CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 13.2
Jingjing Xu,Konstantinos Ntetsikas,Jianyong Yu,Faxue Li,Nikos Hadjichristidis,Leiming Guo
Block copolymers (BCPs), promising materials for next-generation membranes, face unprecedented challenges in water purification due to the difficulty in processing them into nanoporous membranes with pores <2 nm—a key barrier for molecular elimination. While recent progress in tailorable pore chemistry offers a solution, an indiscriminate method to remove nonspecific molecules from water remains urgent. To address this, we developed BCP-Fc catalytic membranes with an average pore diameter of 23.4 nm by functionalizing nanoporous BCP membranes with ferrocene (Fc). These membranes removed 96% of Rhodamine B (RhB) while maintaining a permeance of 750 L/(m 2 ·h·bar), comparable to other state-of-the-art membranes. The effect of pH on removal efficiency and permeance was also examined. The membranes effectively eliminated the positively charged dyes of methyl blue (MB), crystal violet (CV), and neutral red (NR) with the efficiencies of 96.6%, 93.6%, and 99.1%, respectively, and the negatively charged dyes of methyl orange (MO) and acid red 73 (AR 73) with efficiencies of 74.6% and 74.2%, respectively. Moreover, the membranes maintained high elimination efficiencies for dye mixtures. The membranes demonstrated continuous operation for up to 38 h and superior reusability. The molecular elimination mechanism was further revealed. This work presents an innovative strategy for custom-tailored BCP membranes, enabling fast molecular elimination.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2026
·
IF 3.9
Wang Rong,Tian Xiao-Li,Li Jin,Chen Jia-Jia,Hu Yue,Zhang Ji
Ferroptosis is a non-apoptotic form of cell death that offers unique advantages in various cancer therapies. Gene therapy, on the other hand, involves transferring therapeutic genes into cancer cells to regulate related proteins and exert therapeutic effects. Nanomaterials that combine the ability to induce ferroptosis in cancer cells with gene delivery functionality hold great potential for tumor therapy. Herein, we designed and synthesized a series of ferrocene-containing (Fc) cationic lipids (NFC-1~4) based on the Ugi reaction. Fc, as a typical Fenton reaction catalyst, can effectively trigger ferroptosis in cancer cells. The results showed that NFC-1~3 lipoplexes could be efficiently taken up by A549 cells and exhibit excellent gene transfection capabilities, with the best transfection efficiency surpassing that of Lipofectamine 2000. Reactive oxygen species (ROS) detection experiments revealed that NFC-2 possesses Fenton characteristics, enabling it to induce the Fenton reaction and produce ROS. In vitro antitumor experiments demonstrated that NFC-2 LNPs could inhibit tumor cell growth to some extent, with its efficacy significantly enhanced after DNA encapsulation. Mechanistic studies indicated that the Fenton reaction mediated by NFC-2@DNA lipoplexes converted endogenous H 2 O 2 into highly toxic ·OH, leading to increased intracellular ROS levels, glutathione (GSH) depletion, and inactivation of glutathione peroxidase 4 (GPX4). The disruption of the cellular redox balance caused excessive accumulation of lipid peroxides (LPOs), ultimately inducing ferroptosis. NFC-2 holds promise as an efficient ferroptosis agent and a dual-function lipid for co-delivering DNA, offering potential for combined gene therapy and ferroptosis-based cancer treatment. Graphical abstract
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ACS Sensors
·
2023
·
IF 8.9
Jian Yang,Xia Gong,Shuijin Chen,Ying Zheng,Lelun Peng,Bin Liu,Zhipeng Chen,Xi Xie,Changqing Yi,Lelun Jiang
Continuous glucose monitoring (CGM) can mini-invasively track blood glucose fluctuation and reduce the risk of hyperglycemia and hypoglycemia, and this is is in great demand for diabetes management. However, cost-effective manufacture of CGM systems with continuously improved convenience and performance is still the persistent goal. Herein, we developed a smartphone-controlled and microneedle (MN)-based wearable CGM system for long-term glucose monitoring. The CGM system modified with a sandwich-type enzyme immobilization strategy can satisfy the clinical requirement of interstitial fluid (ISF) glucose monitoring for 14 days with a mean absolute relative difference of 10.2% and a cost of less than $15, which correlated well with the commercial glucometer and FDA-approved CGM system FreeStyle Libre (Abbott Inc., Illinois, USA). The self-developed CGM system is demonstrated to accurately monitor glucose fluctuations and provide abundant clinical information. It is better to find the cause of individual blood glucose changes and beneficial for the guide of precise glucose control. On the whole, the intelligently wearable CGM system may provide an alternative solution for home-care diabetes management.
