Science Advances
·
2023
·Vol. 9
·期 35
·
IF 13.6
Depeng Chu,Binxia Jia,Naiming Liu,Yunxia Zhang,Xiaotong Li,Jiangshan Feng,Jiacheng Pi,Zhou Yang,Guangtao Zhao,Yucheng Liu,Shengzhong (Frank) Liu,Nam-Gyu Park
Preliminary theoretical analyses indicate that lattice relaxation may be used to release lattice strain in the FAPbI3 perovskite to warrant both high x-ray detection performance and improved stability. Herein, we demonstrate stable black α-phase FAPbI3 single crystals (SCs) realized by lattice engineering via annealing in the ambient atmosphere. The engineered α-FAPbI3 SC detector shows almost all the best figures of merit including a high sensitivity of 4.15 × 105 μC Gyair−1 cm−2, a low detection limit of 1.1 nGyair s−1, a high resolution of 15.9 lp mm−1, and a short response time of 214 μs. We further demonstrate high-definition x-ray imaging at a dose rate below 10 nGyair s−1 on the FAPbI3 SC, indicating a minimal dose-area product of 0.048 mGyair cm2 to the patient for one-time posteroanterior chest diagnosis, which is more than 3000 times lower than the international reference level of 150 mGyair cm2. In addition, the robust long-term stability enables the FAPbI3 SC x-ray detector to work steadily for more than 40 years.
研究领域:
材料科学
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医学影像
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辐射探测
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DOI
高影响因子
Physica Status Solidi-Rapid Research Letters
·
2019
·Vol. 13
·期 8
·1900094
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IF 3.729
Zongyan Gou,Sibo Huanglong,Wenjun Ke,Hui Sun,Haibo Tian,Xiuying Gao,Xinghua Zhu,Dingyu Yang,Peihua Wangyang
Hybrid perovskite materials have been one of the brightest spotlights in the radiation detection research fields due to their higher carrier mobility and lower trap state density in recent years. In this paper, the CsPbBr 3 microcrystal thick film is successfully prepared using a low-cost facile solution synthesis method. The properties of samples are characterized by field-emission scanning electron microscope (FE-SEM), X-ray diffraction (XRD), and UV-vis diffuse reflectance spectrum (UV-vis DRS). In addition, X-ray detectors based on the CsPbBr 3 microcrystal thick film are fabricated and the photoelectric properties of the detectors are further improved through the multiple-times dissolution–recrystallization method. An improved sensitivity of 470 µC Gy air −1 cm −2 is obtained for X-ray photodetector based on recrystallized CsPbBr 3 microcrystal thick film at zero bias under a remarkably low dose rate (0.053 µGy air s −1 ). This sensitivity is over 20 times higher than that of α-Se X-ray detectors working at a much higher field of 10 V µm −1 . The current investigation can provide an efficient low-cost and facile method to fabricate self-powered X-ray detectors based on CsPbBr 3 microcrystal thick film that work normally at low radiation dose rate.
研究领域:
材料科学
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辐射检测
✓ 已验证
产品关联
DOI
高影响因子
Advanced Science
·
2022
·Vol. 10
·期 5
·2205526
·
IF 17.521
Wenjing Zhao,Yanze Wang,Yuanyuan Guo,Yung Doug Suh,Xiaowang Liu
The search for color-tunable, efficient, and robust scintillators plays a vital role in the development of modern X-ray radiography. The radioluminescence tuning of copper iodide cluster scintillators in the entire visible region by bandgap engineering is herein reported. The bandgap engineering benefits from the fact that the conduction band minimum and valence band maximum of copper iodide cluster crystals are contributed by atomic orbitals from the inorganic core and organic ligand components, respectively. In addition to high scintillation performance, the as-prepared crystalline copper iodide cluster solids exhibit remarkable resistance toward both moisture and X-ray irradiation. These features allow copper iodide cluster scintillators to show particular attractiveness for low-dose X-ray radiography with a detection limit of 55 nGy s −1 , a value ≈100 times lower than a standard dosage for X-ray examinations. The results suggest that optimizing both inorganic core and organic ligand for the building blocks of metal halide cluster crystals may provide new opportunities for a new generation of high-performance scintillation materials.
