BIOORGANIC CHEMISTRY
·
2026
·
IF 5.1
Shaowei Wang,Zhuoqi Chen,Xiya Ren,Yang Zhu,Yunbing Tang,Ren-shan Ge,Wei Chen,Yi Liu
Alkyl phosphate esters (APEs) are mass-produced substances characterized by a wide range of physicochemical properties and applications. Their endocrine-disrupting effects via inhibition of placental 3β-hydroxysteroid dehydrogenase (3β-HSD) remain unclear. The objective of this study was to examine the inhibitory effects of 22 APEs on human 3β-HSD1 (h3β-HSD1) its rat homolog r3β-HSD4, critical enzymes in progesterone synthesis, using placental microsomes and computational analysis. The results demonstrated that h3β-HSD1 was more sensitive to inhibition by 100 μM APEs, exhibiting a V-shaped potency trend. Among the tested APEs, triheptyl phosphate ester showed the strongest inhibition of h3β-HSD1 (IC 50 = 3.33 μM), followed by trihexyl (IC 50 = 5.53 μM), triamyl (IC 50 = 22.67 μM), triethylhexyl (IC 50 = 22.85 μM), and tributyl phosphate esters (IC 50 = 102.53 μM). In contrast, r3β-HSD4 exhibited lower sensitivity, with significant inhibition observed for only three APEs: diethyl, triamyl, and trihexyl phosphate esters, with IC 50 values of 38.94, 109.76, and 51.49 μM, respectively. All tested APEs functioned as mixed-type inhibitors, and they suppressed progesterone production in human JAr cells at 10 and/or 100 μM (noncytotoxic concentrations). Lipophilicity and molecular size were identified as key factors influencing inhibitory potency against h3β-HSD1, as supported by 3D-QSAR modeling and molecular docking. These findings suggest that the mode of inhibition involves interactions at the NAD + /steroid interface, including hydrogen bonds and hydrophobic forces. Network toxicology analysis highlighted the association of h3β-HSD1 with endometrial cancer and preeclampsia. This research provides mechanistic insights into the potential reproductive risks of APEs and emphasizes the need for further studies on their environmental and health impacts.
✓ 已验证
产品关联
DOI
高影响因子
Applied Materials Today
·
2026
·
IF 7
Yilin Guo,Kangping Li,Guangyi Zhang,Junfan Liu,Luyang Jia,Haihan Zhao,Bihe Yuan
A novel microencapsulated PCM (OADP/PG) was constructed. • Excellent thermal conductivity, leakage resistance, and flame retardancy were acquired. • OADP/PG exhibits excellent LIB cooling efficiency. • OADP/PG effectively suppresses the thermal runaway initiation and propagation. Leveraging highly efficient and reversible thermal energy storage and release, phase change materials (PCMs) show immense potential in advanced thermal management. However, the leakage issues, low thermal conductivity, and flammability of organic PCMs severely limit their applications in lithium-ion battery (LIB) thermal management. This work reports the synthesis of a novel microencapsulated PCM (MPCM, OADP/PG), which consists of a polyethylene glycol-modified graphite composite (PEG-g-Graphite, shell) and an intrinsically flame-retardant PCM (OADP, core). With 20 wt% PEG-g-Graphite, OADP/PG20 achieves a thermal conductivity of 0.60 W m −1 K −1 , 130.8% higher than that of OADP, and its leakage ratio is only 1.3% at 65 °C. In the candle ignition test, OADP/PG20 exhibits rapid self-extinguishing behavior within 25 s. In addition, under 5 C charge-discharge conditions, OADP/PG20 reduces the maximum surface temperature of the LIB by 10.8 °C. In the LIB thermal runaway (TR) test, OADP/PG20 significantly delays the onset of TR. It also reduces the peak temperature and suppresses the TR propagation. This work develops an advanced MPCM integrating superior thermal conductivity, leakage resistance, latent heat storage, and flame retardancy. It provides a potential material solution for thermal safety management in LIBs. Download: Download high-res image (201KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2026
·
IF 4.7
Ruiyu Yuan,Yin Lu,Weichen Sheng,Kan Zhang
