ACS Sensors
·
2025
·
IF 9.1
Xiao Ma,Rong Tan,Hong Chen,Jiawei Zhang,Lei Ge,Tingting Zhao,Xinyu Wang,Kaikai Yuan,Hairui Fang,Dong Wang
Nitrogen dioxide (NO2), the main component of pollutants in atmospheric environments, causes and exacerbates respiratory diseases, especially during outdoor sports even at the 100 ppb level. Currently, environmental gas detection still faces challenges such as high detection limits, low SNR, and low sensitivity. A NO2 sensor based on In(OH)3-α-Fe2O3–ZnO was prepared using a hydrothermal method, featuring an ultralow detection limit of 82 ppt, an exceptionally high SNR of 574,000, and an ultrahigh sensitivity of 252.25 mV/ppm (100 ppb to 1 ppm). And this sensor exhibits excellent response, selectivity, and repeatability. These excellent sensing characteristics come from the adsorbed oxygen on the surface of the material with the formation of n–n heterojunctions. Additionally, a low-power, portable, and cost-effective environmental monitoring system (named Smart Breath Sentinel (SBS)) was designed to intelligently upgrade ordinary masks. SBS enables real-time wireless environmental gas monitoring with integrated humidity compensation to ensure accurate measurements in high-humidity environments. SBS has already been tested in multiple environments, and the test results have proven the feasibility of SBS. This sensor based on In(OH)3-α-Fe2O3–ZnO demonstrates significant potential for applications aimed at enhancing human safety.
研究领域:
环境科学
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材料科学
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传感技术
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Wenxin Fan,Xiaohui Zhang,Huilin Cui,Chunzhao Liu,Yanhui Li,Yanzhi Xia,Kunyan Sui
Ionic hydrogel-based resistance strain sensors (IRS-sensors) powered by direct current (dc) enable various wearable applications. However, the unclear signal transmission mechanism causes significant difficulty to solve the problem of their weak detection ability for subtle strain changes. Here, we have conducted a combined theoretical and experimental study to demonstrate that the signal transmission of dc-powered IRS-sensors is determined by the electrochemical redox process. The slow H+ reduction rate and chemical component change within the hydrogel account for their low sensitivity and signal-to-noise ratio (SNR). To address such a challenge, we have introduced Cu2+ into the hydrogels to enhance the cathodic reduction rate and the chemical stability of the IRS-sensors. The as-prepared IRS-sensors show high sensitivity, ultrahigh SNR, and excellent sensing reliability. Besides the inherent ultrawide sensing range (>1500%), the IRS-sensor can also provide recognizable electrical responses to the incredibly small strain (0.005%), which is 2 orders of magnitude lower than previous ones. They demonstrate precise and reliable monitoring for full-range human activities. This new strategy can be easily extended to other ionic hydrogels and electrodes as well as self-driving electrochemical electrodes for the fabrication of various high-performance self-powered IRS-sensors.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2022
·Vol. 10
·期 15
·8195-8207
·
IF 14.511
Zhen Su,Yushu Li,Jiguang Li,Kun Li,Xincun Dou
The accurate, ultrasensitive and rapid onsite analysis of perchlorate either in water, soil or air is urgently needed for public security checking, explosive ordnance disposal, environment monitoring and forensic analysis. To achieve it, a Pt(II) terpyridyl complex-based sensing platform that can realize the onsite ultrasensitive, colorimetric and luminescent dual-mode, rapid and direct detection of perchlorate in water, soil and air was successfully developed by systematic molecular design. The high-contrast color change from pale-yellow to purple-red and turn-on mode red luminescent emission can greatly eliminate environmental fluctuations and background autofluorescence, thus enabling the detection of perchlorate more accurately, discriminatively and efficiently even in a complex environment. The excellent water-solubility of the Pt(II) terpyridyl complex and the introduction of the hydrogel matrix largely enhance the sensing capacity and achieve the direct ultrasensitive detection of perchlorate microparticulates in soil or air, with a limit of detection of 0.45 ng by naked eye and 0.02 fg by common optical microscope. The present study provides a valuable strategy for designing a Pt(II) complex-based sensor with high-contrast color change, high signal-to-noise ratio luminescence, and ultrasensitive detection ability for particulate analytes, which would shine light on the design of high-performance sensing platforms for various analytes.
