POLYMER ENGINEERING AND SCIENCE
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2019
·
IF 1.92
Li Shuai,Zhang Jun,Chen Jianjun,Yao Ming,Liu Xuepeng,Jiang Zhiguo
Biodegradable body temperature-responsive shape memory polyurethanes, with self-healing function, were synthesized here from PCDL, MDI and different chain extenders, in which the chain extenders are designed to adjust their transition temperatures and shape memory properties. Once deformed at proper temperature, they show more than 96% shape fixation until heated near body temperature, where they recover their original shape (100%) within 20 s. Moreover, these polyurethanes could be self-healing at proper temperature, which makes them available in many medical fields. POLYM. ENG. SCI., 59:E310–E316, 2019. © 2019 Society of Plastics Engineers
研究领域:
材料科学
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医学工程
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Xiaoyong Zhang,Haoran Ding,Yujia Zhou,Zhaozhao Li,Yongping Bai,Lidong Zhang
Poly(N-isopropylacrylamide) (PNIPAM) enhances the reversibility and responsiveness of wearable temperature-sensitive devices. However, an open question is whether and how the hydrogel design can prevent adhesive performance loss caused by phase-transition-induced dehydration and unstable mechanical properties between devices and human skin and reduce interfacial failure. Herein, a gelatin-mesh scaffold-based hydrogel (NAGP-Gel) is constructed to inhibit dehydration and volume change, leading to stable mechanical properties, superior adhesiveness, and thermal sensing sensitivity during the phase transition. NAGP-Gel enhances the polymer chains–water interaction and weakens the degree of aggregation of polymer chains–chains, improving antidehydration properties under 45 °C conditions that are higher than the lower critical solution temperature (LCST; i.e., ∼32 °C). The mesh scaffold greatly restricts the phase-transition-induced polymer chain movement and maintains the mechanical performance. In a 60 °C environment, the maximum water loss and volume retention ratio of NAGP-Gel are only 3.58% and 97.3%, respectively. Additionally, NAGP-Gel serves as a temperature sensor, producing a stable thermal–electrical signal within the LCST range. It also can be assembled into an electronic device enabling the transmission of information and recognition of sign language via Morse code. This work broadens the application of PNIPAM in constructing intelligent hydrogels and opens the door to exploring emerging hydrogels for temperature-monitoring applications.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Advanced Energy Materials
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2025
·
IF 26
Lin Li,Qianwen Gao,Jie Miao,Nan He,Qian Zhang,Jun Zhang,Haonan Wang,Dawei Tang
The ability to continuously harvest energy from the human body has immense potential for powering wearable devices and biomedical systems, yet current thermoelectric hydrogels are constrained by rapid dehydration, limiting operational lifespans to less than 120 m and achieving temperature gradients of only ≈5 °C. Here, a self-cycling thermoelectric hydrogel is presented that addresses these challenges by autonomously regulating water-thermal cycling. This strategy achieves a maximum temperature gradient of 13 °C—more than 2.6 times the state-of-the-art—and maintains stable thermoelectric output for over 1500 min, the longest lifespan reported for such materials. Additionally, the hydrogel fully recovers hydration within 5 h, enabling robust reusability. Mechanistic studies reveal that optimized ionic interactions enhance thermal diffusion and elevate the Seebeck coefficient to 4.1 mV K −1 . This study introduces a scalable design for wearable thermoelectric materials, paving the way for advancements in health monitoring, environmental sensing, and wearable electronics.
研究领域:
材料科学
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生物医学工程
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可穿戴设备
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 22
·17888-17895
·
IF 3.289
Lin Gu,Bin Cui,Qing-Yun Wu,Haibin Yu
In this work, a series of bio-based shape memory polyurethanes were synthesized from polylactide copolymer diols, isophorone diisocyanate (IPDI) and chain extenders, in which the chain extenders are used to adjust their transition temperatures and shape memory properties. These bio-based polyurethanes (bio-PUs) show a Tg in the range of 28.7–34 °C, which is very closed to the body temperature and can be adjusted by the carbon chain length of the chain extenders. Moreover, they have low Young's modulus (34.7 MPa) and high elongation (434.0%). Through a series of shape memory tests, the bio-PUs exhibit good shape memory behavior at the body temperature with a shape recovery rate greater than 90%. Especially, the bio-PU from 1,4-cyclohexanedimethanol (CHDM) with a non-planar ring structure displays the highest shape recovery rate, which may be because CHDM in the hard segments acts as a “molecular spring”. Therefore, these shape memory bio-PUs are expected to have many practical applications in medical devices.
