As a widely used semiconductor photocatalyst , TiO 2 has been explored in organic compounds hydrogenation. In this study, the hydrogenation of C=N bonds on the surface of TiO 2 was accomplished for the first time utilizing Cu 2 O/TiO 2 type-II (p-n) heterojunction . The probe reactions, hydrogenation of N -benzylphenylamine with benzyl alcohol, and N -methylation of amines with methanol exhibited that the hydrogenation of C=N bonds on TiO 2 surface can be achieved through borrowing hydrogen reaction (BH, alcohols as hydrogen source). Additionally, the BH reaction rate could be improved by adding external H + to the reaction system. The catalytic activity of Cu 2 O/TiO 2 was discovered to remain at an efficient level even after six reaction cycles.
Mengxuan Bai,Xuetong Zhang,Shengxin Zhang,Caicai Zhang,Zhiqiang Hao,Jin Lin
γ-Amino alcohol is of great importance, as a broad number of bioactive and pharmaceutical alcohols contain this motif. Herein, a selective formal anti-Markovnikov hydroamination of allyl alcohols to access γ-amino alcohols has been achieved by using NNN-pincer Ru complexes. The electronic effect of the catalysts is critical for their catalytic performance. A wide substrate scope (65 examples) and up to 96% yields were achieved at low catalyst loadings via a borrowing hydrogen (BH) process in one pot. This protocol was easily extended to the hydroamination of both primary and secondary allyl alcohols and applications for the synthesis of drug derivatives.
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