Discover Nano
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2026
·Vol. 21
·期 1
·415
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IF 6.7
Long Lin,Zhang Yexi,Xiao Jun,Zang Jianhua
Purpose To fabricate hesperetin-loaded fucoidan-selenium (Hes/Fu-Se) nanoparticles (NPs) for alleviating cisplatin-induced acute kidney injury (AKI), overcoming hesperetin’s low solubility and bioavailability and boosting antioxidant and anti-inflammatory efficacy. Methods Hes/Fu-Se NPs were prepared by encapsulating hesperetin within fucoidan, and then functionalized selenium (Se) NPs. Nanoparticle physicochemical properties and antioxidant activity (FRAP, ABTS) were characterized. Cisplatin-stimulated HK-2 cells were used for in vitro detection of cell viability, apoptosis, ROS accumulation, mitochondrial function and cGAS-STING signaling. A cisplatin-induced AKI mouse model was adopted to test renal biochemical indexes, renal histopathology and renal injury-related protein expression. Results Synthesized Hes/Fu-Se NPs exhibited uniform particle size, superior aqueous solubility and potent antioxidant activity. In vitro, the NPs restored HK-2 cell viability, mitigated apoptosis and ROS overproduction, and inhibited DNA damage and cGAS-STING cascade activation. In vivo, Hes/Fu-Se markedly reduced serum BUN and CRE, alleviated renal histological lesions and inflammatory infiltration, and downregulated the expression of cGAS, STING, γH2AX and TNF-α in kidney tissues. Conclusions Hes/Fu-Se NPs relieve cisplatin-triggered AKI via amplified antioxidation, DNA damage restoration and cGAS-STING pathway suppression. This nanoformulation provides a promising nephroprotective strategy against chemotherapy-related renal toxicity for clinical translation. Graphical abstract
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npj Science of Food
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2026
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IF 9.7
Yang Zhenglei,Wu Yangmeixue,Liu Jun,Yang Yang,Fu Shuang,Hu Hongbo,Yin Shutao
Selenium (Se) is an essential micronutrient for human health; however, the efficient conversion of inorganic Se into organic forms remains challenging. Microalgae have emerged as promising platforms for sustainable production of functional food ingredients due to their rapid growth, metabolic versatility, and capacity to accumulate bioactive compounds. Here, Auxenochlorella pyrenoidosa ZC-1006 was evaluated as a heterotrophic platform for producing Se-enriched biomass. The most favorable heterotrophic conditions within the tested ranges were 15 g/L glucose, 2 g/L urea, an initial pH of 6.0, and cultivation at 31 °C. Supplementation with 5 mg/L sodium selenite (Na 2 SeO 3 ) provided a favorable balance between biomass accumulation and Se enrichment, yielding 108.74 mg/kg total Se on a dry weight (DW) basis. Ion chromatography–inductively coupled plasma mass spectrometry (IC–ICP-MS) analysis showed that organic Se accounted for 95.97% of the measured Se, with selenomethionine (SeMet) and selenocystine (SeCys 2 ) as the predominant identified species. Independent fermentation experiments conducted in 5 L and 3000 L systems further supported the technical feasibility of producing Se-enriched ZC-1006 biomass under the tested conditions. Transcriptomic analysis identified Se-associated expression changes in pathways related to sulfur-containing amino acid metabolism, glutathione metabolism, and antioxidant defense, while quantitative real-time polymerase chain reaction (qRT-PCR) supported selected transcript-level trends. These findings support A. pyrenoidosa ZC-1006 as a candidate platform for producing Se-enriched biomass, and the resulting biomass as a promising food-oriented ingredient for future food product development.
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Current Research in Food Science
·
2026
·
IF 7.7
Jianwei Dong,Jiayue Ma,Yuchen Li,Huan Wang,Jiaxing Huang,Hao He,Gege Zhang,Jingzhang Geng
The rational selection of stabilizers for selenium nanoparticles (SeNPs) is hindered by a lack of mechanistic understanding. Accordingly, this study investigated the deeper polysaccharide-based stabilization mechanism by comparing the effects of linear pullulan polysaccharide (PP), branched amylopectin starch (AS), and network-soluble β-cyclodextrin polymer (SP) on the growth of SeNPs. Growth kinetics showed that bare-SeNPs and SP-SeNPs followed a reaction-limited growth pathway, yielding larger particles due to weak diffusion restriction. In contrast, PP and AS induced a diffusion-limited growth regime, effectively inhibiting Se nucleus diffusion and collision, thus forming small, uniform SeNPs. FT-IR, XPS, TGA and ITC confirmed the interaction strength between the three polysaccharides and SeNPs was AS > PP > SP, correlating with their stabilization capability. AS-SeNPs displayed the smallest size and the highest stability, maintaining high stability even under low-pH and alcohol conditions, likely due to steric hindrance. It is predicted that the shelf life of selenium-enriched Huangjiu supplemented with AS-SeNPs could reach two years. In summary, polysaccharides govern SeNPs growth primarily by restricting nucleus diffusion, supported by interfacial interactions. Steric-hindrance-based stabilizers, such as AS, are particularly suitable for complex food systems, providing a theoretical basis for rational stabilizer selection in selenium-enriched foods.
