MOLECULES
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2022
·Vol. 27
·期 19
·6627
·
IF 4.927
Hao Zhang,Lili Liang,Hailing Xi,Datong Liu,Zhanguo Li,Xiaoyan Lin
Compared with polymers and nanoparticles, fatty alcohols can not only increase the stability of foam, but also maintain better foamability at pH < 2, which is beneficial to reduce waste liquid and increase decontamination efficiency for radioactive surface pollution. However, different fatty alcohols have different hydrophobic chain lengths. The effects of fatty alcohols with different chain lengths on the performance of decontamination foam were studied at pH < 2, to assist in the selection of suitable fatty alcohols as foam stabilizers. Combined with betaine surfactant and phytic acid, biomass-based foams were synthesized using fatty alcohols with different chain lengths. When the hydrophobic tail groups of the fatty alcohol and the surfactant were the same, the foam showed the best performance, including the lowest surface tension, the highest liquid film strength, the greatest sag-resistance and the best stability. However, when the hydrophobic tail groups were different, the space between adjacent surface active molecules was increased by thermal motion of the excess terminal tail segments (a tail-wagging effect), and the adsorption density reduced on the gas-liquid interface, leading to increased surface tension and decreased liquid film strength, sag-resistance and stability. The use of decontamination foam stabilized by fatty alcohols with the same hydrophobic group as the surfactant was found to increase the decontamination rate of radioactive uranium pollution from 64 to over 90% on a vertical surface.Keywords:foam decontamination;radioactive pollution;low pH;chain-length matching;biomass-based
研究领域:
环境科学
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放射化学
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材料科学
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DOI
PubMed
高影响因子
Environmental Chemistry and Ecotoxicology
·
2025
·
IF 8.2
Zhigang Yang,Jiani Liu,Chunyu Chen,Khor Waiho,Chenchen Zhang,Aqin Chen,Youji Wang
Microplastics (MPs) pollution and freshwater acidification represent emerging threats to aquatic ecosystems. The combined toxic effects of these stressors on crustaceans and their underlying immune-metabolic mechanisms remain poorly understood. This study investigated the individual and combined toxic effects of low pH and polystyrene MPs on the Chinese mitten crab ( Eriocheir sinensis ). Through a 21-day exposure experiment combined with enzyme activity analysis, gut microbiota profiling, and hepatopancreas metabolomics, the findings revealed: (1) Combined exposure to low pH (pH 6.5) and MPs exacerbated oxidative damage and immune suppression, demonstrating synergistic toxicity; (2) MPs alone primarily affected pyrimidine metabolism, whereas combined exposure significantly disrupted the tricarboxylic acid (TCA) cycle and arginine biosynthesis while activating serotonin metabolism; (3) Although the α-diversity of gut microbiota remained stable, its COG functional profile underwent significant alterations. The results indicate that freshwater acidification amplifies the toxic effects of MPs on crustaceans through immune-metabolic interactions, highlighting the urgency of assessing multiple environmental stressors in the context of climate change. The study provides novel mechanistic insights for aquatic ecological risk assessment.
