JOURNAL OF CHEMICAL RESEARCH
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2016
·
IF 0.661
Haidong Liu,Bo Chen,Jin Cai,Junqing Chen,Min Ji
Eleven trifluoromethylated amines were synthesised in high yield (up to 98%) under metal-free and oxidant-free conditions using iminium salts as starting material and the addition of trifluoromethyltrimethylsilane in dimethylformide containing potassium fluoride.
研究领域:
有机化学
·
合成化学
✓ 已验证
DOI
高影响因子
SOLAR ENERGY
·
2019
·
IF 4.674
Jinjun Zou,Jihuai Wu,Weihai Sun,Mingjing Zhang,Xiaobing Wang,Pengqiang Yuan,Qianjin Zhu,Jie Yin,Xuping Liu,Yuqian Yang
The performance and stability of perovskite solar cell (PSC) are inseparable from the quality of perovskite film, and the solvent engineering is being seemed as an effective strategy to enhance the properties of perovskite. Acetonitrile (ACN) is often used as a solvent to dissolve bis(trifluoromethane)sulfonimide lithium salt (LiTFSI), but ACN can corrode the perovskite film, which hinders the promotion of PSC efficiency and durability. Herein, a solvent engineering approach is implemented to search for suitable alternatives for ACN to abate the degradation of the perovskite films. The results demonstrate that isopropanol (IPA) with smaller polarity can effectively dissolve LiTFSI and slow down the degradation of the perovskite layer compared with ACN, which can result in the reduction of defects as well as the nonradiative recombination. Consequently, the devices using LiTFSI/IPA as additive achieve superior power conversion efficiencies (PCEs) with relatively less hysteresis effects and get a champion PCE of 19.43%, while the device using LiTFSI/ACN gets an inferior PCE of 17.12%.
研究领域:
材料科学
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能源技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Junqiao Jiang,Min Xiao,Sheng Huang,Dongmei Han,Shuanjin Wang,Yuezhong Meng
Phosphoric acid (PA)-dependent proton conductivity and polymer-offered mechanical properties are contradictory in high-temperature proton exchange membranes (HT-PEMs). Microphase separation strategy contributes to achieve a tradeoff between proton conductivity and mechanical properties. Herein, a kind of phosphonic acid-imidazolium containing polymer (PICP) ionomeric membranes, in which acidophilic (imidazolium) and acidophobic groups (-PO 3 H 2 ) can be induced to form a microphase separation structure by PA, are firstly prepared. The acidophilic phase with adsorbed PA plays the role of proton conduction and the acidophobic phase can not only provides -PO 3 H 2 group synergistically conduct protons but also largely maintains the intrinsic mechanical properties. As a result, the PICP ionomeric membranes with microphase separation structure possess high proton conductivity (48 mS cm −1 , 160 °C) and satisfying mechanical strength (16.5 MPa) simultaneously at a moderate PA doping level (130 wt%). The fuel cell based on such HT-PEMs demonstrates a peak power density of 493 mW cm −2 and high voltage stability. This is the first report of phosphonic acid-imidazolium containing ionomeric membranes with satisfactory fuel cell performance and durability, representing a meaningful step towards practical HT-PEM fuel cells.