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PubMed
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SCIENTIA HORTICULTURAE
·
2026
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IF 4.6
Zhixuan Fan,Shushu Pu,Yuling Dong,Li Li,Yaping Liu,Jianbing Di,Wei Ji,Yu Wang
Gray mold, caused by Botrytis cinerea, is a serious postharvest disease of grapes resulting in significant economic losses. By combining multi-omics in vitro and in vivo assays, we evaluated the antifungal activity of 18 mg/L selenium (supplied as sodium selenite) against B. cinerea . Mechanistically, Se treatment caused severe morphological damage in B. cinerea , with scanning electron microscopy revealing broken hyphae and collapse. Metabolomics and transcriptomics analyses showed that Se disrupted mitochondrial β-oxidation and down-regulated genes involved in cell-wall precursor biosynthesis, compromising structural integrity. Se further perturbed cellular processes and energy metabolism by accumulating tricarboxylic acid cycle inhibitors and modulating amino acid turnover. Virulence-related genes ( Bcbrn2, Bcole1 ), ABC transporters ( ABCB1, PDR5 ) were down-regulated, reducing pathogenicity, efflux and carbohydrate transport. Overall, Se disrupted membrane structure, metabolic homeostasis and pathogenicity of B. cinerea through multiple pathways. The reliability of the transcriptomic data was confirmed by quantitative real-time PCR (qPCR) validation of key differentially expressed genes (R² = 0.9923). Importantly, in vivo trials confirmed that Se effectiveness suppressing B. cinerea infection in grape fruits.
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ACS Applied Nano Materials
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2026
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IF 5.5
Jun Zhu,Ye Huang,Yamin He,Yao Chen,Keqiang Xu,Yufan Xiong,Mingyun Guan,Jian-Guo Dai
Bismuth chalcogenides have gained widespread interest as conversion-alloying-type anode materials for lithium-ion batteries due to their large interlayer space, multielectron reactions, etc. These merits can endow bismuth chalcogenides with a Li+-storage capacity that is higher than that of the commercial graphite anode. Nevertheless, their volume variation upon cycling can destroy the structural integrity, resulting in irreversible capacity damping. Herein, the sheet-like composite (Bi2Se3–CDs), with Bi2Se3 nanosheets uniformly modified with ultrasmall carbon dots (CDs), was successfully designed via a facile one-step solvothermal process. Ultrasmall CDs (∼3.7 nm) efficiently increase the electrical conductivity and surface-specific area, thereby intensifying the lithium-ion/electron transport kinetics of the Bi2Se3 electrode. Additionally, the formation of the covalent bond (C–O–Bi) between Bi2Se3 and CDs further accelerates charge transfer and guarantees structural integrity upon cycling. Consequently, the obtained Bi2Se3–CDs composite anode delivers comprehensive Li+-storage properties, including a relatively high initial Coulombic efficiency (76.2%), high reversible capacity (586 mAh g–1 at 100 mA g–1 after 50 cycles), and decent prolonged cycling stability (93.1% capacity retention after 300 cycles at 500 mA g–1). This study presents an efficient approach to constructing advanced bismuth-chalcogenide-based lithium-ion battery composite anodes.
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INDUSTRIAL CROPS AND PRODUCTS
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2026
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IF 6.4
Wanqing Yao,Yuhua Zhang,Liying Yang,Pingjing Chang,Xianhu Liu,Guohua Zhong
Fusarium wilt, caused by Fusarium oxysporum ( F. oxysporum ), poses a significant threat to global crop production. Conventional fungicides such as carbendazim (CBZ) encounter substantial challenges, including single-target resistance, poor environmental stability, an effective utilization rate of less than 0.1 %, and biosafety concerns. To overcome these limitations and address the core bottlenecks of existing nanopesticides, we developed a novel intelligent nanopesticide (CBZ@Se-CS, CSC) through a straightforward non-covalent self-assembly of chitosan and selenium nanoparticles for targeted delivery of CBZ. CSC has an average particle size of approximately 129 nm and a zeta potential of + 43.1 mV. It exhibited an 85 % cumulative release rate in the acidic microenvironment (pH 5.0) that simulates fungal infection sites.In vitro antifungal assays demonstrated that CSC achieved an EC₅₀ of 0.139 mg/L, showing 4.35-fold higher efficacy compared to free CBZ. Its triple-target synergistic mechanism potentially disrupts fungal cell membranes, induces oxidative stress and inhibits virulence factor synthesis, which may help mitigate resistance risks. Furthermore, CSC exhibits bidirectional vascular translocation in plants, host defense priming capacity, robust environmental stability and minimal toxicity to non-target organisms. It also promotes peanut seed germination. Enabled by green and potentially scalable preparation, CSC may reduce chemical inputs while providing a practical solution for managing vascular-colonizing pathogens such as F. oxysporum . This work aligns with the UN Sustainable Development Goals for food security and sustainable agriculture, presenting an innovative paradigm for the design of eco-friendly smart nanopesticides.
