SCIENCE OF THE TOTAL ENVIRONMENT
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2025
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IF 8
Young-Min Lee,Youyoung Lim,Sohyun Kang,Sunmi Kim
Plasticizers enhance the flexibility of polyvinyl chloride (PVC) products but may migrate over time, posing potential health risks. This study quantified migration rates of ten phthalate and non-phthalate plasticizers from PVC sheet specimens into artificial saliva and sweat, across plasticizer contents ranging from 20 to 50 wt%. Migration experiments at 37 °C, followed by GC-TOF/MS analysis, revealed linear relationships between plasticizer content and both ingestion and dermal migration rates for most compounds. DBP, DiBP, and DiNA exhibited the highest migration (> 0.33 μg/cm 2 /min in saliva; > 3.23 ng/cm 2 /min in sweat), whereas DEHA and DnOP demonstrated minimal release. Key molecular descriptors − including measured content (MC), estimated solubility (ESOL), SpMax2_Bhi, and total connectivity index (Xt) − showed significant correlations with migration behaviors. Multiple linear regression and robust regression models were developed to predict ingestion and dermal migration, achieving R 2 = 0.70 (RMSE = 0.238) and Pseudo R 2 = 0.89, respectively. Internal 5-fold cross-validation confirmed model stability, although external validation revealed limitations related to dataset dependency. Despite these constraints, the proposed models offer a practical and rapid screening approach for estimating plasticizer release and potential human exposure from consumer products.
研究领域:
环境毒理学
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生物材料学
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暴露科学
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分析化学
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风险评估
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分子毒理学
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
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2024
·Vol. 48
·期 23
·10739-10747
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IF 2.7
Lumin Liao,Fen Xu,Lixian Sun,Yumei Luo,Yanxun Guan,Jie Ouyang,Julan Zeng,Zhong Cao,Hongge Pan,Dianpeng Li
Here, ternary layer hydroxide (NiCoFe-LDH) nanosheets have been grafted in situ onto graphene oxide (GO) using a one-pot hydrothermal method to obtain NiCoFe-LDH/GO for the fabrication of a non-enzymatic glucose sensor with high stability. SEM analysis shows that ternary LDHs with a nanosheet layer structure grow on GO at an angle with less stacking, thus imparting NiCoFe-LDH/GO with a large specific surface area (112.32 m2 g−1) that exposes more active sites. The results of cyclic voltammetry (CV) and chronoamperometry (CA) studies show that NiCoFe-LDH/GO/GCE displays a wide linear detection range of 0.005–7.54 mM, a sensitivity of 196.18 μA cm−2 mM−1, and a low detection limit of 0.41 μM (S/N = 3). In particular, NiCoFe-LDH/GO/GCE has high stability, that is, it still holds 90.2% of its initial value even after 90 days. Meanwhile, the study results demonstrate that the NiCoFe-LDH/GO/GCE electrode is suitable for the detection of glucose in artificial saliva, and it also reveals a good recovery ranging from 95.6% to 105.5% in actual saliva. Therefore, NiCoFe-LDH/GO is anticipated to be an ideal sensing material for the creation of noninvasive enzyme-free glucose sensors.
研究领域:
材料科学
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分析化学
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生物传感器
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产品关联
DOI
高影响因子
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
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2023
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IF 3.5
Hao CHEN,Zhi Yuan HOU,Die CHEN,Ting LI,Yi Ming WANG,Marcelo Andrade DE LIMA,Ying YANG,Zhen Zhong GUO
Objective Late 2019 witnessed the outbreak and widespread transmission of coronavirus disease 2019 (COVID-19), a new, highly contagious disease caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Consequently, considerable attention has been paid to the development of new diagnostic tools for the early detection of SARS-CoV-2. Methods In this study, a new poly-N-isopropylacrylamide microgel-based electrochemical sensor was explored to detect the SARS-CoV-2 spike protein (S protein) in human saliva. The microgel was composed of a copolymer of N-isopropylacrylamide and acrylic acid, and gold nanoparticles were encapsulated within the microgel through facile and economical fabrication. The electrochemical performance of the sensor was evaluated through differential pulse voltammetry. Results Under optimal experimental conditions, the linear range of the sensor was 10 −13 –10 −9 mg/mL, whereas the detection limit was 9.55 fg/mL. Furthermore, the S protein was instilled in artificial saliva as the infected human saliva model, and the sensing platform showed satisfactory detection capability. Conclusion The sensing platform exhibited excellent specificity and sensitivity in detecting spike protein, indicating its potential application for the time-saving and inexpensive detection of SARS-CoV-2.
研究领域:
生物医学工程
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分析化学
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材料科学
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病毒学
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产品关联
DOI
PubMed
高影响因子
Materials Advances
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2024
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IF 5.2
Jiaolong Wang,Min Ge,Huizhen Wang,Yunyun Deng,Haiyan Yao,Junchao Wei
Dental caries is a biofilm-mediated dynamic disease with imbalance in teeth mineralization. In this study, a facile and dual-functional hybrid polydopamine@proanthocyanidin (PDA@PC) coating was designed to inhibit cariogenic biofilm and remineralize demineralized dental hard tissues. PDA@PC showed excellent antibiofilm ability with a lower cariogenic bacterial biofilm biomass (0.15 ± 0.03 OD595nm) than the control group (1.45 ± 0.16 OD595nm). In addition, a dense mineral layer was observed on the surface of demineralized enamel. The microhardness of etched enamel with PDA@PC coating reached 329.28 ± 10.16 HV after incubation with artificial saliva, which was similar with the healthy enamel (368.5 ± 17.18 HV). Furthermore, the in vivo rat dental caries model showed that the PDA@PC coating effectively slowed down the progression of caries, with only superficial demineralization and low dental caries scores. The total score was 3-4 times lower than that of the control group. The successful construction of the dual-functional hybrid PDA@PC coating provides a novel approach for dental caries treatment.
