ENVIRONMENTAL POLLUTION
·
2025
·
IF 7.3
Minyi Huang,Wentao Huang,Renyan Duan,Yingfeng Huang,Yongqiang Xia
Baicalein has pharmacological functions, such as antioxidant and anti-inflammatory properties, and has been shown to alleviate damage to organs caused by environmental pollutants. However, the mechanism by which baicalein reduces the toxic effects of metals needs further research. This study used Pelophylax nigromaculatus tadpoles as a model to explore the toxicological effects of lead (Pb) on the gut-liver axis, and the mechanism by which baicalein alleviates lead toxicity. Analysis of the gut microbiota showed that baicalein alleviated abnormal changes in the gut microbiota following Pb exposure, mainly by increasing the abundance of beneficial bacterial genera, including Cetobacterium , Clostridioides , and Monoglobus . Liver metabolomics showed that compared to a natural recovery, baicalein treatment significantly increased the content of metabolites such as uridine, 17α-hydroxypregnenolone, niacin, and cucurbitacin E, and significantly reduced the content of metabolites such as linoleic, gluconic acid, and tetrahydrocortisone. These differential metabolites could be enriched in pathways such as pyrimidine metabolism, nicotinic acid and nicotinamide metabolism, and steroid hormone biosynthesis, which were beneficial for the treatment of liver injury. There was a significant correlation between the gut microbiota and the main differential metabolites in the liver with the addition of baicalein. The improvement of these metabolic pathways by baicalein is beneficial for the repair of the liver and intestines. Therefore, baicalein can increase the abundance of beneficial gut microbiota, improve liver metabolism, and thus reduce the damage of Pb exposure to the gut-liver axis.
研究领域:
环境毒理学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Scientific Reports
·
2016
·Vol. 6
·期 1
·1-10
·
IF 5.228
Huang Wuren,Zhang Jie,Yang Bing,Beerntsen Brenda T.,Song Hongsheng,Ling Erjun
Invertebrate animals have the capacity of repairing wounds in the skin and gut via different mechanisms. Gastrointestinal perforation, a hole in the human gastrointestinal system, is a serious condition and surgery is necessary to repair the perforation to prevent an abdominal abscess or sepsis. Here we report the repair of gastrointestinal perforation made by a needle-puncture wound in the silkworm larval midgut. Following insect gut perforation, only a weak immune response was observed because the growth of Escherichia coli alone was partially inhibited by plasma collected at 6 h after needle puncture of the larval midgut. However, circulating hemocytes did aggregate over the needle-puncture wound to form a scab. While, cell division and apoptosis were not observed at the wound site, the needle puncture significantly enhanced DNA duplication in cells surrounding the wound, which was essential to repair the midgut perforation. Due to the repair capacity and limited immune response caused by needle puncture to the midgut, this approach was successfully used for the injection of small compounds (ethanol in this study) into the insect midgut. Consequently, this needle-puncture wounding of the insect gut can be developed for screening compounds for use as gut chemotherapeutics in the future.
研究领域:
昆虫学
·
医学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2022
·
IF 7.693
Yanxuan Ma,Yajie Ge,Rui Wu,Hao Huang,Gaixin Chen,Yao Xu,Jiatong Liu,Peng Zhang,Fang Xiao
The force-chloride ion triggered microcapsules with PbSO 4 embedded on the wall material were successfully synthesized by a two-step interfacial polymerization method. The structure and properties of the microcapsules were characterized, and the self-healing properties of cementitious composites were studied from the aspect of mechanical properties. The results showed that the microcapsules synthesized are suitable in morphology, the average particle size being 53.8 μm. Fourier Transform Infrared Spectrometer (FT-IR) showed that the structure of the microcapsule with double-core and double-walled has been formed. Scanning Electron Microscopy (SEM) and Energy Dispersive Spectrometer (EDS) confirmed that PbSO 4 was successfully embedded on the capsule wall, and the microcapsules were suitable in the performance triggered by force-chloride ion. Moreover, the strength recovery rate of cementitious composites with 3% microcapsules could gain up to 84%. The microcapsules can survive in the cement mixing process and be evenly distributed in the matrix. Digital Speckle Correlation Method (DSCM) was used to track the deformation behaviors of self-healing cementitious composites during the loading procedure, obtaining the self-healing mechanism based on filling cracks, limiting cracks’ development, and healing cracks from the variation of stress–strain, distribution of strain field and eigenvalue St C and Sts.
