JOURNAL OF ETHNOPHARMACOLOGY
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2015
·
IF 2.998
Zhen-Yu Li,Hui-Min Sun,Jie Xing,Xue-Mei Qin,Guan-Hua Du
Ethnopharmacological relevance Radix Bupleuri (RB) is a commonly used herbal drug in Traditional Chinese Medicine (TCM), and it can be baked with vinegar to afford vinegar-baked Radix Bupleuri (VBRB), which is used in TCM for liver diseases treatment. In this study, the chemical compositions and biological effects between raw and two processed RBs by different vinegars were systematically compared. Materials and methods The chemical compositions of raw and two processed RBs were analyzed by 1 H NMR spectroscopy coupled with multivariate analysis. Two different extraction procedures were used, including direct extraction and liquid–liquid partition. Then HPLC was applied to determine the changes of saikosaponin contents. In addition, their liver protective effects against CCl 4 induced liver injury were also investigated, and the biochemical parameters and histopathology were measured after treatment of mice with raw RB and two processed RBs (5 g/kg/day) for 14 days. Results Multivariate analysis showed clear differences between the raw and the two processed RBs, and the vinegar-baking process induced elevated contents of ssb1, ssb2, acetic acid, malic acid , citric acid, 5-HMF, and ligustrazine , as well as the decreased contents of ssa, ssd, sucrose, glycine, succinic acid etc. In addition, both raw and processed RBs showed liver protective effects against CCl 4 induced liver injury, and the vinegar-baked RBs showed better effects than that of raw RB. Conclusions The raw and vinegar-baked RBs differed not only in the chemical compositions but also in the pharmacological effects. And two processed RBs also showed chemical differences, suggesting that the type of vinegar had an important effect on vinegar baking. In order to ensure the therapeutic effect and safety of TCM, the effect of different vinegars on processing of herbal drugs should be further studied.
研究领域:
中药学
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药理学
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代谢组学
✓ 已验证
DOI
PubMed
高影响因子
Materials
·
2023
·Vol. 16
·期 3
·1107
·
IF 3.4
Hongling Bie,Honghao Chen,Lijun Shan,C. Y. Tan,M. S. H. Al-Furjan,S. Ramesh,Youping Gong,Y. F. Liu,R. G. Zhou,Weibo Yang,Honghua Wang
An ideal artificial bone implant should have similar mechanical properties and biocompatibility to natural bone, as well as an internal structure that facilitates stomatal penetration. In this work, 3D printing was used to fabricate and investigate artificial bone composites based on HA-ZrO2-PVA. The composites were proportionally configured using zirconia (ZrO2), hydroxyapatite (HA) and polyvinyl alcohol (PVA), where the ZrO2played a toughening role and PVA solution served as a binder. In order to obtain the optimal 3D printing process parameters for the composites, a theoretical model of the extrusion process of the composites was first established, followed by the optimization of various parameters including the spray head internal diameter, extrusion pressure, extrusion speed, and extrusion line width. The results showed that, at the optimum parameters of a spray head diameter of 0.2 mm, extrusion pressure values ranging from 1–3 bar, a line spacing of 0.8–1.5 mm, and a spray head displacement range of 8–10 mm/s, a better structure of biological bone scaffolds could be obtained. The mechanical tests performed on the scaffolds showed that the elastic modulus of the artificial bone scaffolds reached about 174 MPa, which fulfilled the biomechanical requirements of human bone. According to scanning electron microscope observation of the scaffold sample, the porosity of the scaffold sample was close to 65%, which can well promote the growth of chondrocytes and angiogenesis. In addition, c5.18 chondrocytes were used to verify the biocompatibility of the composite materials, and the cell proliferation was increased by 100% when compared with that of the control group. The results showed that the composite has good biocompatibility.Keywords:artificial bone;biomanufacturing;finite element analysis;biological scaffold
研究领域:
生物医学工程
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PARTICULATE SCIENCE AND TECHNOLOGY
·
2023
·
IF 2.5
Weijie Mao,Biao Ma,Qianqi Zhang,Xu Hua
Phase change material (PCM) mixed in soil can effectively adjust the subgrade temperature. In order to analyze the temperature field change of soil containing PCM more accurately from the microscopic point of view, it is a key problem to construct a refined geometric model. This paper scans the fracture plane of soil containing PCM through the stereoscopic microscope and prepares the label image corresponding to the sample image. Then a U-Net semantic segmentation model is established, which can accurately recognize PCM area and soil area. Finally, a geometric model of soil containing PCM that is consistent with reality is established, and its heat transfer characteristics are analyzed by finite element method. The accuracy evaluation of the segmentation model and the visualization of the recognition results show that the evaluation indexes of U-Net are the best. P, R, F1, and MIoU of U-Net are 0.889, 0.918, 0.903, and 0.901, respectively. The refined model established in this paper can not only observe the overall temperature regulation effect of the material but also accurately describe the internal temperature distribution details of soil containing PCM during heat transfer. Through numerical simulation, it is found that the maximum temperature of mixture decreases by 1.6 °C and the minimum temperature of mixture increases by 2.3 °C.
