JOURNAL OF CHROMATOGRAPHY A
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2016
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IF 3.926
Haibin Li,Chusheng Liu,Qiqin Wang,Haibo Zhou,Zhengjin Jiang
In order to investigate the effect of charged groups present in hydrophilic monolithic stationary phases on their chromatographic properties, three charged hydrophilic monomers, i.e. N,N -dimethyl- N -acryloyloxyethyl- N -(3-sulfopropyl)ammonium betaine (SPDA), [2-(acryloyloxy)ethyl]trimethylammonium chloride (AETA), and 3-sulfopropyl acrylate potassium salt (SPA) were co-polymerized with the crosslinker N,N '-methylenebisacrylamide (MBA), respectively. The physicochemical properties of the three resulting charged hydrophilic monolithic columns were evaluated using scanning electron microscopy, ζ-potential analysis and micro-HPLC. High column efficiency was obtained on the three monolithic columns at a linear velocity of 1 mm/s using thiourea as test compound. Comparative characterization of the three charged HILIC phases was then carried out using a set of model compounds, including nucleobases, nucleosides, benzoic acid derivatives, phenols, β-blockers and small peptides. Depending on the combination of stationary phase/mobile phase/solute, both hydrophilic interaction and other potential secondary interactions, including electrostatic interaction, hydrogen-bonding interaction, molecular shape selectivity, could contribute to the over-all retention of the analytes. Because of the strong electrostatic interaction provided by the quaternary ammonium groups in the poly (AETA- co -MBA) monolith, this cationic HILIC monolith exhibited the strongest retention for benzoic acid derivatives and small peptides with distorted peak shapes and the weakest retention for basic β-blockers. The sulfonyl groups on the poly (SPA- co -MBA) hydrophilic monolith could provide strong electrostatic attraction and hydrogen bonding for positively charged analytes and hydrogen-donor/acceptor containing analytes, respectively. Therefore, basic drugs, nucleobases and nucleotides exhibited the strongest retention on this anionic monolith. Because of the weak but distinct cation exchange properties of the zwitterionic poly (SPDA- co -MBA) hydrophilic monolith, it exhibited the best separation for most test analytes (including phenols, β-blockers and small peptides) in terms of selectivity, peak shape and analysis time. The poly (AETA- co -MBA) hydrophilic monolithic column provides the best separation of nucleobases and nucleosides. These results could guide the selection and application of these charged HILIC monoliths in the future.
研究领域:
分析化学
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色谱技术
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产品关联
DOI
PubMed
高影响因子
LANGMUIR
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2019
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IF 3.683
Qiangbing Wei,Xiaoqian Liu,Qinyu Yue,Shuanhong Ma,Feng Zhou
Low-friction and hydrophilic surfaces have critical applications in biomedical devices and implants. Existing methods to achieve such surfaces, for example, grafting polymer brushes, usually suffer from tedious steps and harsh reaction conditions, which limit practical applications. In this work, we propose a set of versatile ultralow-friction coatings applicable for diverse biomaterial surfaces via a one-step simple codeposition strategy with dopamine and hydrophilic monomers. The polymer coatings show ultralow-friction performance together with hydrophilic feature and antifouling property. The coefficient of friction of the as-prepared coating can be as low as 0.003 in pure water. The coating also provides superior and stable lubrication in biological fluids due to antifouling capability. Furthermore, the versatility of this strategy allows fabrication of multiple lubricious polymer coatings with different hydrophilic monomers and on diverse material surfaces. The typical application of this low-friction coating on a medical catheter was further demonstrated, which dramatically improved surface wettability and reduced friction of the outer surface of the catheter. In view of the versatility and remarkable lubrication ability, the multifunctional coatings may find important applications in biomedical devices and implants.
研究领域:
生物医学工程
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材料科学
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产品关联
DOI
PubMed
高影响因子
Materials Today Communications
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2020
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IF 2.678
Tingjian Huang,Junfeng Li,Yuan Chen,Tianhaoyue Zhong,Pengqing Liu
Poly (ether ether ketone) (PEEK) ultrafiltration membrane was modified with 2-hydroxylethyl acrylate (HEA) as a hydrophilic monomer through light-initiated grafting polymerization to improve its permeability and antifouling property. The effects of monomer concentration and irradiation time on the surface’s chemical structure and morphology, degree of grafting (DG), surface hydrophilicity and pore volume of the membranes were systematically investigated; meanwhile, the antifouling property were characterized and analyzed using bovine serum albumin (BSA) as a model foulant. The results indicate that the DG and hydrophilicity of the membrane surface are enhanced with the increase of either monomer concentration or irradiation time. The water flux of modified membrane using 0.3 mol/L HEA and 20 min irradiation time is 1.52 times that of unmodified membrane, and the irreversible fouling decreases from 51 % to 10.9 %. In this work, the graft chain length and graft density are considered to be controlled by the factors of monomer concentration and irradiation time, respectively. Compared with increasing the graft density, the increase of the graft chain length is more easily to lead to a decrease in membrane permeability. Meanwhile, the long chain length is more important than the high graft density to achieve excellent antifouling performance.