研究领域:
材料科学
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医学影像
·
光学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2020
·Vol. 8
·期 10
·5217-5226
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IF 11.301
Dou Zhao,Meng Xu,Bao Xiao,Binbin Zhang,Lei Yan,Guoqiang Zeng,Alain Dubois,Paul Sellin,Wanqi Jie,Yadong Xu
Precise detection of low-dose X-radiation using purely organic direct detectors is vital for tissue-equivalent dosimeters and safety control in medical radiation treatment, but it still remains a challenge. Here, we report a promising organic radiation detector based on 4-hydroxycyanobenzene (4HCB, C7H5NO) single crystals. Plate-like 4HCB single crystals up to 18 × 15 × 1.2 mm3 in size are obtained by an optimized solvent evaporation method, thanks to the clarification of the two-dimensional nucleation growth mechanism. After post surface treatment, the leakage current of the 4HCB detector is no larger than 0.1 pA under an electric field of 600 V cm−1. The fabricated detectors show a capability of detecting 241Am 5.49 MeV α particles with a well resolved full energy peak. The calculated hole mobility (μh) and hole mobility lifetime product (μτ)h are 3.40 cm2 V−1 s−1 and 8.50 × 10−5 cm2 V−1, respectively. Simultaneously, under a 50 kVp X-ray beam, a detection limit as low as 0.29 μGyair s−1 with a high sensitivity of 10 μC Gyair−1 cm−2 is achieved in the bias range of 40–100 V, contributing to a superior X-ray imaging capability with a spatial resolution of 0.9 lp mm−1 at a low-dose rate (below 150 μGyair s−1) of exposure.
研究领域:
材料科学
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医学物理
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辐射探测技术
✓ 已验证
DOI
高影响因子
Advanced Energy Materials
·
2023
·Vol. 13
·期 17
·2300092
·
IF 27.8
Zhuzuan Chen,Mingjin Lu,Yong Qian,Yu Yang,Ju Liu,Zhan Lin,Dongjie Yang,Jun Lu,Xueqing Qiu
Polymeric binders stabilize lithium–sulfur (Li–S) batteries by suppressing the shuttle of lithium polysulfide (LiPS) and volume variation, but the dosage of state-of-the-art binders in sulfur cathodes (≈20 wt%) hinders the electron/ion transfer and decreases the cell-specific density. Here, a wood-inspired lignin binder is developed after modification with amino acids for practical Li–S batteries at ultra-low low dosage (2 wt%). Benefiting from strong and balanced adhesions with active/conductive/current collector materials, robust mechanical properties, and super LiPS anchoring capability, the Li–S cell delivers an initial discharge capacity of 864 mAh g −1 at 0.5 C and can readily operate 1000 cycles. Moreover, the pouch cell with high mass loading (4.75 mg cm −2 ) also delivers a high energy density of 484 Wh kg −1 . This work provides important guidance in binder design for the sulfur cathode and paves a new way for the practical application of Li–S batteries.
研究领域:
材料科学
·
电化学
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产品关联
DOI
高影响因子
Advanced Science
·
2023
·Vol. 10
·期 14
·2206833
·
IF 15.1
Xieming Xu,Fang Wang,Weiwei Xu,Hao Lu,Lingfei Lv,Hongyuan Sha,Xiaoming Jiang,Shaofan Wu,Shuaihua Wang
Semiconductor-based X-ray detectors with low detectable thresholds become critical in medical radiography applications. However, their performance is generally limited by intrinsic defects or unresolved issues of materials, and developing a novel scintillation semiconductor for low-dose X-ray detection is a highly urgent objective. Herein, a high-quality rare-earth iodate Tm(IO 3 ) 3 single crystal grown through low-cost solution processing is reported with a wide bandgap of 4.1 eV and a large atomic number of 53.2. The roles of I O and Tm O groups for charge transport in the Tm(IO 3 ) 3 are revealed with the structural difference between the [101] and [ 1 ¯ 01 ] $[{\bar{1}}01]$ crystal orientations. Based on anisotropic responses of material properties and detection performances, it is found that the [ 1 ¯ 01 ${\bar{1}}01$ ] orientation, the path with fewer I O groups, achieves a high resistivity of 1.02 × 10 11 Ω cm. Consequently, a single-crystal detector exhibits a low dark current and small baseline drifting due to the wide bandgap, high resistivity and less ion migration of Tm(IO 3 ) 3 , resulting in a low detection limit of 85.2 nGy air s −1 . An excellent X-ray imaging performance with a high sensitivity of 4406.6 µC Gy air −1 cm −2 is also shown in the Tm(IO 3 ) 3 device. These findings provide a new material design perspective for high-performance X-ray imaging applications.