研究领域:
环境科学
·
分析化学
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2017
·
IF 1.753
Xiaobin Wang,Wenqian Huang,Qingyan Wang,Chen Liu,Chaopeng Wang,Guiyan Yang,Chunjiang Zhao
This study adopted a Raman hyperspectral imaging system to collect the Raman spectra and hyperspectral images of benzoyl peroxide (BPO) additive for subsequent analysis. The raw Raman spectra of BPO were preprocessed by wavelet denoising. Optimal parameters of wavelet denoising were selected by the orthogonal experimental design. The signal-noise (S/N) ratio of the optimal parameter combination was 32.848. The smoothed Raman spectra were divided into three regions (1900–1300, 1300–700, and 700–100 cm −1 ) for assignment and the band vibrational modes of BPO molecule were obtained. Wherein, the Raman bands at 1771, 1597, 1230, 999, 889 and 845 cm −1 are higher than others, and can be used as the Raman characteristic bands. Analysis of the grayscale images corresponding to different characteristic bands, it is found that the order of change of the image gray level was consistent with characteristic bands intensity. Findings of this study provide the research basics for the detection and analysis of BPO additive.
研究领域:
分析化学
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光谱学
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材料科学
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产品关联
DOI
高影响因子
ANALYST
·
2022
·Vol. 147
·期 24
·5623-5632
·
IF 5.227
Jiahai Wang,Le Luo,Yunhui Li,Lanfang Chen,Cenlin Gui,Jianji Zhu,Huizhen Li,Wenlong Wang,Daqi Chen
Solid-state nanopores have been proven as a powerful platform for label-free single-molecule analysis. However, due to its relatively low resolution and selectivity, developing biosensors with good translocation signals faces two significant challenges: (1) small-sized chemical or biological targets show difficulty in producing recognizable translocation signals because of their weak interaction with the nanopore and (2) protein interferents that widely exist in biological samples or buffers would considerably deteriorate the noise level of the nanopore, submerging the translocation signal. Herein, we demonstrate an effective way to overcome both the challenges. DNA cubes were used as signal transducers that can achieve an ultra-high (>50 : 1) signal-to-noise ratio (SNR) translocation signal, which is maintained even in protein interferent-rich buffers. A sensing strategy was constructed via hepatitis B virus (HBV) target-triggered cleavage of the component elements of the DNA cube with the assistance of the CRISPR–Cas12a technology, which caused a great drop in the translocation rate. The elements to cleave were optimized, and the sensor performance was tested in different protein stabilizer-rich buffers and human serum. Coupling with the polymerase chain reaction (PCR) pre-amplification technology, HBV-positive or -negative classification was achieved with the detection limit reaching 5 aM. It is worth noting that in our method, all reaction buffers were directly used without further optimization, which is of great help for the practical application of solid-state nanopores.
研究领域:
生物技术
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纳米技术
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分子生物学
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病毒学
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产品关联
DOI
PubMed
高影响因子
OPTICS AND LASERS IN ENGINEERING
·
2020
·
IF 4.273
Weicheng Cai,Hui Huang,Zhibo Yang,Ruichen Shang,Xuejing Li,Chi Ma,Jian Zhao,Pengbo Liu,Jian Wang,Wei Wang
For laser-induced fluorescence (LIF), the SNR and related concentration detectability was severely limited by background signal (noise). Herein, an axial-excitation LIF based on pinhole metal-capillary (PMC) and direct laser-diode excitation was proposed. An overall ~480 fold improvement on SNR was realized, because the laser-sidewall interaction ( LSI ) and related background signal (noise) can be effectively suppressed in PMC by avoidance of laser leakage and laser contact with capillary sidewall. For rhodamine B detection without sample enrichment, a detection limit of concentration (DLC) of 0.4 pM was obtained, which is 2.5 fold lower than the DLC (1 pM) of commercial LIFs equipped with bulky and expensive Ar + laser. For selective detection of Cu 2+ , a DLC of 5 pM was realized, which is more than 40 fold lower than that of previous fluorimetry detection with similar quantum-dot probe. The PMC-LIF features compact (16 × 4 × 4 cm 3 ), low-cost and high concentration detectability.