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FOOD CHEMISTRY
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2026
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IF 10.4
Yuanye Liu,Mengxin Hou,Shuang Yang,Jingyi Ren,Mengzhen Han,Zhenpeng Gao
This study developed a selenium-fortified functional apple juice by combining Lacticaseibacillus paracasei fermentation with tannic acid (TA)-based self-assembled microencapsulation. Results showed that fermentation with strain CICC 20241 reduced malic acid by 91.6% via malolactic conversion, significantly improving flavor and antioxidant capacity. Meanwhile, strain CICC 20975 was encapsulated to form selenium-rich microcapsules, which improved probiotic survival to 69.7% in simulated intestinal fluid. The final fortified juice achieved a selenium content of 25.85 μg/100 mL and maintained high probiotic viability and physicochemical stability over 32 days of storage at 4 °C. This dual strategy effectively addresses the instability of probiotics in low-pH fruit juice matrices, offering a precise technological approach for designing functional beverages with co-delivery of bioactive selenium and probiotics.
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PubMed
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Frontiers in Nutrition
·
2026
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IF 5.5
Min Zhao,Xin Sun,Yuxiao Wang,Lin Gao,Rentang Zhang
Introduction Natural polysaccharides exhibit promising pharmacological potential in functional foods. However, their structural heterogeneity and limited bioactivity hinder further applications. Methods In this study, a polysaccharide from blackened jujube pomace was selenylated via the conventional HNO 3 -Na 2 SeO 3 route, with systematic optimization of reaction parameters to improve controllability, yielding selenium-enriched polysaccharides (BJPP-Se). Results and Discussion Multimodal characterization confirmed successful selenylation, with a reduction in molecular weight from 88.26 kDa to 74.32 kDa and an increase in crystallinity. Density functional theory calculations identified two distinct Se (IV) coordination modes, with one involving Se (IV) as a bridging atom linking two monosaccharide units and the other restricting Se (IV) coordination to a single monosaccharide unit. BJPP-Se has much stronger immunomodulatory performance than native polysaccharides in cyclophosphamide suppressed immunosuppressed mice. Selenium-induced structural reorganization is a very good example of how to design bioactive polysaccharides. This work supports the potential for valorizing polysaccharides from black jujube pomace; however, large-scale techno-economic feasibility and cost–benefit assessment are beyond the scope of this study and warrant future work with clearly defined boundaries and engineering-scale datasets.
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FOOD CONTROL
·
2026
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IF 7
Jun Yang,Zhengke Zhang,Xiangbin Xu,Mohammad Rizwan Khan,Naushad Ahmad,Abdorreza Mohammadi Nafchi,Haiming Chen,Wanli Zhang
Sodium alginate/pectin (SP) composite film functionalized with Nano-selenium (SeNPs) stabilized with Dendrobium officinale polysaccharides (DOP) was developed to enhance its physicochemical and biological activity properties. The addition of DOP significantly improved the dispersibility and surface potential of SeNPs, and the nanoparticles stabilized with 100% DOP exhibited the smallest particle size (210.45 nm), highest zeta potential (-7.95 mV), and optimal superoxide dismutase (SOD) and catalase (CAT) -like activities. Adding 2% SeNPs to SP film improved UV-blocking performance, matrix density, and thermal stability, as well as extensibility and barrier performance. Among the various formulations, SPS-2 film (SP film ccontaining 2% SeNPs) exhibited the highest antioxidant and antibacterial activity, effectively inhibiting Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) . The high-concentration SeNPs composite film demonstrated high biocompatibility, exhibiting no hemolytic activity against red blood cells and minimal cytotoxicity against RAW 264.7 cells. In a postharvest strawberry preservation test, the SPS-2 coating effectively reduced weight loss and spoilage, maintained firmness and soluble solids, and significantly enhanced antioxidant activity by preserving total phenol and flavonoid content. These results demonstrate that 2% SeNPs-added SP films provide an integrated strategy combining enzyme-mimetic activity, enhanced film performance, and high biosafety, and show promising potential for postharvest fruit preservation.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Zhu Liu,Xinlin Liu,Liwan He,Shengzhe Zhuang,Zhaoyang Li,Shuaipeng Feng,Luping Sha,Siling Wang,Qinfu Zhao
