Desalination and Water Treatment
·
2024
·
IF 1
Shifeng Li,Feng Lu,Shuhua Yao,Shuyan Zang
The mesoporous goethite synthesized by the hydrothermal method was employed to remove selenate (Se(VI)) and selenite (Se(IV)) from wastewater. The adsorption data of kinetics and isotherms were determined and fitted with different models, and the potential adsorption mechanism was discussed according to X-ray photoelectron spectroscopy (XPS) analysis. The maximum adsorption capacities of Se(IV) and Se(VI) on the mesoporous goethite are 71.07 and 21.07 mg/g at 25°C, respectively, which are about two orders of magnitude higher than the natural goethite. The XPS results revealed that the Se(IV) was adsorbed on the surface of the mesoporous by the formation of the inner-sphere complex, but the outer-sphere complexes are formed with Se(IV). The meso-porous goethite is expected to be a potential adsorbent for Se removal from industrial selenium- containing wastewater on a large scale for its properties of easy-preparation and less cost compared with classic nanomaterials.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2024
·
IF 5.3
Jingxuan Lu,Juan Li,Shiyan Fu,Huanhuan Tan,Yuhui Hao
The combined chemotoxicity and radiotoxicity associated with uranium, utilized in nuclear industry and military applications, poses significant threats to human health. Among uranium pollutants, uranyl is particularly concerning due to its high absorptivity and potent nephrotoxicity in its + 6 valence state. Here, we have serendipitously found Na 2 SeO 3 facilitates the conversion of U(VI) to U(IV) precipitates. A novel approach involving nano-chitosan loaded internally with melatonin and externally modified with selenite (NPs Cs-Se/MEL) was introduced. This modification not only enhances the conversion of U(VI) to U(IV) but also preserves the spherical nanostructure and specific surface area, leading to increased adsorption of U(VI) compared to unmodified samples. Selenite modification improves lysosomal delivery in HEK-293 T cells and kidney distribution of the nanoparticles. Furthermore, NPs Cs-Se/MEL demonstrated a heightened uranium concentration in urine and exhibited remarkable efficiency in uranium removal, resulting in a reduction of uranium deposition in serum, kidneys, and femurs by up to 52.02 %, 46.79 %, and 71.04 %, respectively. Importantly, NPs Cs-Se/MEL can be excreted directly from the kidneys into urine when carrying uranium. The results presented a novel mechanism for uranium adsorption, making selenium-containing nano-materials attractive for uranium sequestration and detoxification.
研究领域:
环境科学
·
毒理学
·
纳米医学
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产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2023
·Vol. 25
·期 11
·1675-1682
·
IF 3.1
Junai Lv,Qi Li,Xin Guan,Na Lin,Jian Zhang,Zhitai Jia,Xutang Tao
Selenite and tellurite compounds have garnered a lot of attention in both fundamental and applied chemistry. Se4+ and Te4+ cations possess lone pair electrons, which change the coordination environments and performance of these compounds. Here, three new transition metal selenite and tellurite compounds, MSe2O6 (M = Zr, Hf) and HfTe3O8, have been obtained by conventional hydrothermal reactions. The crystallographic structures of the three compounds are discussed in detail; meanwhile, thermal analysis, optical spectra, birefringence and theoretical calculations are also reported. Isostructural ZrSe2O6 and HfSe2O6 exhibit partially distorted octahedral and tetrahedral configurations. Moreover, ZrSe2O6 and HfSe2O6 have birefringence (Δn = 0.1052, 0.096) and short UV cut-off edges (212, 208 nm), and compared with ZrSe2O6, the thermal stability of HfSe2O6 is slightly larger. ZrSe2O6 and HfSe2O6 are adequate candidates as birefringent crystals in the UV region. Remarkably, HfTe3O8 not only has high thermal stability, but also provides a short UV cut-off edge (234 nm). It can meet the multiple requirements of the developing photoelectric system for UV window materials and has broad application prospects. Furthermore, the intrinsic relationship between the physical properties of the three crystals and their unique electronic structures is revealed.