研究领域:
环境科学
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生态毒理学
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分子生物学
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DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
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2024
·Vol. 22
·期 1
·1-14
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IF 10.6
Sun Xiaodong,Li Yujie,Liu Xiaowan,Cui Dandan,Shi Yujiao,Huang Guojia
Background Properly designed second near-infrared (NIR-II) nanoplatform that is responsive tumor microenvironment can intelligently distinguish between normal and cancerous tissues to achieve better targeting efficiency. Conventional photoacoustic nanoprobes are always “on”, and tumor microenvironment-responsive nanoprobe can minimize the influence of endogenous chromophore background signals. Therefore, the development of nanoprobe that can respond to internal tumor microenvironment and external stimulus shows great application potential for the photoacoustic diagnosis of tumor. Results In this work, a low-pH-triggered thermal-responsive volume phase transition nanogel gold nanorod@poly(n-isopropylacrylamide)-vinyl acetic acid (AuNR@PNIPAM-VAA) was constructed for photoacoustic detection of tumor. Via an external near-infrared photothermal switch, the absorption of AuNR@PNIPAM-VAA nanogel in the tumor microenvironment can be dynamically regulated, so that AuNR@PNIPAM-VAA nanogel produces switchable photoacoustic signals in the NIR-II window for tumor-specific enhanced photoacoustic imaging. In vitro results show that at pH 5.8, the absorption and photoacoustic signal amplitude of AuNR@PNIPAM-VAA nanogel in NIR-II increases up obviously after photothermal modulating, while they remain slightly change at pH 7.4. Quantitative calculation presents that photoacoustic signal amplitude of AuNR@PNIPAM-VAA nanogel at 1064 nm has ~ 1.6 folds enhancement as temperature increases from 37.5 °C to 45 °C in simulative tumor microenvironment. In vivo results show that the prepared AuNR@PNIPAM-VAA nanogel can achieve enhanced NIR-II photoacoustic imaging for selective tumor detection through dynamically responding to thermal field, which can be precisely controlled by external light. Conclusions This work will offer a viable strategy for the tumor-specific photoacoustic imaging using NIR light to regulate the thermal field and target the low pH tumor microenvironment, which is expected to realize accurate and dynamic monitoring of tumor diagnosis and treatment.
研究领域:
生物医学工程
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医学影像学
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纳米医学
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DOI
PubMed
高影响因子
ELECTROPHORESIS
·
2018
·Vol. 39
·期 7
·924-932
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IF 2.569
Heqing Zhao,Haixia Lyu,Wenfei Qin,Zenghong Xie
In this work, an organic-inorganic hybrid boronate affinity monolithic column was prepared via “one-pot” process using 4-vinylphenylboronic acid as organic monomer and divinylbenzene as cross-linker. The effects of reaction temperature, solvents and composition of organic monomers on the column properties (e.g. morphology, permeability, and mechanical stability) were investigated. A series of test compounds including small neutral molecules, aromatic amines, and cis-diol compounds were used to evaluate the retention behaviors of the prepared hybrid monolithic column. The results demonstrated that the prepared hybrid monolith exhibited mixed-interactions including hydrophilicity, cation exchange, and boronate affinity interaction. The run-to-run, day-to-day and batch-to-batch reproducibilities of the prepared hybrid monolith for thiourea's retention time were satisfactory with the relative standard deviations (RSDs) less than 0.09, 1.45 and 4.05% ( n = 3), respectively, indicating the effectiveness and practicability of the proposed method.
研究领域:
分析化学
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材料科学
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色谱技术
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DOI
PubMed
高影响因子
CELLULOSE
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2014
·Vol. 21
·期 5
·3597-3611
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IF 3.033
Wang Xue-San,An Quan-Fu,Zhao Feng-Yang,Zhao Qiang,Lee Kueir-Rarn,Qian Jin-Wen,Gao Cong-Jie
Novel polyelectrolyte complexes based on sulfated carboxymethyl cellulose and chitosan were prepared, containing strongly charged (sulfate (OSO 3 )) and weakly charged (carboxylate (COO − )) groups (SPECs). SPEC homogeneous membranes (SPECMs) for the pervaporation dehydration of ethanol–water mixtures were investigated. The chemical structures and compositions of SPECMs were characterized by Fourier transform infrared spectroscopy and X-ray photoelectron spectra. The swelling behavior and separation performance of SPECMs in low pH feed were evaluated. It was found that the SPECMs containing OSO 3 groups were resistant to acidic feeds and showed very good separation performance even in low pH feed. For instance, the water content in permeate for SPECM-0.35 reached as high as 95.8 wt%, which was much higher than the 60 wt% for SPECM-0 in the dehydration of water–ethanol mixtures with pH 2. The result was attributed to the interplay between the stable complexation formed by OSO 3 groups and the improved ionization degree of COO − groups in SPECMs. Moreover, the SPECMs maintained their operation stability against acidic feeds. The SPECMs could find considerable potential application in the pervaporation dehydration of acidic feeds, especially for enhancing the conversion of ester condensation.
