JOURNAL OF FOOD SCIENCE
·
2023
·Vol. 88
·期 8
·3607-3618
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IF 3.9
Liang He,Jie Zhang,Leiding Shen,Xiaofeng Ji,Rui Li
We investigated the occurrence of 80 pesticide residues in 96 honey samples from apiaries with honeybee poisoning incidences by liquid chromatography–tandem mass spectrometry and subsequently conducted risk assessments of exposure for in-hive honeybees and Chinese consumers. Six pesticides were detected with residue concentrations ranging from 0.5 to 130.9 µg/kg. The mean concentrations of acetamiprid, dinotefuran, hexythiazox, propargite, semiamitraz, and carbendazim in positive samples were 7.9 ± 9.1, 5.9 ± 1.7, 3.0 ± 1.6, 44.2 ± 50.0, 9.0 ± 9.4, and 5.5 ± 4.1 µg/kg, respectively. Carbendazim, semiamitraz, and acetamiprid were the major contaminants in honey, with incidences of 99.0%, 93.8%, and 49.0%, respectively. The cooccurrence of pesticides (≥2 pesticides) was detected in 95.9% of the samples, with up to six residual pesticides found in one sample. The HQ (hazard quotient) values of the six pesticides to in-hive honeybees were from 4.7 × 10 −8 to 0.021, less than 1, indicating their acceptable exposure risk to honeybees. In terms of the representative-case and worst-case scenarios, the sum of separate HQs of each pesticide yielding an HI (hazard index) ranged from 0.012 to 0.016 for in-hive worker honeybees and from 0.015 to 0.021 for in-hive larva honeybees, indicating an overall acceptable potential cumulative risk of multiple pesticides to in-hive honeybees. Both the %ARfD (acute reference dose) value (0.0001–0.075) and %ADI (acceptable daily intake) value (0.00002–0.0046) of risky pesticides were much less than 100, revealing acceptable risk exposure to risky pesticides via honey consumption for human health. Thus, our results showed that multipesticide residual honey from apiaries with honeybee poisoning incidents in East China was safe for humans and in-hive honeybees. Practical Application This analytical approach will be used in detecting multiple pesticide residues in honey and risk assessment for dietary exposure to pesticide residues. It can support various surveillance programs about honey safety and in-hive honeybee health evaluation.
研究领域:
环境科学
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食品科学
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昆虫学
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产品关联
DOI
PubMed
高影响因子
Toxics
·
2024
·Vol. 12
·期 4
·286
·
IF 3.9
Wangxing Luo,Siyu Yao,Jiahui Huang,Haochuan Wu,Haijun Zhou,Mingjiang Du,Ling Jin,Jianteng Sun
Organophosphate esters (OPEs) are frequently used as flame retardants and plasticizers in various commercial products. While initially considered as substitutes for brominated flame retardants, they have faced restrictions in some countries due to their toxic effects on organisms. We collected 37 soil and crop samples in 20 cities along the coast of South China, and OPEs were detected in all of them. Meanwhile, we studied the contamination and potential human health risks of OPEs. In soil samples, the combined concentrations of eight OPEs varied between 74.7 and 410 ng/g, averaging at 255 ng/g. Meanwhile, in plant samples, the collective concentrations of eight OPEs ranged from 202 to 751 ng/g, with an average concentration of 381 ng/g. TDCIPP, TCPP, TCEP, and ToCP were the main OPE compounds in both plant and soil samples. Within the study area, the contaminants showed different spatial distributions. Notably, higher OPEs were found in coastal agricultural soils in Guangdong Province and crops in the Guangxi Zhuang Autonomous Region. The results of an ecological risk assessment show that the farmland soil along the southern coast of China is at high or medium ecological risk. The average non-carcinogenic risk and the carcinogenic risk of OPEs in soil through ingestion and dermal exposure routes are within acceptable levels. Meanwhile, this study found that the dietary intake of OPEs through food is relatively low, but twice as high as other studies, requiring serious attention. The research findings suggest that the human risk assessment indicates potential adverse effects on human health due to OPEs in the soil–plant system along the coast of South China. This study provides a crucial foundation for managing safety risks in agricultural operations involving OPEs.