研究领域:
材料科学
·
无机化学
·
光学工程
·
晶体学
·
物理化学
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2018
·
IF 6.434
Long Liu,Ning Chen,Yong Lei,Xuyan Xue,Lina Li,Jiancheng Wang,Sridhar Komarneni,Huaiyong Zhu,Dongjiang Yang
Removal of the toxic selenium compounds, selenite (SeO 3 2− ) and selenate (SeO 4 2− ), from contaminated water is imperative for environmental protection in both developing and industrialized countries. Providing high selectivity adsorbents to the target ions is a big challenge. Here we report that micro sphere-like δ-Bi 2 O 3 (MS-δ-Bi 2 O 3 ) with surface oxygen vacancy defects can capture hypertoxic SeO x 2− anions from aqueous solutions with superior capacity and fast uptake rate. High capture selectivity to SeO 3 2− anions is observed, since the O atoms of SeO 3 2− anions fill the oxygen vacancies on the (111) facet of δ-Bi 2 O 3 forming a stable complex structure. This mechanism is distinctly different from other known mechanisms for anion removal, and implies that we may utilize surface defects as highly efficient and selective sites to capture specific toxic species. Thus, we present a new route here to design superior adsorbents for toxic ions.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
Environmental Science-Nano
·
2018
·Vol. 5
·期 6
·1441-1453
·
IF 6.087
Jingmiao Wei,Wei Zhang,Weiyi Pan,Chaoran Li,Weiling Sun
Adsorption behaviors and mechanisms of selenite [Se(IV)] and selenate [Se(VI)] on two types of zirconium metal–organic frameworks (MOFs, UiO-66 and UiO-66-NH2) were investigated using batch experiments, spectroscopic analyses, and theoretical calculations. Se(IV) adsorption was substantially greater than Se(VI) adsorption. Intriguingly, with increasing solution pH, Se(IV) adsorption increased to a maximum at pH 7, whereas Se(VI) adsorption monotonically decreased. Se(IV) adsorption was not influenced by coexisting ions except for PO43−, whereas Se(VI) adsorption was in general decreased with increasing coexisting ion concentrations. The underlying molecular binding mechanisms were elucidated via zeta potential, XPS, and FTIR analyses as well as density functional theory calculations. Se(IV) formed a strong inner-sphere complex with the MOFs via Lewis acid/base complexation between the Zr coordinatively unsaturated sites and HSeO3− or SeO32− (−59.4 to −142 kJ mol−1) and hydrogen bonding between Zr–O–C and H2SeO3 (−24.4 to −29.8 kJ mol−1). Se(VI) formed outer-sphere complexes with the MOFs through electrostatic interactions (−50.6 to −62.1 kJ mol−1). Thus, the BET surface area was the predominant factor determining the Se(IV) adsorption, whereas both the surface charge and BET surface area controlled the Se(VI) adsorption. This study provided new insights on the molecular interactions between Se(IV) and the MOFs, and revealed the distinct differences between the Se(IV) and Se(VI) adsorptions.
研究领域:
环境科学
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材料科学
·
化学
✓ 已验证
DOI
高影响因子
Nutrients
·
2024
·Vol. 16
·期 11
·1737
·
IF 4.8
Sheng Zhao,Yuzhou Meng,Wenxun Cai,Qiwen Luo,Hongyang Gao,Qiang Shen,Dongyun Shi
Tumor cells are characterized by a delicate balance between elevated oxidative stress and enhanced antioxidant capacity. This intricate equilibrium, maintained within a threshold known as redox homeostasis, offers a unique perspective for cancer treatment by modulating reactive oxygen species (ROS) levels beyond cellular tolerability, thereby disrupting this balance. However, currently used chemotherapy drugs require larger doses to increase ROS levels beyond the redox homeostasis threshold, which may cause serious side effects. How to disrupt redox homeostasis in cancer cells more effectively remains a challenge. In this study, we found that sodium selenite and docosahexaenoic acid (DHA), a polyunsaturated fatty acid extracted from marine fish, synergistically induced cytotoxic effects in colorectal cancer (CRC) cells. Physiological doses of DHA simultaneously upregulated oxidation and antioxidant levels within the threshold range without affecting cell viability. However, it rendered the cells more susceptible to reaching the upper limit of the threshold of redox homeostasis, facilitating the elevation of ROS levels beyond the threshold by combining with low doses of sodium selenite, thereby disrupting redox homeostasis and inducing MAPK-mediated paraptosis. This study highlights the synergistic anticancer effects of sodium selenite and DHA, which induce paraptosis by disrupting redox homeostasis in tumor cells. These findings offer a novel strategy for more targeted and less toxic cancer therapies for colorectal cancer treatment.
