ACTA PHARMACOLOGICA SINICA
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2026
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IF 10.4
Xu Quan-gang,Gu Ze-yun,Chen Wen-jie,Liu Han,Li Ze-yu,Cai Wen-li,Huang Jing,Muhitdinov Bahtiyor,Liu Er-gang,Aisa Haji Akber,Huang Yong-zhuo
Allicin, a bioactive compound derived from garlic, exhibits therapeutic potential against metabolic disorders but is hindered by instability and a pungent odor, limiting its clinical application. This study develops an allicin oleogel (OG) formulation, leveraging molecular interactions with unsaturated fatty acids and gelators to stabilize allicin and mitigate its odor for transcutaneous delivery. The skin analysis confirmed superior transdermal delivery and accumulation in subcutaneous fat with OG, highlighting its advantages for topical application. In a high-fat diet (HFD)-induced mouse model of obesity, OG demonstrated superior efficacy in suppressing weight gain, reducing food intake, and improving metabolic parameters, including fasting blood glucose, oral glucose tolerance, and insulin sensitivity, compared to orally administered allicin oleogel (OGO) and metformin (MET). OG also ameliorated non-alcoholic fatty liver disease (NAFLD), as evidenced by reduced hepatic lipid accumulation and normalized adipose tissue metabolism. Notably, OG treatment shifted macrophage polarization toward an anti-inflammatory M2 phenotype and increased mitochondrial activity, facilitating adipose tissue remodeling and enhancing energy expenditure and thermogenesis. Safety evaluations revealed no systemic toxicity, supporting its potential for long-term use. This study underscores transcutaneously delivered OG as a promising therapeutic strategy for obesity and related metabolic disorders.
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TRIBOLOGY INTERNATIONAL
·
2023
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IF 6.2
Kang Yang,Yongping Niu,Yang Li,Xiaowei Wang,Sanming Du,Yongzhen Zhang
Double-core microcapsules were prepared via in situ polymerization using poly(urea-formaldehyde) (PUF) as the wall material as well as ionic liquid and linseed oil as the core material. The addition of microcapsules to epoxy matrices can result bifunctional epoxy composites with self-lubricating and self-healing properties. Frictional wear experiments indicated that compared with pure epoxy resin , the friction coefficient of the epoxy composite containing 7 wt% microcapsules was reduced by 93.5% and the wear rate of the composite was reduced by 98%. In addition, the composite material has excellent repair properties for scratches.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·Vol. 141
·期 6
·e54927
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IF 3
Kang Yang,Yongping Niu,Xiaowei Wang,Sanming Du,Yongzhen Zhang,Junkai Zhang,Junqing Cai
Cured epoxy resins have poor abrasion resistance, which shortens the service life of the material. This work aims to improve the tribological properties of epoxy resins by coupling self-lubrication and auto-healing. In this study, linseed oil microcapsules with an average particle size of 38.57 μm and good thermal stability were successfully prepared by in situ polymerization. The effects of microcapsule content on the tribological, mechanical, and self-healing properties of the composite coatings were studied. It was demonstrated that the composite coating has outstanding self-lubricating properties. The coefficient of friction reduced from 0.634 (pure epoxy resin) to 0.0459 (epoxy resin with 10 wt.% linseed oil microcapsules). Wear rate reduced from 7.16 × 10 −4 mm 3 /(N m) to 1.74 × 10 −5 mm 3 /(N m). The self-lubricating mechanism of the coating was investigated by SEM and EDS, which indicated that the formation of uniform and continuous lubricating film on the surface of the friction pairs was the key to improving the wear resistance of the material. In addition, the linseed oil released after the microcapsules rupture can repair the abrasion marks by reacting with oxygen during the friction process. The dual-functional effect of linseed oil microcapsules prolongs the life of epoxy resin coating and expands its application range.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Guoqiang Zhu,Meiting Liu,Zhimin Kou,Guixin Zhang,Caiying Bo,Lihong Hu,Yun Hu,Yonghong Zhou