研究领域:
化学工程
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材料科学
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DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2022
·Vol. 331
·期 7
·3135-3145
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IF 1.754
Zhang Hao,Xi Hailing,Lin Xiaoyan,Liang Lili,Li Zhanguo,Pan Xunhai,Luo Xuegang
Abstract Conventional water-based detergents cannot remove radioactive contamination on the surface below 0 °C. In order to solve this problem, a biodegradable antifreeze foam, containing the antifreeze, the chelating agent and the surfactant in the low pH complex system, has been developed with the small molecule lauryl alcohol (LA) as the foam stabilizer. The developed foam being with short decontamination time which is easy to use and collect, can significantly reduce the amount of radioactive waste. The foam has good stability and decontamination efficiency as low as − 10 °C. The stabilization mechanism of LA on foam was studied. At the range of from 0 to − 10 °C, the decontamination rates of simulated radioactive cesium (Cs) and strontium (Sr) pollution are all above 90% on surfaces with different roughness such as glass, stainless steel, ceramic tile, marble and paint. Graphic Abstract
研究领域:
环境科学
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核工程
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材料科学
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DOI
高影响因子
ACS Applied Materials & Interfaces
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2016
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IF 7.145
Jing Sun,Dennis Curry,Qipeng Yuan,Xu Zhang,Hao Liang
Gold nanoparticle (AuNP)-templated spherical nucleic acids (SNAs) have been demonstrated as an important functional material in bionanotechnology. Fabrication of SNAs having high hybridization capacity to their complementary sequences is critical to ensure their applicability in areas such as antisense gene therapy and cellular sensing. The traditional salt-aging procedure is effective but tedious, requiring 1–3 days to complete. The rapid low-pH assisted protocol is efficient, but causes concerns related to nonspecific DNA adsorption to the AuNP core. To address these issues, we systematically compared the SNAs prepared by these two methods (salt-aging method and low-pH protocol). In terms of the number of complementary DNA that each SNA can bind and the average binding affinity of each thiolated DNA probe to its complementary strand, both methods yielded comparable hybridizability, although higher loading capacity was witnessed with SNAs made using the low-pH method. Additionally, it was found that nonspecific DNA binding could be eliminated almost completely by a simple glutathione (GSH) treatment of SNAs. Compared to conventional methods using toxic mercapto-hexanol or alkanethiols to remove nonspecific DNA adsorption, GSH is mild, cost-effective, and technically easy to use. In addition, GSH-passivated SNAs minimize the toxicity concerns related to AuNP-induced GSH depletion and therefore offer a more biocompatible alternative to previously reported SNAs. Moreover, rational design of probe sequences through inclusion of a polythymine spacer into the DNA sequences resulted in enhanced DNA loading capacity and stability against salt-induced aggregation. This work provides not only efficient and simple technical solutions to the issue of nonspecific DNA adsorption, but also new insights into the hybridizability of SNAs.
研究领域:
生物纳米技术
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纳米医学
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分子生物学
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材料科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
ENERGY & FUELS
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2019
·
IF 3.021
Kaiyu Zhang,Guodong Zhang,Zhuojing Li,Jirui Hou
Low pH fracturing fluids, such as the transition metal cross-linked guar derivative, can reduce the formation damage caused by clay swelling and fines migration in hydraulic fracturing treatments. However, a major disadvantage of the fluids is the uncontrollable rapid viscosity development, especially cross-linking under a pH below 3.0. In this paper, a novel delayed organic zirconium cross-linker with lactate and ethylene glycol as ligands was designed to overcome the shortcoming. Carboxymethyl hydroxypropyl guar (CMHPG), which results in a low gel residue after breaking, was used as the polymer at low concentration. The impact of gelation parameters on the properties of zirconium-CMHPG gel system was systematically investigated using a Sydansk bottle-testing method combined with a controlled stress rheometer. Desirable gelation time delay with agreeable rheological performance could be obtained by optimizing the polymer and cross-linker concentrations even at a pH as low as 2.0. Uniformly and compactly generated 3D network microstructures could firmly lock the free water within the gel, which further improved the thermostability and acid-resistance of the system. Meanwhile, the structures could also maintain the viscoelasticity of the fluid at a high level to ensure the efficient transportation of the proppants. Proppant settling and gel breaking tests demonstrated that the low pH and low polymer concentration gel system generated fewer insoluble residues with an uncompromised suspension performance. Moreover, the formation damage evaluation revealed that the low pH fracturing fluid system produced a better return permeability than the high pH system.
