MOLECULES
·
2019
·Vol. 24
·期 9
·1770
·
IF 3.06
Cuiyan Han,Haitao Huang,Yan Dong,Xiaoyu Sui,Baiyu Jian,Wenquan Zhu
Mesoporous carriers have been extensively applied to improve the dissolution velocity and bioavailability of insoluble drugs. The goal of this work was to compare the drug-loading efficiency (LE) and drug-dissolution properties of mesoporous silica nanoparticles (MSN) and mesoporous carbon nanoparticles (MCN) as drug vectors oral delivery of water-insoluble drugs. For this purpose, MSN and MCN with similar particle size, surface area, and mesoporous diameter were prepared to precisely evaluate the effects of different textures on the drug-loading and dissolution behavior of insoluble drugs. Carvedilol (CAR), a Bio-pharmaceutic Classification System (BCS) class II drug, was loaded in the MSN and MCN by the solvent adsorption method and solvent evaporation method with different carrier–drug ratios. The carboxylated MCN (MCN–COOH) had a higher LE for CAR than MSN for both the two loading methods due to the strong adsorption effect and π–π stacking force with CAR. In vitro drug dissolution study showed that both MSN and MCN-COOH could improve the dissolution rate of CAR compared with the micronized CAR. In comparison to MSN, MCN-COOH displayed a slightly slower dissolution profile, which may be ascribed to the strong interaction between MCN-COOH and CAR. Observation of cell cytotoxicity and gastrointestinal mucosa irritation demonstrated the good biocompatibility of both MSN and MCN–COOH. The present study encourages further research of different carriers to determine their potential application in oral administration.Keywords:mesoporous silica;mesoporous carbon;carvedilol;in vitro dissolution;water–insoluble drug
研究领域:
药剂学
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBON
·
2016
·
IF 6.198
Aibing Chen,Yuetong Li,Yifeng Yu,Yunqian Li,Kechan Xia,Yuying Wang,Shuhui Li,Linsong Zhang
A synthetic procedure to prepare hollow mesoporous carbon spheres (HMCSs) with uniform mesopore size on the shell was developed using the “dissolution-capture” method. The dissolution-capture process was performed in the polystyrene core and silica shell. The polystyrene core template was dissolved by tetrahydrofuran treatment to form a hollow cavity. Then, the polystyrene was entrapped into the mesochannel of the silica shell. After carbonization and etching of silica, HMCSs with uniform mesopore size (4.1 nm) were produced. The HMCSs exhibit a greater capacity for phenol adsorption and reuse, thus making them ideal adsorbents for phenol adsorption.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2023
·
IF 5.2
Bei Liu,Kaijun Quan,Xiaoming Yang,Jia Chen,Hongdeng Qiu
It is important to explore well-defined materials to further improve the performance of chromatographic stationary phase. Periodic mesoporous organosilica (PMO) with uniform-distributed organic functionalities and high chemical stability is rising star of chromatography . In this work, ethylene-bridged PMO with excellent organization over distances of several dozen nm was coated on silica cores to form core-shell particles with radially-oriented mesopores . The separation performance for naphthalene was 9.7 × 10 4 plates/m after derivatization of the C18 group on the terminal vinyl of vinyltriethoxysilane by “thiol-ene” click reaction. These hybrid core-shell particles had good mechanical strength , as well as adequate chemical stability (0.1%TEA, pH 9.5), so it has the potential for HPLC separation.
研究领域:
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Physical Chemistry C
·
2015
·
IF 4.772
Jinsong Shi,Weibin Li,Dan Li
Porous carbons are important adsorbents for hydrogen. In this work mesoporous carbon material with ultrahigh surface area is prepared with hexagonally packed mesoporous silica (HMS) as template. After a systematic optimization of different synthesis parameters, carbon material with a specific surface area of 2644 m2/g is obtained with resol as carbon precursors, the highest value reported so far for silica-templated mesoporous carbons. The material can be loaded with nickel nanoparticles through addition of nickel chloride hexahydrate into the resol solution. Hydrogen uptake of the nickel-decorated carbon at room temperature and 20 bar reaches 2.66 mmol/g, 78% higher than that of the pristine carbon. Due to the sharp decrease of the specific surface area and pore volume after nickel decoration, the improvement is attributed to effects of nickel nanoparticles.