Recently, researchers have shown great interest in the development of biobased and reprintable 3D printing materials for sustainable 3D printing. Herein, a method for developing plant oil (PO)-based digital light processing (DLP) printing resins that are both reprocessable and reprintable is proposed. Biobased UV-curable monomers (POPITs) containing dynamic hindered urea bonds (HUBs) from POs were synthesized via the thiol-ene click reaction. A range of DLP printing resins (POPIT-I) with high biobased content (52.6%–58.1%) were prepared by blending POPITs with the biobased dilute monomer isobornyl acrylate . These resins demonstrated good mechanical and thermal properties (e.g., tensile strength : 45.1–49.5 MPa and T g : 74–92 °C), as well as high DLP printing quality. Reprocessable DLP printing was employed to fabricate large-volume parts through the dissociation and reorganization of HUBs, thereby reducing printing difficulty and printing time. Additionally, a powder blending and modification method was used to recycle and reprint printed materials. The printing materials, including printed green parts and discarded supporting material s, were milled into micron-sized powders and then blended with POPIT-I to prepare the powder blending resins. The milled powders in the powder blending resins were further modified by 2-( tert -butylamino) ethyl methacrylate to prepare reprinting resins. This process resulted in the grafting of C = C onto the powder surface, which eliminated heterogeneity between the powders and POPIT-I. The mechanical and thermal properties of the reprinting resins were comparable with those of POPIT-I even after three rounds of recycling. Furthermore, the reprinting method reported here is applicable to other dynamic covalent bond-based 3D printing systems.
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ACS Sustainable Chemistry & Engineering
·
2023
·
IF 8.4
Yugao Ding,Liu Feng,Zhe Zhang,Sihao Zhang,Xuelian Zhang,Yingzhan Li,Xiong Fang,Xiaowen Hu,Xiaojing Wang,Kam Chiu Tam,Guofu Zhou,Zhen Zhang
Nanocelluloses have attracted much attention in both academic and industrial fields. However, nanocelluloses, including cellulose nanocrystals and cellulose nanofibers, are generally produced by a “top-down” strategy with tedious violent chemical reactions and energy-intensive mechanical treatments. Fabrication of nanocellulose via facile and green approaches with a low cost is always challenging and promising. The digestion of grass by ruminants resembles the extraction processing of nanocelluloses from plants. Herein, lignocellulose nanoparticles (LCNPs) were extracted from cattle dung via facile filtration and centrifugation separation methods, indicating that LCNPs occurred naturally in cattle dung and were formed during digestion of grass. LCNPs are mainly composed of lignin, cellulose, and hemicellulose and possess an average diameter of ∼50 nm, high surface charge of −36.2 mV, and outstanding water dispersity. LCNPs show excellent Pickering emulsifying ability just as classic nanocellulose due to their partial wettability with both oil and water phases. LCNP stabilized Pickering emulsions were then employed as templates to prepare phase change material (PCM) microcapsules with melamine-formaldehyde shells to prevent leakage of PCM. The obtained PCM microcapsules display good thermal stability, durability, high PCM core content of 88.9% and phase change enthalpy of 214.3 J g–1, and are promising for thermal energy storage and temperature regulation applications. This study provides a sustainable approach to extract nanocellulose as Pickering emulsifier and will facilitate the high-value-added utilization of cattle dung.
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Environmental Science-Nano
·
2019
·Vol. 6
·期 12
·3699-3711
·
IF 7.704
Wenjing Ma,Mengjie Zhang,Yuansheng Li,Mengmeng Kang,Chaobo Huang,Guodong Fu
One of the most pervasive environmental issues is water contaminated with various oils. Developing an efficient and novel functional membrane for oil/water separation is urgently needed. Herein, a flexible, durable and magnetic pH-responsive F3O4/MA–TiO2/PI electrospun nanofibrous membrane (ENM) was fabricated via an electrospinning and green dip-coating route. Combining the rough hierarchical structure and pH-responsive wettability, the as-prepared hybrid membrane can controllably separate a range of not only heavy oil/water but also light oil/water mixtures by only adjusting the pH of the aqueous medium. Both separations exhibit a large flux and outstanding efficiency for the tested oil/water mixtures even after 20 reuse cycles due to the hierarchical structure and flexibility of the membrane. In addition, the flexibility and magnetism of the membrane make it easily removed with a magnet after the separation of the oil/water mixtures. More importantly, the as-prepared membrane not only has excellent stability towards high temperature, corrosive organic solvent/salt solution immersion, and UV irradiation but also shows great resistance to mechanical abrasion and ultrasonic treatment, and the preparation method is facile, environmentally friendly, and cost-effective. Thus, such a membrane may offer exciting opportunities in the application of oily wastewater treatment and on-demand oil/water separation.