研究领域:
牙科学
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材料科学
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生物材料
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口腔微生物学
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DOI
高影响因子
Analytical Methods
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2024
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IF 2.7
Guo Yang,Boxuan Xu,Hui Chang,Zhiqi Gu,Jiadong Li
The abundant bio-markers in saliva provide a new option for non-invasive testing. However, due to the presence of impurities in the saliva backgroud, most of the existing saliva testing methods rely on pre-processing, which limits the application of saliva testing as a convenient means of testing in daily life. Herein, a disposible-gate AlGaN/GaN high electron mobility transistor (HEMT) biosensor integrated with micro-sieve was intoduced to solve the problem that signal interference caused by charged impurities in saliva for HEMT based biosensors, where the micro-sieve was ultilized as a pre-treatment unit to remove large particles of impurities from saliva through size effect and thus greatly inproving the accuracy of detection. The experimental results showed that the HEMT based biosensor has has excellent linearity (R2 = 0.9977) and a high sensitivity of 6.552 µA·dec−1 for urea sensing from 1 fM to 100 mM in 0.1×PBS solution. When it comes to artificial saliva detection, compare to the HEMT sensor without micro-sieve (sensitivity = 3.07432μA·dec−1), the sensitivity of HEMT sensor integrated with micro-sieve had almost no change. Moreover, to verify that urea can be detected in actual saliva, urea is sensed directly in human saliva. The addition of the microsieve module provides a new way for biosensors to detect specific markers in saliva in real time, and the designed HEMT biosensor with microsieve function has a wide range of application potential in rapid saliva detection.
研究领域:
生物医学工程
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电气工程
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材料科学
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分析化学
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医疗器械
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Chunhui Wang,Xiutao Yang,Guopeng Zhu,Tianye Wang,Dengbin Yu,Yongzheng Lu,Hongwen Yu
In this work, copper-platinum nanoparticles (Cu-Pt NPs) were successfully modified on a glassy carbon electrode (GCE) by a facile electrodeposition process for non-enzymatic glucose detection. The composition and morphology of Cu-Pt NPs were characterized by scanning electron microscopy, transmission electron microscopy and X-ray photoelectron spectroscopy. The electrochemical properties were evaluated through cyclic voltammetry , electrochemical impedance spectroscopy and amperometric methods . The as-obtained Cu-Pt NPs/GCE displayed a high sensitivity of 2209 µA mM −1 cm −2 toward glucose detection in a linear range of 10–750 µM with a low limit of detection (LOD) of 1.8 µM (S/N = 3). Overall, Cu-Pt NPs/GCE was advantageous in terms of selectivity , reproducibility, long-term stability and rapid response time. The detection of glucose by Cu-Pt NPs/GCE was able to be renewed to satisfactory levels through an unsophisticated reduction processing program. Additionally, Cu-Pt NPs/GCE was able of detecting glucose in artificial saliva and human serum samples. In sum, these findings look promising for future.
研究领域:
纳米技术
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电化学
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生物传感器
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分析化学
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材料科学
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产品关联
DOI
高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
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2024
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IF 4.2
Rufang Wei,Junjie Deng,Xiangshu Guo,Yanyu Yang,Jiru Miao,Ashuang Liu,Haiyang Chai,Xinqi Huang,Zhihe Zhao,Xiao Cen,Rong Wang
Invisible aligners have been widely used in orthodontic treatment but still present issues with plaque formation and oral mucosa abrasion, which can lead to complicated oral diseases. To address these issues, hydrophilic poly(sulfobetaine methacrylate) (polySBMA) coatings with lubricating, antifouling, and antiadhesive properties have been developed on the aligner materials (i.e., polyethylene terephthalate glycol, PETG) via a simple and feasible glycidyl methacrylate (GMA)-assisted coating strategy. Poly(GMA- co -SBMA) is grafted onto the aminated PETG surface via the ring-opening reaction of GMA (i.e., “grafting to” approach to obtain G- co -S coating), or a polySBMA layer is formed on the GMA-grafted PETG surface via free radical polymerization (i.e., “grafting from” approach to obtain G- g -S coating). The G- co -S and G- g -S coatings significantly reduce the friction coefficient of PETG surface. Protein adsorption, bacterial adhesion, and biofilm formation on the G- co -S- and G- g -S-coated surfaces are significantly inhibited. The performance of the coatings remains stable after storage in air or artificial saliva for 2 weeks. Both coatings demonstrate good biocompatibility in vitro and is not caused irritation to the oral mucosa of rats in vivo over 2 weeks. This study proposes a promising strategy for the development of invisible aligners with improved performance, which is beneficial for oral health treatment.
研究领域:
材料科学
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正畸学
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生物医学工程
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牙科材料
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表面化学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）