Rhabdomyolysis-induced acute kidney injury (RM-AKI) is a life-threatening clinical condition characterized by excessive myoglobin release, leading to kidney tubular obstruction, oxidative stress, and iron-mediated lipid peroxidation. However, current therapies fail to effectively suppress oxidative stress cascades and lack kidney targeting. Herein, we developed a kidney-targeted nanodrug delivery system with multimodal antioxidant functionality (DFO@SOC) for RM-AKI therapy. Using antioxidant capacity as the decisive screening criterion, Se/S co -doped onion-derived carbon dots (SOC) were identified as the optimal nanocarrier through systematic natural polyphenol precursor selection and heteroatom-doping optimization. SOC exhibited pronounced superoxide dismutase-like and catalase-like activities. The iron chelator deferoxamine (DFO) was subsequently loaded onto SOC, yielding uniformly sized, negatively charged DFO@SOC nanoparticles. In vitro studies demonstrated efficient cellular uptake, robust intracellular scavenging of reactive oxygen species (ROS) and iron ions, and negligible cytotoxicity. In an RM-AKI mouse model, DFO@SOC selectively accumulated in injured kidneys. Notably, Sound Touch Visco-elastography (STVi) and Quantitative Tissue Scattering Coefficient (QTSC) enabled noninvasive and real-time evaluation of therapeutic efficacy with kidney stiffness decreasing significantly from ~14 to 7 kPa. Combined biochemical and histopathological analyses, DFO@SOC treatment significantly reduced Scr from ~193.31 to ~93.82 μmol/L and blood urea nitrogen (BUN) from ~52.99 to ~30.68 mmol/L compared to the model group. In summary, the synergistic antioxidant and iron-chelation effects of DFO and SOC, establishing DFO@SOC as a promising nanotherapeutic strategy for RM-AKI.
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Gels
·
2026
·Vol. 12
·期 3
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IF 6.4
Yongxin Guo,Jianxun Ma,Yuhan Zheng,Gang Wang,Hongda Zhang,Yong Yu,Jinpeng Zhang
Sustainable agricultural techniques can ensure food security around the world. Hydrogel based soilless culture is an ecological and efficient alternative compared to conventional agriculture. Here, a multi-component hydrogel (pectin, Kelcogel, and chitosan/Se hydrogel, PKCH) was prepared by synthesizing natural biomolecules to cultivate dandelion for stimulate dandelion growth and improve nutritional value. The germination percentage of dandelion on PKCH (88.89%), was significantly higher than that in traditional hydroponics and pure Kelcogel (p< 0.05). Compared with hydroponics, the long-term dandelion cultivation experiments demonstrated that the PKCH cultivation mode enhanced root vitality, further increasing the growth and yield of dandelions (shoot length: 18.36 ± 0.30 cm, root length: 9.28 ± 0.21 cm, main root diameter: 0.94 ± 0.02 cm). The hydrogel substrate was associated with improved nutrient solubilization and sustained release, which may be linked to the accumulation of low-molecular-weight organic acids in the rhizosphere. Exogenous Se was effectively assimilated and transported to the above-ground parts of dandelion, which stimulated the photosynthetic efficiency and nutritional accumulation of dandelion. The polysaccharide content of dandelion reached 69.40 ± 0.13% (expressed as glucose-equivalent total sugars), which demonstrated the potential antioxidant properties and medicinal value. Technical economic analysis revealed the cost-effectiveness of PKCH synthesis and application. This study enriches the application of hydrogels in dandelion cultivation and provides an alternative approach for cultivating dandelion in soilless environments and medicinal crop production techniques.
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Journal of Functional Foods
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2026
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IF 3.9
Zixuan Cui,Xiaojing Chen,Yufeng Wei,Danfei Huang,Chang Li
Jujube polysaccharides and nano‑selenium have gained attention for their bioactivity. This study used jujube polysaccharides to stabilize selenium nanoparticles (JP-SeNPs) via redox method. The optimized JP-SeNPs had an average size of 142.0 nm (PDI 0.1989), contained zero-valent selenium, showing no HepG2 toxicity at 5–40 μg/mL. In DSS-induced colitis mice, JP-SeNPs alleviated weight loss, disease activity, and colon shortening, reduced histopathological damage, restored goblet cells and tight junctions, and lowered colonic TNF-α, IL-1β, IFN-γ, and serum endotoxin. Cecal short-chain fatty acids (acetate, propionate, butyrate) rebounded. 16S rRNA sequencing revealed enhanced α-diversity, enrichment of butyrate-producers, and restored carbohydrate metabolism. JP-SeNPs ameliorate colitis via barrier repair, inflammation suppression, microbiota modulation, and SCFA promotion, supporting its development as a functional formulation.
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