SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Xingchi Li,Guowei Chen,Yiping Zhao,Yang He,Li Chen
The primary issues impeding oxygenation efficacy in extracorporeal membrane oxygenation (ECMO) are low CO 2 /O 2 selectivity and insufficient permeability of CO 2 . Herein, sulfonated polyphenylene oxide (SPPO) was chosen as a candidate for the oxygenation membrane material. The CO 2 -affinitive sulfonic acid groups on the molecular chain of SPPO enhance the interaction between CO 2 and the SPPO membrane; thereby, the CO 2 /O 2 selectivity is effectively enhanced. When the solid content of the casting solution is 23 %, the SPPO membrane achieves a CO 2 /O 2 selectivity of 17.0, almost as selective as human alveoli. The blood clotting time, red blood cell adhesion, platelet adhesion, and hemolysis ratio were employed to evaluate the blood compatibility of SPPO materials. The results demonstrated that the manufactured SPPO membranes exhibited good hemocompatibility. This work offers novel thinking for researching and applying effective artificial lung membranes.
研究领域:
生物医学工程
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材料科学
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Bingyang Lu,Junchang Guo,Hao Yang,Xiao Han,Peng Yu,Shengjun Cheng,Zhenxu Shi,Dehui Wang,Weifeng Zhao,Jing Luo,Xu Deng
Gas exchange membranes, as the crucial components of extracorporeal membrane oxygenation (ECMO) systems, enable efficient O 2 /CO 2 exchange in blood while maintaining adequate oxygen saturation in patients. However, clinical gas exchange membranes remain prone to thrombosis complications, which severely compromise their gas exchange effectiveness. To address this, we propose a blood-repellent gas exchange membrane (BRGEM) that helps in preventing thrombosis due to its minimal solid-liquid contact areas, while significantly enhancing gas exchange through a gas-liquid direct contact diffusion strategy. Notably, the BRGEM exhibits a 22.09-fold reduction in thrombus formation without anticoagulants compared to commercial ECMO membranes, demonstrating its exceptional anti-fouling properties. Furthermore, the membrane enables rapid oxygen recovery in the acute respiratory distress syndrome rabbit model, achieving approximately 12.97-fold improvement. We anticipate this strategy will significantly advance the development of next-generation blood oxygenation membranes and artificial lung technologies, offering transformative potential for future clinical applications.
研究领域:
生物医学工程
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膜技术
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呼吸医学
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生物材料
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人工器官
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产品关联
DOI
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
·
2016
·Vol. 105
·期 7
·1737-1746
·
IF 2.881
Weiping Wang,Zhi Zheng,Xin Huang,Wenling Fan,Wenkui Yu,Zhibing Zhang,Lei Li,Chun Mao
Polyethylene glycol (PEG) and heparin (Hep) were grafted onto polysulfone (PSF) membrane by plasma-induced surface modification to prepare PSF–PEG–Hep membranes used for artificial lung. The effects of plasma treatment parameters, including power, gas type, gas flow rate, and treatment time, were investigated, and different PEG chains were bonded covalently onto the surface in the postplasma grafting process. Membrane surfaces were characterized by water contact angle, PEG grafting degree, attenuated total reflectance-Fourier transform infrared spectroscopy, ultraviolet–visible spectrophotometry, X-ray photoelectron spectroscopy, critical water permeability pressure, and scanning electron microscopy. Protein adsorption, platelet adhesion, and coagulation tests showed significant improvement in the hemocompatibility of PSF–PEG–Hep membranes compared to pristine PSF membrane. Gas exchange tests through PSF–PEG6000–Hep membrane showed that when the flow rate of porcine blood reached 5.0 L/min, the permeation fluxes of O 2 and CO 2 reached 192.6 and 166.9 mL/min, respectively, which were close to the gas exchange capacity of a commercial membrane oxygenator. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1737–1746, 2017.