研究领域:
土木工程
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计算机视觉
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热力学
✓ 已验证
产品关联
DOI
高影响因子
ACTA MECHANICA SOLIDA SINICA
·
2024
·
IF 2
Liu Qiuhong,Sun Shuo,Wu Xiang,Chen Zhiqiang,Guo Hongjie,Duan Chen,Wang Zhengjin
Brittle materials, such as silicon, glass, and ceramics, are widely used in engineering via adhesive bonding. The assessment of adhesive strength of brittle materials to other adherends is essential for their applications. Compared with metals and composites, for which standard testing methods have been established, the experimental method for brittle adherends has been much less explored. During the adhesive strength test, the brittleness of these materials makes them prone to failure, rather than the interface. It remains a challenge to measure the adhesive strength of brittle adherends. Here we develop an experimental method to address this issue by using a strap joint specimen with a backing layer. We use a single crystal silicon wafer and two PCB (printed circuit board) strips as adherends to make a strap joint specimen. A steel backing layer is glued to the silicon wafer to prevent the failure of silicon. This method enables the measurement of adhesive strength up to 35 MPa. In contrast, that without backing layer can only measure the adhesive strength below 10 MPa. It is found that the backing layer can reduce the stress in the silicon remarkably, while it has much less effect on the stress in the adhesive layer. We confirm that the backing layer has a negligible effect on the measured adhesive strength but expands the working space greatly. Combining finite element analysis and experiments, we establish the phase diagram for the failure modes. This work provides guidance for the measurement of adhesive strength of brittle materials.
研究领域:
工程学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOM
·
2019
·Vol. 72
·期 2
·658-664
·
IF 2.305
Shen Zheng-Jun,Lin Yan,Zhang Yan-Nan,Rong Ju,Yu Xiao-Hua,Zhan Zhao-Lin
The porosity of a self-lubricating chromium-free passivation film is evaluated by means of a novel finite element model and structural parameter, λ ( λ represents the porosity of passive film). The applicability of this equivalent model is validated via thin-film thermocouple measurements and laser interferometry. Our results revealed that the roughness of the film can be improved by a lubricating filler. A value of λ = 0.25 yielded the optimal friction and wear characteristics of the self-lubricating chromium-free passivation film. This optimal condition corresponded to temperature values and stress values of 77.99°C (theoretical) and 81.24°C (experimental), and 1.67 × 10 5 Pa (theoretical) and 1.65 × 10 5 Pa (experimental), respectively. The close correspondence between the experimental and the theoretical results indicate that the model is reasonable.
研究领域:
材料科学
·
机械工程
✓ 已验证
DOI
高影响因子
Journal of Nanomaterials
·
2020
·
IF 1.98
Dongjing Li,Ganming Li,Qing Wan,Wuxiong Xu,Jianghua Liu,Zeping Li
We study the mechanical behavior of Au nanomeshes (AuNMs) based on finite element analysis (FEA) simulation and deformation tests. The simulated results of mechanical flexibility indicate that polyethylene terephthalate (PET) substrate can release the stress of AuNMs under mechanical stretching and bending, the displacement of stretched AuNMs yields a 2% promotion, and the displacement of bent AuNMs yields a 3.5% promotion under buffering of PET substrate at 5 GPa yield strength of nanoscale Au. The stress and displacement distribution of the AuNMs/PET is demonstrated and analyzed. The further deformation tests of AuNMs under compressive and tensile loading indicate that the simulation data are in good agreement with experimental results. This paper is conducive to understanding the mechanical behavior and corresponding structural response and structural fracture dynamics of AuNMs.