研究领域:
材料科学
·
医学影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2025
·
IF 5.1
Long Jiang,Chengzhi Xue,Jiatian Cheng,Nan Li,Xinyu Fan,Yuanbo Yang,Tiantian Li,Liwei Li,Yucheng Liu,Jiangshan Feng,Shengzhong Frank Liu,Zhou Yang
Lead halide perovskites have emerged as promising materials for sensitive, low-dose-rate X-ray imaging. However, the dark current drift caused by ion migration poses challenges to their long-term operational stability and performances. To address this issue, we explored the synergistic effects of precursor reduction and ion migration blocking have been investigated. Reducing the precursor solution decreases the defect density, enhancing the carrier lifetime and mobility-lifetime product, thus boosting X-ray sensitivity. However, this approach alone does not effectively suppress dark current drift. By incorporating ion migration blocker, the optimized device exhibits a significantly reduced dark current drift of 3.62 × 10−4 nA cm−1 s−1 V−1, an improved X-ray sensitivity of 1.22 105 μC Gyair−1 cm−2 and a low detection limit of 3 nGyair s-1 under 12.66 V mm-1 electrical field, positioning it among the best of polycrystalline perovskite X-ray detectors. Additionally, it can capture a clear X-ray image of a metal key at an X-ray dose of 2.85 μGyair s−1, highlighting its potential for low-dose X-ray imaging applications.
研究领域:
材料科学
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医学影像
·
半导体物理
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产品关联
DOI
高影响因子
BIOLOGICAL TRACE ELEMENT RESEARCH
·
2021
·Vol. 199
·期 10
·3728-3736
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IF 3.738
Han Gaochao,Tan Zhuangsheng,Jing Haiming,Ning Junyu,Li Zinan,Gao Shan,Li Guojun
Due to the wide application of rare-earth elements (REEs) in the last decades, lanthanum has increasingly entered the environment and has gradually accumulated in the human body through the food chain. Lanthanum is worth paying attention in terms of food safety. Although the genotoxicity of lanthanum has been studied in vitro, data on its DNA damage in vivo rodent are limited, moreover, which have also presented some controversy. This study aimed to conduct an in vivo rodent alkaline comet assay, and as a companion test to the lanthanum nitrate carcinogenicity test. We conducted an oral gavage experiment for 180 days (26 weeks) to test for the persistence of DNA damage of long-term low-dose accumulation of lanthanum nitrate (12.5, 25, and 50 mg/kg body weight), in F1 hybrid C57-ras transgenic mice (CB6F1) by using alkaline comet assay in the blood and liver. The comet assay revealed that all the tested concentrations of lanthanum nitrate did not induce DNA damage in any of the tissues investigated, whereas DNA damage was induced in the positive control group. These results could indicate that lanthanum nitrate can accumulate in tissues and organs of the mice after exposure, and does not possess DNA damage in C57-ras transgenic mice after repeated treatments at oral doses up to 50 mg/kg·BW for 26 weeks; also, it did not cause pathological changes in the liver of the mice.
研究领域:
毒理学
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遗传学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2015
·
IF 2.729
Jianping Li,Jianming Guo,Erxin Shang,Zhenhua Zhu,Kevin Yue Zhu,Shujiao Li,Buchang Zhao,Lifu Jia,Jing Zhao,Zhishu Tang,Jinao Duan
The drug combination of Danhong injection (DHI) and low-dose aspirin (ASA) was frequently applied for the treatment of cardiovascular and cerebrovascular diseases. Due to the drug interactions, a lot of potential benefits and risks might exist side by side in the course of combination therapy. However, there had been no studies of interaction between DHI and ASA. Metabolomics was a powerful tool to explore endogenous biomarkers and metabolic pathways. In present study, metabolic profiling with ultra-high-performance liquid chromatography coupled to quadrupole time of flight mass spectrometry (UHPLC-QTOF/MS) coupled with multivariate statistical analysis was performed to provide insight into understanding the interaction between DHI and low-dose ASA. Eleven potential biomarkers of three types were identified and seven metabolic pathways were constructed. The results showed that the interaction between DHI and low-dose ASA during synergistic treatment indeed affected some key endogenous biomarkers and metabolic pathways, which could not happen when DHI or low-dose ASA was used alone. The quality and quantity of endogenous metabolite were both influenced by interaction between DHI and low-dose ASA. In details, the amount of flavin mononucleotide, L-2, 4-diaminobutyric acid (DABA) and 4-aminohippuric acid were significantly increased. On the contrary, the amount of 3-methyluridine, 4, 6-dihydroxyquinoline, cortolone-3-glucuronide, and serotonin were significantly decreased. Furthermore, O -phosphotyrosine, 3-methyl-2-butenal, indoxyl sulfate and dolichyl diphosphate were disappeared in urine. As to metabolic pathways, riboflavin metabolism, pentose and glucuronate interconversions, and tryptophan metabolism were all significantly influenced. The emerging alterations of biomarkers and metabolic pathways were associated with a lot of drugs and diseases based on literature researches, which might influence the co-administration of other drugs or the treatments of relevant diseases. Our paper presented some hints to uncover the mechanism of interaction between DHI and low-dose ASA, which would provide some references for application of DHI and low-dose ASA combination.