研究领域:
材料科学
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化学工程
·
能源技术
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Immunology
·
2023
·
IF 7.3
Han Xiangning,Lin Hong,Chen Xiangfeng,Wang Luefeng,Zhang Ziang,Wei Xiaojing,Sun Xun,Xie Hanyi,Pavase Tushar Ramesh,Cao Limin,Sui Jianxin
For a long time, people have suffered from uncertainty, complexity, and a low success rate in generating and screening antibodies against small molecules, which have become the core bottlenecks of immunochemistry. Here, the influence of antigen preparation on antibody generation was investigated at both molecular and submolecular levels. Neoepitopes (amide-containing neoepitopes) formed in the preparation of complete antigens are one of the most important factors limiting the efficiency of generating hapten-specific antibodies, which was verified by different haptens, carrier proteins, and conjugation conditions. Amide-containing neoepitopes present electron-dense structural components on the surface of prepared complete antigens and, therefore, induce the generation of the corresponding antibody with much higher efficiency than target hapten. Crosslinkers should be carefully selected and not overdosed. According to these results, some misconceptions in the conventional anti-hapten antibody production were clarified and corrected. By controlling the content of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) during the synthesis of immunogen to limit the formation of amide-containing neoepitopes, the efficiency of hapten-specific antibody generation could be significantly improved, which verified the correctness of the conclusion and provided an efficient strategy for antibody preparation. The result of the work is of scientific significance in the preparation of high-quality antibodies against small molecules.
研究领域:
免疫学
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生物化学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Packaging and Shelf Life
·
2023
·
IF 8
Xiangyu Jiao,Jiaxuan Xie,Haiyu Du,Xiaochun Bian,Changtao Wang,Liping Zhou,Yongqiang Wen
In this work, an antibacterial smart absorbent pad with Janus structure was prepared to preserve and indicate the quality of meat. The pad had two layers, polyurethane (PU) nanofibers as the top hydrophobic layer and polyvinyl alcohol (PVA) nanofibers as the bottom absorbent layer. Polyhexamethylenebiguanide hydrochloride (PHMB) was added to the top layer as cationic antimicrobial agent because guanidine group could maintain its strong positive charge in alkaline environment, which keeps the antibacterial ability during meat spoilage that is a process of pH increasing. Besides, the juice of the meat can be absorbed to the bottom layer while the hydrophobic top layer in contact with meat remains dry, which can reduce the multiplication of bacteria. Furthermore, anthocyanin was added to the bottom layer as an indicator to detect spoilage of meat. The experiments show the new antibacterial indicator absorbent pad can effectively inhibit bacterial growth (less than 5 lg CFU/g after 8 days), prolong the shelf life of fresh meat (total volatile base nitrogen less than 20 mg/100 g) to 7 days when stored at 4 °C and indicate the deterioration of meat.
研究领域:
材料科学
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食品科学
·
生物技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2020
·
IF 4.152
Chaoyue Che,Lin Liu,Xiaodan Wang,Xu Zhang,Shifang Luan,Jinghua Yin,Xue Li,Hengchong Shi
Uncontrolled hemorrhage is the leading factor causing death in military trauma and clinical practice and is usually accompanied with bacterial infection. The fabrication of a functional hemostatic sponge for combating bacteria is of vital importance. Poly(hexamethylene biguanide) hydrochloride (PHMB) has been shown to have a remarkable bactericide effect. However, PHMB after use might have a toxic effect on humans. Herein, a powerful surface-adaptive, on-demand antibacterial hemostatic sodium alginate/gelatin sponge is fabricated by sequential spray-assisted layer-by-layer assembly of PHMB and hyaluronic acid (HA). The HA upper layer could endow the coating surface with better biocompatibility under physiological conditions. Once bacteria invade, the secreted hyaluronidase could degrade the upper HA layer, and then the exposed PHMB layer could kill the bacteria. The coated sponge shows excellent biocompatibility, as negatively charged HA can prevent the exposure of bactericidal PHMB. Moreover, the coated sponge exhibited excellent hemostatic properties in vitro and in vivo by aggregating and activating blood cells. Our strategy provides a novel approach to the design of surface-adaptive and on-demand bactericidal coatings on the surface of hemostatic sponges, which has the advantage of avoiding infection complications during hemostasis.
