EUROPEAN JOURNAL OF PEDIATRICS
·
2017
·Vol. 177
·期 2
·257-264
·
IF 1.921
Li Li,Guo Li,Chen Xingjie,Xiang Mingli,Yang Fang,Ren Jing-chao,Zhang Guang-hui
Secondhand smoke (SHS) has adverse effects on health, particularly for children. Our purpose was to analyze the correlation between SHS exposure and heavy metal concentrations in children. The investigation was conducted in Xinxiang County, Henan Province, China, from August 2015 to December 2015. In total, 821 students (433 boys and 388 girls) were recruited, and the contents of heavy metals in their hair—including chromium, manganese, nickel, arsenic, lead, and cadmium—were detected by ICP-MS. The children’s parents were informed, and a questionnaire was conducted, which included questions about smoking habits and demographic characteristics. Our results indicate that all parent smokers are fathers, 48.9% of fathers who are smokers, but 25.2% of fathers smoke in front of their children. The levels of chromium (median girls vs boys, μg/g) (2.36 vs 2.06, p < 0.001), nickel (1.28 vs 0.97, p < 0.001), arsenic (0.55 vs 0.49, p < 0.001), and lead (2.73 vs 2.16, p < 0.001) in girls were significantly higher than in boys. The levels of cadmium (median, SHS group vs control: 0.43 vs 0.29 (μg/g), p < 0.001) and lead (median, SHS group vs control: 2.71 vs 2.27 (μg/g), p = 0.007) in the SHS group were significantly higher than in the control. Multi-linear regression analysis indicated that SHS exposure in children is very likely to be correlated with increasing levels of lead (β (95% CI): 0.53 (0.99–5.14), p = 0.023) and cadmium (β (95% CI): 0.43 (0.14–0.73), p = 0.003) in their hair. In conclusion, children exposed to SHS have increased lead and cadmium accumulations in the body.
Conclusion : In our study, 821 students (433 boys and 388 girls) were recruited, and the contents of heavy metals in their hair—including chromium, manganese, nickel, arsenic, lead, and cadmium—were detected by ICP-MS. And the secondhand smoking (SHS) exposure was inquired by face-to-face investigation of their parents. We illustrated that children exposed to SHS have increased lead and cadmium accumulations in the body.
What is Known:
• Secondhand smoke (SHS) has adverse effects on health, particularly for children.
• There might be correlation between SHS exposure and heavy metal concentrations in children .
What is New:
• The levels of chromium, nickel, arsenic, and lead in girls were significantly higher than in boys . • SHS exposure in children was correlated with increasing levels of lead and cadmium in their hair because of exposure to SHS .
研究领域:
公共卫生
·
环境医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nutrients
·
2022
·Vol. 14
·期 3
·618
·
IF 6.706
Zhi Huang,Xing Liu,Ziming Li,Luwei Cui,Candi Liu,Weifeng Wang,Yuming Hu,Bo Chen
Background. Minerals play important biological roles in lipid metabolism. The primary aim of this study was to examine the relationships between erythrocyte fatty acids (FAs) levels with whole blood mineral elements concentrations among Chinese children. Methods. A cross-sectional study was conducted. A total of 435 children aged 4–7 years were recruited. Whole blood mineral elements were determined by atomic absorption spectrometry and erythrocyte FAs composition by gas chromatography-mass spectrometer. Results. There were direct correlations between Zn and C18:2n-6 (FDR correctedp= 0.019), total n-6 PUFAs (FDR correctedp= 0.034), and total PUFAs (FDR correctedp= 0.034). Direct correlations were found between whole blood Zn and C18:1n-9 (FDR correctedp= 0.035), C24:1n-9 (FDR correctedp= 0.023), total MUFAs (FDR correctedp= 0.023), and C18:2n-6 (FDR correctedp= 0.048) in the Cu < P50 group. In the Cu ≥ P50 group, Mg was inversely related to most FAs (All FDR correctedp< 0.05). In the Zn < P50 group, Cu was directly related to C24:1n-9, total MUFAs, C20:5n-3, C22:6n-3, total n-3 PUFAs, C20:4n-6, total n-6 PUFAs, total PUFAs, and total FAs (All FDR correctedp< 0.05). Conclusions. Whole blood Cu and Zn levels were directly linked to several FAs levels in the erythrocytes of children. The interactions of Mg, Cu, and Zn with fatty acids may affect FA metabolism, in which Mg influences FA absorption.Keywords:erythrocyte;mineral elements;fatty acids;children
研究领域:
营养学
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生物化学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF TECHNOLOGY AND DESIGN EDUCATION
·
2024
·Vol. 34
·期 5
·1687-1704
·
IF 2
Cai Lu
Based on Folk theory, Media Equation, and AI literacy research, the study constructed an interview outline and selected 72 students in 4th and 5th grade in three primary schools located in the Minhang and Putuo districts of Shanghai (two in the Minhang district and one in the Putuo district) as the study participants for focus group interviews. The study found that the availability of voice interaction is an essential basis for children to judge the level of intelligence of a machine; additionally, chatting is also the starting point for young children to build a close relationship with AI. Although AI cannot replace their friends, it can become a friend to them. While children expect the future of AI to be beyond the current level of intelligence and emotion and to enable the full use of machines in multiple scenarios and various fields, they are also concerned about issues such as privacy breaches that devices may cause in the future and believe that technology should not develop outside of human control.
