Polymers
·
2021
·Vol. 13
·期 16
·2812
·
IF 4.329
Meng Zhang,Dong Wang,Nana Ji,Shaoxiang Lee,Guohui Wang,Yuqi Zheng,Xin Zhang,Lin Yang,Zhiwei Qin,Yang Yang
Due to the spread of drug-resistant bacteria in hospitals, the development of antibacterial dressings has become a strategy to control wound infections caused by bacteria. Here, we reported a green strategy for in situ biomimetic syntheses of silver nanoparticles@organic frameworks/graphene oxide (Ag@MOF–GO) in sericin/chitosan/polyvinyl alcohol hydrogel. Ag@MOF–GO was synthesized in situ from the redox properties of tyrosine residues in silk sericin without additional chemicals, similar to a biomineralization process. The sericin/chitosan/Ag@MOF–GO dressing possessed a high porosity, good water retention, and a swelling ratio. The hemolysis rate of the composite was 3.9% and the cell viability rate was 131.2%, which indicated the hydrogel possessed good biocompatibility. The composite also showed excellent lasting antibacterial properties against drug-sensitive and drug-resistant pathogenic bacteria. The composite possessed excellent hemostatic activity. The coagulation effect of the composite may be related to its effect on the red blood cells and platelets, but it has nothing to do with the activation of coagulation factors. An in vitro cell migration assay confirmed and an in vivo evaluation of mice indicated that the composite could accelerate wound healing and re-epithelialization. In summary, the composite material is an ideal dressing for accelerating hemostasis, preventing bacterial infection, and promoting wound healing.Keywords:biomimetic synthesis;hemostasis;antibacterial activity;wound healing
研究领域:
生物材料学
·
医学
·
纳米生物学
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产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2020
·
IF 5.88
Tingyu Yang,Jilagamazhi Fu,Liang Ma,Hong Du,Xiaoqing Yue,Bosheng Zhao,Cuiyan Wang
In biomineralization, organisms have the abilities to produce biominerals with superior properties. One of the most attractive features of biominerals is the presence of the proteins consisting of different contents of amino acids in crystals. In the present work, L-phenylalanine (Phe) was used as an additive for the controllable crystallization of calcium carbonate (CaCO 3 ). The obtained CaCO 3 crystals were characterized by field emission scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), elemental analysis and high-resolution transmission electron microscopy (HRTEM). The experimental results suggest that single calcite crystals are formed at low Phe concentrations. High concentrations of Phe inhibit the nucleation and growth of calcite, and promote the formation of vaterite crystals with solid or hollow structures. The morphology and crystal form of CaCO 3 are also significantly affected by the flow rate of CO 2 . After that, a possible mechanism (competition mechanism) action of Phe in the formation of CaCO 3 is proposed. Finally, the effects of temperature on the formation of vaterite were determined to explore the growth mechanism of hexagonal vaterite. The work of controlling the preparation of CaCO 3 crystals in the presence of Phe will help us to imitate and learn nature, and bring new insights into understanding bionics. Meanwhile, it provides a new method for the synthesis of CaCO 3 biomaterials with different crystal forms and morphologies.
研究领域:
材料科学
·
生物矿化
✓ 已验证
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2015
·
IF 3.088
Jing Li,Lu Xu,Nan Zheng,Hongyu Wang,Fangzheng Lu,Sanming Li
The present paper innovatively reports bimodal nanoporous silica synthesized using biomimetic method (B-BNS) with synthesized polymer (C 16 - l -serine) as template. Formation mechanism of B-BNS was deeply studied and exploration of its application as carrier of poorly water-soluble drug ibuprofen (IBU) was conducted. The bimodal nanopores and curved mesoscopic channels of B-BNS were achieved due to the dynamic self-assembly of C 16 - l -serine induced by silane coupling agent (3-aminopropyltriethoxysilane, APTES) and silica source (tetraethoxysilane, TEOS). Characterization results confirmed the successful synthesis of B-BNS, and particularly, nitrogen adsorption/desorption measurement demonstrated that B-BNS was meso–meso porous silica material. In application, B-BNS loaded IBU with high drug loading content due to its enlarged nanopores. After being loaded, IBU presented amorphous phase because nanoporous space and curved mesoscopic channels of B-BNS prevented the crystallization of IBU. In vitro release result revealed that B-BNS controlled IBU release with two release phases based on bimodal nanopores and improved dissolution in simulated gastric fluid due to crystalline conversion of IBU. It is convincible that biomimetic method provides novel theory and insight for synthesizing bimodal nanoporous silica, and unique functionalities of B-BNS as drug carrier can undoubtedly promote the application of bimodal nanoporous silica and development of pharmaceutical science.