研究领域:
环境科学
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毒理学
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产品关联
DOI
PubMed
高影响因子
BMJ Open
·
2018
·Vol. 8
·期 1
·e017832
·
IF 2.413
Qiang Sun,Yang Wang,Anette Hulth,Yonghong Xiao,Lennart E Nilsson,Xuewen Li,Zhenwang Bi,Yuqing Liu,Hong Yin,Yanbo Luo,Maud Nilsson,Chengtao Sun,Yiqing Zhu,Beiwen Zheng,Baoli Chen,Pan Sun,Lilu Ding,Xi Xia,Jakob Ottoson,Sonja Löfmark,Oliver James Dyar,IMPACT Consortium,Stefan Börjesson,Cecilia Stalsby Lundborg
Introduction To effectively minimise the emergence and dissemination of antibiotic resistant bacteria, a holistic One Health approach is called for. The Sino-Swedish Integrated Multisectoral Partnership for Antibiotic Resistance Containment is a cross-sectoral and integrated project on antibiotic resistance, conducted in Shandong Province in China. This paper outlines the overall study protocol for the project. To our knowledge, this is the first research programme aiming to take a true holistic approach across multiple sectors simultaneously in China, and the first to incorporate both antibiotic use and infection prevention and control in addition to antibiotic resistance patterns. The project aims to address gaps in current knowledge and seeks to improve the situation through a system-wide intervention. By using a One Health approach we can address important research questions that individual discipline investigations are unable to. The results obtained should thus more closely reflect the world in which human health, animal health and the environment are inextricably and intimately interlinked. Methods and analysis Both quantitative and qualitative studies are included for households from 12 villages, their surrounding environment and a tertiary care hospital in a nearby town. The studies include analyses of antibiotic consumption for humans and pigs; qualitative and quantitative data on perceptions, knowledge and attitudes; faecal carriage of extended spectrum β-lactamase and carbapenemase-producing Enterobacteriaceae from pigs and humans, and occurrence in household drinking water, surface water, waste water and clinical bacterial isolates from the hospital. Carriage of methicillin-resistant Staphylococcus aureus in humans, household pigs and clinical bacterial isolates is also investigated. Furthermore, potential inter-relationships between these sources are analysed. A multifaceted One Health intervention is designed and implemented in 6 of the 12 villages. Repeated and continuous data collections take place over 2 years, where the repeated data collection is performed after 1 year of intervention. Comparisons are made between intervention and control villages, before and after the intervention. Ethics Ethics approval was obtained from the first Affiliated Hospital, College of Medicine, Zhejiang University, China, reference number 2015#185 and 2015#283.
研究领域:
公共卫生
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微生物学
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流行病学
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产品关联
DOI
PubMed
高影响因子
Journal of Analysis and Testing
·
2022
·Vol. 6
·期 4
·382-392
·
IF 0
Bai Li-Wei,Shi Yu-Fen,Zhang Xue,Liu Xue-Bo,Wu Feng,Liu Chang,Jia Jian-Feng,Lu Wen-Bo
Hydroquinone (HQ) poses immeasurable risk to human health and the natural environment on the grounds of high toxicity of organic phenolic compounds. Herein, an innovative electrochemical sensor based on two-dimensional nickel molybdate nanowires (NiMoO 4 NWs) is constructed for the ultra-sensitive determination of HQ, which can provide useful reference for the human health and environment protection. Two-dimensional NiMoO 4 NWs are prepared successfully through a facile hydrothermal reaction and annealing process. The obtained two-dimensional NiMoO 4 NWs are characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution TEM (HRTEM), energy-dispersive X-ray spectroscopy (EDS) mapping and X-ray photoelectron spectroscopy (XPS). The accurate contents of Ni and Mo have been characterized by inductively coupled plasma atomic emission spectroscopy (ICP-AES), confirming that the lower content of the nickel in NiMoO 4 NWs possesses the higher catalytic activity of HQ. Under the optimized conditions, the constructed HQ sensor exhibits satisfactory electrocatalytic activity with a low detection limit of 0.0355 μmol/L ( S/N = 3), a wide linear range of 0.05–4600 μmol/L and sensitivity of 170.064 μA/(mmol cm 2 ). The sensor has been successfully applied to the detection of HQ in rainwater, tap water, domestic sewage and drinking water samples with satisfactory recovery. At the same time, this sensor has excellent reproducibility, selectivity, and stability. The constructed sensor has potential practical application value and broad application prospect in human health and environmental monitoring.