研究领域:
材料科学
·
能源存储与转换
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 33
·13997-14004
·
IF 3.288
Yangyi Sun,Yijing Mao,Ningyu Di,Xiaolong Chen,Dongming Qi,Baoqing Shentu
Herein, using an acid-hydrolyzed tetraethyl orthosilicate (TEOS)/bis(triethoxysilyl)ethane (BTEE) mixture as a precursor for the traditional surfactant-assembly synthesis of mesostructured silica spheres instead of directly purchased commercial precursors, molecularly ethane-bridged hollow mesoporous silica spheres (MEB-HMSs) with radial mesochannels and an enlarged pore size were successfully synthesized without any additional core templates. The composition, pore size, particle size, shell thickness, and rate could be controllably tailored by only changing the amount of reagents used in the reaction. The cytotoxicity assay confirmed that MEB-HMSs have good biocompatibility, together with good Dox-loading capacity.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2020
·Vol. 43
·期 18
·3655-3664
·
IF 2.878
Herman Maloko Loussala,Sen Han,Juanjuan Feng,Min Sun,Jiaqing Feng,Jing Fan,Meishan Pei
To enhance the extraction performance, a mesoporous silica was modified with ordered mesoporous carbon for solid-phase microextraction. Three stainless-steel wires coated with the mesoporous material were placed in a polyetheretherketone tube for getting an extraction tube. The tube was coupled to high-performance liquid chromatography with diode array detector, and the online analysis system was constructed. Then its extraction performance was evaluated using hydrophobic polycyclic aromatic hydrocarbons, phthalates, and hydrophilic neonicotinoids. The best selectivity was presented for polycyclic aromatic hydrocarbons. Several main conditions were optimized such as sampling volume, sampling rate, methanol concentration in the sample, and desorption time, a rapid and sensitive analytical method was established toward polycyclic aromatic hydrocarbons. The analytical method exhibited wide linear range from 0.017 to 15 µg/L with acceptable correlation coefficients more than 0.9990, limits of detection in 0.005-0.020 µg/L, limits of quantification ranging from 0.017 to 0.066 µg/L as well as large enrichment factors of 377-2314. It was successfully applied to detect trace polycyclic aromatic hydrocarbons in some real water samples including tap water, snow water, and domestic sewage.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2019
·
IF 5.589
Dandan Zhu,Jing Zuo,Yinshan Jiang,Jinyi Zhang,Jiupeng Zhang,Cundi Wei
Coal gasification fine slag (CGFS) was produced in the coal gasification process which was classified as an industrial solid waste. It was featured with naturally formed amorphous structures and an abundance of silicon, carbon and metal oxides . In this study, on the basis of the composition and structure characteristics of CGFS, a simple hydrochloric acid (HCl) leaching technology was applied to in situ prepare carbon-silica mesoporous composites (CSMCs) from CGFS by fully considering the value of the residual carbon. Special focus was put on the novel mechanism of pore formation in amorphous silica glass microspheres (SGM) during acid leaching. Experimental evidences showed that the metal oxides were uniformly distributed in SGM thus the dissolution of the metal oxides were starting from the surface of SGM, then gradually extending to the interior, and finally leading to form “tree branch” mesoporous channels. In addition, a response surface method was used to predict the optimal reaction conditions and the optimal sample (named as CGFS-O) was successfully prepared. CGFS-O possessed a prominent specific surface area (SSA) (337.51 m 2 /g) as well as an excellent pore volume (0.341 cm 3 /g). CGFS-O also exhibited a desirable capacity for NO 3 − removing and the adsorption process was studied detailed by changing different adsorption conditions. Adsorption results proved that CSMCs have the potential to purify wastewater in an economically and environmentally way. Therefore, combined with a proof-of-concept adsorption performance experiment, our study has not only provided a cost-effective strategy to industrially prepare CSMCs, reutilizing CGFS in an environmentally friendly way, but also contributed to the future applications of CSMCs with valuable insights into the pore formation mechanism in SGM during acid leaching process.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Yu Wu,Linna Shao,Cai Cheng,Xianyong Kou,Shi Huang,Liexiong Zhang,Jie Yu,Xuehan Xu,Xingyu Xiang,Xiaoliang Guo,Lingling Feng
