Guoqing Wang,Jianfei Wang,Xinping Wang,Yuanyuan Meng,Xiangzhen Feng,Gaoli Liu,Dong-An Wang,Changjiang Fan
Uncontrolled traumatic hemorrhage is a leading cause of preventable death. As two main forms of hemostatic materials, however, both sponges and hydrogel adhesives usually fail to control massive hemorrhage due to their respective shortcomings. Hemostatic sponge shows weak tissue adhesion, while the gelation process of hydrogel makes it difficult to seal high-pressure bleeding wounds. There is an urgent need to develop next-generation hemostats combining the advantages of sponges and hydrogel adhesives. Herein, a general methodology to prepare novel Fe 3+ -laden porous material (Fe 3+ @GCS) for rapid hemostasis of the high-pressure and severe hemorrhages is proposed, which is fabricated by loading ferric chloride with ethanol into the catechol-modified carboxylated gelatin sponge (GCS). Notably, porous Fe 3+ @GCS can undergo water-triggered rapid transformation to robust-adhesive hydrogels. The sealing strength of Fe 3+ @GCS on wet tissues reaches an astonishing ≈600 mm Hg. Rapid water uptake of Fe 3+ @GCS around wound not only concentrates blood components but also excludes interfacial water, facilitating blood clotting and wound sealing with the in situ formed sticky hydrogel. Fe 3+ @GCS can efficiently stop the high-pressure hemorrhaging from traumatic injuries of arteries and hearts in rats and pigs, respectively, via a simple and short-time pressing. Furthermore, the wound sealing by Fe 3+ @GCS promotes wound repair and healing.
Rong Wang,Weishi Zheng,Yuxuan Huang,Rui Zhang,Yi Zhang,Jingying Yan,Yuqing Gu,Jingyun Xi,Tun Yuan,Hua Su,Xianzhu Zhang,Xiaozhao Wang,Shaohui Xiong,Zhenfeng Cheng,Hongwei Ouyang,Yi Hong
Achieving strong adhesion under wet and bleeding conditions remains a major challenge for medical adhesives. Existing strategies that utilize polymer chain penetration to overcome this have shown promise but typically rely on complex external stimuli, limiting clinical use. Here, MonoSeal is introduced, a body-fluid-triggered adhesive sponge composed of a single oxidized polysaccharide, operating via a newly proposed mechanism termed Autopenetrative Adhesion (APA). Unlike conventional approaches, APA enables spontaneous polymer chain penetration into moist tissues via concentration-gradient-driven diffusion, without any external activation. This self-driven penetration dramatically increases the interfacial density and depth of reactive groups, which then form covalent bonds with tissue amines, establishing strong tissue anchoring. Meanwhile, the proteins present in body fluids serve to cross-link the sponge matrix, forming a rapid in situ barrier that mechanically seals the wound. By tailoring the molecular weight and sponge architecture, the dissolution–cross-linking kinetics is fine-tuned to optimize adhesive penetration and mechanical sealing. The resulting MonoSeal achieved robust tissue adhesion and effectively sealed the 12 Fr puncture wound on the porcine femoral artery within 30 s. When delivered via a customized applicator, MonoSeal also demonstrates promising performance as a vascular closure device following interventional access in the porcine carotid artery.
危险品化学品经营许可证（带存储）