Copper(II)-catalyzed dehydration of primary amides to nitriles with the aid of trichloroacetonitrile
A method for the preparation of nitriles from primary amides using trichloroacetonitrile and a catalytic amount of cupric acetate is described. Using this method, amides including aromatic amides, aromatic heterocyclic amides and aliphatic amides were converted into the corresponding nitriles in moderate to good yields. Trichloroacetonitrile reacted with amide in the presence of cupric acetate to form trichloroacetamide, which has been isolated and confirmed.
研究领域:
有机化学
·
合成化学
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DOI
高影响因子
危险品化学品经营许可证（带存储）