研究领域:
石油工程
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化学工程
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材料科学
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DOI
高影响因子
Advanced Science
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2024
·
IF 14.3
Mengmeng Xiong,Ying Zhang,Huan Zhang,Qiaoqiao Shao,Qifan Hu,Junjie Ma,Yiqun Wan,Lan Guo,Xin Wan,Haitao Sun,Zhongyi Yuan,Hao Wan
Aggressive nature of colon cancer and current imprecise therapeutic scenarios simulate the development of precise and effective treatment strategies. To achieve this, a tumor environment-activated photosensitized biomimetic nanoplatform (PEG 2000 -SiNcTI-Ph/CpG-ZIF-8@CM) is fabricated by encapsulating metal-organic framework loaded with developed photosensitizer PEG 2000 -SiNcTI-Ph and immunoadjuvant CpG oligodeoxynucleotide within fusion cell membrane expressing programmed death protein 1 (PD-1) and cluster of differentiation 47 (CD47). By stumbling across, systematic evaluation, and deciphering with quantum chemical calculations, a unique attribute of tumor environment (low pH plus high concentrations of adenosine 5′-triphosphate (ATP))-activated photodynamic effect sensitized by long-wavelength photons is validated for PEG 2000 -SiNcTI-Ph/CpG-ZIF-8@CM, advancing the precision of cancer therapy. Moreover, PEG 2000 -SiNcTI-Ph/CpG-ZIF-8@CM evades immune surveillance to target CT26 colon tumors in mice mediated by CD47/signal regulatory proteins α (SIRPα) interaction and PD-1/programmed death ligand 1 (PD-L1) interaction, respectively. Tumor environment-activated photodynamic therapy realized by PEG 2000 -SiNcTI-Ph/CpG-ZIF-8@CM induces immunogenic cell death (ICD) to elicit anti-tumor immune response, which is empowered by enhanced dendritic cells (DC) uptake of CpG and PD-L1 blockade contributed by the nanoplatform. The photodynamic immunotherapy efficiently combats primary and distant CT26 tumors, and additionally generates immune memory to inhibit tumor recurrence and metastasis. The nanoplatform developed here provides insights for the development of precise cancer therapeutic strategies.
研究领域:
肿瘤学
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生物医学工程
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纳米技术
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免疫学
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化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PNAS Nexus
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2024
·Vol. 3
·期 9
·
IF 2.2
Cai Baohua,Wang Yixiang,Yang Xin,Li Yanchen,Zhai Jinghao,Zeng Yaling,Ye Jianhuai,Zhu Lei,Fu Tzung-May,Zhang Qi
Dark aqueous-phase reactions involving the nitrosation and nitration of aromatic organic compounds play a significant role in the production of light-absorbing organic carbon in the atmosphere. This process constitutes a crucial aspect of tropospheric chemistry and has attracted growing research interest, particularly in understanding the mechanisms governing nighttime reactions between phenols and nitrogen oxides. In this study, we present new findings concerning the rapid dark reactions between phenols containing electron-donating groups and inorganic nitrite in acidic aqueous solutions with pH levels <3.5. This reaction generates a substantial amount of nitroso- and nitro-substituted phenolic compounds, known for their light-absorbing properties and toxicity. In experiments utilizing various substituted phenols, we demonstrate that their reaction rates with nitrite depend on the electron cloud density of the benzene ring, indicative of an electrophilic substitution reaction mechanism. Control experiments and theoretical calculations indicate that the nitrosonium ion (NO+) is the reactive nitrogen species responsible for undergoing electrophilic reactions with phenolate anions, leading to the formation of nitroso-substituted phenolic compounds. These compounds then undergo partial oxidation to form nitro-substituted phenols through reactions with nitrous acid (HONO) or other oxidants like oxygen. Our findings unveil a novel mechanism for swift atmospheric nitrosation and nitration reactions that occur within acidic cloud droplets or aerosol water, providing valuable insights into the rapid nocturnal formation of nitrogen-containing organic compounds with significant implications for climate dynamics and human health.