研究领域:
教育心理学
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人机交互
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儿童发展研究
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DOI
高影响因子
Early Childhood Education Journal
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2024
·
IF 2.3
Li Hui,He Huihua,Luo Wenwei,Li Hui
Early childhood digital pedagogy (ECDP) has been widely implemented and studied, but the empirical evidence has not been systematically reviewed. This scoping review aimed to synthesize the existing studies to understand the practices and profiles of ECDP and the redefined roles of teacher, child, and technology. Thirty-eight studies on ECDP published from January 2010 to October 2024 were collected from three academic databases: EBSCO, Web of Science, and ProQuest. Synthesis of the findings of these studies revealed that: Firstly, digital technologies increasingly hold transformative potential for instructional practices at the level of modification and redefinition based on the SAMR framework. Secondly, play-based, project-based, problem-based, and co-operative and collaborative pedagogy with constructivist tendencies are the trademarks of ECDP. Lastly, in pedagogical interactions, teachers, children, and digital technologies each play diverse roles. This review study sheds some light on the practical characteristics of ECDP, which can inspire the effective designs and implementation of ECDP in the future.
研究领域:
教育学
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学前教育
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教育技术
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数字化学习
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教学设计
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发展心理学
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课程与教学论
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学习科学
✓ 已验证
DOI
高影响因子
JOURNAL OF HEALTH POPULATION AND NUTRITION
·
2024
·Vol. 43
·期 1
·1-9
·
IF 2.4
Huang Zhi,Ma Keyu,Yin Xiaochen,Li Ziming,Chen Ming,Duan Yujie,Li Li,Hu Yuming
Background Childhood overweight and obesity is becoming an emerging face of malnutrition. The aims of this study were to develop fatty acid (FAs) related dietary patterns and explored the associations of FAs related dietary patterns with overweight and obesity among Chinese children. Methods An observational study was conducted on 435 children aged 4 to 7 years old in South Central China. Erythrocyte FAs composition was analyzed by gas chromatography-mass spectrometry. Diet was collected by food frequency questionnaires and dietary patterns were evaluated by reduced rank regression. The logistic regression analysis was used to exploring the association of dietary patterns with overweight and obesity. Results The prevalence of overweight, obesity, and overweight or obesity were 6.52, 4.59, and 11.11% in Chinese children, respectively. Twenty five types of FAs were detected in erythrocyte of children and four FAs related dietary patterns were identified. The dietary pattern positively correlated with n-3 PUFAs, but negatively with SFAs,was characterized by high intake of fish, shrimp, crab and shellfish, leaf-off vegetable, nuts, and tubers, which have a significantly decreased overweight risk (OR = 0.580, 95%CI: 0.375 ∼ 0.895, P = 0.014).The pattern positively strong associated with n-6 PUFAs, but negatively strong with n-3 PUFAs, had high intake of snacks, leaf-off vegetable, fresh beans, and coarse cereals, which have a significantly decreased obesity risk (OR = 0.518, 95%CI: 0.325 ∼ 0.827, P = 0.006). Conclusion Four FAs related dietary patterns were identified. The dietary pattern with high intake of fish, shrimp, crab and shellfish decreased overweight risk by increasing n-3 PUFAs, and decreasing SFAs. The dietary pattern with high intake of plant food, decreased obesity risk by providing an balanced n-6/n-3 PUFAs ratio.