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ACS Omega
·
2024
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IF 3.7
Yang Xie,Peng Li,Dong Fu,Fan Yang,Xin Sui,Bo Huang,Jiaying Liu,Jialong Chi
Cannabidiol (CBD) has demonstrated its potential to enhance depression treatment through various biological pathways. However, the application potential of CBD is significantly impeded by its polymorphic nature, limited water solubility, and hepatic first-pass metabolism. To improve chemical stability and water solubility, nanostructured lipid carriers loaded with CBD (CBD-NLCs) were developed using a hot-melt emulsification method and optimized by response surface methodology (RSM). The process parameters were optimized using a four-factor and three-level Box–Behnken experimental design consisting of 29 experiments. The CBD-NLCs were formulated and characterized, demonstrating desirable properties, including a mean particle size of 54.33 nm, a PDI value of 0.118, a zeta potential of −29.7 mV, and an impressive encapsulation efficiency rate of 87.58%. The nanoparticles were found to possess an approximately spherical shape, as revealed by scanning and transmission electron microscopy. The stability studies have demonstrated that CBD-NLCs effectively mitigated the photodegradation of CBD and exhibited a stable behavior for 42 days when stored. The CBD-NLCs displayed a biphasic release profile characterized by an initial burst release (over 50% of CBD released within 20 min) followed by a subsequent gradual and sustained release, aligned with first-order kinetics and Fickian diffusion. These findings demonstrate the potential suitability of this formulation as a carrier for CBD in food fortification and pharmaceutical applications.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xin-Yi Hui,Cheng Zuo,Ying Xu,Bo Wang,Jia-Long Wen,Tong-Qi Yuan
The conversion of biomass feedstocks into bio-based nanomaterials was made easier with hydrated DES (HDES) pretreatment , which can boost the value-added applications of lignocellulosic biomass. In this study, two types of HDESs were initially prepared by 3-Chloro-2-hydroxypropyltrimethyl ammonium chloride (CHPTAC) with formic acid (FA) and acetic acid (AA), respectively. We achieved rapid conversion of bamboo feedstock into bio-based nanomaterials (including lignin nanoparticles, LNPs ; lignin-containing cellulose nanofibers, LCNFs) through one-pot microwave-assisted HDES pretreatment coupled with robust nanofabrication strategies. The findings demonstrated that an impressive delignification ratio of 92.10 % and a cellulose retention ratio of 92.95 % were achieved under the optimal DES pretreatment conditions (120 °C, 20 min). The fractionated lignin fractions were effortlessly self-assembled into dispersed, uniformly shaped circular LNPs (<100 nm) using a novel proposed strategy, which was successfully applied to stabilizing oil-in-water (O/W) Pickering emulsions. To produce LCNFs, we conducted functionalization of cellulose-rich residue in aqueous citric acid followed by simple ultrasonic treatment. Compared to the control LCNF, the LCNF-based self-assembly films exhibited significantly improved mechanical properties and hydrophobicity (water contact angle 106.26°). In short, the proposed HDES pretreatment combined with robust nanofabrication strategies will broaden the fractionation and fabrication of bio-based nanomaterials, enhancing their potential in promising fields.
