turn-off response to Cu 2+ . This study would provide valuable insights into the molecular engineering of functional fluorescence materials based on benzophenone hydrazone derivative.
研究领域:
有机合成
·
荧光材料
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光物理
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刺激响应材料
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化学传感
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2018
·Vol. 25
·期 1
·1-9
·
IF 1.434
Li Hanyuan,Wang Wei,Chen Guofei,Liu Yinfeng,Fang Xingzhong
Novel highly soluble phenylethynyl-endcapped oligoimides derived from mixed thioetherdiphthalic anhydride isomers ( m -TDPA) and 5(6)-amino-1-(4-aminophenyl)-1,3,3-trimethylindane (DAPI), 4,4′-oxydianiline (4,4’-ODA) with 4-phenylethynylphthalic anhydride (PEPA) as a reactive endcapping agent were synthesized. The calculated molecular weights of all the oligoimides were 2500 g·mol −1 .The effect of the mole ratio of DAPI/4,4’-ODA on solubility and melt viscosity of oligoimides as well as the thermal and mechanical properties of cured polyimide films was investigated. Experimental results indicated that DAPI greatly improved the solubility (>30 wt.%) of the oligoimides in low boiling points solvents when the content of DAPI was more than 10 mol% per total diamine. All the oligoimides exhibited very good processability with minimum melt viscosity lower than 60 Pa·s at about 330 °C. Tough and brown films were obtained after thermally cured at 370 °C for 1 h and dynamic mechanical analysis (DMA) showed that glass transition temperatures of the cured films increased up to 340 °C with the increasing content of DAPI. However, the thermal stability and mechanical properties decreased with the increase of DAPI content. The temperature of 5% weight loss was higher than 470 °C in both air and N 2 atmosphere obtained by thermogravimetric analysis (TGA). And the tensile strengths of the cured films were about 60 MPa.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2025
·
IF 5.1
Shumin Jiang,Hangzhou Wang,Jun Shi,Xiaobin Li,Xiaoyan Xiong,Chenguang Kong,Cunzhi Li,Youcheng Huang,Kun Wu,Li Yang
In the semiconductor precision device processing and wafer cutting industry, products are typically etched or sliced to meet specific requirements. During this process, a novel type of adhesive is often utilized for bonding and securing purposes. After processing, some methods, such as light exposure and thermal application, can be used to make the adhesive lose its adhesiveness, so as to facilitate the peeling of the product without damaging the product. In this work, acrylate prepolymers containing photopolymerization groups were synthesized from 4-acryloyloxybenzophenone (4-ABP) and other acrylic monomers. UV-induced tack-loss of the acrylate pressure-sensitive adhesive (PSA) was achieved by blending the acrylic prepolymer with a small molecule isocyanate compound in an appropriate ratio and then coating for heat curing. It was observed that the incorporation of multifunctional isocyanate small molecule groups can enhance the overall performance of the tape. An addition amount of 0.6 wt% hexamethylene diisocyanate (HDI) was found to be more suitable than isophorone diisocyanate (IPDI), as it maintained good bonding performance and resulted in less residual glue. The increase in 4-ABP initially led to an improvement in bonding performance of the pressure sensitive adhesive tape, followed by a decrease, with an optimal addition amount of 1.2 wt%. After UV curing, the 180° peel strength of the adhesive tape measured below 1.0 N/25 mm, exhibiting the most significant decrease in peel strength and minimal residual adhesive content. This characteristic categorized it as a UV-induced tack-loss easy peeling pressure-sensitive adhesive tape. These results contribute to the further research and development of UV-induced tack-loss PSA.
研究领域:
材料科学
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聚合物化学
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胶粘剂技术
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半导体制造
·
光聚合
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产品关联
DOI
高影响因子
CHEMISTRY & BIODIVERSITY
·
2025
·
IF 2.5
Zebin Huang,Wanying Zhang,Qi Shu,Xiao-Chun Guo,Xi Zheng,YuJing Lu
Inflammation is an important predisposing factor for many chronic diseases. The dietary flavonoid silibinin has excellent anti-inflammatory properties in cells, but its low bioavailability in the blood compromises its therapeutic potential. This study aims to investigate the potential of dibenzoylmethane (DBM) to synergistically enhance the anti-inflammatory benefits of silibinin (SB). The synergistic effects of DBM and SB in combination were evaluated in LPS-induced RAW264.7 cells and TPA-induced mice. In addition, a network pharmacology approach and molecular docking were used to explore the key targets and signaling pathways of DBM and SB in combination. The results showed that DBM and SB synergistically inhibited the production of NO, ROS, IL-1β, and TNF-α in a 1:1 concentration ratio. These two compounds may exert their synergistic effects by modulating the NF-κB and HIF-1 signaling pathways, among others. Molecular docking revealed that both compounds exhibited high binding affinities to iNOS and COX-2. Compared with single compound use, the two compounds in combination significantly reduced ear edema and inflammatory cell infiltration, and inhibited the protein expression of iNOS and COX-2 in TPA-induced mice. This research provides a rationale for the combination of DBM and SB as an effective anti-inflammatory agent.