研究领域:
营养学
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流行病学
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产品关联
DOI
PubMed
高影响因子
International Journal of Environmental Research and Public Health
·
2021
·Vol. 18
·期 22
·12051
·
IF 3.39
Yifei Duan,Hua Shi,Yongmei Jiang
In order to understand current blood lead levels (BLLs), we investigated the BLLs of children in Sichuan Province from 2011 to 2020. We then monitored the treatment effects of calcium in children with high BLLs to assess their treatment status. Finally, we explored the effects of lead on Ca2+through in-situ experiments. Whole blood samples were used for BLL tests. The BLLs of 76,362 children aged 0–7 years were measured using atomic absorption spectrometry. The median BLL was 35 μg/L (interquartile range: 28–47). The BLLs were significantly higher in boys than in girls (p< 0.001). The BLLs generally decreased annually and increased with age. The overall prevalence of BLLs ≥ 100 μg/L was 1.20%. The children with high BLLs received subsequent check-ups, and the median time required for effective treatment was 18 months. We observed that lead exposure led to a gradual and persistent loss of Ca2+levels in neurons of mice brain slices, and the effect did not subside immediately even after the lead was removed. China has made rapid progress in pediatric healthcare, but the treatment status remains unsatisfactory. Because lead causes an irreversible loss of Ca2+, there is an urgent need to develop new standardized treatments to reduce the treatment duration.Keywords:blood lead levels;treatment status;calcium supplement;Ca2+imaging
研究领域:
公共卫生
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神经生物学
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儿科医学
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产品关联
DOI
PubMed
高影响因子
Environmental Sciences Europe
·
2024
·Vol. 36
·期 1
·1-12
·
IF 6
Wang Beibei,Zhang Liwen,Feng Weiying,Zhang Han,Duan Xiaoli,Qin Ning
Dietary exposure to heavy metals and metalloids [metal(loid)s] deserves increased attention; however, there is a lack of a comprehensive understanding of the risks of dietary exposure from multi-type food intake and multi-metal(loid) exposure using a bioaccessibility-corrected method. Here, we determined the concentration and bioaccessibility of six toxic metal(loid)s in six major food groups in an industrial city with intensive smelting activity. By incorporating children’s dietary patterns, the probability distribution of health risks from dietary metal(loid)s exposure was assessed. Marked differences were observed in the dietary exposure characteristics within metal(loid)s and major food groups. Cereal and vegetables were the major food groups local children intake. Cereals, meat, beans, and aquatic products had the highest concentrations of Cu and Cd, Pb and Cr, Ni, and As, respectively. Generally, meat, eggs, and aquatic products exhibited higher bioaccessibility than cereals, beans, and vegetables. The bioaccessibility of metal(loid)s decreased in the following order: Pb > Cr > Cu > Ni > As > Cd. For non-carcinogenic risks, the average hazard index was 7.3, with 99.6% exceeding acceptable levels. Arsenic was the dominant risk element and aquatic product was the main risk source. The aggregated carcinogenic risk was 3.4 × 10–3, with Cr the major risk contributor and cereals and meat the dominant food sources. The findings demonstrated that (1) the metal(loid) dietary exposure risk of children from areas with intensive smelting activities should be taken seriously, and (2) it is necessary to identify the specific food category and metal(loid) based on a comprehensive analysis of the metal(loid) concentration and bioaccessibility, and dietary habits of the population to effectively reduce risk.
研究领域:
环境科学
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公共卫生
✓ 已验证
产品关联
DOI
高影响因子
Arabian Journal of Chemistry
·
2021
·
IF 5.165
Hong-Xia Song,Ting Lei,Fang Wu,Xiaoyu He,Jiang Wang
This article has been retracted: please see Elsevier Policy on Article Withdrawal ( http://www.elsevier.com/locate/withdrawalpolicy ). This article has been retracted at the request of the Editor-in-Chief. In investigating concerns brought up regarding the authenticity of the article, the editors reached out to the corresponding author for an explanation. The authors failed to reply. The editors therefore feel that the findings of the manuscript cannot be relied upon and that the article needs to be retracted.
研究领域:
配位化学
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医学应用
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材料科学
✓ 已验证
DOI
高影响因子
Frontiers in Chemistry
·
2021
·
IF 5.221
Xiao Chaoqiang,Zhu Li,Zhang Xia,Gao Rumeng,He Shuwang,Lv Zhihua,Hu Changqin
Calcium carbonate which is extracted from the Earth in combination with other mineral impurities, is largely used in preparations for pediatric supplements. Elemental impurities in drug products pose toxicological concerns without therapeutic benefits. Thus, it is very urgent to assess the safety of chronic exposure to elements that may be present in trace amounts. In the present study, we developed high throughput ICP-MS method for the quantitative determination of 62 elemental impurities in high matric calcium carbonate samples and validated according to USP 233. Calcium carbonate preparations which state clearly used for child (including neonates, infants, toddlers and children) from 9 manufactures and two types of raw materials (light calcium carbonate and ground calcium carbonate) were investigated in terms of the content and variability of 62 elemental impurities. According to the results, ground calcium carbonate was more suitable to be used in pediatric preparations concerning elemental impurities. Parts of elemental impurities in CaCO3 preparations which are derived from the raw materials and the preparation process, may cause potential risks for children. These results indicate that it is necessary to establish a modern instrumental analysis method to evaluate and control elemental impurities in CaCO3 raw materials and preparations.
