POLYMER
·
2022
·
IF 4.432
Xue Liao,Zhenyu Xiang,Ying Lei,Zijun Zhu,Junling Guo,Shaojian Lin,Jiaojiao Shang
The drug release system is emerging as a novel dosage form for multipurpose prevention against the undesired cytotoxic side effect caused by large doses of oral administration via the site-specific and on-demand control of drugs. Herein, a drug release system with a large dose of encapsulation-free drugs loading and site-specific controlled release was facilely built via engineering 3D reversible gel-like nanofibers based on pH-responsive copolymer containing sensitive photo-crosslinker and stiffness tunable polymer. This strategy can be used to address the case-by-case issue of drugs loaded in the matrix via in-situ-trapping drugs in the crosslinked gel-like nanofibers. The cumulative release profiles and release kinetics upon different pH indicate that 3D reversible gel-like nanofibrous mat can stably control the drug release for more than 80 h. Moreover, the 3D nanofibrous release system behaves sustained and pH-controlled release of drugs, thereby contributing to satisfying targeted drug release therapy for weakly acidic pathological tissues.
研究领域:
生物材料学
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药剂学
·
纳米医学
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DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2016
·Vol. 408
·期 25
·6945-6956
·
IF 3.125
Kumar Saroj,Kumar Dileep,Ahirwar Rajesh,Nahar Pradip
Bioconjugation and functionalization of polymer surfaces are two major tasks in materials chemistry which are accomplished using a variety of coupling agents. Immobilization of biomolecules onto polymer surfaces and the construction of bioconjugates are essential requirements of many biochemical assays and chemical syntheses. Different linkers with a variety of functional groups are used for these purposes. Among them, the benzophenones, aryldiazirines, and arylazides represent the most commonly used photolinker to produce the desired chemical linkage upon their photo-irradiation. In this review, we describe the versatile applications of 4-fluoro-3-nitrophenyl azide, one of the oldest photolinkers used for photoaffinity labeling in the late 1960s. Surprisingly, this photolinker, historically known as 1-fluoro-2-nitro-4-azidobenzene (FNAB), has remained unexplored for a long time because of apprehension that FNAB forms ring-expanded dehydroazepine as a major product and hence cannot activate an inert polymer. The first evidence of photochemical activation of an inert surface by FNAB through nitrene insertion reaction was reported in 2001, and the FNAB-activated surface was found to conjugate a biomolecule without any catalyst, reagent, or modification. FNAB has distinct advantages over perfluorophenyl azide derivatives, which are contemporary nitrene-generating photolinkers, because of its simple, single-step preparation and ease of thermochemical and photochemical reactions with versatile polymers and biomolecules. Covering these aspects, the present review highlights the flexible chemistry of FNAB and its applications in the field of surface engineering, immobilization of biomolecules such as antibodies, enzymes, cells, carbohydrates, oligonucleotides, and DNA aptamers, and rapid diagnostics.
An overview of the FNAB-engineered activated polymer surfaces for covalent ligation of versatile biomolecules
研究领域:
生物化学
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材料化学
·
医学诊断
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DOI
PubMed
高影响因子
Light-Science & Applications
·
2025
·Vol. 14
·期 1
·1-9
·
IF 23.4
Chen Zhong,Man Zhongwei,Rao Shichao,Zhao Jinxing,Wang Shuaibing,Zhang Runtong,Teng Feng,Tang Aiwei
Recently, colloidal quantum dots (QDs) with high luminescent efficiency and tunable colors have become ideal materials for next-generation display devices. Direct photolithography is a powerful tool for patterning QD devices, but it faces the serious issue of degradation in the photophysical properties of the patterned QDs. Here, we use relatively rigid cyclopentane as a bridging group to design the crosslinker CPTA, achieving high-resolution direct photolithography of QDs with nearly nondestructive under ambient conditions. The key to the crosslinker design is the introduction of a rigid bridging group that elevates the LUMO level, providing a stronger energy barrier to prevent QD electrons from being trapped or undergoing non-radiative recombination, thus preserving their PL and EL properties. The efficient and high-resolution RGB line and dot arrays were fabricated with pixel sizes down to 1 μm and a resolution of up to 6350 PPI. The patterned RGB QD films, especially red QDs, maintained their optical and optoelectronic properties, with patterned red QLEDs achieving peak external quantum efficiency (EQE) of 21% and a maximum luminance ( L max ) of ~180,000 cd m⁻², matching pristine devices. These results highlight the importance of photo-crosslinker design for nondestructive QDs patterning, paving the way for advanced display applications in patterned QLED technology.
研究领域:
材料科学
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纳米技术
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光电子学
·
显示技术
·
光刻技术
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产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2016
·Vol. 7
·期 1
·1-10
·
IF 11.329
Yang Yi,Song Haiping,He Dan,Zhang Shuai,Dai Shizhong,Lin Shixian,Meng Rong,Wang Chu,Chen Peng R.
Coupling photocrosslinking reagents with mass spectrometry has become a powerful tool for studying protein–protein interactions in living systems, but it still suffers from high rates of false-positive identifications as well as the lack of information on interaction interface due to the challenges in deciphering crosslinking peptides. Here we develop a genetically encoded photo-affinity unnatural amino acid that introduces a mass spectrometry-identifiable label (MS-label) to the captured prey proteins after photocrosslinking and prey–bait separation. This strategy, termed IMAPP ( I n-situ cleavage and M S-label transfer A fter P rotein P hotocrosslinking), enables direct identification of photo-captured substrate peptides that are difficult to uncover by conventional genetically encoded photocrosslinkers. Taking advantage of the MS-label, the IMAPP strategy significantly enhances the confidence for identifying protein–protein interactions and enables simultaneous mapping of the binding interface under living conditions.
研究领域:
生物化学
·
分子生物学
·
蛋白质组学
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产品关联
DOI
PubMed
高影响因子
Polymers
·
2024
·Vol. 16
·期 13
·1805
·
IF 4.7
Peng Zhang,Hehe Wang,Pengcheng Xia,Xiaolei Chen,Wei Zhao,Chengqian Wang,Xiao Meng,Bin Jia
Negative-tone photosensitive polyimides (PSPIs) with a low coefficient of thermal expansion (CTE) were prepared by dissolving polyimide precursor-poly(amide ester) (PAE) resins, photoinitiators, photocrosslinkers and other additives in organic solvents. Using triamine as a monomer and dianhydride and diamine as polycondensates, tri-branched structure PAE resins with different molecular weights named PAE-1~5 were prepared. A series of corresponding PSPI films named PSPI-1~5 were prepared from PAE-1~5 resins with the same formulation, respectively. The PSPI-1~5 films prepared from resins of this structure have excellent mechanical, thermal and electrical properties after being thermally cured at 350 °C/2 h in nitrogen. The PSPI-1~5 films’ coating solution also show good photolithographic performance and are able to obtain photolithographic patterns with a resolution of about 10 μm after homogenization, exposure and development. Among the PSPI-1~5 films, PSPI-2 has the most excellent lithographic properties with a weight average molecular weight (Mw) of 2.9 × 104g/mol, a CTE of 41 ppk/°C, a glass transition temperature (Tg) of 343 °C and a 5% weight loss temperature (Td5) of 520 °C, making it suitable for industrial scale-up. The mechanical properties of elongation at breakage of 42.4%, tensile moduli of 3.4 GPa and tensile strength of 153.7 MPa were also measured.
研究领域:
材料科学
·
聚合物化学
·
微电子封装
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）