ADVANCED FUNCTIONAL MATERIALS
·
2023
·Vol. 33
·期 31
·2303306
·
IF 19
Weicheng Gao,Jie Chang,Xueping Li,Sidi Li,Yuwei Zhou,Xin Hou,Lixia Long,Jin Zhao,Xubo Yuan
With the emergence of various hydrogels with excellent functions, the air-drying of hydrogels has attracted extensive attention. Improving the water retention capacity is critical in the application of hydrogels. Herein, inspired by the dense aggregation structure of natural hydrophilic macromolecules, hydrophilic substances (gelatin and glycerol) are first applied to enhance the water retention capacity of hydrogels by constructing a quenched double-hydrophilic coating. The weight retention ratio of the modified hydrogels is increased to 72.5% at 25 °C and 40 RH% after 5 days. Furthermore, the construction of hydrophilic coating on the surface does not affect the mechanical properties, and the modified hydrogels still retain strong water retention capacity after loading. In addition, this approach is applicable to hydrogels with different shapes and types, and various materials can be selected. Therefore, the proposed method provides new insights for expanding the application scope and service life of hydrogels.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2016
·
IF 4.219
Feifei Sun,Hong Niu,Dongdong Wang,Yuanyuan Wu,Haibo Mu,Lili Ma,Jinyou Duan
Current studies have revealed the excellent moisture absorption-retention capacity of hyaluronan (HA); however, HA is easily degraded by hyaluronidase on the surface of skin. So, it is very necessary to develop an alternative derivative with low cytotoxicity and resistance to hyaluronidase. Herein, a HA decorated with photocaged groups was synthesized. The moisture absorption-retention capacity and hyaluronidase resistance of photocaged HA (HA-DMNB) and products of HA-DMNB irradiated by ultraviolet for different time (IHA-DMNB), were investigated. Results show that HA-DMNB is more resistant to hyaluronidase than HA, and HA-DMNB could release free carboxyl groups of HA upon ultraviolet to bond with H 2 O. More importantly, HA-DMNB was protective against UV light. In addition, HA-DMNB and IHA-DMNB were observed to be nontoxic to HaCat cells. This study indicates that HA-DMNB may be effectively used as a moisture-preserving reagent.
研究领域:
生物化学
·
皮肤科学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
Polymers
·
2025
·Vol. 17
·期 10
·1365
·
IF 4.9
Wei Li,Yang Ming,Libing Yang,Yimeng Ni,Yu Chen,Weidong Xu,Lefei Li,Chan Zheng,Wanyang Lin
Hydrogels with conductive properties hold significant promise in the realm of flexible electronics, owing to their pliability, outstanding conductivity, and diverse functionalities. Nevertheless, the majority of conductive hydrogels are prone to being brittle and easily damaged; as such, they are not adapt to cold environments, which seriously hinders their practical applications. Therefore, hydrogels that possess both conductivity and anti-freezing, as well as moisturizing, capabilities have garnered considerable interest, and these hydrogels can work stably in harsh environments. Phytic acid (PA), which mainly exists in plant seeds, is a kind of natural compound widely existing in nature that can be recycled; it provides electrical conductivity and anti-freezing to hydrogels. Here, a highly conductive hydrogel with excellent anti-freezing and moisturizing capabilities was prepared by incorporating PA into a polyacrylamide/gelatin hydrogel. The incorporation of PA endowed the hydrogel with an excellent conductivity of 5.8 S·cm−1. In addition, robust hydrogen bonding was formed between water and phytic acid molecules, and the hydrogel demonstrated remarkable anti-freezing and water retention. On this basis, hydrogels can be used for human winter sports sensing and low-temperature environmental alarm devices to provide faster rescue. This study provides a novel method for the development of hydrogels with low-temperature stability, and provides a revelation for the application of anti-freezing hydrogels in icy and snowy environments.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Medicinal Chemistry
·
2025
·
IF 3.6
Zhenyuan Wang,Mi Wang,Qingsheng Tao,Yufei Li,Hao Wang,Mei Zhang,Xueli Liu,Jiaheng Zhang
Salicylic acid (SA) is a natural lipophilic active ingredient commonly used in cosmetics and skin disease treatments, offering benefits such as exfoliation, anti-inflammation effects, antibacterial properties, oil control, and acne alleviation. However, its poor water solubility, low bioavailability, and potential side effects, such as allergies, irritation, and dryness, hinder its widespread application. In this study, we prepared a betaine–salicylic acid (BeSA) cocrystal and systematically characterized its crystal structure, biological activity, and clinical efficacy. The results showed that BeSA has significantly lower irritancy and cytotoxicity than SA, but exhibits excellent anti-inflammatory and antioxidant properties as well as high moisturizing and anti-acne efficacy, making it a potential alternative to SA. Further, quantum chemical calculations and molecular docking simulations were conducted to investigate the intrinsic mechanisms underlying the excellent bioactivity of BeSA cocrystals. This study introduces an innovative solution for safer and more effective skincare formulations based on SA and offers theoretical guidance regarding material engineering and further material optimization, which has crucial implications for both industry and academia.