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高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2022
·Vol. 169
·期 4
·047514
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IF 4.386
Qiwen Yu,Jing Chen,Jingpin Xu,Long Chen,Yanhua Song,Xiaoya Xie,Jinjiang Jin,Hong Liu,Jun Liu,Fengjiang Zhang,Xing Chen
Real-time detection of L-lactate is crucial in monitoring tissue oxygenation and organ metabolism in surgery patients during the perioperative period. Traditional commercial L-lactate detection techniques using bulky and expensive instruments are time-consuming, hindering timely feedback in the operating room. Herein, utilizing the modified screen-printed carbon electrode, a portable and user-friendly smartphone-based electrochemical biosensing system, integrated with a miniaturized potentiostat via wireless transmission, was successfully constructed for bedside detection of L-lactate. It has a wide sensing range from 0.05–10 mM and a low limit of detection (9.1 μM). Bland–Altman analysis shows an acceptable agreement with the values of a mean difference (0.114 ± 0.3482) between results obtained with the commercial blood gas analysis instrument and the developed portable system. Accordingly, the developed portable system exhibits a great potential in point-of-care testing owing to its portability and rapid response in L-lactate detection during perioperative monitoring.
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Molecular Catalysis
·
2023
·
IF 4.6
Jinyi Liu,Haojie Yu,Li Wang,Sergey Z. Vatsadze,Dingning Chen,Xudong Wu,Xiaodan Gong,Yu Wang
Ferrocene (Fc)-based compounds as the burning rate catalysts (BRCs) for the thermal decomposition of ammonium perchlorate (AP), a vital oxidizer in composite solid propellants (CSPs), were received extensive attention due to its excellent catalytic effect. However, most of them are easy to migrate and the in situ produced metal oxide nanoparticles at high temperature tend to agglomerate, affecting the catalytic efficiency. Herein, a series of GOs functionalized with Fc were fabricated and studied as BRCs in this work. The results showed that these compounds can accelerate AP decomposition and enhance the combustion performance of CSPs, which was ascribed to the good thermal conductivity, electrical conductivity, larger steric hindrance and specific surface area. Among them, GO Cu-AMTZ-Fc showed the best catalytic performance. The pyrolysis temperature of AP was reduced from 420.9 °C to 337.6 °C. Meanwhile, the burning rate of propellant was increased from 1.64 mm/s to 2.20 mm/s and the related pressure index was decreased by nearly half. Moreover, their anti-migration ability was improved greatly. The work indicated that GOs functionalized with Fc have a potential application as BRCs in CSPs.
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JOURNAL OF MOLECULAR STRUCTURE
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2023
·
IF 3.8
Lina Guo,Ligang Yan,Ruijun Xie,Limin Han,Ning Zhu
A simple ferrocene-based Schiff base (probe L ) exhibiting aggregation-induced emission ( AIE ) effect has been synthesized and investigated. The probe L showed selective detection for trivalent metal ions (Al 3+ , Cr 3+ and Fe 3+ ) over a range of monovalent and divalent metal ions in methanol via multi-channel of detection using colorimetry , fluorescence and electrochemistry . Upon binding with trivalent metal ions, color change from faint yellow to pink for Al 3+ , Cr 3+ and Fe 3+ was observed by the naked-eye, which was consistent with the change of UV–Vis absorption spectra. In addition, probe L showed a dramatic off-on fluorescence emission along with a large Stocks-shift of about 33 nm in the emission wavelength. The fluorescence enhancement with a blue shift may be attributed to the combined effect of rotation inhibition and an extended intramolecular charge transfer ( ICT ) mechanism. Moreover, electrochemical detection demonstrated that the oxidation potential difference between probe L and probe l -metal complexes was 0.028 V (Al 3+ ), 0.044 V (Cr 3+ ) and 0.015 V (Fe 3+ ), respectively, indicating that trivalent metal ions induced charge transfer from the ligand to the metal ( LMCT ) and reduced the electron density of ferrocene moiety. Therefore, Al 3+ , Cr 3+ and Fe 3+ can be selectively detected using multi-channel of detection techniques. Finally, 1 H NMR titration study confirmed that two molecules of probe L bind with one metal ion through the nitrogen atom and oxygen atom of the probe L .