研究领域:
材料科学
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力学
✓ 已验证
产品关联
DOI
高影响因子
MEAT SCIENCE
·
2022
·
IF 7.077
Yu Shi,Yueying Wang,Xuetao Hu,Zhihua Li,Xiaowei Huang,Jing Liang,Xinai Zhang,Di Zhang,Xiaobo Zou,Jiyong Shi
The quality of marinated meat could be assessed by the uniformity of marinade distribution within it. In this study, the diffusion behavior of sucrose inside the marinated beef was quantitatively characterized from 2D plane and 3D space using hyperspectral imaging (HSI) and finite element analysis (FEA), respectively. Visualization of sucrose content based on HSI showed that the distribution state of sucrose on marinated beef was not uniform. Subsequently, the diffusion behavior of sucrose in the 3D beef geometric model was simulated using FEA. Results revealed that the diffusion rate of sucrose on muscle tissues is significantly higher than other tissues, and the difference in diffusion behavior is the main reason for the inhomogeneous distribution of sucrose. The quantitative characterization of marinade diffusion behavior makes it possible to predict the marinade's transient distribution state, thereby determining the optimal marinade conditions for the meat. Therefore, the method proposed has practical significance for evaluating and regulating the quality of marinated meat products.
研究领域:
食品科学
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生物物理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Anfeng Li,Manman Yang,Peng Tang,Xia Hao,Lili Wu,Wenbo Tian,Dingyu Yang,Jingquan Zhang
Cs3Bi2I9 (CBI) single crystal (SC) is a promising material for a higher-performance direct X-ray detector. However, the composition of CBI SC prepared by the solution method usually deviates from the ideal stoichiometric ratio, which limits the detector performance. In this paper, based on the finite element analysis method, the growth model of the top-seed solution method has been established, and then the influence of precursor ratio, temperature field, and other parameters on the composition of CBI SC has been simulated. The simulation results were used to guide the growth of the CBI SCs. Finally, a high-quality CBI SC with a stoichiometric ratio of Cs/Bi/I = 2.87:2:8.95 has been successfully grown, and the defect density is as low as 1.03 × 109 cm–3, the carrier lifetime is as high as 16.7 ns, and the resistivity is as high as 1.44 × 1012 Ω·cm. The X-ray detector based on this SC has a sensitivity of 29386.2 μC·Gyair–1 cm–2 at an electric field of 40 V·mm–1, and a low detection limit of 0.36 nGyair·s–1, creating a record for the all-inorganic perovskite materials.
研究领域:
材料科学
·
物理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS A-PHYSICAL
·
2025
·
IF 4.9
Tao Luo,Dongyang Chen,Chongjie Jiang,Yingying Dai,Jinyang Le,Wei Zhou,Yu Xie
Ultrasound-actuated microrobots that incorporate entrapped microbubbles rely on acoustic streaming thrust for propulsion. While bubble size and resonance have been extensively studied, the role of opening size remains less understood. In this study, we numerically investigate how the opening size affects both streaming flow and the resulting thrust. Finite element analysis (FEA) reveals that although streaming velocity increases with oscillation amplitude and opening size, the generated thrust does not always scale proportionally. Counterintuitively, microbubbles with larger openings are more likely to produce greater thrust than those with smaller openings under identical acoustic excitation, despite generating weaker streaming flows. This phenomenon is experimentally confirmed using a microcantilever-based thrust measurement system. Our study provides key insights into the mechanics of microbubble-driven propulsion and highlight the the critical role of opening size in acoustic streaming thrust, offering valuable guidance for the design of next-generation microbubble-based acoustic microrobots for various biomedical applications.