研究领域:
化妆品科学
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药物化学
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材料工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2021
·Vol. 9
·期 39
·22615-22625
·
IF 12.732
Qin Zhang,Xin Liu,Jiawei Zhang,Lijie Duan,Guanghui Gao
Conductive hydrogels with anti-freezing and moisturizing properties have attracted huge attention for application in flexible electronics, which can work stably in harsh environments. However, it is challenging and urgent to enhance the environmental adaptability of hydrogels, while maintaining high conductivity. Here, a highly conductive hydrogel featuring remarkable freezing resistance and moisture-holding ability is fabricated via incorporating phytic acid (PA) into polyacrylamide/chitosan hydrogels. The addition of PA not only endows the hydrogels with a marvelous conductivity of 0.105 S cm−1 due to the ionization of PA, but also promotes their antibacterial properties against Gram-negative bacteria and Gram-positive bacteria. Besides, based on the strong hydrogen bonding between PA and water molecules, the hydrogels exhibit excellent flexibility and great conductivity (0.041 S cm−1) at −20 °C and could function well after storage for 15 days under ambient conditions. More importantly, the hydrogels can serve as reliable electrodes for electrocardiography (ECG) signal detection. Meanwhile, with the imperceptible strain perceivability (0.1% of strain) and a high gauge factor of 10.87, the hydrogel wearable sensors are capable of precisely monitoring and recognizing both drastic and subtle human motions under diverse working environments. This work provides a novel and promising method for developing flexible wearable electronics with environmental stability.
研究领域:
材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2024
·
IF 4.4
Aili Wang,Xi Ruan,Xuejiao Wang,Yuyu Ren,Chunjiao Shen,Kaiyi Zhang,Zhenjie Song,Bai Xiang,Yinling Ma,Feng Zhao
Diabetic ulcers present a formidable obstacle in diabetes management, typically leading to high mortality and amputation rates. To overcome traditional monotherapy drawbacks, We developed a novel microneedle strategy for combined antimicrobial action: ingeniously integrating quercetin with Platelet-derived Growth Factor-BB(PDGF-BB) and Sucrose Octasulfate(SOS) into the microneedle system(QPS MN). This method allows to penetrate through biofilms, administering quercetin nanocrystals and PDGF-BB deep into the tissue to combat microbial infection, mitigate inflammation, and promote angiogenesis. The accompanying backing material contains SOS, which absorbs wound exudate and forms a dressing that provides a moist environment for wound healing In an in vitro wound-scratch assay demonstrated that co-cultivating Human Umbilical Vein Endothelial Cells(HUVEC) with QPS MN for 48 h (90.3 ± 2.51 %) significantly enhanced cell migration compared to the control group (20.2 ± 1.41 %). Moreover, treatment of streptozotocin-induced diabetic wounds in rats with QPS MN for 14 days resulted in a wound healing rate of 96.56 ± 3.44 %, far surpassing the healing rate of only 40.34 ± 7.26 % observed in the untreated control group. Furthermore, the QPS MN treated wounds exhibited a notable increase in skin appendages and neovascularisation, indicating promising potential for achieving complete wound healing. These results suggest that QPS MN may offer substantial therapeutic benefits for addressing diabetic wounds.