The severity of fire accidents and sustainable development concerns have made people increasingly aware of the importance of producing flame-retardant materials using biomass resources. Herein, we successfully synthesized an asymmetric biobisbenzoxazine monomer with a single diethyl phosphite-substituted oxazine ring (ST-fa-DEP) based on natural, renewable salicylaldehyde, tyramine, and furfurylamine. The structural characterization of ST-fa-DEP was performed using Fourier-transform infrared (FT-IR) and nuclear magnetic resonance (NMR) spectroscopies as well as high-resolution mass spectrometry (HR-MS), which confirms the successful inheritance of the single diethyl phosphite into the oxazine ring substituted bisbenzoxazine monomer. The ring-opening polymerization behavior of ST-fa-DEP was examined by using differential scanning calorimetry (DSC) and in situ FT-IR analysis. In addition, the resulting polybenzoxazine, poly(ST-fa-DEP), showed excellent thermal performance and flame retardancy with a Td10 of 413 °C, a Yc of 62.5,% and an HRC value of 53 J·g–1·K–1. Moreover, we used ST-fa-DEP as a property modifier for enhancing the comprehensive properties of the well-commercialized bisbenzoxazine resin (PH-ddm). Notably, the glass transition temperature of the resulting thermoset increased to 290 °C, and a V-0 rating in UL-94 testing was also achieved by adding only 3 wt % ST-fa-DEP in PH-ddm, which breaks the trade-off between the thermal stability and flame retardancy of other reported flame-retardant polybenzoxazines. The results obtained in the current work provide molecular-level insights into the structure–property relationship of polybenzoxazines as well as an angle for the design of highly thermal stable and intrinsically flame-retardant biothermosets.
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2026
·
IF 19.7
Chen Wang,Meiyi Li,Maoning Xu,Ye Li,Quanqi Yang,Wanjing Jia,Jianjun Wang
Herein, phosphorylated MOF@COF (UiO-66-NH 2 @HDU-27-P) Type-II heterostructures were constructed to achieve selective and efficient uranium extraction. These composites were synthesized via the covalent linking of MOFs with COFs at varying ratios, and their electronic properties were analyzed using density functional theory (DFT) calculations. The optimized 6:1 composite exhibited exceptional performance, achieving (> 92.9 %) U(VI) removal in pure water and maintaining high efficiency across complex aqueous environments, including seawater. Mechanistic studies revealed that the Type-II heterojunction significantly enhances charge separation, enabling uranium capture through synergistic adsorption, photocatalytic reduction, and immobilization under non-sacrificial air conditions. This work provides a new paradigm for designing high-performance heterojunctions, offering a superior alternative to current materials for sustainable environmental remediation and uranium recovery.
✓ 已验证
产品关联
DOI
高影响因子
Energy & Environmental Materials
·
2026
·
IF 14.1
Shichao Feng,Shuofan Yue,Jiapeng Wei,Dong Zhang,Yajie Gui,Ruijuan Wang,Dongying Hu,Fangchao Cheng
Batteries face critical challenges in thermal management, including overheating risks, poor interfacial contact, and mechanical vibration–induced performance attenuation. To address these issues, we developed a flame-retardant bio-based thermo-flexible phase-change composite (VHPs) by integrating vanillin-derived polyols (VED), hexachlorocyclotriphosphazene-modified expanded graphite (HPEG), and polyethylene glycol (PEG). The HPEG hybrid filler effectively suppresses the “popcorn effect” of EG while significantly enhancing thermal conductivity, achieving a 246.90% improvement over neat polyurethane (PU). The thermally flexible polyurethane matrix reduces interfacial thermal resistance by 40% at 60 °C due to PEG soft-segment melting, enabling conformal wrapping around batteries. During 36 000 s of charge/discharge cycles, the VHPs reduced the battery temperature by 10 °C and increased the discharge capacity by 53.84% at 3C rates. Compared to the reported phase-change materials, VHPs uniquely integrate flame retardancy (peak of heat release rate reduced to 136.58 kW m −2 ), vibration resistance (compressive strength of 0.28 MPa at 50% strain), and infrared stealth (IR transmittance <0.04% in 3–25 μm). This work provides a sustainable, multifunctional solution for advanced battery thermal management, enhancing both safety and energy efficiency in high-power applications.
