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MOLECULES · 2013 ·Vol. 18 ·期 11 ·13910-13919 · IF 2.428

The Henry Reaction in [Bmim][PF6]-based Microemulsions Promoted by Acylase

Wen-Jian Xia,Zong-Bo Xie,Guo-Fang Jiang,Zhang-Gao Le

An environmentally-friendly, enzyme-promoted procedure for the Henry reaction was first studied using water-in-[Bmim][PF6] microemulsions as reaction medium. The Amano acylase fromAspergillus oryzaeshowed better catalytic activity for the addition reactions of nitromethane with a series of aromatic aldehydes, and a highest yield of 90% was obtained.Keywords:Henry reaction;acylase;water-in-[Bmim][PF6] microemulsion;enzyme promiscuity

CAS / MDL: 9048-46-8 9001-62-1

研究领域: 生物化学 · 环境科学

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JOURNAL OF CHEMICAL RESEARCH · 2024 · IF 1

Synthesis research on the herbicide safe agent Furilazole

Yinuo Wang,Yan Liang,Yutong Li,Yue Zhang,Haiwen Song,Aibing Ke

Furfural and nitromethane were utilized as raw materials for the synthesis of the herbicide-safe agent Furilazole through the Henry reaction, nitro reduction and addition-cyclization-acylation. A comprehensive investigation into the involved reaction processes was conducted, leading to the identification of barium hydroxide octahydrate as the catalyst for the Henry reaction. The continuous use methodology of the excess catalyst was determined through TGA/DSC curve analysis, and a rational purification method for Henry reaction products was proposed. The nitro reduction reaction employed Pd/C catalysis, while the subsequent addition-cyclization-acylation reaction was achieved in a single step. Five impurities affecting the reaction process were identified, and their potential mechanisms of formation were postulated. Optimization of synthetic process conditions was carried out for all involved reactions. The structures of intermediates, impurities, and products were characterized using NMR, HRMS, TGA/DSC and FTIR.

研究领域: 化学合成 · 农药科学

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The Henry Reaction in [Bmim][PF6]-based Microemulsions Promoted by Acylase

Synthesis research on the herbicide safe agent Furilazole