研究领域:
生物医学工程
·
材料科学
·
伤口护理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2022
·Vol. 22
·期 11
·2200150
·
IF 5.859
Wenjie Wang,Yilin Wang,Weifeng Zhao,Changsheng Zhao
Preventing bacterial infection and controlling the inflammatory response occupy important positions in wound treatment. Although loading wound dressings with antibacterial or anti-inflammatory drugs/molecules is an effective approach to address these issues, simultaneous sustained release of these drugs remains challenging. Herein, hydrophilic polyhexamethylene guanidine hydrochloride (PHGC) and hydrophobic indomethacin (Indo) are loaded in hydrophilic polyvinyl alcohol (PVA) and hydrophobic polycaprolactone (PCL) nanofibers respectively by bidirectional electrospinning to form an antibacterial and anti-inflammatory PCL-Indo/PVA-PHGC wound dressing. The fabricated nanofiber membrane exhibits 100% disinfection activity to both Gram-negative ( E. coli) and Gram-positive ( S. aureus ) bacteria because of the release of the broad-spectrum antibacterial molecule PHGC. Additionally, the loading of Indo in the nanofiber membrane enhances the expression level of IL-10, while inhibiting those of IL-6 and TNF- α in the RAW264.7 mouse cells. In the interwoven membrane of PCL and PVA fibers, the release of hydrophobic Indo is hindered by hydrophilic PHGC and PVA fibers, and similarly, the release of hydrophilic PHGC is hindered by hydrophobic Indo and PCL fibers. In conclusion, the PCL-Indo/PVA-PHGC nanofiber membrane has excellent antibacterial, anti-inflammatory, and sustained-release effects, and thus regulates the immune microenvironment of the cells to potentially promote wound healing.
研究领域:
材料科学
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生物医学工程
·
药学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2024
·
IF 5.4
Jianxin Wen,Xiaomei Liu,Zhuoyue Han,Zhijuan Wang,Hidetoshi Saitoh,Hua Li
Biofouling has been persisting as a global problem due to the difficulties in finding efficient and environmentally friendly antifouling coatings for long-term applications. Initial attachment of bacteria on material surface and subsequent formation of biofilm are the predominate phenomena accounting for subsequent occurrence of biofouling. Among the various factors influencing the bacterial attachment, conditioning layer formed by organic macromolecules usually plays the key role in mediating bacterial attachment through altering physicochemical properties of substrate surface. In this study, a guanidine-modified polysaccharide conditioning layer with the capability of tuning the bacterial attachment is constructed and characterized. Dextran, a polysaccharide widespread in bacteria extracellular polymeric substances (EPS), is oxidized by sodium periodate, and cationic polymer polyhexamethylene guanidine hydrochloride (PHMG) is anchored to oxidized dextran (ODEX) by Schiff base reaction. AFM characterization reveals morphological changes of the polysaccharide conditioning layer from tangled chain to island conformation after the PHMG modification. The guanidine-based dextran conditioning layer promotes attachment of both P. aeruginosa and S. aureus and disrupted bacterial cytomembranes are seen for the attached bacteria due to electrostatic interaction of the electropositive guanidine group with the electronegative bacteria. The guanidine-based dextran conditioning layer shows a low survival ratio of 22 %-34 % and 1 %-4 % for P. aeruginosa and S. aureus respectively after incubation in the bacterial suspension for 72 hours. The results would give insight into further exploring the potential applications of the newly designed polysaccharides conditioning layer for combating occurrence of biofouling.