研究领域:
分析化学
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环境科学
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材料科学
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产品关联
DOI
ATMOSPHERIC ENVIRONMENT
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2023
·
IF 5
Fangjie Wang,Xiaoning Chen,Huichen Li,Bowen Huang,Yu He,Zongwei Cai
The interest in the contaminants in PM 2.5 1 (PMs with a diameter of <2.5 μm) has increased because of its potential adverse effects on human health. In this study, seven alkylphenols (APs), which are a typical endocrine-disrupting chemicals (EDCs), were measured by atmospheric pressure gas chromatography-tandem mass spectrometry (APGC-MS/MS). The methods were successfully applied to analyze the PM 2.5 samples collected from Taiyuan and Guangzhou. The total concentration of seven APs was 700.58 pg m −3 in Guangzhou and 916.12 pg m −3 in Taiyuan. The dominant PM 2.5 -bound APs were 4-pentylphenol (4-PeP), 4-nonylphenol (4-NP), and 2-6-di-tert-butyl-4-(hydroxymethyl)phenol (BHT-OH). Meanwhile, a higher concentration of APs was observed in Taiyuan during spring and winter, according with obvious seasonal variation. The presence of APs in air samples from Guangzhou was primarily attributed to human activities. Furthermore, estimated daily intakes (EDIs) of APs via ambient inhalation were calculated for different age groups to evaluate human exposure risk, which revealed that the worst-case EDI for children was 61.29 pg kg bw −1 day −1 , indicating that the presence of APs in the atmospheric environment should not be underestimated.
研究领域:
环境科学
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公共卫生
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分析化学
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产品关联
DOI
高影响因子
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
·
2023
·
IF 3.3
Xing Jiali,Xu Xiaorong,Li Yang,Chen Cancan,Mao Lingyan,Luo Xiaohu,Shen Jian,Cheng Hai,Zhang Shufen,Guo Yahui,Gan Ning
Owing to the difficult degradation of phenolic compounds, the existence of phenolic compound residues accumulated through the food chain in crustaceans and their effects on human health have garnered considerable and more attention. However, the current detection methods for phenolic compounds are not only complex and time-consuming but can also detect fewer types of phenols simultaneously. Thus, a simple, high-throughput method without derivatization for the determination of 18 phenolic compounds in crustaceans was developed using a modified QuEChERS sample preparation method combined with gas chromatography-mass spectrometry. The results indicated that the average recovery of the 18 phenolic compounds was 80.2–106.5% at three spiked levels, and the relative standard deviation was 2.6–12.4%. The limits of detection and quantitation were 0.001–0.014 and 0.003–0.042 mg/kg, respectively. Good linear relationships were observed for the phenolic compounds in their corresponding concentration ranges ( R 2 > 0.999). The applicability of the method was assessed by analyzing 16 actual shrimp samples, among which five samples contained residues ranging from 0.013 to 0.042 mg/kg. Moreover, the establishment of this method has important theoretical and practical significance for the determination and control of the residue levels of phenolic compounds in crustaceans. In addition, it can provide a reference for the development of similar detection standard methods in the future.
研究领域:
分析化学
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食品科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL POLLUTION
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2024
·
IF 7.6
Yankun Zhang,Fengtong Chang,Muhammad Junaid,Hanye Ju,Yongqiang Qin,Lianzheng Yin,Jin Liu,Jiliang Zhang,Xiaoping Diao
Organic ultraviolet filters (OUVFs) are extensively incorporated into both cosmetic items and industrial products and have been commonly found in water ecosystems. This study aims to examine the environmental levels, sources, ecological and human health risks of 14 commonly used OUVFs both in coastal water and beach deposit samples collected from the nearshore regions of Hainan Island and the South China Sea. This is first study highlighting the contamination of OUVFs in Hainan Island and utilizing economic and tourism data to confirm the potential source of OUVF pollution in costal aquatic and coastal ecosystem. Along the coastal tourist regions of Hainan Island, the median concentrations in coastal waters and beach deposits of these OUVFs fall within the range from 1.2 to 53.2 ng/L and 0.2–17.0 ng/g dw, respectively. In coastal water and beach deposit, the concentration of BP-3 was the highest, with median concentrations of 53.2 ng/L and 17.0 ng/g dw, respectively. Regarding human health risks, the daily intake of all 14 OUVFs through swimming was found to be 40–48 ng/kg/day. Ecological risk assessment indicates that BP-3 presents a medium risk for marine microalgae with a concurrent low risk for corals. The correlation analysis underscores a substantial interrelation of OUVFs in both coastal waters and beach deposits with various economic indicators, including annual rainfall, overnight tourists, total hotel rooms (unit), room occupancy rate, and sewage treatment capacity.