研究领域:
生物医学工程
·
药剂学
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组织修复与再生
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE RESEARCH
·
2025
·
IF 2.5
Yu Yi,Qingying Chen,Ye Zhou,Jianfeng Mei,Yanlu Zhang,Bailong Wang,Guoqing Ying
This study aims to develop an excellent pharmaceutical excipient based on crosslinked hydroxyethyl chitosan (G-HECTS(GA)), designed to exhibit high intrinsic viscosity and superior moisture absorption and retention properties for wound healing applications. Hydroxyethyl chitosan (HECTS) was synthesized from chitosan through a derivatization reaction with bromoethanol under alkaline conditions, achieving a maximum solubility of 6.8 ± 0.2 g/100 g water. The HECTS was further crosslinked with glutaraldehyde (GA) to produce G-HECTS(GA). Structural characterization of the product was performed using Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Key parameters, including crosslinker dosage, reaction time, temperature, and stirring speed, were optimized to evaluate their effects on intrinsic viscosity. The physicochemical properties and wound healing efficacy of G-HECTS(GA) were systematically assessed in a rat wound model. Under optimal conditions (35°C, 25 μL GA, 18 h reaction time), the crosslinked product demonstrated an intrinsic viscosity of 1870 ± 70 mL/g, a moisture retention rate of 39% ± 3% , and a moisture absorption rate of 39.1% ± 0.7% . G-HECTS(GA) rapidly formed a stable film on wound surfaces, effectively absorbing exudates and promoting wound healing. The material exhibited excellent stability, biocompatibility, and antibacterial activity, along with significant anti-inflammatory effects. These properties highlight the potential of G-HECTS(GA) as a high-performance pharmaceutical excipient for hemostatic spray formulations, offering a promising solution for mucosal wound repair and related biomedical applications.
研究领域:
药学
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生物材料
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医学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·
IF 2.7
Wei Lu,Liman Liu,Jinliang Li,Yunlong Chen,Jinhu Li
The poor plasticity of coal results in a large amount of dust during the mining process, thereby posing a significant impact on mine safety and the health of workers. In order to address this issue, a method has been proposed to suppress dust by enhancing the plasticity of coal through injecting a reactive material, which forms a colloid within the coal. The results implicated that the self-active colloidal dust suppressant, composed of sodium alginate, gluconolactone, calcium disodium EDTA, and sodium dodecyl sulfate, effectively improved the moisture content of coal seams and decreased the brittleness of coal. Scanning electron microscopy and specific surface area test revealed that the dust suppressant not only tightly adheres to the surface of the coal after the reaction, but also penetrates the coal pores and forms a colloid on both the inner and outer surfaces of the coal. The material is rich in carboxyl and hydroxyl groups, which forms hydrogen bonds with the carboxyl and hydroxyl groups present in coal. This interaction enhances the toughness of coal. Simultaneously, it has the ability to adsorb water and function as a moisturizer. The combined synergistic effect of these mechanisms fundamentally reduces dust production during the coal mining process.
研究领域:
矿业工程
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材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Na Wu,Zhicheng Ye,Kangfu Zhou,Feifei Wang,Cheng Lian,Yazhuo Shang
Liquid crystal emulsion is a new type of emulsion, in which the emulsifier molecules are located at the oil/water (O/W) interface and form a long-range ordered and short-range disordered lamellar liquid crystal. The lamellar liquid crystal formed by the emulsifier is similar to the skin stratum corneum lipid structure, which enables it to have a broad application prospect in the fields of cosmetics, pharmaceuticals, etc. In this work, a liquid crystal nanoemulsion was obtained by passing a liquid crystal emulsion stabilized by hydrogenated lecithin and phytosterol combination through a microfluidizer. The microstructure of the prepared liquid crystal nanoemulsion was investigated experimentally by dynamic light scattering, transmission electron microscopy, and small-angle X-ray scattering. The results have shown that the nanoemulsion inherited the liquid crystal emulsion property, namely, the long-range ordered and short-range disordered lamellar structure still existed at the oil/water interface even though they underwent extrusion, friction, and acceleration. At the same time, the underlying mechanisms of the existence of lamellar liquid crystal between the oil phase and the water phase for the nanoemulsion were explored theoretically by molecular dynamics simulations. The simulation results elucidated that the hydrogenated lecithin and phytosterol combination improved the flexibility of the bilayer structure composed of emulsifiers. The bilayers were the basic structure units of lamellar liquid crystals, and thus, the improved flexibility of bilayers provided insurance for the existence of lamellar liquid crystals with larger curvature around the oil droplets. In addition, the applicable properties of liquid crystal nanoemulsion were studied, and the results have shown that the liquid crystal nanoemulsion presented better slow-release and moisturizing properties than traditional nanoemulsions due to the existence of multilayers between oil and water phases. This work not only provides necessary information for the development and effective application of liquid crystal emulsions but also is helpful for in-depth understanding the inner properties of lamellar liquid crystal at molecular level.
