SAUDI PHARMACEUTICAL JOURNAL
·
2021
·
IF 4.33
Hao Liu,Sijiao Wang,Houyin Shi,Ruirui Zhang,Kunyan Qu,Yue Hu,Xingyu Qu,Chenyun Gan,Jingjing Chen,Xinyu Shi,Mengwu Zhang,Weiling Zeng
Gossypol (Gos) is a natural polyphenolic compound that has shown a number of valuable biological properties such as antifertility, antioxidation, and antitumor activities. However, the clinical application of Gos has been hindered by its notable adverse effects such as hypokalemia, hemolytic anemia, and so on. Using sustained-release dosage form provides a hopeful solution to this problem. In this study, a gastric floating tablet for sustained-release of Gos (Gos-GFT) was developed using polyvinylpyrrolidone, hydroxypropyl methyl cellulose, ethyl cellulose, lactose, sodium bicarbonate, and magnesium stearate. Gos-GFT had an average weight of around 200 mg with a drug content percentage of around 13.66%. The physicochemical properties of Gos-GFT satisfied the pharmacopoeial requirements for tablets. Gos-GFT was able to float in an acidic medium and had a sustained drug release for over 12 h. In vivo studies showed that the relative bioavailability of Gos-GFT, as compared with Gos powders, was larger than that of a non-gastric floating tablet which was a dosage form used for comparison with Gos-GFT. Furthermore, compared with the Gos powders and the non-gastric floating Gos tablets, Gos-GFT could prolong the in vivo action time of Gos, and significantly relieve hypokalemia which is a major adverse effect of Gos. These properties made Gos-GFT a promising Gos preparation that warrants further investigation for more extensive clinical applications of this natural compound.
研究领域:
药剂学
·
药物代谢动力学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Tianya Hu,Duan Yuan,Xiao Fu,Shuai Zhang,Fanfan Cui,Fengchen Li,Huixia Zhou,Xiaoyu Wang,Yong Hong Meng,Yurong Guo
The K + -induced pectin-based vitrimer hydrogel ink, with dynamic exchange properties, offers an innovative solution for single-channel extrusion-based 3D food printing. However, forming hydrogen-bonded cross-linked vitrimer traditionally requires over 150 mM of K + to overcome the electrostatic repulsion between enzyme-modified pectin (EMP) molecules, which raises health concerns due to the high K + content. This study developed a novel strategy to introduce Ca 2+ bridges to partially weaken the electrostatic repulsion, fabricating low-K + vitrimer gel inks. Using 67 mM K + and 0.9 mM Ca 2+ , a densely cross-linked gel (Ca-EMP-K 67 mM) was formed at 25 °C, exhibiting excellent mechanical performance (~140 g hardness). Meanwhile, the gel possessed excellent self-healing properties, with a relaxation time of 8.3 s at 80 °C, confirming its vitrimer status. Notably, the Ca-EMP-K 67 mM gel ink achieved a ~ 55 % reduction in K + doses while enabling an increase in shaping temperature from 4 °C to 25 °C, compared to the traditional EMP-K 150 mM gel ink. These advancements enabled a low-K + pectin ink for ambient 3D printing. The introduction of Ca 2+ not only reduces the K + concentration requirement but also increases the shaping temperature, broadening the gel ink's applications in the food industry.
研究领域:
食品科学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
Soft Matter
·
2023
·Vol. 19
·期 26
·4880-4890
·
IF 3.4
Yan-Lin Wang,Xi Wang,Hai-Rong Yu,Ting Liang,Xing-Bin Lv,Chang-Jing Cheng
Potassium ions (K+) play crucial roles in many biological processes. Abnormal K+ levels in the body are usually associated with physiological disorders or diseases, and thus, developing K+-sensitive sensors/devices is of great importance for disease diagnosis and health monitoring. Herein, we report a K+-sensitive photonic crystal hydrogel (PCH) sensor with bright structural colors for efficient monitoring of serum potassium. This PCH sensor consists of a poly(acrylamide-co-N-isopropylacrylamide-co-benzo-15-crown-5-acrylamide) (PANBC) smart hydrogel with embedded Fe3O4 colloidal photonic crystals (CPCs), which could strongly diffract visible light and endow the hydrogel with brilliant structural colors. The rich 15-crown-5 (15C5) units appended on the polymer backbone could selectively bind K+ ions to form stable 2 : 1 [15C5]2/K+ supramolecular complexes. These bis-bidentate complexes served as physical crosslinkers to crosslink the hydrogel and contracted its volume, and thus reduced the lattice spacing of Fe3O4 CPCs and blue-shifted the light diffraction, and finally reported on the K+ concentrations by a color change of the PCH. Our fabricated PCH sensor possessed high K+ selectivity and pH- and thermo-sensitive response performances to K+. Most interestingly, the K+-responding PANBC PCH sensor could be conveniently regenerated via simple alternate flushing with hot/cold water due to the excellent thermosensitivity of the introduced PNIPAM moieties into the hydrogel. Such a PCH sensor provides a simple, low-cost and efficient strategy for visualized monitoring of hyperkalemia/hypokalemia, which will significantly promote the development of biosensors.
研究领域:
生物传感器
·
材料科学
·
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）