研究领域:
药理学
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免疫学
·
分子生物学
·
炎症研究
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产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Kang Liu,Li Deng,Tonghui Zhang,Ke Shen,Xuefen Wang
Wearable smart membranes applied in fabrics as a functional core layer, featuring high ultraviolet (UV) resistance, ease of breathability, and desirable waterproof performances, have received much attention. However, using a facile and environmentally friendly process to design such versatile protective materials that have satisfactory comprehensive performances has turned out to be a tremendous challenge and has not yet been reported. Herein, we report a simple and high-efficiency strategy to fabricate waterproof and breathable membranes with outstanding UV-resistant properties by introducing 2-hydroxy-4-methoxybenzophenone (UV9) and hydrophobic nanotitanium dioxide that has been modified with a short-chain fluoroalkylsilane coupling agent (CF3CH2CH2SiCl3, TFPTCS) (named F-TiO2) into a poly(vinylidene fluoride) (PVDF) solution for facile one-step electrospinning. Because of the addition of F-TiO2 NPs, the waterproof properties of the PVDF nanofibrous membranes were dramatically enhanced; meanwhile, F-TiO2 NPs acted as inorganic UV shields to impart durable UV resistance to the PVDF membranes. Additionally, the organic UV absorber UV9 was utilized to further strengthen the UV-resistant property of the PVDF/F-TiO2 membranes. By slightly adjusting the addition amount of F-TiO2 NPs and UV9, ecofriendly and multifunctional PVDF/F-TiO2/UV9 nanofibrous membranes were systemically optimized with good moisture breathability (10.6 kg m–2 d–1) and waterproof performance (60.2 kPa), satisfactory tensile strength (15.1 MPa), and an outstanding ultraviolet protection factor (UPF value reached up to 1690.7). Such versatile materials would be very suitable for the design of wearable textiles for various applications, especially in outdoor protective clothing and health care and military products.
研究领域:
材料科学
·
纺织工程
·
纳米技术
·
环境科学
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产品关联
DOI
高影响因子
Soft Science
·
2025
·Vol. 5
·期 4
·N
·
IF 9
Yuyang Sun,Dongsheng Li,Ruxiao Yang,Zhicun Zhou,Tianci Ji,Bo Lu,Lining Sun,Huicong Liu
Current human-robot interaction (HRI) systems for training embodied intelligent robots often suffer from limited motion dimensionality and unintuitive control. This work presents the Touch-Code Glove, a multimodal HRI interface integrating functional materials, structural intelligence, and deep-learning decoding. A triboelectric digital interface is embedded into the Wrist-pad via a mosaic-patterned array of polyamide/polytetrafluoroethylene-doped silicone rubber films, generating polarity-dependent digital signal pairs upon contact. A co-electrode layout enables 16 touch points with minimal wiring, allowing multiplexed, programmable tactile input via sliding or multi-point gestures. Coupled triboelectric signals are accurately decoded using a convolutional neural network and long short-term memory model, achieving over 98% recognition accuracy. Complementarily, a double-network conductive hydrogel composed of sodium alginate, polyacrylamide, and sodium chloride is integrated into the Finger-fibers and the Wrist-pad to provide strain-sensing capabilities with excellent stretchability, high linearity, low hysteresis, and long-term stability. The system incorporates three concurrent sub-mapping strategies: gesture-driven control, wrist posture-based movement, and touch path-guided input, which together enable real-time control of robotic hands and arms without requiring professional training. This triboelectric-hydrogel hybrid interface offers a materials-centric solution for intelligent, wearable, and accessible HRI, paving the way for next-generation multimodal robotic control systems in assistive and industrial applications.
研究领域:
人机交互
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可穿戴电子
·
软体机器人
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智能传感器
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机器人中的机器学习
·
功能材料
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摩擦电传感
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水凝胶传感器
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产品关联
DOI
高影响因子
npj Flexible Electronics
·
2025
·Vol. 9
·期 1
·1-10
·
IF 15.5
Hu Qiyun,Wu Zikun,Tian Ye,Wang Jiaxin,Pan Zhangqi,Yu Yang,Cheng Yifan,Yang Yueying,Tang Hanchuan,Zang Jianfeng
Underactive bladder (UAB) patients experience straining to void and typically cannot sense bladder fullness. Previous closed-loop bladder volume control systems are limited in neurogenic UAB patients and face infection risk due to wired connections. Here, we propose an intelligent bladder volume control system (IBCS) combining an implantable meshed magnetic soft robot (MMR) with a wearable magnetic field sensor. The MMR, tightly sutured to the bladder, compresses the bladder to facilitate urination under magnetic actuation, achieving a voiding efficiency of 94.8%. The wearable magnetic field sensor outside the abdomen achieves continuous and wireless monitoring of bladder volume with a 4.8% error in time. The MMR was validated on a UAB pig model, demonstrating a pressure increase of up to 33 cmH 2 O and voiding efficiency of over 83%. Our IBCS provides a biocompatible solution for wireless and continuous bladder volume management by integrating wearable sensors and magnetic robotics.
研究领域:
生物医学工程
·
软体机器人
·
泌尿学
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可穿戴传感器
·
无线医疗设备
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）