研究领域:
化妆品科学
·
药学
·
材料科学
·
分子动力学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2022
·
IF 6.978
Lilong Cao,Zhijie Zhao,Junjie Li,Yunfeng Yi,Yuping Wei
Strong mechanical performance, appropriate adhesion capacity, and excellent biocompatibility of conductive hydrogel-based sensors are of great significance for their application. However, conventional conductive hydrogels usually exhibit insufficient mechanical strength and adhesion. In addition, they will lose flexibility and conductivity under subzero temperature and a dry environment owing to inevitable freezing and evaporation of water. In this study, a tough, flexible, self-adhesive, long-term moisturizing, and antifreezing organohydrogel was prepared, which was composed of gelatin, zwitterionic poly [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) (PSBMA), MXene nanosheets, and glycerol. Natural gelatin was incorporated to enhance mechanical performance via the entanglement of a physical cross-linked network and a PSBMA network, which was also used as a stabilizer to disperse MXene into the organohydrogel. Zwitterionic PSBMA endowed the organohydrogel with good adhesion and self-healing properties. Long-term moisturizing properties and antifreeze tolerance could be achieved owing to the synergistic water retention capacity of PSBMA and glycerol. The resulting PSBMA–gelatin–MXene–glycerol (PGMG) organohydrogel exhibited high mechanical fracture strength (0.65 MPa) and stretchability (over 1000%), excellent toughness (3.87 MJ/m3), strong and repeated adhesion to diverse substrates (e.g., paper, glass, silicon rubber, iron, and pig skin), good fatigue resistance (under the cyclic stretching–releasing process), and rapid recovery capacity. Moreover, the PGMG organohydrogel showed good stability under −40 °C. The sensor based on PGMG organohydrogel could tightly attach to the human skin and real-time-monitor the motions of joints (e.g., bending of the finger, wrist, elbow, and knee) and the change in mood such as smiling and frowning. Therefore, PGMG organohydrogels have a huge potential for wearable sensors under room temperature or extreme environments.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2023
·
IF 8.4
Jiawei Lu,Xiaokun Fan,Jiawei Hu,Jie Li,Jingjing Rong,Weijia Wang,Ying Chen,Wenyong Liu,Jin Chen,Yi Chen
The main limit of hydrogel used as an independent wound dressing is its poor water retention, brittleness, and weak skin adhesion. Focusing on it, the macromolecular cross-linked chitosan and polyacrylamide double network hydrogel (C-A) is chosen as a functional layer, another robust poly(vinyl alcohol)-polyacrylamide/glycerin (P-A) protective layer is designed to cover its surface, an interfacial reaction happens to link two layers tightly for achieving the function synergy. In this double-layer hydrogel (DH) dressing, the surface P-A layer with strong water locking ability could keep the wound surface moist for a long time, high strength and toughness make the dressing maintain integrity under large deformation and stress to strengthen wound protection, and the C-A layer with modest adhesion ensures the dressing fit the skin, the synergistic swelling ability could guarantee the fast absorption for the wound exudate. Moreover, in vitro and in vivo tests, the DH dressing exhibits excellent antibacterial and cytocompatibility, it could significantly accelerate skin tissue regeneration and wound closure than the commercial hydrocolloid dressings. In general, this DH dressing is easy to prepare and shows superior comprehensive performance, revealing the great potential for use as an independently applied wound dressing.
研究领域:
生物材料
·
医学工程
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
FITOTERAPIA
·
2023
·
IF 3.4
Dan Huang,Fanghua Li,Anquan Yang,Jing Wang,Min Xie,Meiling Mao,Jing Li,Xiaoli Zhang,Qingli Qu,Ranhua Xiong,Chaobo Huang
The study on the extraction conditions, purification, and biological activity of slash pine ( Pinus elliottii. ) is important for the development of slash pine resources. The optimal process conditions for the extraction of slash pine polysaccharide (SPP) were determined, resulting in a liquid-solid ratio of 66.94 mL/g, extraction temperature of 83.74 °C and extraction time of 2.56 h by using the response surface methodology, and the yield of SPP was 5.99% under the optimized conditions. Following the purification of SPP, the SPP-2 component was obtained and its physicochemical properties, functional group composition, antioxidant capacity, and moisturizing capacity were determined. Structural analysis suggested that SPP-2 has a molecular weight of 118.407 kDa, and was composed of rhamnose, arabinose, fucose, xylose, mannose, glucose, and galactose in a ratio of 5.98: 14.34: 1: 1.75: 13.50: 3.43: 15.79. The antioxidant activity analysis showed that SPP-2 has good free radical scavenging activity, and it was also found to have in vitro moisturizing activity and low irritation. These results suggest that SPP-2 has the potential for applications in the pharmaceutical, food, and cosmetic industries.
研究领域:
林业
·
生物化学
·
药学
·
化妆品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）