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ANALYTICAL CHEMISTRY
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2021
·
IF 6.986
Datong Wu,Cong Ma,Fei Pan,Yongxin Tao,Yong Kong
In the past, various chiral isomers accompanied by electroactive units have been distinguished using electrochemical techniques, which can produce electrochemical signals by themselves. However, it is still difficult to use an electrochemical technique to detect nonelectroactive samples. To address this bottleneck, an electroactive chiral polymer (S,S)-p-CVB-Fc that contains one redox-active ferrocene unit was designed and synthesized in this study. The electroactive polymer can give electrochemical signals as an alternative to the tested chiral samples, regardless of whether the isomers have electroactive units. Then, it was fixed on the surface of a glassy carbon electrode as an electrochemical chiral sensor. When nonelectroactive amino acids including proline, threonine, and alanine were examined by the sensor, clear discrimination in the response of peak current could be observed toward l- and d-isomers at pH 6.5. The peak current ratios (IL/ID) for proline and alanine were 1.47 and 1.48, respectively. In contrast, for threonine, the d-isomer exhibited a higher peak current than the l -isomer with a ratio of 2.59. In summary, the results ensure that the current work can enlarge the testing scope of chiral samples in the field of chiral electroanalysis using an electroactive sensor.
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高影响因子
ANALYTICAL CHEMISTRY
·
2020
·
IF 6.785
Datong Wu,Fei Pan,Li Gao,Yongxin Tao,Yong Kong
Although an increasing number of researchers are developing electroanalytical protocols for the chiral recognition of amino acids, the electroactive units of the tested isomers still need to provide corresponding electrical signals. In this study, a supramolecular system was developed for the chiral electroanalysis of amino acids regardless of electroactive units. As a model system, an enantiopure electroactive molecule Fc-(S,S)-1 that includes a ferrocenyl group was synthesized and acted as a guest. Moreover, hydrophobic cyclobis-(paraquat-p-phenylene) (CBPQT4+-2) was used as the host. In the presence of π–π stacking and the attraction of π-electrons, CBPQT4+-2 can encapsulate Fc-(S,S)-1 into its cavity. Next, a screen-printed electrode was utilized for electrochemical chiral recognition. The host was fixed on the surface of the working electrode, and the guest was used as the electroactive chiral selector to support electron transfer. Once different configurations of amino acids (threonine, histidine, glutamine, and leucine) were mixed with the guest, regardless of whether they contained electroactive units, differences in the cyclic voltammetry results of the probe enantiomers could be observed, namely, in the peak currents or peak potentials. However, glutamine was an exception because the L-isomer had a stronger binding affinity with Fc-(S,S)-1 + Cu(II), which would limit the transport of the complex into the cavity of CBPQT4+-2, thereby resulting in a low peak current. Thus, an inverse phenomenon was observed with glutamine. In summary, we believe that this work can increase the testing scope for the chiral recognition of different kinds of isomers using electrochemical tools.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2020
·Vol. 55
·期 11
·4780-4791
·
IF 3.553
Zeng Zhaowei,Yi Lei,He Jianwei,Hu Qian,Liao Yucong,Wang Yadong,Luo Wenbin,Pan Mu
Highly dispersed electrocatalysts and single-atom catalysts receive extensive attention in the field of multiple reactions involving water spitting, oxygen reduction, and CO 2 reduction. Herein, we develop a Fe/N co-doped hierarchically structured porous carbon (Fe/N/C-DT) by the dual-templating approach, involving the incorporation of ferrocenecarboxaldehyde (Fc–CHO) into the polyimide, followed by carbonization at 900 °C and etching. A steric hindrance offered by the ferrocene and the porosity of the obtained nanostructure prevent the aggregation of Fe atoms, resulting in the maximization of catalytic efficiency of iron-based sites. FeCl 2 /N/C-DT and FeSO 4 /N/C-DT using FeCl 2 and FeSO 4 as iron sources, respectively, are prepared for comparison, to further confirm the potential positive effect of Fc–CHO and explore the synergistic effect of the pentagon defects and Fe–N 4 on the catalytic performance in oxygen reduction reaction (ORR). The prepared Fe/N/C-DT exhibits outstanding electrochemical activity toward ORR ( E 1/2 = 0.902 V vs RHE) and impressive OER activity ( E j =10 = 1.66 V) in alkaline conditions. The rechargeable Zn–air battery using Fe/N/C-DT as a cathode catalyst shows a peak power density of 220 mW cm −2 and a high open–circuit voltage of 1.451 V in the all-solid-state Zn–air battery.