研究领域:
生物材料
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生物医学工程
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表面化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Yunbo Feng,Qian Wang,Lunhao Zhi,Shudong Sun,Changsheng Zhao
Artificial lung membrane as extracorporeal blood-gas barriers could execute similar functions as human alveoli, whereby accomplish blood gas exchange process, providing imperative life support for patients with cardiopulmonary failure. However, the gas exchange performance for current membranous modules is restrained to the dense polymer matrix with low CO 2 permeability. Meanwhile, it has long been difficult to balance the contradiction between haemorrhagic risk generated by heparin systemic anticoagulation and thrombogenesis during extracorporeal blood circulation. Here, inspired by the natural mammalian alveoli, a biomimetic consecutive gas exchange network (CGEN) is constructed on porous PES substrate by using aperture-modulated UIO-66-NH 2 nanoparticles and hydrophilic CO 2 -affinitive polymer matrix to simulate the physiological structures and gas exchange features of human alveoli in vitro. The porous MOF particles within CGEN establish the main gas exchange channels, which not only enhance the total gas permeation, but also improve the CO 2 /O 2 permselectivity to 13.17, approaching to the level of natural alveoli. Additionally, the prepared composite membrane with good hemocompatibility could effectively inhibit the formation of thrombus and provide a reliable local self-anticoagulation state during extracorporeal blood circulation. Overall, this biomimetic thin film composite membrane could provide new ideals for the preparation of advanced artificial lung membrane.
研究领域:
生物医学工程
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材料科学
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组织工程
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产品关联
DOI
高影响因子
LANGMUIR
·
2023
·
IF 3.9
Donghai Sheng,Lin Zhang,Hao Jia,Baoming Guo,Xiangjun Zhang,Yuan Li
As the key component of extracorporeal membrane oxygenation (ECMO), artificial lung membranes have low gas permeability and plasma leakage problems, and the contact between membrane materials and blood can cause coagulation, leading to the blockage of medical equipment and seriously threatening the safety of human life. In our work, poly(4-methyl-1-pentene) hollow fiber membranes (PMP HFMs) were prepared by the thermally induced phase separation (TIPS) method, the redox method was adopted for the surface hydroxylation of PMP HFMs, and then, heparin (Hep) and 2-(methacryloyloxy)ethyl(2-(trimethylammonio)ethyl) phosphate (MPC) were grafted to the surface of PMP HFMs to prepare anticoagulant coatings. The gas permeability and hemo-compatibility of the coatings were investigated by various characterization methods, such as gas flow meter, scanning electron microscope, extracorporeal circulation experiment, etc. The results show that PMP HFMs possess a bicontinuous pore structure with a dense surface layer, which could maintain good gas permeability with an oxygen permeance of 0.8 mL/bar·cm2·min and stable gas selectivity. Furthermore, the whole blood circulation of rabbit indicated that a composite surface of bioactive Hep and biopassive MPC might be used as artificial lung membranes without the formation of thrombosis within 21 days.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
LANGMUIR
·
2023
·
IF 3.9
Donghai Sheng,Lin Zhang,Hongfei Shang,Baoming Guo,Yuan Li
The contact between the blood and the surface of medical materials causes a series of rejection reactions. In this process, the plasma protein is adsorbed to the surface of materials within seconds and binds to glycoprotein receptors on platelets, causing platelet activation, coagulation cascade, and complement activation to form thrombus, which greatly limits the application of medical materials. In our work, the surface of poly(4-methyl-1-pentene) hollow fiber membranes (PMP HFMs) was coated with a diamond-like carbon (DLC) film by the ion plating method. The blood compatibility of the DLC coating was evaluated by protein adsorption, platelet adhesion, clotting time, red blood cell (RBCs) hemolysis, dynamic coagulation, and extracorporeal blood circulation tests. Compared with the unmodified PMP membrane, the DLC film could effectively reduce protein adsorption and platelet adhesion and prolong the coagulation time. The DLC coating showed BSA adsorption of as low as 0.53 μg/cm2 as well as a long activated partial thromboplastin time (APTT) value of 71.84 s. Furthermore, the PMP membrane modified with the DLC coating was used for extracorporeal blood circulation without thrombosis forming within 28 days. The DLC coating is one of the most promising medical coatings as an artificial lung membrane in extracorporeal membrane oxygenation (ECMO) equipment.