研究领域:
药剂学
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纳米材料科学
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药物递送系统
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仿生合成
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介孔材料
✓ 已验证
DOI
高影响因子
Soft Matter
·
2024
·Vol. 20
·期 22
·4422-4433
·
IF 2.9
Xiubin Hou,Yingxia Wang,Xinbing Song,Juan Gao,Yurong Ma
Biogenic purine crystals can function in vision as light scatters, mirrors, and multilayer reflectors and produce structural colors or depolarization for camouflage. Xanthine crystals form irregular multifocal mirrors in the median ocellus of Archaeognatha. It is important to broaden the study of crystallization strategies to obtain organic crystals with purine rings in the laboratory. In this work, a facile one-step synthesis route to fabricate bio-inspired xanthine crystals is reported for the first time. The obtained rhomboidal xanthine nanoplates have similar morphology and size to biogenic xanthine crystals. Their length and thickness are about 2–4 μm and 50 nm, respectively. Lattice parameters, crystal structure, formation mechanism and optical properties of synthetic single-crystalline xanthine nanoplates were investigated in detail in this work. The obtained xanthine nanoplate crystals are proposed to be anhydrous xanthine with monoclinic symmetry, and the xanthine nanoplates mainly expose the (100) plane. It is proposed that the anhydrous xanthine nanoplates are formed via an amorphous xanthine intermediate precursor. The synthetic anhydrous xanthine nanoplates exhibit excellent optical properties, including high diffuse reflectivity, strong depolarization and pearlescent luster. This work provides a new design to synthesize bio-inspired organic molecular crystals with excellent optical properties.
研究领域:
晶体学
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生物材料
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光学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 47
·11235-11250
·
IF 7
Chan Chen,Haisheng Ren,Weikang Tang,Mengqi Han,Qinfei Chen,Hong Zhou,Jiadong Chen,Yuyue Gao,Wenbin Liu
L-3,4-Dihydroxyphenylalanine (L-DOPA) is widely used in Parkinson's disease treatment and is therefore in high demand. Development of an efficient method for the production of L-DOPA is urgently required. Nanozymes emulating tyrosine hydroxylase have attracted enormous attention for biomimetic synthesis of L-DOPA, but suffered from heterogeneity. Herein, a spherical porous iron–nitrogen–carbon nanozyme was developed for production of L-DOPA. Tannic acid chelated with ferrous ions to form a tannin-iron coordination framework as a carbon precursor. Iron and nitrogen co-doped carbon nanospheres were assembled via an evaporation-induced self-assembly process using urea as a nitrogen source, F127 as a soft template, and formaldehyde as a crosslinker. The nanozyme was obtained after carbonization and acid etching. The nanozyme possessed a dispersive iron atom anchored in the Fe–N coordination structure as an active site to mimic the active center of tyrosine hydroxylase. The material showed spherical morphology, uniform size, high specific surface area, a mesoporous structure and easy magnetic separation. The structural properties could promote the density and accessibility of active sites and facilitate mass transport and electron transfer. The nanozyme exhibited high activity to catalyze the hydroxylation of tyrosine to L-DOPA as tyrosine hydroxylase in the presence of ascorbic acid and hydrogen peroxide. The titer of DOPA reached 1.2 mM. The nanozyme showed good reusability and comparable enzyme kinetics to tyrosine hydroxylase with a Michaelis–Menten constant of 2.3 mM. The major active species was the hydroxyl radical. Biomimetic simulation of tyrosine hydroxylase using a nanozyme with a fine structure provided a new route for the efficient production of L-DOPA.
研究领域:
生物化学
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材料科学
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医学
✓ 已验证
DOI
PubMed
高影响因子
Materials Chemistry Frontiers
·
2022
·Vol. 6
·期 18
·2678-2689
·
IF 8.683
Meng Cai,Haoyue Song,Qihang Wang,Zhaoyong Zou,Zhengyi Fu
Enameloid is the most highly mineralized tissue of shark teeth with excellent mechanical properties, which consists of fluorapatite (FAP) crystallites in the form of an intricate hierarchical arrangement. However, the crystallization process of FAP within biological confined volumes is still unknown. Here, we introduce track-etched membranes with cylindrical channels as an available alternative to synthesize biomimetic FAP nanorods in confinement. We show that amorphous calcium phosphate (ACP) nanoparticles first precipitate and aggregate within the channels and then transform into crystalline FAP nanorods through a solid-state transformation pathway. During the crystallization process, crystal domains with different orientations are observed, which further fuse into large crystalline grains oriented along the [002] direction. More interestingly, we find that all additives, such as Mg2+, Sr2+ and poly(acrylic acid sodium salt) (PAAs), could accelerate the crystallization process of FAP nanorods at low concentrations while significantly stabilizing amorphous nanorods at high concentrations. Overall, these results demonstrate the important roles of confinement and additives in controlling the crystallization kinetics and morphology of inorganic crystals and provide inspiration for the rapid synthesis of biomimetic materials with outstanding properties.