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DYES AND PIGMENTS
·
2018
·
IF 3.767
Xiaojing Lv,Conghui Huang,Alexey Tameev,Liang Qian,Rui Zhu,Konstantin Katin,Mikhail Maslov,Alexander Nekrasov,Cheng Zhang
A novel triphenylamine (TPA) derivative (E) N-(4-(Diphenylamino)phenyl)- formimidoylferrocene) (TPAFc) containing ferrocene (Fc) unit was designed and synthesized successfully. Theoretical calculation and experimental data show TPAFc possesses higher HOMO energy level and the lower onset oxidative potential compared to TPA monomer . Cyclic voltammetry test demonstrates coupling reaction between TPA units and the formation of an electroactive polymer film during successive scans. This intriguing phenomenon may be ascribed to the multi-step oxidation process and Fc unit plays an important role as charge transport center for electrons moving from TPA units and the surface of the forming oligomer film to the electrode. SEM images indicate PTPAFc film shows the surface morphology of uniform tubular structures, which may largely increase the area of interface between the electrolyte solution and the polymer film. Interestingly, PTPAFc film exhibits reversible multicolor changes switched from neutral transparent color to light orange and blue in fully oxidized state, which are attributed to that the existence of Fc unit brings out multiple redox states. In addition, the polymer film presents excellent electrochromic performances in the aspect of high optical contrast (∼58%), good coloration efficiency (∼130 cm 2 C −1 ) and fast switching time (∼2 s). In view of these excellent features, the developed PTPA derivative is very satisfactory for applications on high-performance electrochromic devices .
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ACS Applied Materials & Interfaces
·
2014
·
IF 5.9
Jiyang Liu,Xiaohui Wang,Tianshu Wang,Dan Li,Fengna Xi,Jin Wang,Erkang Wang
Biological modification of monolithic and porous 3D graphene is of great significance for extending its application in fabricating highly sensitive biosensors. The present work reports on the first biofunctionalization of monolithic and freestanding 3D graphene foam for one-step preparation of reagentless enzymatic biosensors by controllable chitosan (CS) electrodeposition technology. Using a homogeneous three-component electrodeposition solution containing a ferrocene (Fc) grafted CS hybrid (Fc-CS), glucose oxidase (GOD), and single-walled carbon nanotubes (SWNTs), a homogeneous biocomposite film of Fc-CS/SWNTs/GOD was immobilized on the surface of 3D graphene foam by one-step electrodeposition. The Fc groups grafted on chitosan can be stably immobilized on the 3D graphene surface and keep their original electrochemical activity. The SWNTs doped into the Fc-CS matrix act as a nanowire to facilitate electron transfer and improve the conductivity of the biocomposite film. Combined with the extraordinary properties of 3D graphene foam including large active surface area, high conductivity, and fast mass transport dynamics, the 3D graphene based enzymatic biosensor achieved a large linear range (5.0 μM to 19.8 mM), a low detection limit (1.2 μM), and rapid response (reaching the 95% steady-state response within 8 s) for reagentless detection of glucose in the phosphate buffer solution.
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高影响因子
JOURNAL OF APPLIED ELECTROCHEMISTRY
·
2014
·Vol. 45
·期 1
·21-31
·
IF 2.147
Li Meng,Ma Xiuxiu,Wu Yanying,He Xingquan
A novel non-noble-metal electrocatalyst, abbreviated as CoFcPc/PSS-Gr, was fabricated through a solvothermally assisted π–π assembling approach by anchoring cobalt tetraferrocenylphthalocyanine (CoFcPc) onto poly(sodium- p -styrenesulfonate) modified graphene (PSS-Gr). The as-prepared hybrid was characterized by scanning electron microscopy, transmission electron microscopy, UV–Vis absorption spectroscopy, and X-ray photoelectron spectroscopy. Cyclic voltammetry, rotating disk electrode, and rotating ring-disk electrode measurements were employed to investigate the kinetics and mechanism of the ORR on the CoFcPc/PSS-Gr electrode. Besides, the chronoamperometric measurements were utilized to evaluate the stability of the CoFcPc/PSS-Gr composite in an alkaline solution. The obtained results demonstrated that CoFcPc supported on PSS-Gr showed good tolerance to methanol crossover, high kinetic current density (9.51 mA cm −2 ), high stability (84.6 % after 10,000 s), and an almost four-electron transfer process in an alkaline medium.
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