研究领域:
药理学
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代谢组学
·
心血管疾病研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Matter
·
2021
·
IF 15.589
Wei Qian,Xiuwen Xu,Jian Wang,Yangbing Xu,Jianwei Chen,Yongshuai Ge,Jun Chen,Shuang Xiao,Shihe Yang
Medical X-ray computed tomography requires imaging at a low dose rate and in a large area. Halide perovskites have shown high potential for X-ray detection, but a pressing challenge is the current lack of low-cost methods for large-scale fabrication of high-quality thick perovskite films. Here we demonstrate and elucidate an aerosol-liquid-solid process to enable continuous growth of uniform halide perovskite films at low temperature over a large area of 100 cm 2 , which are vertically monolithic, and thus beneficial to carrier transport. Direct-conversion X-ray detectors based on the representative CsPbI 2 Br films in conjunction with a deliberated, interface-engineered C-electrode have realized an unprecedented sensitivity (≥1.48 × 10 5 μC Gy air −1 cm −2 ) and a low limit of detection (280 nGy air s −1 ). We have further demonstrated the high-resolution radiographic imaging capability of these films. These results lay the groundwork for large-scale application of halide perovskites in radiation detectors.
研究领域:
材料科学
·
医学影像
·
辐射探测
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Liu Chenwei,Yang Liang,Zhou Chenru,Wang Zhiyuan,Li Mingzhong
The effects of hydrate inhibitors on the adhesion of sintered hydrate deposits on pipe walls are still unexplored. Herein, a custom-built adhesion strength measurement apparatus was utilized to quantify the adhesion strengths of sintered cyclopentane (CyC5) hydrate deposits with thermodynamic inhibitors (ethylene glycol, glycerol) and low-dosage inhibitors (dodecylbenzene sulfonic acid (DBSA), sorbitan oleate (Span 80)). It was found that the hydrate adhesion strengths decreased by 69.82%-97.06% and 40.24%-94.36% with the concentration of ethylene glycol and glycerol increased from 2 wt% to 6 wt%, respectively. For DBSA and Span 80, the hydrate adhesion strength increased with concentration less than 0.01 wt% due to the acceleration on hydrate growth. The further increment of concentration leads to a dramatic reduction in adhesion strengths. Furthermore, the relatively large deviations with the predicted strengths led to the discussions of the effects of change in hydrate formation rate, crystal morphology , and also the adaption of the fitting model. Two modified models were proposed to give a better prediction/explanation of the hydrate adhesion with thermodynamic inhibitors and low-dosage inhibitors, respectively. This work provides a fundamental understanding of the adhesion mechanism of hydrate deposits with hydrate inhibitors, which is important in advancing the management of hydrate formation for preventing plugging in pipelines.
研究领域:
化学工程
·
石油工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER TESTING
·
2023
·
IF 5.1
Lvzhu Cheng,Amjad Farooq,Hai Wei Yang,Peng Wang,Qifan Qiao,Mingming Guo,Yong Wang,Zongqian Wang
Golden cocoon silk fibers suffer a lot from limited yield and serious color losing, which greatly restrict their uses. The development of golden cocoon-like silk fibers can effectively address the above issues. Herein, a low-dosage chemicals, short process alternative approach to reactive dyeing of golden cocoon-like silk fibers with robust color fastness was proposed. Investigation involves the pretreatment of the above silk via one-bath method followed by reactive dyeing. The results indicate that the color of as-prepared golden cocoon-like silk fiber is comparable with the commercial golden cocoon one. The short-process dyeing and robust color fastness with reactive dyes of silk fiber can be realized via the introduction of alkali. Importantly, no obvious color degradation following cyclic washing was observed, with the value of color difference within 2.0. Additionally, the tensile behavior of reactive dyed golden cocoon-like silk fiber was not significantly decreased as compared with the raw fiber.
研究领域:
纺织科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）