研究领域:
材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
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2024
·
IF 6.7
Zeng-Qiang Wu,Xiao-Qing Cao,Yu Hua,Chun-Mei Yu
Wearable sensors for non-invasive, real-time detection of sweat lactate have far-reaching implications in the fields of health care and exercise physiological responses. Here, we propose a wearable electrochemical sensor with gold nanoelectrode arrays fabricated on the nanoporous polycarbonate (PC) membrane by encapsulating lactate oxidase (LOx) in chitosan (CS) hydrogel for detecting body temperature and sweat lactate concurrently. Flexible gold nanoporous electrodes not only enhance electrode area but also offer a nanoconfined space to accelerate the catalytic reaction of LOx and control substrate concentration on the surface of LOx to decrease substrate inhibition. The proposed sensor has a long durability of 13 days and better selectivity for the detection of sweat lactate over a wide linear range (0.01–35 mM) with a low detection limit (0.144 μM). Furthermore, temperature-dependent transmembrane currents passing through the sensor are used to estimate body temperature. We then use multiple linear regression to adjust the effect of temperature on lactate detection and succeed in monitoring lactate molecules in sweat and body temperature during exercise.
研究领域:
生物医学工程
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分析化学
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运动生理学
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产品关联
DOI
PubMed
高影响因子
Polymer Chemistry
·
2019
·Vol. 10
·期 25
·3488-3496
·
IF 4.76
Tian Tian,Jiao Wang,Shanshan Wu,Zijian Shao,Tao Xiang,Shaobing Zhou
Shape memory hydrogels with capacity of shape deformation after being triggered by physiological stimuli have potential to be used in biomedical fields. In this study, a body temperature and water-responsive shape memory hydrogel with excellent mechanical properties was prepared by crosslinking dopamine-terminated tetra-poly(ethylene glycol) (4-arm PEG) with an oxidation reaction. By adjusting the water content of hydrogels, the temperature/water responsivity and the mechanical properties could be well controlled. Under the synergistic effect of body temperature and water stimulation, the hydrogels can achieve fast shape recovery with a recovery time of 1 min 14 s, and a recovery ratio of 98.9%. Tensile tests reveal that the gel has good mechanical properties. The tensile fracture strength can reach the megapascal level ranging from 2.68 to 13.02 MPa, and the elongation at break can reach 2501%. The integration of body temperature and water-induced shape memory properties and mechanical properties will broaden the application of the 4-arm PEG hydrogel in the biomedical field.
研究领域:
生物材料学
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医学工程
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2018
·
IF 6.042
Juan Qiao,Chuanfang Chen,Dihua Shangguan,Xiaoyu Mu,Shutao Wang,Lei Jiang,Li Qi
Real-time monitoring of the distribution of energy released during oxidative phosphorylation (OXPHOS) in living cells would advance the understanding of metabolic pathways and cell biology. However, the relationship between intracellular temperature and ATP fluctuation during the OXPHOS process is rarely studied due to the limitation of the sensing approach. Novel fluorescent polymer probes were developed for accurate simultaneous measurements of intracellular temperature and ATP. Utilizing the fluorescence imaging techniques, it was demonstrated for the first time that the temperature in mitochondria increased 2.4 °C and the ATP fluctuation level simultaneously decreased 75% within 2 min during the OXPHOS process. Moreover, the resultant fluorescent polymer probes had good performance and properties for mitochondrial targeting, providing an effective way for investigating mechanisms by which energy is released during the OXPHOS process.
研究领域:
细胞生物学
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代谢组学
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生物化学
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产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR MATERIALS AND ENGINEERING
·
2021
·Vol. 306
·期 11
·2100370
·
IF 4.367
Xin Qi,Enyun Xu,Manman Jia,Jichuan Zhang,Liqun Zhang,Dongmei Yue
At present, the synthesis of body temperature triggering shape memory polymers usually requires elaborate structural design, which limits their wide application. Herein, starting from bio-based Eucommia ulmoides gum (EUG), a series of EUG/silica hybrids (ESHs) are prepared through a facile one-pot process, in which EUG is epoxied and then self-crosslinked with SiO 2 by epoxy ring-open reaction. Varying the amount of H 2 O 2 , the shape memory transition temperature ( T trans ) of ESHs is adjusted to 47.4–36.6 ℃, which is close to human body temperature (37 ℃). Among them, ESH-17 exhibited the best body temperature triggering shape memory ability ( T trans = 36.6 ℃), which can restore the permanent shape within 60 s at 37 ℃ with a shape fixity ratio of 99% and shape recovery ratio near 100%. In addition, the shape memory mechanism is discussed and shows some application scenarios of ESHs. The as-produced materials can be used as smart biomaterials such as self-tightening sutures, self-sealing root canal filling materials, and so on.