Harmful Microcystis blooms (HMBs) and their hepatotoxic metabolites microcystins (MCs) pose escalating threats to aquatic biodiversity and public health due to their recalcitrance to conventional remediation approaches. To address this dual challenge, mesoporous silica (MSN) and hollow mesoporous organosilica (HMON) nanostructures were engineered via structure-guided design principles, enabling the development of the crude extract microcystinase A (CMlrA)-tailored immobilized platform (CMlrA@MSN and CMlrA@HMON) for synchronized HMBs suppression and MCs detoxification. Systematic optimization of carrier physicochemical properties (including specific surface area, hydrophilicity, and pore size) significantly enhanced the immobilization efficiency and catalytic durability of CMlrA. Kinetic modeling revealed 201.3% and 44.1% K cat / K m enhancements in MC-LR degradation for CMlrA@MSN and CMlrA@HMON relative to free CMlrA. Immobilized enzyme systems achieved 77.06% and 83.03% growth inhibition rates in Microcystis aeruginosa FACHB-905 after six-day treatment. This biocatalytic immobilization strategy establishes an eco-efficient framework for synergistic HMB suppression and MC degradation, providing the technical groundwork for practical water remediation systems.
研究领域:
环境科学
·
生物技术
·
生态毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 45
·23853-23860
·
IF 3.708
Pranav K. Tripathi,Mingxian Liu,Lihua Gan
Synthesis of carbon materials with enhanced surface areas, and regular and tuned pore diameters is always a great challenge. In this report, ordered mesoporous carbons (OMCs) were synthesized by the one-step assembly of tri-constituents, and the OMCs were applied as an adsorbent for the removal of the highly hazardous water pollutant di(2-ethylhexyl)phthalate (DEHP). Phloroglucinol–formaldehyde based carbon precursor was in situ prepared during the assembly of the tri-constituents, and the surface area and mesopore diameter of the OMCs were tuned by variation of the molar ratio of formaldehyde to phloroglucinol. Small angle X-ray diffraction patterns revealed that the obtained carbons are highly ordered, which is in agreement with the measuring results of transmission electron microscopy at low and high resolution. Scanning electron microscopy images demonstrate that OMC-F2.0 has a hierarchical morphology. Nitrogen adsorption–desorption measurements revealed that the surface area of the OMCs (956–1801 m2 g−1) was dependent on the molar ratio of the carbon precursor constituents (formaldehyde to phloroglucinol). By varying the molar ratio of formaldehyde to phloroglucinol from 1.0 to 4.0, the mesopore diameter of the OMCs was shifted to the higher side, from 2.1 to 3.1 nm. DEHP was efficiently removed from a model water pollutant by the OMCs. OMC-F2.0 achieved the highest adsorption capacity of 364 mg g−1 for the removal of DEHP. The adsorption equilibrium data were treated with the two mathematical models of Langmuir and Freundlich, and the results revealed that decontamination was more favorable with the Langmuir model. This concludes that the removal of DEHP by OMCs depends on the surface area, and the DEHP molecules occupied the porous space of the OMCs in a monolayer manner.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF POROUS MATERIALS
·
2025
·
IF 3.2
Yin Hailiang,Zhou Tongna,Shen Zhonglan,Li Huanhuan,Zhang Guangyan,Guo Lingxiao,Liu Chenguang
A new strategy has been developed for the preparation of ordered mesoporous carbon materials (OMCs) using weak organic acid induction assisted by 1,3,5-Trimethylbenzene (TMB). The type of acid, reaction temperature, TMB addition amount, and salt type all have different significant effects on the microstructure and morphology of carbon materials. In the absence of salt as a pore forming agent and inducing phase separation, OMCs was prepared by acetic acid induction at a reaction temperature of 100 °C and a TMB addition of 1 ml. The specific surface area and pore volume of mesoporous carbon are as high as 927 m 2 /g and 0.78 cm 3 /g, respectively, with a high mesoporous proportion of 72%. The catalyst obtained by loading MoO 2 and NiO nanoparticles on OMCs shows a higher specific surface area and a higher proportion of easily reducible octahedral molybdenum species compared to the catalyst obtained by loading metal on alumina. In the hydrodesulfurization (HDS) experiment of dibenzothiophene, the catalysts showed better HDS catalytic performance and higher hydrogenolysis activity.