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF CATALYSIS
·
2026
·
IF 17.2
Hua Gao,Yong Zhu,Zhibing Wen,Ran Zhao,Zhi Chen,Siyao Wang,Shuanglin He,Kuang Peng,Yiwen Tang,Licheng Sun,Fei Li
Solar-driven photocatalytic CO 2 conversion offers a sustainable solution for greenhouse gas mitigation and renewable energy storage. While metal phthalocyanines (MPc) exhibit excellent CO 2 reduction capabilities, their practical application in dispersed photocatalytic systems faces limitations of the stacking of MPc molecules that reduces active site accessibility, and inefficient electron transfer limited by diffusive mass transport. To address these challenges, we developed a bioinspired dye-sensitized RuP-TiO 2 -FePc nanosheets (NSs) hybrid system, where ultrathin FePc NSs obtained by liquid-phase ultrasonic exfoliation enhance active site exposure and mass transfer, while TiO 2 serves as a mediator to facilitate electron transfer between the photosensitizer and FePc NSs. Time-resolved spectroscopic studies demonstrate that TiO 2 plays a dual role: it spatially organizes functional components to enable surface electron transfer by shortening intermolecular distances, while also functioning as a semiconductor bridge to facilitate charge transport. This synergistic design achieves a remarkable CO production rate of 27.3 mmol g –1 h –1 (> 98% selectivity) and exceptional stability (TON CO = 1363 over 100 h), outperforming many noble-metal-based systems. Our work demonstrates a robust strategy for optimizing bulk catalysts through 2D exfoliation and controlled heterogenization, offering a versatile platform for efficient and durable artificial photosynthesis.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2023
·Vol. 332
·期 3
·607-616
·
IF 1.6
Zhou Zhulin,Fu Yongmei,Wang Xiaoqin,Si Xuting,Lu Youcai
Rare earth (RE) elements is usually associated with radioactive thorium (Th) in nature. Here, we develop a new solid-phase extraction system for the separation of Th, and the effects of acidity, equilibrium time and cycle times on the adsorption performance of the resin were investigated. Kinetic studies show the extraction system has excellent chemical stability and cyclic stability. Further study the application of the resin in industry demonstrated that the separation efficiency is still up to 88%. Therefore, this work not only provides a new strategy for solid-phase extraction system, but also opens up a new way for Th separation.
✓ 已验证
产品关联
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2022
·
IF 5.204
Rong Yang,Guozhang Gu,Chen Tang,Zhicheng Miao,Hongwei Cao,Guoxiang Zou,Jinchun Li
It is a great challenge to simultaneously prepare flame-retardant and super-tough poly(lactic acid) (PLA) materials. Herein, we reported a facile approach that PLA reactively blends with phosphorus-containing copolyester. In this paper, a quinary aliphatic copolyester (PPE) containing phosphorus and pendent hydroxyl group was synthesized with sebacic acid, dimethyl malate, diethyl phosphite, 1,6-hexanediol, and 1,3-propanediol by polycondensation. Then, flame-retardant and super-tough PLA materials (PLA/PPEU) can be achieved by reactively blending with PPE and hexamethylene diisocyanate. The results showed that the toughness of PLA was significantly enhanced. The maximum notched impact strength is 75.3 kJ/m 2 indicated a super toughness performance. Meanwhile, the flame retardance of the PLA was improved obviously. The limited oxygen index (LOI) of PLA increased from 20 to 26%. Moreover, the PLA blends can pass the UL-94 V-0 rating. In addition, both the total heat release and total smoke production of PLA were decreased. The resultant super-tough and flame-retardant PLA materials could be widely applied in electrical and electronic equipment.
