JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2019
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IF 6.361
Ye He,Mengyang Wang,Haotian Zhang,Youxi Zhang,Yikun Gao,Siling Wang
Numerous types of mesoporous silica nanoparticles (MSNs) have been studied as carriers for small molecular drugs. However, few reports have been conducted on small MSNs having large pores, and that are suitable for loading and orally delivering therapeutic proteins. In particular, their protective properties against aggregation and enzymatic hydrolysis of loaded proteins have been rarely studied. In this study, mesocellular silica foams (MCFs) with large and different pore sizes were prepared. The loading and release behaviors of three model proteins with different molecular weights were studied. The protective properties of the MCFs against enzymatic hydrolysis of the loaded proteins were tested by sodium dodecyl sulfate polyacrylamide gel electrophoresis and high-performance liquid chromatography. The protecting effects of the MCFs against conformational change and aggregation of the loaded proteins were evaluated by circular dichroism and synchronous fluorescence spectra . Diabetic mice were inducted to evaluate in a preliminary manner the in vivo hypoglycemic effect of insulin loaded MCFs. The prepared MCFs showed rapid and high drug loading (up to 43%) of proteins. The release of proteins was tunable depending on the pore size. The lysozyme loaded MCFs could release 87% intact protein after incubation with pancreatin for 0.5 h. The digestion times for the insulin loaded in MCFs were prolonged to twice that of naked insulin. The secondary conformational changes for the insulin loaded in MCFs were only 1/40 to 1/20 of that of naked insulin incubated with Zn 2+ . Orally administered insulin-loaded MCF could reduce the blood glucose level to 69%. The prepared MCFs could effectively protect the loaded proteins from aggregation and enzymatic hydrolysis, thus exhibiting potential for application as carriers for protein delivery.
研究领域:
药剂学
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生物材料
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蛋白质工程
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产品关联
DOI
PubMed
高影响因子
FIBERS AND POLYMERS
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2017
·Vol. 18
·期 12
·2476-2480
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IF 1.113
Hao Youwei,Zhao Jie,Wang Gang,Cao Liqin,Wang Jide,Yue Fan
Mesocellular silica foam (MCF) grafted with thermo-responsive and pH-responsive copolymer poly( N -isopropylacrylamide- co -acrylic acid), was prepared by precipitation polymerization using supercritical carbon dioxide (scCO 2 ) as entrainer and solvent. Vinyl-functionalized MCF was first synthesized through post-synthesis via using vinyltriethoxysilane as a coupling agent for surface modification. Entrapped monomers of N-isopropylacrylamide (NIPA) and acrylic acid (AA) were then introduced and assembled onto the vinyl-modified MCF with the aid of scCO 2 . The grafting copolymer performed here as an on/off switch in the release of 5-fluorouracil, as confirmed by using UV-visible absorption spectroscopy. The grafted organic content and drug loading efficiency were 65.2 wt% and 11.5 wt%, respectively. The resultant grafting composite showed potential for application in drug delivery and exhibited thermo- and pH-responsiveness to external environmental changes.
研究领域:
材料科学与工程
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生物医学工程
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药学
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Haitao Shi,Jiajia Yang,Zia Ahmad,Haijun Zhang,Jiping Chen
Solid amine materials have emerged as a class of adsorbent with promising potential for CO 2 capture from gas mixtures, such as biogas and flue gas. In this work, we developed a novel CO 2 capture material via co-grafting of polyethyleneimine (PEI) on mesocellular silica foam (MCF), and (3-glycidyloxypropyl)triethoxysilane (GPTES) was first used as a bridging medium. In the fabrication procedure of MCF@G-35.6 %PEI, a simple impregration of PEI in MCF modified with epoxy groups was conducted. In this procedure, the co-grafting of PEI was realized in terms of a portion of PEI (21.3 wt%) was anchored on the pore surface of MCF via the epoxy/amine reaction and the rest of PEI (14.3 wt%) could be stably attached to the pore surface of MCF via its interaction with anchored PEI. After systematic evaluation, the MCF@G-35.6 %PEI exhibited a maximum CO 2 adsorption capacity of 2.78 mmol/g at 50 °C and 50 %RH and fast adsorption kinetics with equilibrium time (break through from C/C 0 = 5 % to 95 %) is 22.85 min. Meanwhile, outstanding CO 2 adsorption capabilities within a wide temperature range of 30–90 °C and a large concentration range of 5–30 % vol. CO 2 were obtained by the use of MCF@G-35.6 %PEI. More importantly, the MCF@G-35.6 %PEI also exhibited an excellent long-term stability over 50 consecutive cycles. CO 2 adsorption kinetics of the sorbent was found to follow Avrami’s fractional order model and intraparticle diffusion model. Furthermore, temperature-programmed desorption was conducted to investigate the desorption kneitics and adsorption mechanism. All these findings demonstrate the great potential of MCF@G-35.6 %PEI for carbon capture and sequestration (CCS) technology.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2023
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IF 15.1
Jiajia Yang,Yun Li,Tian Tian,Haitao Shi,Zia Ahmad,Ningbo Geng,Jing Jin,Yanqiang Huang,Haijun Zhang,Hongjun Fan,Jiping Chen
