Research
·
2022
·
IF 11.036
Yiqun Liu,Qi Yu,Xiaojin Luo,Le Ye,Li Yang,Yue Cui
Diabetes is a chronic metabolic disease with a high blood glucose level, leading to both seriously acute and chronic complications. The closed-loop system is an ideal system for diabetes management. However, the large size and high cost of the commercial systems restrict their widespread uses. Here, we present for the first time a microtube-based wearable closed-loop minisystem for diabetes management. The closed-loop minisystem includes a biosensing device, an electroosmotic micropump, and a printed circuit board (PCB) with an algorithm. The microtube-based sensing device coated on the outer surface of the microtube is inserted into subcutaneous tissue for detecting interstitial glucose; the current signal for sensing glucose is processed by the PCB to power the electroosmotic micropump intelligently for the delivery of insulin into the subcutaneous tissue via the microtube channel. The closed-loop minisystem worn on a diabetic SD rat can successfully maintain its blood glucose level within a safe level. It is expected that this new closed-loop paradigm could open up new prospects for clinical diabetes management.
研究领域:
医学工程
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生物技术
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糖尿病研究
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DOI
高影响因子
Journal of Materials Chemistry C
·
2022
·Vol. 10
·期 46
·17675-17683
·
IF 8.067
Jia Yang,Bin Zhang,Xiyu Tian,Shuzheng Liu,Zhichao Xu,Gengzhi Sun,Gang Qin,Qiang Chen
As a new type of flexible electronics, without an external power supply, wearable self-powered sensing devices have attracted more and more attention. However, poor flexibility, anti-fatigue and anti-freezing properties limit their applications. Hence, we synthesized a physically crosslinked poly(N-hydroxyethyl acrylamide)/ammonium sulfate/glycerol (PHEA/AS/Gly) ionic conductive hydrogel by means of photoinitiation and soaking, and the synthesized hydrogel exhibited high strength and toughness, good ionic conductivity, quick self-recovery, as well as excellent mechanical and sensing properties of fatigue and frost resistance. Based on the PHEA/AS/Gly hydrogel, a novel flexible ammonium-ion battery and a flexible sensor were designed and prepared to assemble self-powered wearable sensing devices, which exhibited highly sensitive, ambient-stable, long-term fatigue-resistant and frozen-resistant electrochemical/sensing performances, as well as deformation-insensitive electrochemical properties, and could detect different human movements sensitively and stably without an external power supply at room and low temperatures or after long-term storage. Therefore, this work will provide a simple strategy to fabricate a self-powered flexible sensing system with integrated high performances for wearable smart electronics.
研究领域:
材料科学
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电子工程
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生物医学工程
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产品关联
DOI
高影响因子
PLoS One
·
2015
·Vol. 10
·期 6
·e0127610
·
IF 3.234
Ling Yu,YunLi Tian,AnXiu Gao,ZhuanZhuan Shi,YingShuai Liu,ChangMing Li
Cell migration is one of the key cell functions in physiological and pathological processes, especially in tumor metastasis. However, it is not feasible to monitor the important biochemical molecules produced during cell migrations in situ by conventional cell migration assays. Herein, for the first time a device containing both electrochemical sensing and trans-well cell migration modules was fabricated to sensitively quantify biochemical molecules released from the cell migration process in situ . The fully assembled device with a multi-wall carbon nanotube/graphene/MnO 2 nanocomposite functionalized electrode was able to successfully characterize hydrogen peroxide (H 2 O 2 ) production from melanoma A375 cells, larynx carcinoma HEp-2 cells and liver cancer Hep G2 under serum established chemotaxis. The maximum concentration of H 2 O 2 produced from A375, HEp-2 and Hep G2 in chemotaxis was 130±1.3 nM, 70±0.7 nM and 63±0.7 nM, respectively. While the time required reaching the summit of H 2 O 2 production was 3.0, 4.0 and 1.5 h for A375, HEp-2 and Hep G2, respectively. By staining the polycarbonate micropore membrane disassembled from the device, we found that the average migration rate of the A375, HEp-2 and Hep G2 cells were 98±6%, 38±4% and 32 ±3%, respectively. The novel bi-module cell migration platform enables in situ investigation of cell secretion and cell function simultaneously, highlighting its potential for characterizing cell motility through monitoring H 2 O 2 production on rare samples and for identifying underlying mechanisms of cell migration.