研究领域:
声学
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微流控
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机器人学
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生物医学工程
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流体力学
✓ 已验证
DOI
高影响因子
Polymers
·
2021
·Vol. 13
·期 18
·3043
·
IF 4.329
Qinying Yan,Jiaqi Weng,Shulin Shen,Yan Wang,Min Fang,Gensuo Zheng,Qingliang Yang,Gensheng Yang
In this study, a micro-molding technology was used to prepare the microneedles (MNs), while a texture analyzer was used to measure its Young’s modulus, Poisson’s ratio and compression breaking force, to evaluate whether the MNs can penetrate the skin. The effects of different materials were characterized by their ability to withstand stresses using the Structural Mechanics Module of COMSOL Multiphysics. Carboxymethylcellulose (CMC) was chosen as the needle formulation material with varying quantities of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and hyaluronic acid (HA) to adjust the viscosity, brittleness, hardness and solubility of the material. The results of both the experimental tests and the predictions indicated that the hardest tip material had a solids content of 15% (w/w) with a 1:2 (w/w) CMC: HA ratio. Furthermore, it was shown that a solid content of 10% (w/w) with a 1:5 (w/w) CMC: PVA ratio is suitable for making patches. The correlation between the mechanical properties and the different materials was found using the simulation analysis as well as the force required for different dissolving microneedles (DMNs) to penetrate the skin, which significantly promoted the research progress of microneedle transdermal drug delivery.Keywords:biodegradable dissolving microneedle;mechanical properties;Young’s modulus;Poisson’s ratio;finite element analysis
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Wenbo Zhang,Shihui Jiao,Weiming Sun,Yue Jiang,Shouhua Feng,Ming Yang
Living organisms employ a key strategy to construct resilient load-bearing structures: the strategic layering of anisotropic elements. Natural biomineralized tissues showcase a remarkable attribute—an exact alignment of multiple building units, a quality notably absent in contemporary biomimetic reproductions. We demonstrate the fabrication of artificial shells by integrating vertically aligned TiO 2 nanorods into a polymer matrix atop clay multilayers. This approach combines chemical synthesis with molecular assembly to mimic the bilayer structure of mollusk shells, which consists of polygonal prismatic units on a brick-and-mortar architecture. Our study reveals a critical design principle for artificial shells through a combination of nanoindentation and finite element analysis. This design minimizes stress concentration factors at the interface and enhances penetration resistance, mainly attributed to the properties of the bottom layer. In comparing our artificial shells with their natural counterparts, we uncover additional design principles, such as hierarchical architecture and microscale prism size. These artificial shells possess the intriguing ability to partially self-heal due to a dynamic hydrogen bonding network. Furthermore, they can serve as humidity-sensitive actuators , with bending direction controlled by the aspect ratios of clay nanosheets . Our work offers valuable insights for the rational design of multifunctional, multilayer materials with enhanced impact resistance.
研究领域:
材料科学
·
仿生学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2022
·
IF 9.463
Fan Wang,Hang Luo,Di Zhai,Zhida Xiao,Li Zeng,Xueying Wang,Zhitao Hu,Huan Wang,Lihong Liu,Dou Zhang
Dielectric capacitors consisting of ceramic/polymer nanocomposites have been widely used in electrical and electronic fields due to the advantages of high power density, high stability and improved energy density . However, the mismatching of dielectric constant between ceramics and polymers seriously limits the improvement of energy density of dielectric capacitors. In this work, a novel kind of core-double shell structured ceramic filler BaTiO 3 @TiO 2 @SiO 2 (BT@TO@SO) is prepared by a two-step hydrolysis method and introduced into PVDF for high performance dielectrics. This core-double shell structured filler forms multi-layer interface with gradually reduced dielectric constants of BT, TO, and SO, which is beneficial to enhance the interface polarization and reduce the electric field concentration caused by dielectric mismatch. In addition, the high insulating properties of the outer layer of SO can greatly limit the electron migration and reduce the leakage current. The experimental results show that when the loading of BT@TO@SO filler is low, the nanocomposite can achieve an energy density of up to 19.7 J/cm 3 and an efficiency of 57.6% at 620 MV/m, which shows an obvious improvement compared with filling BT or BT@SO. The results of finite element analysis further verify the superiority of this core-double shell structure.
研究领域:
材料科学
·
电气工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）