研究领域:
分析化学
·
生物医学工程
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DOI
高影响因子
OPTICS AND LASER TECHNOLOGY
·
2024
·
IF 4.6
Junjuan Shang,Mengmeng Sun,Hongfang Song,Junya Ma,Wei Zhang,Huinan Huang,Zhihua Yuan,Jiandong Hu,Mengjiao Zhang,Muhammad Awais
In this study, we propose a approach that nanoparticles enhanced double-pulse laser-induced breakdown spectroscopy (DP-LIBS). We also compare the effects of nanoparticles on pre-ablation and reheating orthogonal DP-LIBS. The aim is to improve the sensitivity, signal-to-noise ratio (SNR), and repeatability of LIBS emission spectra, which are inadequate for detecting of complex matrix samples. Gold nanoparticles (AuNPs) are synthesized chemically. The spacing between particles,which significantly influences spectral enhancement, is controlled by adjusting the AuNPs solution concentration applied to the Al surface. The optimal concentration is determined to be 0.168 mg/ml. We examined the impact of laser pulse energy, the interval delay time between two laser pulses, and detector gate delay time on the enhancement effect. Under optimum conditions, The SNR and Relative Standard Deviation (RSD) of both DP-NELIBS and DP-LIBS are Evaluated. Our findings real that reheating DP-LIBS, in the presence of AuNPs, results in a 1.5-fold to 3-fold increase in enhancement effects, and a 29% improvement in SNR. However, the presence of NPs in the pre-ablation structure slightly reduces performance. Overall, reheating DP-NELIBS can enhance sensitivity and lower detection limits through nanoparticle methods, thereby improving the accuracy of complex matrix samples.
研究领域:
分析化学
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光谱学
·
材料科学
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Guangyuan Dong,Yunsong An,Peikai Yan,Jiahui Wu,Chao Li,Tao Liu
Telomerase is a potential tumor biomarker, which is overexpressed in various types of tumor cells. Herein, we describe a zeta potential-based assay for homogeneous and amplified detection of telomerase activity. To do so, a peptide nucleic acid-modified antifouling nanocomplex (PNA-ANC) and ultralong DNA chains are prepared. In the presence of telomerase, the enzyme will add telomeric sequences on its substrates attached on the DNA chains. Thus, the DNA chains can specifically bind to PNA-ANCs via PNA-DNA hybridization, which brings thousands of negatively charged nucleotides on the ANCs and results in dramatic potential change. Combination of zwitterionic PNA-ANCs and highly negatively charged DNA chains, the signal-to-noise ratio of this assay is significantly improved, allowing amplified detection of telomerase with a limit of detection of 3 nasopharynx cancer cells. Moreover, thanks to the potential technique and prefabricated DNA chains, the detection procedure is simple and time-saving, making it potential to be a technological innovation in the field of telomerase analysis.
研究领域:
癌症生物学
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分子诊断
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纳米技术
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生物物理学
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产品关联
DOI
高影响因子
Nature Protocols
·
2020
·Vol. 15
·期 10
·3499-3526
·
IF 10.419
Tang Yonghe,Zhao Yuping,Lin Weiying
Formaldehyde (FA) is the simplest active carbonyl species that can be spontaneously produced in the body and plays important roles in human cognitive ability and spatial memory. However, excessive intake of FA may cause a series of diseases, including cancer, diabetes, heart and liver diseases and various neuropathies. Hence, the exploration of sensitive and fast detection methods for FA is crucial to understand and diagnose these diseases. Recently, fluorescent probes have been increasingly employed as powerful tools for detecting a broad range of different small molecules due to their high selectivity, rapid response, convenient operation and relatively non-invasive nature. Thus, we have developed two naphthalimide-based fluorescent probes for detecting FA in cells and in lysosomes. Compared with other FA fluorescent probes, these two probes have several advantages, including high sensitivity and selectivity, excellent two-photon properties and high signal-to-noise ratio. In this protocol, we provide detailed procedures for the synthesis of the two probes; characterization of their sensitivity, selectivity and stability in solution; and representative application procedures for detecting FA in living cells and mouse liver tissue slices. The protocol requires ~88 h to synthesize the probes, ~24 h to characterize the probes in solution and ~25 h to carry out the biological fluorescence imaging experiments in cells and liver tissue slices.