研究领域:
生物医学工程
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细胞生物学
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分析化学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2017
·Vol. 5
·期 31
·7806-7812
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IF 5.256
Lin Chen,Ying Huang,Tian Tian Xing,LingPu Ge,Tong Yang,Bin Chen,Cheng Zhi Huang
Facile detection of melamine in milk was realized through a portable multi-channel sensing device using Au nanoparticles with urchin-like structures as sensing probes. The detection mechanism was based on the aggregation of Au nano-urchins, induced by the formation of Au–N bonding with melamine. The Au nano-urchins were synthesized by a seed-mediated growth method in the presence of hydroquinone, which has the localized surface plasmon absorption at about 680 nm. The results showed that the melamine detection was environment pH dependent. The optimal melamine detection condition occurred when the pH of the BR buffer was 5.72. A better selectivity to melamine was fulfilled when compared with its structurally similar compounds: cytosine, uracil, and thymine. The multi-channel sensing device has a detection limit of 18 nM for melamine in milk, which could meet the requirement for monitoring the melamine amount in milk.
研究领域:
分析化学
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食品科学
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纳米技术
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产品关联
DOI
高影响因子
ACS Omega
·
2025
·
IF 4.3
He Gong,Hongli Chao,Lingyun Ni,Hang Zhu,Mengchao Chen,Jinghuan Hu,Daming Zhang,Tianli Hu,Yu Sun,Ying Guo,Shijun Li,Ye Mu,Xiuling Yu
Flexible sensors are mainly used in medical treatment, human body signal monitoring, and other fields and are an important part of flexible electronic devices, with high sensitivity, good mechanical properties, and other advantages. However, human signal monitoring devices are often hindered from being put to medical use due to the disadvantages of large size, slow response time, and poor mechanical properties. In this regard, in this paper, by means of electrostatic spinning technology, the composite spinning of polyacrylonitrile, N,N-dimethylformamide, and AgCl, AgOCN piezoresistive sensors with a gradient pore structure were constructed, combined with the sandwich packaging process integrated into the fixture, integrated with sensors such as coin cell, AD acquisition module, and 4G communication module on STM32 microcontroller, assembled into lightweight, flexible sensing devices. By doping the proportion of Ag+, having significantly optimized sensor performance, the wide detection range was boosted to 300 kPa (60× improvement over Fe+ doping), and the response/recovery times were 110 and 340 ms. In addition, tests of basic human movement, such as finger flexion, phonation, and breathing, were all found to have good applications. Based on their excellent mechanical properties, homemade foot sensors are used for critical point monitoring of walking, stair climbing, and other behaviors. A series of experiments reflect that the present AgOCN piezoresistive sensor has a good ability to detect human motion.
研究领域:
生物医学工程
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材料科学
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电子工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Wenfei Ren,Yuan Liu,Baiyi Zu,Jiguang Li,Da Lei,Tianshi Zhang,Xincun Dou
Leakage and contamination of hazardous chemical substances have been widely recognized as the critical issue in ensuring human health, maintaining environmental sustainability, and safeguarding public security. Urotropin as a crucial raw material in industrial holds a potential threat to aquatic/atmospheric environment with refractory degradation problem, hence, there remains a severe challenge to effectively and on-site monitor urotropin. Here, a general design with all-in-one strategy was presented, in which a highly integrated “pocket sensing chip” combining a sampling unit and a detecting unit together endows a rapid and ultrasensitive colorimetric detection without dead-zone towards urotropin. By loading fast blue B as sensing reagent in the detecting unit, a moderate and sensitive detection towards urotropin via electrostatic interaction was achieved with detection limits of 9 μM for liquid and 17.19 ng for particulates . Furthermore, an expandable sensing chip for the purpose of simultaneously screening on multi-target exhibited remarkable applicability for examining suspicious objects with all sorts of surface in real scenes, being unacted on environmental complexity. We expect this design would provide a universal strategy and the high referential value to propel the development of handy and portable sensing device to efficiently screen the environmental relevant critical substance on-site.