✓ 已验证
产品关联
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2021
·
IF 5.03
Weimiao Lu,Zhenfu Jin
Intumescent flame retardants (IFR) with phosphorus (P)/nitrogen (N)-containing diphenols (DH, DV and DS) were synthesized from p -hydroxybenzaldehyde (H), vanillin (V) and syringaldehyde (S) with different methoxyl groups on its aromatic ring. The FTIR, 1 H NMR, 13 C NMR, XPS methods were used to characterize the structures of IFR, and LOI, CCT, SEM, TG methods were used to investigate the flame retardancy and thermal stability of rigid polyurethane (RPU) foams when the three IFR were incorporated into RPU foams. Compared with H, V and S, the DH, DV and DS FTIR spectra showed absorption peaks at 3450 cm −1 , 1160 cm −1 , and 1222 cm −1 , 1050 cm −1 and 740 cm −1 , respectively, which attributed to N H, C N, and P = O , P-O, P-C groups. The 1 H NMR spectra of DH, DV and DS showed proton signals at 4.8 and 6.0 ppm, which were corresponding to H1 and H2 of C N groups, and corresponding C1 signal appeared around 62.3 ppm in the 13 C NMR spectra. The XPS spectra of DH, DV, DS showed peaks at 285, 398 eV and 133.5, 532 eV, which may be due to corresponding C1s, N1s of C N groups and P2p and O1s of P-O-C groups, respectively. These results indicated that the target compounds P/N-containing diphenols DH, DV and DS were synthesized successfully. Flame retardancy index (FRI) values of RPU-DH, RPU-DV, and RPU-DS were 2.33, 2.30 and 2.43, respectively, suggesting that DH, DV, and DS were good flame retardant additives. The THR and HRR values of RPU-DH, RPU-DV, RPU-DS foams were much lower than that of RPU foam. The fire growth rate (FIGRA) of RPU-DH, RPU-DV, and RPU-DS was 29.4%, 30.3%, and 24.4% lower comparing to RPU foam. The LOI value of RPU foam was 19%, while LOI values of RPU-DH, RPU-DV and RPU-DS foams increased to around 26%. These results suggested that the flame retardancy of RPU foams were improved by incorporating DH, DV, and DS. Compared with RPU foam, the CY 600 of RPU-DH, RPU-DV and RPU-DS foams increased by 215.2%, 152.2% and 195.6%, respectively, and the char residue after CCT were much compact and homogeneous, which could reduce heat and mass transfer, protecting underlying materials from further combustion in a fire. In conclusion, the P/N-containing diphenols DH, DV and DS were synthesized successfully, and they were good flame retardant additives. The char residue of RPU-DH, RPU-DV and RPU-DS foams increased remarkably, and formed compact and homogeneous char layer. The flame retardancy and thermal stability of RPU-DH, RPU-DV, RPU-DS foams were improved by incorporating DH, DV, and DS.
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 7
·3441-3447
·
IF 3.591
Mei Wang,Xianghai Kong,Xianghai Song,Yunliang Chen,Quan Bu
Developing lauraldehyde-derived Mannich base grafted PVC materials (PVC-ML-g, g = 1, 2, 3, 4, where the lauraldehyde-derived Mannich base is abbreviated as ML) via clean and efficient strategies is an effective way to resolve the increasing diseases in humans and environmental pollution caused by toxic dioctyl phthalate (DOP) traditionally used to plasticize PVC materials. Thus, in this study, the lauraldehyde-derived Mannich base, which contains both phosphate ester groups and highly flexible long carbon chains, was grafted onto PVC chains to efficiently plasticize PVC materials. The PVC-ML-g materials displayed a lower glass transition temperature than pure PVC and were comparable to conventional DOP plasticized PVC. The good plasticization behavior in the PVC-ML-3 materials was due to the simultaneous introduction of more ester groups and mobile, unentangled longer alkyl chains into the structure of PVC, which decreased the molecular interactions between the PVC chains. Moreover, the PVC-ML-g materials showed improved thermal stability and outstanding anti-migration ability because of the covalent bonds between PVC and lauraldehyde-derived Mannich base grafts.