研究领域:
生物化学
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细胞生物学
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分析化学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
Nano Energy
·
2021
·
IF 17.881
Wei Xu,Jiayi Yang,Shuangshuang Liu,Yan Meng,Di Feng,Lingjie Jia,Sida Liu,Baolong Wang,Xiuhan Li
Liquid-solid triboelectric nanogenerator (LS-TENG) has emerged as a powerful tool in energy harvesting and motion detecting. There is a recognized need for improving the power output and signal-to-noise ratio of LS-TENG. The instantaneous discharging mechanism of LS-TENG is studied and experimentally realized by a controllable switch structure in this paper. The peak short circuit current and peak power output (at 1 MΩ) are increased by over 26 and 1700 times, respectively, with respect to the control LS-TENG working in the single electrode mode. This research provides a fresh insight in designing sensors with high signal-to-noise ratio and energy harvestors that have a superior performance in driving devices with low load resistance.
研究领域:
纳米技术
·
能源工程
·
材料科学
·
电气工程
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2023
·
IF 12.6
Longshua Qin,Ting Huang,Hanfeng Cui,Mengqing Cheng,Guobing Wei,Fusheng Liao,Wei Xiong,Hedong Jiang,Jing Zhang,Hao Fan
Herein, an fluorescence (FL)−electrochemiluminescence (ECL) dual-mode biosensor is constructed based on the dual-signal “turn-on” strategy of functionalized metal-organic frameworks nanosheets (RuMOFNSs)-tetraferrocene for K-ras gene detection, and the mechanism of bursting through front-line orbital theory is explained for the first time. Amino-functionalized tetraferrocene-labeled probe DNA molecules are linked to RuMOFNSs by covalent amide bonds, acting as FL and ECL intensity switches. The target DNA, complementary to the probe DNA, triggers cyclic amplification of the target by nucleic acid exonuclease III (Exo III), repelling tetraferrocene reporter groups away from RuMOFNSs and inhibiting the electron transfer process and photoinduced electron transfer (PET) effect. These phenomena induce a double turn-on of FL and ECL signals with a high signal-to-noise ratio. The developed FL-ECL dual-mode sensing platform provides sensitive detection of the K-ras gene with detection limits of 0.01 fM (the detection range is 1 fM to 1 nM) and 0.003 fM (the detection range is 0.01 fM to 10 pM), respectively. In addition, the proposed dual-mode sensor can be easily extended to detect other disease-related biomarkers by changing the specific target and probe base sequences , depicting potential applications in bioanalysis and early disease diagnosis.
研究领域:
生物化学
·
分析化学
·
生物技术
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Yan Liu,Shengbo Chen,Lichen Shi,Shuaijian Yang,Junrui Zhang,Chenqi Liu,Jinhao Cheng,Jiajie Shi,Chenxi Shen,Dongfeng Gu,Xingyu Jiang
Flexible wearable electrodes play a critical role in establishing a stable and high-performance skin-device interface for human health monitoring. However, the signal quality of conventional electrodes is significantly compromised by sweat-moistened skin, leading to a reduced signal-to-noise ratio (SNR) and limiting their capacity for long-term monitoring. To solve this problem, a sweat-adaptive polymer electrode PEDOT:PSS-PMVEMA (PPMA) is proposed, which demonstrates superior adhesion properties compared to conventional electrodes, with a vertical peel-off strength of ≈60 N/m. Unexpectedly, the adhesion of PPMA electrodes improves upon wetting with water. The shear strength between the PPMA material and porcine skin can be tuned within the range of 5.1 to 12.7 kPa by adjusting the amount of added water, thereby enhancing their adaptability to perspiration while preserving a stable SNR. The PPMA electrode patch can be customized in size and shape to suit different recording tasks, including electroencephalography, electrocardiography, and electromyography. Combined with an in-house developed wireless recording system, these three most widely used and clinically significant physiological signals can be tracked continuously with high quality for up to 12 h. In the future, PPMA holds great potential for applications in telemedicine and smart healthcare.
研究领域:
生物医学工程
·
柔性电子学
·
生理传感
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转化医学
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智能健康监测
·
表皮电子器件
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）