研究领域:
分析化学
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环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2023
·Vol. 52
·期 11
·7193-7207
·
IF 2.1
Yuan ChongXiao,Zhang Chao,Yang Cheng,Wu Fuling,Xiao Shibing,Sun Huajun
Flexible wearable sensing devices are in great demand for self-powered systems. In this study, we fabricated fiber films of poly(vinylidene fluoride) (PVDF) matrix embedded with modified lead zirconate titanate nanoparticles (PZT NPs) using the electrospinning process. Each fiber film was cut into small pieces of 2 × 2 cm 2 , and pairs of pieces were pressed with a hot-pressing method. Modified PZT NPs with a high piezoelectric coefficient were embedded in PVDF fibers as a piezoelectric-reinforcing phase, which promoted the formation of the polar β phase in PVDF. The embedded PZT NPs affected the distribution of the polarized electric field and formed a local electric field between two PZT NPs, which promoted the polarization of PVDF, thereby enhancing the piezoelectric properties of PVDF/PZT NPs fiber films. The piezoelectric coefficient ( d 33 ) of the PVDF/PZT NPs fiber films embedding 4 wt.% PZT NPs showed the most significant enhancement, from 12 pC/N for neat PVDF to 21 pC/N, which is an approximately 75% improvement. The results of this work demonstrate the great potential application of piezoelectric composite fiber films in flexible wearable sensing devices.
研究领域:
材料科学
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纳米技术
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传感器
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可穿戴技术
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产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2021
·
IF 10.618
Jiantao Ping,Lubin Qi,Quanbo Wang,Shuhua Liu,Yifei Jiang,Li Yu,Jin-Ming Lin,Qiongzheng Hu
The abnormal levels of trypsin in biological fluids can cause some acute illnesses, such as acute pancreatitis, cystic fibrosis and malnutrition. In this paper, we report the development of an integrated liquid crystal (LC) sensing device for simple, rapid and sensitive detection of trypsin assisted by the surfactant-embedded smart hydrogel. The gelatin hydrogel mixed with CTAB is added into the side channel of the LC sensing device. In the presence of trypsin, the gelatin hydrogel is decomposed, which triggers instant release of CTAB into the aqueous solution. The CTAB molecules are then captured by the LCs and form CTAB monolayers at the aqueous/LC interface, which leads to change of the LC images from the bright to the dark appearance under the crossed polarizers. The integrated LC sensing device has a remarkable detection limit of 3.4 × 10 −5 mg/mL. It is successfully employed to single-step detection of trypsin in human serum within 30 min. The integrated LC sensing device with use of the surfactant-embedded hydrogel takes advantages of single-step detection, high portability, remarkable sensitivity and fast response time, which provides a new perspective to facilitate development of user-friendly LC-based sensors.
研究领域:
生物医学工程
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分析化学
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生物传感器
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2023
·Vol. 33
·期 28
·2214544
·
IF 19
Yutie Gong,Jiayu Zhao,Zhenzhen Li,Jing Huang,Yang Zhang,Lijie Dong,Chuanxi Xiong,Ming Jiang
Dielectric switching materials are prospective candidates for smart electronic/electrical applications, and high dielectric switching ratios are crucial for their practical applications. However, the substantial improvement of the dielectric switching ratio is limited by the available dielectric switching mechanisms, and obtaining high dielectric switching ratios is a major challenge. Here, an unparalleled dielectric switching effect is reported in a water-in-oil emulsion system, caused by dual polarization synergy below the dielectric transition temperature in concert with suppression of the electrode polarization above the dielectric transition temperature. The synergistic dielectric switching effect of interfacial polarization and electrode polarization endows the emulsion with unprecedentedly high dielectric switching ratios. The highest room temperature dielectric switching ratio of this emulsion system up to 2.86 × 10 6 at 20 Hz, is four orders of magnitude higher than the highest switching ratio reported so far. The unparalleled high dielectric switching ratio, reliable cycle stability, good frequency adaptability, and satisfactory scalability make the inorganic salt solution/octadecane emulsions potentially excellent candidates for high-sensitivity room-temperature smart switching or sensing devices.