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Frontiers in Immunology
·
2024
·
IF 5.7
Yifei Geng,Yuchen Liu,Min Wang,Xi Dong,Xiao Sun,Yun Luo,Xiaobo Sun
Background Ischemic stroke (IS), caused by blood and oxygen deprivation due to cerebral thrombosis, has links to activated and aggregated platelets. Discovering platelet-related biomarkers, developing diagnostic models, and screening antiplatelet drugs are crucial for IS diagnosis and treatment. Methods and results Combining and normalizing {"type":"entrez-geo","attrs":{"text":"GSE16561","term_id":"16561"}} GSE16561 and {"type":"entrez-geo","attrs":{"text":"GSE22255","term_id":"22255"}} GSE22255 datasets identified 1,753 upregulated and 1,187 downregulated genes. Fifty-one genes in the platelet-related module were isolated using weighted gene co-expression network analysis (WGCNA) and other analyses, including 50 upregulated and one downregulated gene. Subsequent enrichment and network analyses resulted in 25 platelet-associated genes and six diagnostic markers for a risk assessment model. This model’s area under the ROC curve outperformed single genes, and in the peripheral blood of the high-risk group, immune infiltration indicated a higher proportion of CD4, resting CD4 memory, and activated CD4 memory T cells, along with a lower proportion of CD8 T cells in comparison to the low-risk group. Utilizing the gene expression matrix and the CMap database, we identified two potential drugs for IS. Finally, a rat MACO/R model was used to validate the diagnostic markers’ expression and the drugs’ predicted anticoagulant effects. Conclusion We identified six IS platelet-related biomarkers (APP, THBS1, F13A1, SRC, PPBP, and VCL) for a robust diagnostic model. The drugs alpha-linolenic acid and ciprofibrate have potential antiplatelet effects in IS. This study advances early IS diagnosis and treatment.
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Journal of Cleaner Production
·
2025
·
IF 10
Yongyin Zhu,Henghui Deng,Huizhou Luo,Yufei An,Xujiao Yu,Ying Luo,Rafael L. Quirino,Chaoqun Zhang
A B S T R A C T The creation of bio-based internal emulsifiers with highly active primary hydroxyl groups from renewable resources is a key challenge from the perspective of sustainable development. In this study, a combination of transamidation and thiol-ene click reaction was used to synthesize three novel plant oil-based internal emulsifiers with an excellent carbon-carbon double bond conversion exceeding 94 % at room temperature. Combining these internal emulsifiers with commonly used polyols, a series of bio-based waterborne polyurethanes (WPU) with tailored mechanical properties, thermo-physical properties, and thermal stability were prepared through self-ionic emulsion strategy. The results indicated that, due to the unique structures of these plant oil-based internal emulsifiers, the WPU films prepared with them demonstrated better anti-ultraviolet performance (1.18 % transmittance) than those prepared from commercially available internal emulsifiers. Additionally, they also exhibited fluorescence performance under 365 nm excitation, and no fluorescence quenching occurs under stretching state. These bio-based WPU are promising for applications in advanced coatings, sunscreen formulations, and fluorescent pigments.
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FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Mahmoud Abou-Elsoud,Ibrahim Khalifa,Mohamed Salama,Zuyue Li,Hamdy Zahran,Zhaoxia Cai,Dong Uk Ahn,Xi Huang
This work aimed to determine the impact of fatty acid composition on the physicochemical, oxidative, and digestive properties of emulsion-templated oleogels structured using pectin (PE) and egg yolk low-density lipoprotein (LDL). Four oils with varying degrees of unsaturation, including olive oil (OO), soybean oil (SO), linseed oil (LO), and fish oil (FO), were incorporated into PE/LDL-based oleogels. Results showed that oleogels formulated with polyunsaturated fatty acid (PUFA)-rich oils (FO and LO) exhibited higher viscosity (4856 and 4456 Pa s), hardness (745 and 721 g), oil-binding capacity (98.85 and 97.69 %), and thermal stability than others, due to stronger intermolecular bonds in the gel matrix. Oxidative stability assessments revealed that oleogelation significantly suppressed both primary and secondary lipid oxidation in PUFA-rich systems, with further improvements when BHA was added. The in vitro digestion showed that oleogels effectively reduced free fatty acids release and fat bioaccessibility compared to bulk oils, with FO-based oleogels showing the lowest. Furthermore, correlation analyses establish clear relationships between fatty acid profiles and oleogel performance, providing a scientific basis for optimizing formulations. These findings provide valuable insights for tailoring functional oleogels with improved oxidative stability and modulated lipid digestion.
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