研究领域:
材料科学
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生物学
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医学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Applied Biomaterials & Functional Materials
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2020
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IF 2
Xue Xia,Rui Shi,Jinhui Huang,Yubao Li,Yi Zuo,Jidong Li
The aim of the current study is to alleviate the adverse effect of the strongly exothermic polymerization of polymethyl methacrylate (PMMA) bone cement in clinical applications. In this study, paraffin/poly(methyl methacrylate–methylene bisacrylamide) (paraffin/P(MMA-MBA)) phase change microcapsules (MPn; n = 1, 2) were developed via the emulsion polymerization method. The reduction of the maximum temperature of polymerization (Tmax) and physicochemical properties were evaluated after doping commercial PMMA cement with MPn in specific proportions (10%, 20%, and 30%). The results reveal that the MPn-doped PMMA exhibited an effective reduction in Tmax, which can help alleviate the adverse effect of the strong exothermic reactions during PMMA setting. After doping with the MPn, the mechanical properties of the PMMA cement decrease and the values are close to that of body cancellous bone. The Tmax of the cement doped with 20 wt% MP1 is 37.6°C, which is close to body temperature. Significantly, the setting and compressive properties of the optimized group can still adhere to clinical requirements. The MPn doping PMMA technique holds much promise in clinical practice.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
POLYMER
·
2019
·
IF 3.771
Yulin Zhang,Yueshan Li,Kaixuan Chen,Zixun Ma,Xiangdong Wang,Lingying Shi,Rong Ran
With the rapid development of mobile networks and smartphones, quick response (QR) code has been more and more applied to various fields. Many individuals also have a QR code containing their own information. But because of its low cost and easy imitation, the QR code not only facilitated people's life but also brought the risk of revealing personal privacy. Therefore, it is very necessary to improve the security of the QR code by some simple encryption methods. Herein, by combining self-healing hydrogel and thermos-sensitive hydrogel, multifunctional dual network hydrogel with good mechanical properties , self-healing ability, and fast temperature sensitivity was synthesized. Moreover, customized patterned thermos-sensitive hydrogels can be obtained by the simple assembly. And the patterns can be triggered by human body temperature and disappeared after cooling at room temperature . Based on these performances, a QR code hydrogel with low cost, accessibility, durability and security features was fabricated for the storage and display of information. And this simple strategy is of universal significance for the synthesis of multifunctional and high-performance hydrogels.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2020
·Vol. 8
·期 23
·11695-11711
·
IF 11.301
Youchao Teng,Jing Wei,Hongbiao Du,Mansoorianfar Mojtaba,Dagang Li
A solar and thermal multi-sensing all-solid-state microfiber supercapacitor (ASSMFSC) with prominent electrochemical and mechanical performance, reliable environmental responsivity, and intelligent self-conditioned capacitance was constructed using a cellulose nanofibril-graphene-conjugated polymer, which was assembled as both a core-sheath microfiber electrode (CSMFE) and a sensing unit. The multicomponent hierarchical synergistic design fully exploited the unique attributes and synergistic interaction of each component to endow the well-designed CSMFE with high capacitance and mechanical robustness as well as excellent thermal sensitivity and photothermal conversion, enabling the valid modulation of redox reactions, interface performance, or electronic/ionic transfer in the microfiber supercapacitors toward complex external stimulations and building interrelated working responses. The fabricated ASSMFSC presented a total volumetric capacitance of 85.8 mF cm−3 (vs. the whole device), excellent cycle stability, and a volumetric energy density of 11.9 mW h cm−3. Moreover, ASSMFSC showed excellent solar-thermal conversion capacitance enhancement. At one solar power density (1 kW m−2), the capacitance was two times that of the device in the dark and the device exhibited self-regulation capacitance ability with the change in the solar intensity. As a thermosensitive device, ASSMFSC with a current sensitivity of 0.47437 ± 0.00549 °C displayed a fast response and excellent reproducibility to sense subtle temperature changes. This work demonstrates that the CSMFE-driven microfiber supercapacitor can be used as a photothermal conversion energy storage system and for body temperature monitoring, which provides an essential reference and optimistic incentives for new generation energy-related devices.
研究领域:
材料科学
·
能源存储
·
传感器技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Sensors
·
2024
·
IF 8.2
Yue Wu,Yong Liu,Xueting Yang,Mingqiong Tong,Xubao Jiang,Xiangling Gu
Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders during pregnancy, leading to serious complications for pregnant women and a threat to life safety of infants. Therefore, it is particularly important to establish a multipurpose monitoring pathway to important physiological indicators of pregnant women. In this work, three kinds of double network hydrogels are prepared with poly(vinyl alcohol) (PVA), borax, and cellulose ethers with varying substituents of methyl (methyl cellulose, MC), hydroxypropyl (hydroxypropyl cellulose, HPC), or both (hydroxypropyl methyl cellulose, HPMC), respectively. The corresponding toughness (143.9, 102.3, and 135.9 kJ cm–3) and conductivity (0.69, 0.45, and 0.51 S m–1) of the hydrogels demonstrate that PB-MC was endowed with the prominent performance. Molecular dynamics simulations further revealed the essence that hydrogen bond interactions between PVA and cellulose ethers play a critical role in regulating the structure and properties of hydrogels. Thermochromic capsule powders (TCPs) were subsequently doped in to achieve a composite hydrogel (TCPs@PB-MC) to indicate the change in human body temperature. Furthermore, the process of the TCPs@PB-MC response to glucose, pH, and temperature was tracked in-depth through the electrochemical window. This work provides a novel strategy for all-in-one health management of GDM.
研究领域:
生物医学工程
·
材料科学
·
健康管理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）