研究领域:
土木工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CEMENT & CONCRETE COMPOSITES
·
2025
·
IF 13.1
Yanxuan Ma,Shuaifei Wang,Meiyu Li,Gongbin Wang,Jiatong Liu,Yuhua Gao,Peng Wang,Zhipeng Zhang
The performance of microcapsules in terms of “chloride response” and their electrochemical remediation mechanism is investigated. Electrochemical testing methods are used, i.e., kinetic potential polarization and electrochemical impedance testing. The variation rules of corrosion behavior of self-healing cementitious composites with different contents of microcapsules, both intact and pre-damaged, were investigated in a chloride ion environment. Based on this, the equivalent circuit change model is established. By fitting the parameters of the circuit elements, the change rule of the fitted parameters of the circuit elements is derived. To analyze the internal changes of self-healing cementitious composites in the corrosion process, and to reveal the self-healing mechanism of self-healing cementitious composites on the protective effect of its internal steel reinforcement. It was shown that the corrosion current density could be reduced as low as 0.87 μA/cm 2 for the intact samples immersed for 3 days and as low as 1.95 μA/cm 2 for damaged samples. The self-healing cementitious composites remained protective of the internal reinforcement after 56 days of immersion; Studies on the electrochemical self-healing mechanism have shown that microcapsules improve corrosion protection based on increasing the electrical resistivity of cementitious composites. The addition of 9 wt% microcapsules provided up to 39.16 % restoration efficiency at 56 days of immersion, and the restoration efficiency increased to up to 55.62 % in response to the combination of cracks and chloride ions. The microcapsules act together through mechanical and chloride ion response to retard the corrosion rate of steel reinforcement inside the self-healing cementitious composite by protecting the reinforcement passivation film.
研究领域:
土木工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Anyao Ma,Guanglin Wang,Zhenglong Yang,Liangjiu Bai,Hou Chen,Wenxiang Wang,Huawei Yang,Donglei Wei,Lixia Yang
Janus nanomaterials can be highlighted to design a series of smart materials with the remarkable characteristic of two different properties or constituents. In this manuscript, functional Janus graphene oxide-type (GO-type) nanomaterials were fabricated by Pickering emulsion template and successfully applied to develop of dual self-healing nanocomposite hydrogels. Asymmetric functionalization of Janus nanosheets were achieved in typical oil-in-water Pickering emulsion by atom transfer radical polymerization (ATRP) and mussel-inspired chemistry. Poly(2-(acryloyloxy)ethyl ferrocenecarboxylate) (PMAEFc) and polydopamine (PDA) were unsymmetrically grafted on the two sides of GO (Janus GO-PMAEF/PDA (JGNs)), which successfully applied in self-healing nanocomposite hydrogels. The collaborative effect of metal-ligand coordination and host-guest interaction make the dual self-healing hydrogels have excellent self-healing properties (self-healing efficiency can reach to 93.4% within 1 h) and mechanical strength (tensile strength of 0.94 MPa and strain of 508.5%). Therefore, these chemical asymmetric JGNs have outstandingly application prospect in the development of smart materials.