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2021
·
IF 4.598
Guangxu Bo,Xiaoling Xu,Xiaoke Tian,Jiao Wu,Xin He,Li Xu,Yunjun Yan
In this study, gutter oil biodiesel-based polyols (GOBP) and a reactive-type flame retardant named diethyl bis(2-hydroxyethyl)-aminomethylphosphonate (BHAPE) were both synthesized. Subsequently, gutter oil biodiesel-based flame-retardant rigid polyurethane foams (BPUFs) were prepared with GOBP, BHAPE, aluminum hydroxide (an additive-type flame retardant) and polymeric diphenylmethane diisocyanate. The properties of the BPUFs, including density, thermal conductivity, compressive properties, chemical component, morphology, thermal stability, limiting oxygen index, cone calorimetry testing, char residues stability were characterized. Among them, BPUF-AB owning 6.97 wt% of GOBP, 18.59 wt% of BHAPE and 39.77 wt% of aluminum hydroxide obtained a lower density of 0.097 g/cm 3 , a lower thermal conduction of 0.048 W/(m * k) and the highest compressive strength of 187 ± 13 kPa. Fire testing revealed a highest limiting oxygen index value of 30.1% and passed the UL-94 standard test. Cone calorimetry testing revealed that the peak heat release rate and peak smoke production release of BPUF-AB were reduced by 51.08% and 57.10%, respectively. Meanwhile, the total heat release rate and total smoke production were respectively decreased by 36.88% and 40.79%. The results indicate that BPUFs derived from gutter oil biodiesel are prosperously potential biomaterials with good thermal stability for fire insulation porous materials in future architecture applications.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2020
·
IF 5.065
Linru Guo,Yanzhu Liu,Jibo Dou,Qiang Huang,Yuan Lei,Junyu Chen,Yuanqing Wen,Yongxiu Li,Xiaoyong Zhang,Yen Wei
The removal of environmental pollutants through adsorption by nanomaterials or nanocomposites has attracted great attention over the past few decades. In this work, a novel strategy that combined with Diels-Alder (DA) and multicomponent reactions has been developed to fabricate carbon nanotubes (CNT) based polymer composites and their potential utilization for removal of rare earth ions from wastewater. First, the amino groups were introduced on the CNT through the DA reaction between CNT and furfurylamine. The obtained amino group-terminating CNT composites (named as CNT-FFA) were further conjugated with the polymers through Kabachnik–Fields (KF) reaction. To evidence the successful fabrication of these CNT based polymer composites, a variety of characterization methods, such as Fourier transform infrared spectroscopy (FT-IR), transmission electron microscope (TEM), thermogravimetric analysis (TGA) and X-ray photoelectron spectroscopy (XPS), were used to measure the chemical structure, compositions and thermal stability of CNT based polymer composites. Furthermore, a series of adsorption experiments were implemented to explore the influence of contact time, temperature, initial concentration and pH for adsorption behavior . The results demonstrated that the adsorption capability of resultant CNT based composites (CNT-FFA-PAA) towards Eu 3+ ions is about 130.8 mg g −1 , which is much greater than that of pristine CNT (46.67 mg g −1 ). The above results demonstrated that the method described in this work is a facile and effective tool for fabrication of functional CNT polymer composites, which possess promising prospects for environmental adsorption applications. More importantly, this method in this work could be generally applied in the surface modification of other materials for various applications.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）