研究领域:
大气化学
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环境科学
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气候科学
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分析化学
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DOI
PubMed
高影响因子
Biomaterials Science
·
2020
·Vol. 8
·期 23
·6754-6763
·
IF 6.183
Zhiming Zhang,Li Zhang,Chenlu Huang,Qing Guo,Yueyue Zuo,Nannan Wang,Xu Jin,Linhua Zhang,Dunwan Zhu
Chemophotothermal combination therapy has emerged as a novel and promising strategy to treat cancer. To improve anticancer effectiveness and reduce systemic toxicity, it is essential to trigger drug release at tumor sites or within tumor cells for maximal drug exposure. Herein, we constructed gas-generating mesoporous silica nanoparticles (MSNs) that can load ammonium bicarbonate (ABC) and doxorubicin (DOX) within the pores, encapsulate indocyanine green (ICG) onto the polydopamine (PDA) layer, and modify the RGD peptide on the outer surface [denoted as M(abc)-DOX@PDA-ICG-PEG-RGD] for triggered drug release and targeted chemophotothermal combination therapy. Upon hyperthermia or low pH value, the encapsulated ABC can efficiently generate CO2 gas, thus enhancing the damage to the PDA layer and accelerating DOX release. In vitro experiments showed that the M(abc)-DOX@PDA-ICG-PEG-RGD significantly enhanced cellular uptake and cytotoxicity, and laser irradiation further increased the endocytic and cytotoxic effects. An in vivo study indicated that the nanoparticles can effectively accumulate at the tumor site and significantly inhibited tumor growth with no side-effects to the normal organs. Thus, this gas-generating MSN-based nanocarrier that can trigger drug release in response to laser irradiation or low pH value holds great potential in enhancing cancer chemophotothermal combination therapy.
研究领域:
纳米技术
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癌症治疗
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Engineering
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2024
·
IF 10.1
Ruogu Qi,Shanshan Wang,Jiayi Yu,Tianming Lu,Zhiqiang Bi,Weibo Liu,Yuanyuan Guo,Yong Bian,Jianliang Shen,Xuesong Zhang,Wenhao Hu
Multiple myeloma (MM) is the second most prevalent hematological malignancy. Current MM treatment strategies are hampered by systemic toxicity and suboptimal therapeutic efficacy. This study addressed these limitations through the development of a potent MM-targeting chemotherapy strategy, which capitalized on the high binding affinity of alendronate for hydroxyapatite in the bone matrix and the homologous targeting of myeloma cell membranes, termed T-PB@M. The results from our investigations highlight the considerable bone affinity of T-PB@M, both in vitro and in vivo . Additionally, this material demonstrated a capability for drug release triggered by low pH conditions. Moreover, T-PB@M induced the generation of reactive oxygen species and triggered cell apoptosis through the poly(ADP-ribose) polymerase 1 (PARP1)–Caspase-3–B-cell lymphoma-2 (Bcl-2) pathway in MM cells. Notably, T-PB@M preferentially targeted bone-involved sites, thereby circumventing systemic toxic side effects and leading to prolonged survival of MM orthotopic mice. Therefore, this designed target-MM nanocarrier presents a promising and potentially effective platform for the precise treatment of MM.
研究领域:
肿瘤学
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纳米技术
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药理学
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细胞生物学
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DOI
高影响因子
危险品化学品经营许可证（带存储）