Bo Zhi,Hong Ding,Dongmei Wang,Yu Cao,Ye Zhang,Xue Wang,Yunling Liu,Qisheng Huo
Ordered mesoporous MnO2 nanoarrays were successfully prepared via a vacuum-assisted nanocasting route from an SBA-15 template. To achieve better purification performance for As(III), iron oxides with varied ratios were dispersed into the 2D hexagonal channels, and a series of FeMn-x adsorbents were obtained. Consisting of both iron and manganese oxides, these adsorbents could realize powerful oxidation and effective adsorption of As(III) simultaneously, revealing a synergetic arsenic removal process. The saturation adsorption capacity was 10.55 mg g−1 and >95% adsorption stability could be reached within a relatively short time. Furthermore, owing to the optimum Fe/Mn ratio, the FeMn-2 sample could easily bring the residual concentration down to below 10 ppb, when dealing with trace As(III) concentrations as low as 300 ppb, which provides a convenient method to efficiently capture trace As(III) from water for in-depth purification.
A natural killer (NK)-92 cell membrane-camouflaged mesoporous MnO 2 -enveloped [email protected] ( [email protected] @MnO 2 ) nanoparticles (denoted as APMN NPs)-based versatile biomimetic theranostic nanoplatform was developed for magnetic resonance (MR) imaging-guided multimodal synergistic antitumor treatments. In this core-shell nanostructure , an [email protected] core induced near-infrared (NIR)-activatable hyperthermal effects and nanozyme catalytic activity , while a mesoporous MnO 2 shell not only afforded a high drug-loading capability, tumor microenvironment (TME)-triggered MR imaging and drug release, but also endowed catalase-, glutathione peroxidase-, and Fenton-like activities. Furthermore, the NK-92 cell membrane camouflaging endowed the NPs with enhanced tumor-targeting capability, immune escape function, and membrane protein-mediated tumoral uptake property. The doxorubicin-loaded APMN (D-APMN) NPs exhibited TME-responsive drug release properties. Furthermore, the cellular uptake, in vivo MR imaging, and NIR thermal imaging confirmed the active tumor-targeting capability and TME-responsive MR imaging property of these biomimetic NPs. An antitumor efficacy test, histological analyses, and blood biochemical profiles suggested that the developed D-APMN NPs possessed a high antitumor activity and biosafety in tumor-bearing nude mice . Therefore, the developed APMN NPs held great potential as an intelligent and comprehensive theranostic nanoplatform for tumor-specific bioimaging and TME-responsive multimodality treatment based on photothermal therapy, chemodynamic therapy, and chemotherapy. Statement of significance Exploring intelligent and comprehensive theranostic nanoplatforms to integrate tumor-specific bioimaging and TME-responsive multimodal therapy effectively is a challenge. Herein, we successfully developed a new kind of NK-92 cell membrane-camouflaged mesoporous MnO 2 -enveloped [email protected] nanoparticles (APMN NPs)-based versatile biomimetic theranostic nanoplatform for the potential MR imaging-guided multimodal synergistic antitumor treatments. These NPs could integrate unique structural, optical, multiple-catalytic, paramagnetic, and biological merits of NK-92 cell membrane, [email protected] cores and mesoporous MnO 2 shell in a single nanoplatform. The NK-92 cell membrane camouflaging endowed the NPs with enhanced tumor-targeting capability, immune escape function, and membrane protein–mediated tumoral uptake property. The new information obtained from this study may be beneficial to promote the development of novel TME-responsive versatile “Trojan horse” theranostic nanoplatforms for efficient MR imaging-guided multimodal synergistic treatment.
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