研究领域:
材料科学
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环境工程
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2022
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IF 9.221
Xin Guan,Yunlong Yu,Zhaonan Hou,Ke Wu,Hongran Zhao,Sen Liu,Teng Fei,Tong Zhang
Self-supported polymer films were fabricated by the thiol-ene click cross-linking reaction in this work. The cross-linked frameworks were used to guarantee the stability the films. The hydrophilic monomer with different contents were introduced into the self-supported thick films and uniformly dispersed in the polymer frameworks. The interdigitated electrodes were screen printed with silver paste on the self-supported films to obtain humidity sensors . Herein, the self-supported film acts as both the sensor substrate and the humidity-sensing material. The humidity sensing performances of the obtained sensors were systematically researched. By optimizing the ratio of hydrophilic monomer in the polymer films, the sensitivities of the sensors were enhanced from 1.58 to 103.75 (in the humidity from 11% RH to 95% RH), the response under low RH environment was significantly improved with good linearity. The response/recovery times of the sensor within the humidity range are measured to be 12.5 s and hundreds of seconds. The prepared flexible sensors possess certain mechanical properties, and exhibit good stability under bending and long-term tests up to 60 days. The applications of the as-prepared sensor in the detection of non-contact human skin humidity, human respiration and relative humidity of green plant were explored. The sensor shows excellent sensing performance in various applications and indicates the potential application in wearable and multifunctional devices.
研究领域:
材料科学
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传感器技术
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产品关联
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
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2014
·Vol. 215
·期 10
·1012-1021
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IF 2.451
Wenchao Ma,Haochuan Chen,Yuhong Ma,Changwen Zhao,Wantai Yang
With fac -Ir(ppy) 3 as photoredox catalyst and ethyl 2-bromoisobutyrate (EBiB) as initiator, the homopolymerization of methyl methacrylate (MMA) in different solvents, such as N , N -dimethylformamide (DMF), acetonitrile, and anisole are run under irradiation of an LED lamp. The results show that anisole is a better solvent for the polymerization with regard to the polydispersity index (PDI). A well-controlled polymerization of poly(ethylene glycol) methyl ether methacrylate (PEGMA) is demonstrated and the clean block copolymer of PMMA- b -PPEGMA is prepared with PDI less than 1.3; however, the 2-(dimethylamino) ethyl methacrylate (DMAEMA) polymerization is poorly controlled. With the PMMA as macromolecular initiator, the block copolymer PMMA- b -PDMAEMA can be prepared with PDI around 2.0.
研究领域:
材料科学
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高分子化学
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DOI
高影响因子
JOURNAL OF POLYMER SCIENCE
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2021
·Vol. 59
·期 15
·1701-1710
·
IF 0
Jianlei Lu,Xionglin Zhou,Jialin Sun,Mengdi Xu,Mingming Zhang,Chuanzhuang Zhao
Poly(methylacrylamide) (PMAM) is a thermo-responsive polymer with an upper critical solution temperature (UCST). Its cloud point ( T cp ) is around 60 °C, unsuitable for certain biomedical and industrial applications. This study brought up a copolymerization strategy to tune the T cp of PMAM with hydrophilic comonomers. Surprisingly, with a small portion of hydrophilic monomer doped, the T cp of the PMAM copolymer can be significantly shifted. For instances, with ≤7 mol% of acrylamide or 1 mol% of oligo(ethylene glycol) methacrylate, the T cp can be shifted in a wide range from ~69 to ~0 °C. Microdifferential scanning calorimetry demonstrated that the enthalpic effect during the phase transition of the solutions is indistinctive, while fluorescence measurement with pyrene as a probe revealed that the hydrogen-bonding within polymer chains is enhanced by the hydrophobic aggregation of methyl groups. Therefore, the doped hydrophilic monomer could remarkably alter the ordering of water-molecules and the extent for the aggregation of methyl groups, leading to the pronounced shifting in the T cp of the copolymers. This work would facilitate the application of PMAM as smart polymer materials and guide the inventions of functional materials based on UCST polymers. Graphical
研究领域:
材料科学
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高分子化学
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生物医学工程
✓ 已验证
产品关联
DOI
危险品化学品经营许可证（带存储）