研究领域:
材料科学
·
化学工程
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2018
·Vol. 2019
·期 1
·51-58
·
IF 2.507
Hangle Guo,Tongguang Ge,Jian Lv,Changlin Du,Jian Zhou,Zhicheng Liu,Zile Hua
Graphical A facile and eco-friendly mesoporogen-free steam-assisted crystallization strategy has been developed for the synthesis of hierarchically structured ZSM-5 zeolites with superior MTP catalytic performance, and a new “in situ alkali etching-hydrothermal restoring“ mechanism is discussed. A series of hierarchically structured ZSM-5 zeolites (ZSM-5 HSZs) with a Si/Al ratio of about 200 have been successfully synthesized in the absence of additional mesoporous agents. XRD, N 2 sorption isotherms, SEM, TEM and NH 3 -TPD results showed that the obtained HSZs materials possess high crystallinity, interconnected micro/mesoporous structures and similar total acid amounts. Meanwhile, in the methanol-to-propylene (MTP) reaction, compared to the microporous counterpart, all synthesized ZSM-5 HSZs demonstrated superior performance benefitting from their hierarchical porous structures. Interestingly, 27 Al MAS NMR and Py-FTIR results confirmed the inter-transformation of framework and extra-framework Al species with the extension of materials crystallization duration and consequently the variation of materials surface acidity. As a result, the optimized catalyst achieved the highest initial propylene selectivity of 54.4 % and the longest catalyst lifetime ( t 90 ) of 175 h under the weight hourly space velocity (WHSV) of 1.0 g g –1 h –1 . Moreover, a new “in situ alkali etching-hydrothermal restoring“ mechanism has been proposed to elucidate the structural evolution of here reported high-silica ZSM-5 HSZs during the synthesis.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
MINERALS ENGINEERING
·
2022
·
IF 5.479
Huizhen Xiao,Guifang Wang,Guangchuan Liang,Jinliang Zhu,Jun Qiu,Chenhui Ding,Sridhar Komarneni
The mining and processing of lead-zinc ores produce many lead-zinc ore tailings, which can cause harm by releasing toxic metal ions to the environment. Therefore, the leaching characteristics, acid generation capacity, and fractions of released heavy metals from two Pb-Zn tailings, one from Guangxi designated as F and another from Inner Mongolia designated as YD, have been investigated in this work. Here, sodium diethyl dithiocarbamate functionalized montmorillonite (DDTC-Mt) was synthesized to remediate both F and YD tailings. It was found that YD tailings have a stronger acid generation potential than F tailings, and both of them could be further oxidized and release acid. Moreover, YD showed a certain buffering capacity to acid rain due to its higher calcite content, while the leaching amounts of heavy metals from F was larger than YD resulting from the former’s higher weathering degree. DDTC-Mt resulted in a superior stabilization performance to Zn, Mn and Pb from both tailings with optimal stabilization ratios, which are all above 94%. The remediating effect of DDTC-Mt on F was better than that of YD, which could be ascribed to the fact that F contained lower amount of carbonate minerals because of a higher degree of weathering in the latter. The leaching amounts and stabilization ratios of the four elements increased with increasing time and dose of DDTC-Mt, however, temperature and pH showed little or no effect. Mineralogical analysis showed minerals in F and YD before and after leaching were mainly quartz, while the contents of sphalerite and pyrite in F-DDTC-Mt and YD-DDTC-Mt decreased although they were more than those in F and YD without DDTC-Mt after leaching for 72 h. DDTC-Mt could inhibit the release of heavy metals to a certain extent by covering the surface of tailings via complexation and precipitation. Furthermore, DDTC-Mt coating can prevent the oxidation of tailings.
研究领域:
环境科学
·
矿物加工
·
土壤化学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Yang Luo,Yan Song,Jiahui Ma,Jingzhi Yang,Dongxiang Chen,Hanjun Gong,Guo Liang Li
This study presents an intelligent polymer coating material with synergistic healing mechanisms that combine autonomous damage healing and inhibitor release, addressing critical challenges in metal corrosion protection. The synthesized polymer, composed of polythioctic acid incorporating cerium ions, selectively releases corrosion inhibitors and self-heals mechanical damage upon corrosion onset. The cerium ions serve dual roles as corrosion inhibitors and crosslinkers in the polythioctic acid matrix. The damaged coating nearly fully recovered its barrier properties within 12 h without external stimuli, achieving a healing efficiency of up to 94 % in 3.5 wt% NaCl solution. At the end of its service life, the coating could be recycled under mild conditions, achieving a monomer recovery efficiency of 82 %. This study offers a promising corrosion protection strategy that combines sustainability with high performance for harsh environmental applications.