研究领域:
环境科学
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海洋生物学
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公共卫生
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENT INTERNATIONAL
·
2023
·
IF 11.8
Yanpeng Gao,Xinyi Hu,Chuyue Deng,Mei Wang,Xiaolin Niu,Na Luo,Yuemeng Ji,Guiying Li,Taicheng An
Hydroxylated metabolites in the living body are considered as a potential biomarker of exposure to emerging contaminations (ECs) and breast cancer, but their formation mechanism has not received enough attention. Besides, the adverse impacts of metabolites during the metabolic transformation of ECs largely remain unknown. In this study, we employed a density functional calculation combing with in-vitro incubation of human liver microsomes to explore the bio-transformation of preservative methylparaben (MPB) in human bodies. Our results showed that hydroxylated metabolites of MPB (OH-MPB) were observed experimentally, while a formation mechanism was revealed at the molecular level. That is, hydroxylated metabolite was exclusively formed via the hydrogen abstraction from the phenolic hydroxyl group of MPB followed by the OH-rebound pathway, rather than the direct hydroxylation on the benzene ring. The increasing of hydroxyl groups on ECs could improve the metabolisms. This was confirmed in the metabolism of ECs without hydroxyl group and with multiple-hydroxyl groups, respectively. Furthermore, toxicity assessments show that compared to parent MPB, the hydroxylated metabolites have increased negative impacts on the gastrointestinal system and liver. A semiquinone product exhibits potential damage in the cardiovascular system and epoxides are toxic to the blood and gastrointestinal system. The findings deepen our insight into the biotransformation of parabens in human health, especially by providing health warnings about the potential impacts caused by semiquinone and epoxides.
研究领域:
环境生物学
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毒理学
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计算生物学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENT INTERNATIONAL
·
2021
·
IF 9.621
Qianyu Chen,Yayun Zhang,Langjie Ye,Shuai Gong,Hong Sun,Guanyong Su
Lipidomic analysis has been proven to be a powerful technique to explore the underlying associations between xenobiotics and health status of organisms. Here, we established a strategy that combined the lipidomic analysis with high-throughput suspect contaminant screening technique with an aim to efficiently identify active xenobiotics in humans. Firstly, in the light of single liquid phase equilibrium of chloroform-methanol-water (15:14:2, v/v/v), we developed an efficient method that was able to simultaneously extract both polar and nonpolar lipids in serum samples. By use of this method, targeted and non-targeted lipid analyses were conducted for n = 120 serum samples collected from Wuxi city, China. Secondly, we established a suspect database containing 1450 contaminants that have been previously reported in human samples, and contaminants in this database were screened in the same batch of serum samples by use of high-resolution mass spectrometry (HR-MS). Thirdly, the underlying associations between suspect contaminants and lipids were explored and discussed, and we observed that levels of some lipids were statistically correlated with concentrations of numerous contaminants. Among these active contaminants, 23 ones were identified on the basis of HR MS 1 and MS 2 characteristics, and these contaminants belonged to the classes of phthalates, phenols, parabens, or perfluorinated compounds (PFCs). Three active xenobiotics were fully validated by comparison with authentic standards, and they were perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), and diethyl phthalate (DEP). There were statistically significant changes in levels of triglyceride (TG), lysophosphocholine (LPC), and sphingomyelin (SM) as peak areas of xenobiotics increase. We also observed that, among target lipid molecules, 18:0 lysophosphatidylethanolamine (LPE(18:0)) was very sensitive, and this lipid responded to exposure of various contaminants. Our present study provides novel knowledge on potential alteration of lipid metabolism in humans following exposure to xenobiotics, and provides an efficient strategy for efficiently identifying active xenobiotics in humans.