研究领域:
材料科学
·
生物技术
·
微生物学
·
表面化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2015
·Vol. 40
·期 1
·755-763
·
IF 3.086
Zhihong Zhang,Hongfei Ji,Shuai Zhang,Donglai Peng,Qixuan Fu,Minghua Wang,Linghao He,Lingyu Yue
We report a novel nanocomposite of hollow TiO2 microspheres and plasma polyacrylic acid (TiO2@PPAA) modified with rhodamine B (TiO2@PPAA-RhB). This nanocomposite was further used as an electrochemical sensor for the ultra-sensitive and selective detection of Cu2+ in water. A gold electrode was modified with hollow TiO2 nanospheres, followed by the closely bonded layer of PPAA via plasma polymerization. Subsequently, the carboxyl groups of TiO2@PPAA nanocomposites were activated to ester groups by N-hydroxysuccinimide/1-ethyl-3-(3-dimethylaminoprolyl) carbodiimide hydrochloride. The resultant activated ester groups reacted with the amino groups on rhodamine to form the amide groups, leading to the modification of TiO2@PPAA nanocomposites with rhodamine. Considering the synergistic effect of strong electrostatic interaction between the carboxyl groups of PPAA and Cu2+, the direct adsorption of Cu2+ on the TiO2 surface, and the coordination chemistry formed between Cu2+ and rhodamine, the developed electrochemical biosensor exhibited high sensitivity of Cu2+ detection, with a detection limit of 0.404 pM within the range of 0.001–10 nM of Cu2+. Therefore, the fabricated electrochemical sensor based on TiO2@PPAA-RhB can be obtained via plasma polymerization and represents a highly promising tool for use in environmental monitoring.
研究领域:
电化学
·
材料科学
·
环境监测
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Tongyu Wang,Wanli Kang,Hongbin Yang,Zhe Li,Haiming Fan,Wangang Zheng,Tongyu Zhu,Saule Aidarova,Maratbek Gabdullin
The “graft onto” method is used to obtain the “stimuli-responsive water-soluble polymer” with low concentration, where 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and n-hydroxysulfosuccinimide sodium salt as catalyst and sodium polyacrylate as backbone chain. The molecular structure of the polymer is characterized by Nuclear Magnetic Resonance ( 1 H NMR). The influence of temperature on polymer rheological properties and aggregation is studied by rheometer and fluorescence probe respectively. The results show that when the polymer concentration is higher than 1500 mg/L, the thickening properties can be controlled by diacetoneacrylamide, thermal-responsive monomer , NaCl and polymer concentration, where the apparent viscosity max / viscosity min (η max /η min ) changes from 18.3 to 39.4, from 2.6 to 45.5, from 9.3 to 36, from 7.8 to 36.9 respectively and the lower critical solution temperature (LCST) changes from 60 °C to 40 °C. The reason for the polymer with controllable thickening properties is that the thermal-responsive monomers change from hydrophilicity to hydrophobicity , thus forming aggregations. At this time, the polymer chains form network structures. Because of controllable thickening properties at low concentration, it has potential application prospects.
研究领域:
高分子科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Zixun Wang,Yang Yang,Yunbo Gao,Zhaoxian Xu,Shulin Yang,Mingjie Jin
Bioinks are one of the key elements in realizing three-dimensional (3D) bioprinting. However, bioinks prepared from conventional collagen are hindered to their further applications due to concerns of collagen purity, unstable mechanical properties, and low solubility under neutralized conditions. This study aimed to develop a reliable UV-curable bioink system from a novel water-soluble recombinant human collagen (RHC). RHC was modified by methacrylic anhydride (MAA) and later crosslinked by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC)/N-hydroxysuccinimide (NHS) to obtain Pro-RHCMA. 1 H nuclear magnetic resonance ( 1 H NMR) confirmed the methacryloyl grafts, Fourier transform-infrared spectroscopy (FT-IR) illustrated the chemical crosslinking in producing the Pro-RHCMA. Internal morphology, mechanical properties and degradation of UV cured boinks were MAA and EDC/NHS modification-dependent. Photorheological properties and printability of the bioinks were determined. Cellular bioactivities were sustained within the printed bioinks, validating the bioinks biocompatibility in vitro . Finally, qRT–PCR revealed that the Pro-RHCMA bioinks provided a cell-friendly microenvironment for human umbilical vein endothelial cells (HUVECs) and human foreskin fibroblasts (HFFs), by supporting the expression of extracellular matrix (ECM) and angiogenesis-associated proteins, respectively. Taken together, this novel RHC-based bioink system shows great potential in tissue engineering and regenerative medicine.
研究领域:
组织工程
·
再生医学
·
生物打印
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）