研究领域:
材料科学
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生物矿化
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牙科研究
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Qinghe Liu,Sen Wang,Fei Han,Shupei Lv,Zairong Yan,Yunfei Xi,Jing Ouyang
Highly efficient three-dimensional (3D) kaolinite/MnO2–CuO (KM@CuO–NO3) catalysts were synthesized by a mild biomimetic strategy. Kaolinite flakes were uniformly wrapped by ultrathin tremelliform MnO2 nanosheets with thicknesses of around 1.0–1.5 nm. Si–O and Al–O groups in kaolinite hosted MnO2 nanosheets to generate a robust composite structure. The ultrathin MnO2 lamellar structure exhibited excellent stability even after calcination above 350 °C. Kaolinite/MnO2 exhibited abundant edges, sharp corners, and interconnected diffusion channels, which are superior to the common stacked structure. Open channels guaranteed fast transportation and migration of CO and O2 during CO oxidation. The synthesized KM@CuO–NO3 achieved a 90% CO conversion efficiency at a relatively low temperature (110 °C). Furthermore, the abundant oxygen vacancies on KM@CuO-NO3 assisted the adsorption and activation of oxygen species and thus enhanced the oxygen mobility and reactivity in the catalytic process. The mechanism results suggest that CuO introduced to the catalyst not only acted as CO active sites but also weakened the Mn–O bond, subsequently improved the mobilities of the oxygen species, which was found to contribute to its high activity for CO oxidation. This study provides new conceptual insights into rationally regulating structural assembly between transition metal oxides and natural minerals for high-performance catalysis reactions.
研究领域:
材料科学
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催化化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Chemistry
·
2022
·
IF 5.545
Wang Yangyang,Xu Jianfeng,Wang Xiaoshu,Li Tongtong,Zhang Gen,Yan Zheng,Liu Jiancong,Wang Lei
The background value of iron in red soil is superior, primarily absorbed and homogeneously encapsulated in harvested biomass. However, this property on the high-value utilization of bionic iron-encapsulated biomass remains unknown. In this study, special biochar (Fe@BC) was obtained from this kind of biomass by one-step pyrolysis method, which was further used to activate peroxydisulfate (PDS) and degrade 2,4-dichlorophenol (2,4-DCP). The results showed that Fe3O4 was formed and homogeneously embedded in biochar at 500oC. Comparing to catalysts prepared by impregnation pyrolysis (Fe/BC), Fe@BC exhibited excellent degradation performance (90.9%, k = 0.0037 min−1) for 2,4-DCP. According to the free radicals quenching studies, hydroxyl radicals (·OH) and superoxide radicals (·O2−) were the dominant reactive oxygen species (ROS) in Fe@BC/PDS system. Importantly, a PDS adsorption model was established, and the electron transport and PDS activation in the core-shell structure were demonstrated by DFT calculations. Therefore, this study could supply a high-performance catalyst and significant implications for high-value biomass utilization in red soil.
研究领域:
环境科学
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材料科学
✓ 已验证
DOI
高影响因子
Polymers
·
2019
·Vol. 11
·期 9
·1503
·
IF 3.164
Junkai Gao,Xi Tang,Zhengshou Chen,Han Ding,Yi Liu,Xuebin Li,Yan Chen
Polydopamine microspheres (PDAMs), synthesized using a biomimetic method, were used as a matrix for polyethylene glycol (PEG) to develop a novel high-efficient form-stable phase change material (PEG/PDAM) using a simple vacuum impregnation strategy. The PDAMs were first used as a support for the organic phase change materials, and the biomimetic synthesis of the PDAMs had the advantages of easy operation, mild conditions, and environmental friendliness. The characteristics and thermal properties of the PEG/PDAMs were investigated using SEM, FTIR, XRD, TGA, DSC, and XPS, and the results demonstrated that the PEG/PDAMs possessed favourable heat storage capacity, excellent thermal stability, and reliability, and the melting and freezing latent heats of PEG/PDAM-3 reached 133.20 ± 2.50 J/g and 107.55 ± 4.45 J/g, respectively. Therefore, the PEG/PDAMs possess great potential in real-world applications for thermal energy storage. Additionally, the study on the interaction mechanism between the PEG and PDAMs indicated that PEG was immobilized on the surface of PDAMs through hydrogen bonds between the PEG molecules and the PDAMs. Moreover, the PDAMs can also be used as a matrix for other organic materials for the preparation of form-stable phase change materials.Keywords:biomimetic synthesis;polydopamine microsphere;phase change material;polyethylene glycol;thermal energy storage
研究领域:
材料科学
·
能源工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Dan Zhang,Yu Fan,Gaojie Li,Wei Du,Runlong Li,Yiming Liu,Zhixuan Cheng,Jiaqiang Xu
A series of zeolitic imidazolate frameworks (ZIFs) were synthesized by a facile and environmental friendly biomimetic method. The textural properties of the ZIFs were characterized by PXRD, FESEM, TEM and FT-IR spectra. These results showed ZIF 90 having typical rhombic dodecahedron crystals with a diameter of 800–1200 nm. Furthermore, the presence of rich aldehyde groups is confirmed through chemical analysis. Gas-sensing tests of quartz crystal microbalance (QCM) transducers based on ZIFs were investigated. The results showed that ZIF-90 based sensors exhibited excellent sensing performance towards low concentration of acetone vapor, such as high sensitivity (the frequency shift was 95 Hz @ 1 ppm), fast response (the response/recovery time was 12 s/17 s, respectively) and good selectivity. On the basis of temperature-varying experimental method, a moderate adsorption enthalpy (the value of ΔH θ was −57.93 kJ/mol) was obtained, indicating the existence of weak and reversible chemisorption between ZIF-90 and acetone molecules. The value of adsorption enthalpy (ΔH = −60.10 kJ/mol) obtained from Density functional theory is in close agreement with the experimental results.