研究领域:
药学
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毒理学
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分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2025
·
IF 2.8
Saisai Ling,Ying Jin,Cuiyao He,Lisha Fu,Yuhua Deng,Xiaohui Qi,Zhenglei Wang,Yiying Wu
Tacrolimus is a potent macrolide immunosuppressant widely used in pediatric liver transplant patients. However, its narrow therapeutic window and significant inter-individual pharmacokinetic differences result in a poor correlation between blood concentrations and administered doses. To support its individualized dose, a sensitive, fast and robust ultra-high performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was developed to measure tacrolimus concentrations in whole blood of pediatric liver transplant patients. The method employed acetonitrile for protein precipitation, and sample separation was achieved using an Acquity UPLC CSH C 18 column (2.1 × 50 mm, 1.7 μm) with gradient elution. The mobile phase consisted of ammonium solution–water (0.5:1000, v /v) and methanol. The method demonstrated good linearity within a concentration range of 0.20–50.00 ng/mL. The intra- and inter-day precisions of tacrolimus in whole blood were less than 13.5 %, with the accuracy ranged from −7.2 % to 13.0 %. Selectivity, carryover, matrix effects, recovery, dilution reliability, and stability all met the standards set by relevant guidelines. The established UPLC–MS/MS method was successfully applied to measure the concentration of tacrolimus in the whole blood of pediatric liver transplant patients and support its individualized dose. Under the rapid UPLC–MS/MS method, 25 (65.8 %) patients required a dose increase, 3 (7.9 %) patients needed a dose reduction, and 10 (26.3 %) patients maintained their original dosage without adjustment.
研究领域:
药理学
·
临床医学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2021
·
IF 3.196
Hang-Wei Wen,Huan Xia,Yin Yu,Xiaoyu He,Jiang Wang
This article has been retracted: please see Elsevier Policy on Article Withdrawal ( http://www.elsevier.com/locate/withdrawalpolicy ). This article has been retracted at the request of the Editor-in-Chief. In investigating concerns brought up regarding the authenticity of the article, the editors reached out to the corresponding author for an explanation and to request the original data. Per journal policy, the editors, at their discretion, may request deposition of any or all original data files for examination by the reviewers and/or editors. As a result of the author’s unsatisfactory explanation and failure to provide these data—in violation of journal policy—the editors feel that the findings of the manuscript cannot be relied upon. The corresponding author does not agree to this retraction.
研究领域:
化学
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材料科学
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医学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2022
·
IF 3.571
Jing Li,Xue Li,Xiaolei Liu,Xin Wang,Jie Li,Kexin Lin,Shuxin Sun,Hao Yue,Yulin Dai
Acute exacerbation of pediatric asthma (AEPA) has always been one of the most common reasons for children to visit the emergency department, whereas unified diagnostic criteria in the clinic are lacking. The purpose of this study was to determine potential biomarkers, and provide a basis for predictive and diagnostics AEPA. Urine samples were collected from 40 pediatric patients, including 19 patients with AEPA (PA) and 21 healthy controls (HCs). The samples were analyzed by high-performance liquid chromatography-quadrupole orbitrap mass spectrometry (HPLC-Q-Orbitrap-MS), and the data were statistically analyzed by principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA) and orthogonal partial least squares discriminant analysis (OPLS-DA). Differential metabolites were selected by VIP (variable importance for the projection) > 1, and a p value ≤ 0.05 was used as the standard. The corresponding metabolic pathways of differential metabolites were subjected to analysis by the KEGG database, and further analysis and characterization of differential metabolites were conducted through the HMDB database. A total of 26 potential biomarkers were selected, of which 17 were found to be associated with respiratory diseases . Nine metabolites with obvious fluctuations in patients with AEPA, such as 13- L -hydroperoxylinoleic acid, gentisate aldehyde, L-3-phenyllactic acid, hydrocinnamic acid , and gentisic acid, could be used as potential biomarkers to further explore the prediction and diagnosis of AEPA for the first time. The contents of 3 potential biomarkers showed a positive correlation. Abnormalities in seven metabolic pathways, such as phenylalanine metabolism, tyrosine metabolism and beta-alanine metabolism, are also related to AEPA. This study further confirmed the reliability of this method to detect differences in urine metabolites of patients with AEPA. By monitoring the content of these 26 potential biomarkers and their related metabolic pathways, it provides a basis for further effective prediction and diagnosis of AEPA to avoid further development of this disease.
研究领域:
医学
·
代谢组学
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儿科
·
呼吸系统疾病
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）