研究领域:
材料科学
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电气工程
·
纳米技术
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产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2024
·Vol. 37
·期 1
·2410312
·
IF 27.4
Xin Wang,Guirong Wu,Xikuan Zhang,Fei Lv,Zekun Yang,Xueli Nan,Zengxing Zhang,Chenyang Xue,Huanyu Cheng,Libo Gao
Reliable, non-invasive, continuous monitoring of pulse and blood pressure is essential for the prevention and diagnosis of cardiovascular diseases. However, the pulse wave varies drastically among individuals or even over time in the same individual, presenting significant challenges for the existing pulse sensing systems. Inspired by pulse diagnosis methods in traditional Chinese medicine (TCM), this work reports a self-adaptive pressure sensing platform (PSP) that combines the fully printed flexible pressure sensor array with an adaptive wristband-style pressure system can identify the optimal pulse signal. Besides the detected pulse rate/width/length, “Cun, Guan, Chi” position, and “floating, moderate, sinking” pulse features, the PSP combined with a machine learning-based linear regression model can also accurately predict blood pressure such as systolic, diastolic, and mean arterial pressure values. The developed diagnostic platform is demonstrated for highly reliable long-term monitoring and analysis of pulse and blood pressure across multiple human subjects over time. The design concept and proof-of-the-concept demonstrations also pave the way for the future developments of flexible sensing devices/systems for adaptive individualized monitoring in the complex practical environments for personalized medicine, along with the support for the development of digital TCM.
研究领域:
生物医学工程
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医疗器械
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医疗健康中的人工智能
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传统医学
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可穿戴技术
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个性化医疗
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DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Zhehang Tian,Xieyang Zhang,Yuting Zhang,Zimeng Wu,Guanqun Luan,Luqian Bao,Yixin Ji,Mengyao Cui,Chunhua Li
The misuse of tetracyclines in livestock production poses significant health risks. Thus, establishing convenient detection methods to replace complex laboratory tests for food safety is crucial. In this study, a heterostructure Zn-BTC/IRMOF-3 (denoted as ZBI) asynchronous response fluorescence sensor was developed for the qualitative and quantitative detection of tetracyclines in foods. The ZBI solution exhibited blue fluorescence under UV excitation; upon the introduction of tetracyclines, ZBI selectively recognized the tetracycline molecules through electron transfer, π-π stacking, and chelation, resulting in blue fluorescence quenching and green fluorescence enhancement. The ZBI sensor for tetracycline detection achieved recovery rates ranging from 93.91 to 111.91% in food samples, with a detection limit of as low as 0.086 μmol/L. Lastly, a portable sensing device using support vector classifier was constructed for detecting tetracyclines in real-life scenarios. Our findings introduce a new approach for fabricating fluorescence sensors and offer a novel method for detecting tetracyclines.
研究领域:
材料科学
·
分析化学
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食品安全
·
机器学习
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Jiuchuan Guo,Yudong Zhou,Jie Cheng,Fuli Chen,Jiahui Xu,Lirong Yang,Huifang Shi,Zhongfu An,Jinhong Guo,Xing Ma
Lateral flow immunoassay (LFIA), a classical point-of-care testing (POCT) technique, plays an important role in disease screening and healthcare monitoring. However, traditional LFIA is either designed for qualitative analysis or requires expensive equipment for quantification, limiting its use in household diagnosis. In this study, we proposed a new generation of LFIA for household health monitoring by using ultralong organic phosphorescence (UOP) nanomaterials as afterglow nanoprobes with a self-developed palm-size sensing device. The UOP nanoprobes exhibit a phosphorescence signal with a second-level lifetime, which completely avoids the interference from excitation light and biological background fluorescence. Therefore, an ultraminiaturized and low-cost UOP nanosensor was successfully designed by eliminating the complex optical path and filtering systems. We chose an inflammatory factor, C-reactive protein (CRP), for household POCT validation. The whole analysis was completed within 9 min. A limit of detection (LOD) of 0.54 ng/mL of CRP antigen was achieved with high stability and good specificity, which is comparable to laboratory instruments and fully satisfying the clinical diagnosis requirement.
研究领域:
生物医学工程
·
分析化学
·
医学诊断
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纳米技术
·
即时检测设备
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）