研究领域:
材料科学
·
高分子化学
·
腐蚀防护
·
自修复材料
·
可持续涂层
✓ 已验证
DOI
高影响因子
ChemistrySelect
·
2025
·Vol. 10
·期 28
·e02937
·
IF 2
Yuhua Gao,Gongbin Wang,Meiyu Li,Yanxuan Ma,Qin Chang,Siyuan Wang,Dongying Xu,Shuangyang Fu
Graphical The active groups on the PDA surface interact with the polymer network via reversible hydrogen bonds, imparting self-healing capabilities to the PDA/EP composite. When microcracks emerge, active groups at the fracture interface realign, and “adhesion” is restored through hydrogen bond reformation. Self-healing is achieved through the cleavage and reformation of hydrogen bonds. Thermosetting resins, due to their polymer structure, are easily damaged by mechanical, chemical, thermal, ultraviolet radiation and other factors, inevitably leading to local damage and microcracks difficult to detect, which impair mechanical properties and durability. To improve and test the self-healing properties of epoxy thermosetting resin, a protective coating with self-healing performance, polydopamine (PDA) self-healing modified epoxy resin (EP) composite material, was designed. The self-healing behavior and mechanism were tested and analyzed through tensile properties and digital speckle technology. Nano-PDA particles, synthesized via self-polymerization at pH = 9, exhibited uniform morphology and were incorporated into EP. Tensile performance experiments and digital speckle analysis were carried out on three types of composite materials, namely, PDA/EP, PDA/EP pre-damaged once, and PDA/EP pre-damaged three times. Therefore, 0.5wt%, 1.0wt%, and 1.5wt% PDA/EP composites exhibit varying degrees of reversible self-healing. When the PDA content is 1.0wt%, the strength recovery rate of the composite material reaches 87.1% after one pre damage and still reaches 83.9% after three pre damages. The strain cloud maps in the X and Y directions also indicate that PDA/EP materials can recover the structural stability at a certain degree after being per-damaged once or three times.
研究领域:
材料科学
·
高分子化学
·
纳米技术
·
机械工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Ningning Dong,Bangjun Li,Yue He,Liuxin Chao,Yun Zhu,Lu Liu,Jiongjie Liu,Guobing Ying
This work demonstrates a strategic approach to enhance the thermomechanical performance of Si 3 N 4 /BN composites through interface optimization and control of powder particles. By adding the MgO sintering additive at BN interfaces coupled with 0.5 μm Si 3 N 4 fiber precursor, we achieved full densification with mechanical properties, attaining a density of 3.19 g·cm −3 , the remarkable flexural strength of 627.36 MPa, and fracture toughness of 13.48 MPa·m 1/2 . The composites exhibit exceptional thermal shock resistance, retaining 586.19 MPa (93.44 % retention) after 1000 ℃ thermal shocking, facilitated by in situ formation of a continuous SiO 2 glass barrier that effectively prevents oxidation. Intriguingly, the residual strength shows a trend of first decreasing and then increasing with the increase of Δ T . At Δ T = 1500 ℃, the composite maintains the residual strength of 469.46 MPa (74.83 % retention), outperforming conventional monolithic ceramics through a self-healing mechanism enabled by viscous flow of the glass phase. Microstructural evolution analysis coupled with fracture morphology establishes direct correlations between the interface, mechanical properties, and thermal-shock resistance. These findings provide fundamental insights into designing composites with excellent thermal-shock resistance for ultrahigh-temperature structural applications.
研究领域:
材料科学
·
陶瓷
·
复合材料
·
热力学分析
·
界面工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）