研究领域:
肿瘤学
·
细胞生物学
·
药物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POULTRY SCIENCE
·
2024
·
IF 3.8
Xinzhang Chen,Xu Lin
Trimethyl tin (TMT) is a good stabilizer for plastic products but is also a toxic environmental pollutant. Selenium has good antioxidant and anti-inflammatory properties and has been widely used in the poultry industry. However, it has not been reported whether selenium enrichment can antagonize TMT-induced viral hepatitis in poultry. To fill this gap, AA broiler models exposed to TMT for 42 d were established and fed a Se-enriched diet at the same time. H&E staining showed that selenium could significantly alleviate TMT-induced liver inflammation. Further analysis of the underlying mechanism revealed that TMT induced nitrosation stress (RNS), increased NO content and iNOS expression, which in turn activated the NF-κB/NLRP3 pathway and induced pyroptosis. However, selenium enrichment can reverse this situation, that is, reduce the occurrence of RNS, reduce the degree of pyroptosis, and thus alleviate the occurrence of inflammation. In our study, we demonstrated for the first time that TMT could induce hepatotoxicity other than neurotoxicity in poultry and that selenium could antagonize TMT-induced hepatotoxic hepatitis in chickens through the RNS/NF-κB/NLRP3 pathway.
研究领域:
毒理学
·
兽医学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Cancers
·
2022
·Vol. 14
·期 2
·345
·
IF 6.575
Hui Chen,Han Zhang,Lixing Cao,Jinling Cui,Xuan Ma,Chong Zhao,Shutao Yin,Hongbo Hu
Simple SummarySelenite, a representative inorganic form of selenium, is preferentially accumulated in tumors. The therapeutic potential of sodium selenite in tumors has received significant attention. However, the effect of sodium selenite in the treatment of established tumors is hampered by its systemic toxicities. In this study, we found selenite exerted a stronger lethality to the cancer cells under the condition of glucose limitation in vitro and an enhanced inhibitory effect on tumor growth when combined with intermittent fasting in vivo. In addition, this treatment showed no obvious toxicity to normal cells and mice. The findings of the present study provide an effective and practical approach for increasing the therapeutic window of selenite and imply that combination of selenite and fasting holds promising potential to be developed a clinically useful regimen for treating certain types of cancer.AbstractCombination of intermittent fasting and chemotherapy has been drawn an increasing attention because of the encouraging efficacy. In this study, we evaluated the anti-cancer effect of combination of glucose limitation and selenite (Se), a representative inorganic form of selenium, that is preferentially accumulated in tumors. Results showed that cytotoxic effect of selenite on cancer cells, but not on normal cells, was significantly enhanced in response to the combination of selenite and glucose limitation. Furthermore, in vivo therapeutic efficacy of combining selenite with fasting was dramatically improved in xenograft models of lung and colon cancer. Mechanistically, we found that SLC7A11 expression in cancer cells was up-regulated by selenite both in vitro and in vivo. The elevated SLC7A11 led to cystine accumulation, NADPH depletion and the conversion of cystine to cysteine inhibition, which in turn boosted selenite-mediated reactive oxygen species (ROS), followed by enhancement of selenite-mediated cytotoxic effect. The findings of the present study provide an effective and practical approach for increasing the therapeutic window of selenite and imply that combination of selenite and fasting holds promising potential to be developed a clinically useful regimen for treating certain types of cancer.Keywords:selenite;glucose limitation;SLC7A11;NADPH;ROS
研究领域:
肿瘤学
·
药理学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2024
·
IF 4.3
Han Luo,Yu Zhang,Tingyu Wang,Ling Huang,Liling Cao,Xuehua Dong,Guohong Zou
Two antimony selenites, Sb2O2SeO3 and Sb2O(SeO3)2, were synthesized by simultaneously incorporating stereochemically active lone pair electrons containing SeO32– and Sb3+. These compounds are structured with [SbOx] polyhedra and [SeO3] units within a two-dimensional framework. Both of them exhibit cutoffs at 300 and 330 nm within the ultraviolet (UV) range and demonstrate significant birefringence, with indices of 0.069 and 0.126 at 546 nm, respectively. These properties highlight their potential as UV birefringent materials. Structural analyses and theoretical calculations reveal that their exceptional birefringence results from the synergistic interactions between SeO32– anions and Sb3+ cations.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 71
·40984-40988
·
IF 2.936
Xiaonan Gao,Wenfei Guo,Lihong Ge,Fanpeng Kong,Kehua Xu,Bo Tang
Sodium selenite (Na2SeO3), as an anti-tumor drug for inducing tumor cells' apoptosis, has been widely studied under normoxic conditions and has been shown to exhibit oxidative stress process-induced apoptosis. However, since the real tumor environment is hypoxic, the actual mechanism is still unclear. Hence, considering the main metabolite of Na2SeO3 in the metabolic process to be hydrogen selenide (H2Se) and also that it can be converted to superoxide anion (O2˙−) instantaneously in the presence of oxygen, a dual-ratiometric fluorescence imaging system for simultaneous monitoring of the changes of H2Se and O2˙− induced by Na2SeO3-guided tumor cell apoptosis under hypoxic conditions was constructed. Two molecular probes NIR-H2Se and dihydroethidium were used to detect H2Se and O2˙−, respectively, whereas Rhodamine 110 was used as the reference fluorophore. Notably, H2Se levels significantly increased under hypoxic conditions, but there was no change in the level of O2˙−, which is inconsistent with the results of the previous researches. Therefore, we hypothesize that the mechanism of Na2SeO3-induced apoptosis for tumor cells is caused by reductive stress; also, this method can be applied for the future study of other anti-cancer selenium compounds.