研究领域:
材料科学
·
化学工程
·
传感器技术
✓ 已验证
产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2017
·Vol. 46
·期 19
·6425-6432
·
IF 4.029
Yuling Liu,Qingsheng Wu,Yaping Zhao
1D Ag3PO4-NPs/Cu-NWs have been constructed to enhance visible-light-driven photocatalytic activity via biomimetic synthesis. Cu nanowires (NWs) were synthesized by a facile hydrothermal method. During the process of biomimetic synthesis, the porous PTFE film, which can mimic the transport process of cell membranes, plays an important role in controlling the transport speed of silver ions (Ag+) to decrease the reaction speed. Thus inhibition of the replacement reaction of Ag+/Cu and the uniform growth of Ag3PO4 nanoparticles (NPs) with a diameter of about 10 nm on Cu-NWs can be realized simultaneously. The diameter of Ag3PO4-NPs/Cu-NW is about 70 nm. Owing to the high electron transport of single crystal Cu-NWs, the free electrons in Ag3PO4 are transferred out to promote photogenerated electron–hole pair separation. The stability of Ag3PO4 NPs of the Ag3PO4-NPs/Cu-NWs was improved and the photodecomposition no longer occurred. Meanwhile, the band-gap of Ag3PO4 decreased to 2.07 eV after being coated on Cu-NWs and expanded the absorption scope of visible-light. In addition, the active species-trapping experiments indicated that the holes and ˙O2− play important roles in the photocatalytic reactions. The novel Ag3PO4-NPs/Cu-NWs were used for the degradation of ciprofloxacin (CPFX) for the first time and showed high photocatalytic degradation performance. After visible-light irradiation for 15 min, the degradation rates of CPFX with pure Ag3PO4 NPs and AC0.3 as catalysts were about 27% and 53%. In the end, the degradation efficiency of Ag3PO4-NPs/Cu-NWs was 6.07 times that of the pure Ag3PO4 NPs.
研究领域:
材料科学
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环境科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2023
·
IF 6.1
Mengqi Han,Weikang Tang,Qinfei Chen,Hong Zhou,Jiadong Chen,Wenbin Liu
Amino acid surfactants have gained significant importance in overcoming the limitations of conventional surfactants, notably, their low biocompatibility and biodegradability. However, the current amino acid surfactants lack multifunctional properties due to the nonreactivity of their aliphatic chains, necessitating the development of a new type of amino acid surfactant. A novel melanin-like amino acid surfactant and a biomimetic synthesis route were devised by mimicking the biosynthesis of melanin. Renewable natural polyphenol compounds with catechol moieties were utilized as building blocks for the hydrophobic group. In a proof-of-concept experiment, ethyl protocatechuate was oxidized to o-quinone and subsequently covalently linked to the amino group of lysine via Michael addition. The chemical structure was verified using liquid chromatography–tandem mass spectroscopy. The melanin-like amino acid surfactant exhibited excellent surface-active properties, with a critical micelle concentration of 1.59 mN m–1. Furthermore, it demonstrated remarkable emulsifying, foaming, solubilizing, dispersing, and wetting capabilities. Notably, it also possessed multifunctionality, including antibacterial activity, antioxidant activity, robustness, and mildness. These outstanding properties indicate significant potential for various applications. This strategy offers innovative insights and a versatile, modular toolbox for synthesizing multifunctional amino acid surfactants that mimic melanin. The approach allows for the easy interchange of o-quinone building blocks, which is akin to snap jewelry.
研究领域:
生物化学
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材料科学
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有机化学
✓ 已验证
DOI
PubMed
高影响因子
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