研究领域:
生物医学工程
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材料科学
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血液学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Xiujuan Zhang,Zelin Liao,Xinlu Zhang,Xuehua Ruan,Hao Gong,Xiaokun Wang,Wenji Zheng,Yan Dai,Gaohong He
Excellent hemocompatibility and long-term stability against blood wetting are important properties required for artificial lung membrane, the core component in extracorporeal membrane oxygenator which is life-saving for patients with severe lung dysfunctions. Herein, novel hydrophilic modified polyethersulfone (PES) asymmetric membranes were synthesized via thermal cross-linking, and characterization via SEM, FTIR, 1 HNMR and surface water contact angle measurements demonstrated that the modified asymmetric membranes composing a dense layer with hydrophilic surface on top of a microporous support layer were successfully fabricated without any observed defects. Among all the modified membranes, PEGylated PES membrane exhibited the smoothest membrane surface, improved mechanical property, good gas permeability and the best performance in hemocompatibility in terms of blood coagulation, protein adsorption and platelet adhesion. Moreover, the PEGylated PES membrane showed excellent long-term stability in membrane surface wettability as well as long-term stable performance against blood fouling and wetting. This research work provides valuable insights and new idea into synthesizing membranes, with simple synthesis process, long lasting high hemocompatibility and stability against wetting, for application as artificial lung membranes.
研究领域:
材料科学
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生物医学工程
·
膜技术
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产品关联
DOI
高影响因子
Biomedical Materials
·
2015
·Vol. 10
·期 6
·065022
·
IF 3.697
Weiping Wang,Xin Huang,Haiyan Yin,Wenling Fan,Tao Zhang,Lei Li,Chun Mao
In this study, polyethylene glycol acrylate (PEGA) was introduced onto the surface of polysulphone (PSF) membrane to prepare PSF–PEGA membranes through low-temperature plasma technology for haemocompatibility improvement of artificial lungs. The effects of plasma power, PEGA solution concentration and dipcoating temperature on surface modification were systematically investigated. Results of Fourier transform infrared spectroscopy, x-ray photoelectron spectroscopy and PEGA grafting degree confirmed that PEGA was successfully grafted onto the PSF membranes. Contact angle values showed that the hydrophilicity of the PSF–PEGA membrane surface increased by 21.5%. The results of the protein adsorption, platelet adhesion and coagulation tests further showed the excellent haemocompatibility of the modified membrane. Gas exchange tests also revealed that at a porcine blood flow rate of 5 l min−1, O2 and CO2 exchange rates through the PSF–PEGA membrane were 198.6 and 170.9 ml min−1, respectively; approximately this is the gas exchange capacity of commercial respiratory assistance devices.
研究领域:
材料科学
·
生物医学工程
·
医疗器械
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Yiwen Wang,Yang Liu,Qiu Han,Haibo Lin,Fu Liu
Extracorporeal membrane oxygenation is a technique that provides short-term supports to the heart and lungs. It removes CO 2 from the blood and provides enough oxygen, which is a huge help in the fight against COVID-19. As the key component, the artificial lung membranes have evolved in three generations including silicon, polypropylene and poly (4-methyl-1-pentene). Herein, we for the first time design and fabricate a novel poly (4-methyl-1-pentene)/polypropylene (PMP/PP) thin film composite (TFC) membrane with the anticoagulant coating composed of poly (sodium 4-styrenesulfonate) and cross-linked poly (vinyl alcohol). Poly (sodium 4-styrenesulfonate) provides sulfonic acid groups to inhibit the coagulant factors (FVIII and FXII), and cross-linked poly (vinyl alcohol) increase the stability of the anticoagulant coating and further improve the hydrophilicity via abundant hydroxyl groups to depress the protein adsorption. Long-term anticoagulant property was demonstrated by whole human blood for 28 days. Blood compatibility was evaluated by hemolysis rate, anticoagulation activity (APTT, TT and PT), complement activation, platelet activation and contact activation. Pure CO 2 , O 2 and N 2 permeation rates were determined to evaluate the mass transfer properties of PMP/PP TFC membranes. Gas permeation results revealed that gas permeation flux increased in the TFC membranes because of the decrease of crystallinity. Overall, the so prepared PMP/PP membrane shows good CO 2 /O 2 selectivity and blood compatibility as novel TFC artificial lung membrane.
研究领域:
生物医学工程
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材料科学
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医疗器械
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血液相容性
·
气体分离膜
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）