研究领域:
生物化学
·
医学影像学
·
肿瘤学
✓ 已验证
DOI
高影响因子
Food Analytical Methods
·
2021
·Vol. 14
·期 7
·1345-1358
·
IF 3.366
Wei Yihua,Zhang Jinyan,Qiu Shuyan,Huang Qingqing,Yuan Linfeng,Chen Liumeng,Dai Tingcan,Tu Tianhua,Zhang Biaojin,Yan Han,Li Weihong
A simple, rapid, and accurate method for determination of selenocystine (SeCys 2 ), methyl selenocysteine (MeSeCys), selenourea (SeUr), selenite (Se(IV)), selenotmethionine (SeMet), and selenate (Se(VI)) in grain crops was developed, based on the coupling of ion-pair reversed-phase high-performance liquid chromatography (IP-RP-HPLC) and ultraviolet irradiation hydride generation atomic fluorescence spectrometry (UV-HG-AFS). The conditions of IP-RP-HPLC-UV-HG -AFS were studied. The conditions of the pretreatment sample, such as types and dosage of proteinases, were investigated. The detection limits (LODs) for six Se species were between 0.77 and 1.77 μg·L −1 . Then, the proposed method has been successfully used to analyze selenium (Se) species in Se-enriched rice paddy ( Oryza sativa L. ), soybean ( Glycine max (Linn.) Merr. ), and sweet potato ( Ipomoea batatas (L.) Lam. ) with foliar application of sodium selenite solution. SeMet was the major Se spices in Se-enriched grain crops, ranged from 77–90% of the total Se contents. The capabilities of Se enrichment were relatively larger differences in three-grain corps as follows: soybean > rice paddy > sweet potato.
研究领域:
植物学
·
分析化学
·
营养学
✓ 已验证
产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2018
·
IF 6.14
Hao Zhou,Lin Che,Zhaoming Guo,Minghuo Wu,Wenqing Li,Weiping Xu,Lifen Liu
Bismuth selenide (Bi2Se3) attracts a lot of attention nowadays due to its unique electronic and thermoelectric properties. In this study, fabrication of Bi2Se3 nanosheets by selenite-reducing bacterium (SeRB) was first reported. Morphology, size, and location of the biogenic Bi2Se3 are bacteria-dependent. It is difficult to separate Bi2Se3 generated by Bacillus cereus CC-1 (Bi2Se3-C) from the biomass because of strong interaction with the cell membrane. However, Bi2Se3 produced by Lysinibacillus sp. ZYM-1 (Bi2Se3-Z), is highly dispersed in extracellular space with high stability. Further characterization by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and atomic force microscopy (AFM) on Bi2Se3-Z indicates that the product is a rhombohedral-phase, ultrathin nanosheet-like structure with an average size of ∼100 nm. Subsequently, the photothermal performance of Bi2Se3-Z with the irradiation of 808 nm near-infrared (NIR) laser was determined. When the Bi2Se3-Z concentration was 26 mg L–1, and irradiation power was 2 W, the photothermal conversion efficiency was calculated as 30.7%. At the same condition, 100% of the MCF7 and A549 cancer cells were killed within 10 min of irradiation in vitro. Moreover, using 1% (v/v) PVP as surfactant, a novel nanodumbbell structure of Bi2Se3 was obtained. Overall, this bacteria-driven Bi2Se3 fabrication paves a new way for biocompatible photothermal nanomaterials.
研究领域:
材料科学
·
纳米技术
·
癌症治疗
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）