研究领域:
环境科学
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生物医学工程
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毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
·
2024
·Vol. 38
·期 10
·e9737
·
IF 1.8
Shen-hui Cai,Baixue Wang,Jianfeng Zhang,Jiubiao Guo,Bin Hu
Rationale Human exhaled breath usually contains unique proteins that may provide clues to characterize individual physiological activities and many diseases. However, the concentration of exhaled proteins in exhaled breath is extremely low and usually does not reach the detection limits of all online breath mass spectrometry instruments. Therefore, developing a new breath sampler for collecting and characterizing exhaled proteins is important. Methods In this study, a new mask-based wearable sampler was developed by fixing metal materials into the inner surface of the KN95 mask. Human exhaled proteins could be directly adsorbed onto the metal material while wearing the mask. After sampling, the collected proteins were eluted, digested, and identified using nano-liquid chromatography–tandem mass spectrometry (nano-LC–MS/MS). Results The adsorption of exhaled proteins was evaluated, showing that modified gold foil is an effective material for collecting exhaled proteins. Various endogenous proteins were successfully identified from exhaled breath, many of which can be potential biomarkers for disease diagnosis. Conclusions By coupling the newly developed mask sampler with nano-LC–MS/MS, human exhaled proteins were successfully collected and identified. Our results show that the mask sampler is wearable, simple, and convenient, and the method is noninvasive for investigating disease diagnosis and human health.
研究领域:
分析化学
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生物医学工程
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蛋白质组学
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呼吸医学
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DOI
PubMed
高影响因子
ChemistrySelect
·
2023
·Vol. 8
·期 40
·e202300913
·
IF 2.1
Jiarui Pang,Wenjie Ren,Baoshan He,Zhui Tu
Graphical A rapid gold nanoflowers (AuNFs) immunochromatographic test strip (ICTS) based on the nanobody (Nb) was successfully fabricated and used for rapid detection of Aflatoxin B 1 (AFB 1 ). The G8-DIG nanobody was produced via expression and purification which could specifically recognize not only AFB 1 but also DIG-BSA. The proposed ICTS applies nanobody as recognition elements and exhibits excellent performance for detection of AFB 1 for food safety and human health. A rapid gold nanoflowers (AuNFs) immunochromatographic test strip (ICTS) based on the nanobody (Nb) was developed and used for rapid detection of Aflatoxin B 1 (AFB 1 ). Thanks to remarkable physicochemical stability, structural adaptability, ease of genetic manipulation, expression in the prokaryotic system with high yield and tolerance to harsh environments of nanobodies, the G8-DIG was produced via expression and purification, which was labeled with AuNFs by electrostatic adsorption as signal probes in the ICTS. The AuNFs-anti-G8-DIG nanobodies as a probe of ICTS could specifically recognize not only AFB 1 but also DIG-BSA. In this study, the DIG-BSA replaced the anti-6×His-tag antibody of traditional nanobody-based ICTS was coated on the control line, which was easier to synthesize, cheaper, and more stable. Under the optimal conditions, the AuNFs-based nanobody ICTS system accurately detected AFB 1 linearly and dynamically over the range (IC 20 ~IC 80 ) of 1.02~27.86 ng/mL, with the IC 10 and IC 50 of 0.1 ng/mL and 5.46 ng/mL respectively. In addition, these developed nanobodies ICTS had a universal application in the analysis of AFB 1 in corn samples.
研究领域:
分析化学
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食品科学
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生物技术
✓ 已验证
产品关联
DOI
高影响因子
Nano Research
·
2023
·
IF 9.9
Hu Dejia,Jiang ShangZuo,Xia Tianhao,Xiao Danyang,Li Yan,Hou Yanbing,Zhang Jin Zhong,Pu Ying-Chih
Ti 2 C quantum dots (QDs) with rich surface functional groups have been synthesized using a hydrothermal method, and used to detect tetracycline (Tc) based on enhanced fluorescence. The interaction between the surface functional groups of Ti 2 C QDs and Tc enhanced the fluorescence of Tc at 514 nm, which is used to detect Tc quickly and accurately. Under optimal conditions, the fluorescence intensity was linear to the concentration of Tc in the range of 50.0–30.0 μM, with a detection limit of 21.6 nM. Furthermore, the Tc-Ti 2 C QDs detection system was evaluated for detection of Tc in milk and artificial urine. This study demonstrates a new and simple strategy for Tc detection, which is important for food safety and human health.
研究领域:
分析化学
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环境科学
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材料科学
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食品安全
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）