According to the global vision of “carbon peak and carbon neutrality”, extracting uranium from natural seawater is regarded as a promising candidate for meeting nuclear fuel demand. Nevertheless, owing to the very low uranium concentration and complexity of natural seawater, the development of adsorbent materials for extracting uranium from seawater with satisfactory efficiencies remains a great challenge. In this work, we for the first time developed a novel mesocellular silica foam (MSF) supported hyperbranched poly(amidoxime-ethyleneimine) (PAO-PEI) network ( [email protected] ). After systematic evaluation, the [email protected] exhibited high adsorption capacity and excellent reusability, fast adsorption kinetics as well as good adsorption selectivity and affinity towards uranyl ions, simultaneously. Besides the obtained short equilibrium time of ∼ 20 h, the [email protected] achieved a remarkable adsorption capacity of 926.2 mg-U/g-Ads. for 100 mg/L of uranium water solution. Meanwhile, the [email protected] showed evident higher selectivity towards uranium (29.3 mg g −1 ) against vanadium (7.2 mg g −1 ) and other coexisting metal ions in simulated seawater. Moreover, excellent reusability of [email protected] in eight consecutive adsorption–desorption cycles was also observed. More importantly, satisfactory extraction efficiencies (90.6–92.9 %) for U-spiked real seawater was obtained in 48 h. Finally, a uranium adsorption capacity of 1.102 mg g −1 for coastal seawater in 20 days was obtained. All these findings demonstrate the relatively good potential of [email protected] for extracting uranium from real seawater.
研究领域:
材料科学
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环境科学
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核工程
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化学工程
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
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2019
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IF 8.456
Chengwei Wang,Haoyi Niu,Xiaoyu Ma,Hua Hong,Yuan Yuan,Changsheng Liu
Massive bleeding control and anti-infection are the major challenges for urgent trauma with deep and noncompressible hemorrhage in both clinic and battlefield. Inspired by the coordinated primarily blood clot formation and secondly coagulation cascade activation in natural hemostasis process, an injectable, quaternized hydroxyethyl cellulose/mesocellular silica foam (MCF) hydrogel sponge (QHM) for both hemorrhage control and antibacterial activities were prepared via one-pot radical graft copolymerization. The as-prepared QHMs exhibited instant water-triggered expansion and superabsorbent capacity and thereby effectively facilitated blood components concentration. Moreover, the QHM1 with appropriate amount of MCF (9.82 w/w %) could further activate the coagulation factors. Synergistically, the QHM1 could reduce the plasma clotting time to 59 ± 4% in vitro and showed less blood loss than commercially available hemostatics in vivo noncompressible hemorrhage models of lethal rabbit-liver defect. Furthermore, the QHM with a quaternary ammonium groups density of 2.732 mmol/g exhibited remarkable antibacterial activities and excellent cytocompatibility. With the efficient hemostasis efficacy and excellent antibacterial behavior, QHM dramatically facilitated the wound healing in a full-thickness skin defect model in vivo. Thus, this QHM represents a promising hemostatic in more widespread clinical application.
研究领域:
材料科学
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生物材料
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生物医学工程
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止血
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伤口愈合
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组织工程
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Feng Yan,Heijin Chen,Tong Chi,Junyang Lu,Xuehua Shen,Feng Xie,Pengju Wang,Zuotai Zhang
Amine-impregnated adsorbents play a crucial role in direct air capture (DAC) technologies, however, challenges remain in balancing high amine loading, enhanced amine efficiency and long-term stability against urea formation. This study introduces a highly efficient and regenerable GI-PEI@MSF adsorbent, synthesized by impregnating glycerol-modified polyethyleneimine (GI-PEI) onto a mesoporous silica foam (MSF) support with ultra-large pore structure derived from coal fly ash (CFA). The 30 %GI-PEI@MSF adsorbent exhibited a remarkable CO 2 uptake of 9.70 mmol·g PEI −1 with an enhanced amine efficiency of 115.9 %, while maintaining excellent cyclic stability under harsh regeneration conditions. Hydroxyl-rich GI formed the intermolecular hydrogen bonds with PEI and facilitated the PEI dispersion, enabling a lower optimal adsorption temperature and faster adsorption kinetics, which are critical for lowering DAC energy demands. Characterization and Density Functional Theory (DFT) analysis provided molecular-level insights into the dual-functionality mechanism of GI modification: The secondary hydroxyl groups of GI, acting as Bronsted bases, can partially replace the primary or secondary amines of PEI in CO 2 adsorption, thereby enhancing the amine efficiency and inhibiting the urea formation. These findings demonstrate the feasibility of CFA recycling and GI modification for enhanced CO 2 adsorption, providing a promising strategy for scalable and cost-effective DAC applications.
研究领域:
环境科学
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材料工程
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化学工程
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气候技术
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吸附技术
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）