研究领域:
材料科学
·
催化化学
·
纳米材料
·
能源与化学工程
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 18
·8022-8031
·
IF 3.591
Huan Liu,Zi-yuan Zhou,Shi-han Li,Bing-an Lu,Hong-wei Zhao,Qing-quan Liu
In view of the problems surrounding the research and application of carbon materials, the process of choosing a carbon source is still not perfect. There are few studies concentrating on the establishment of structure–property relationships based on the choice of carbon source. In this regard, our present work contributes the design of an organic precursor that is expected to allow the controllable construction of the carbon material, thus regulating its functionality. A highly π-conjugated Schiff base moiety with alternating imine groups (CN) and benzene rings was incorporated into the main chain of a mesoporous polymer. For comparison, a bisphenol-A-type moiety was employed in the main chain of another mesoporous polymer. Using the mesoporous polymers as organic precursors for porous carbon sources, the formation of mesoporous carbon can be attributed to the presence of the highly π-conjugated Schiff base moiety due to its self-supporting effect and char-forming ability, which are absent in the bisphenol-A-type moiety. However, we are not only concerned with the contribution from the chemical structure of the designed precursor to the controllable construction of mesoporous carbon, but also concerned with its regulation of the electrochemical performance of the resulting material. Through characterization using cyclic voltammetry (CV), galvanostatic charge–discharge profiles, and electrochemical impedance spectroscopy (EIS), this kind of mesoporous carbon has been found to have excellent charge storage and transportation abilities and shows potential for application in the electrodes of electrochemical capacitors.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Fengqin Yin,Feng Xu,Kun Zhang,Min Yuan,Hui Cao,Tai Ye,Xiuxiu Wu,Fei Xu
The double-mesoporous-layer imprinted polymer of mesoporous silica/mesoporous molecularly imprinted nanoparticles (MIP), with high specific surface area, rich porosity, excellent mass transfer rate and selectivity, were synthesized using imidacloprid (IDP) as a template. Under the optimal conditions of pH, contact time, concentration and temperature, MIP showed high adsorption capacity of 13.86 μg·mg −1 toward IDP and the imprinting factor reached 3.5. The adsorption process model including binding isotherm and kinetics was investigated. MIP exhibited excellent regeneration and its adsorption and selectivity were outstanding among its structurally pesticide analogues. The recovery of spiked IDP for MIP in fortified real samples can reach 96.0 ± 8.5% for cabbage and 105.0 ± 9.9% for apple. The limit of detection of the enrichment method can be as low as 0.037 μg·mL- 1 with a good linear relationship (R 2 = 0.996) from 0.30 to 10.0 μg·mL −1 . The results indicated that the proposed method allowed class-specific detection of IDP in food samples.
研究领域:
食品科学
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）