PHYSICAL CHEMISTRY CHEMICAL PHYSICS
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2018
·Vol. 20
·期 38
·24796-24806
·
IF 3.906
Chensheng Ma,Chris Tsz-Leung Chan,Ruth Chau-Ting Chan,Allen Ka-Wa Wong,Bowie Po-Yee Chung,Wai-Ming Kwok
Apart from being an analogue of the prototype for photoinduced intramolecular charge transfer (ICT), 2-ethylhexyl 4-dimethylaminobenzoate (EHDMABA) is also one of the earliest patented and most commonly used sunscreen components. There is, however, little documented information about the photophysics and factors affecting the photophysics of this molecule. Such information is of importance for both the understanding of the ICT reaction and assessing the underlying process of photoprotection, especially in view of the “sunscreen controversy” that has arisen from the contrasting in vivo vs. in vitro photobiological results on this and related UV filters. We report herein a femtosecond broadband time-resolved fluorescence (fs-TRF), complemented by transient absorption (fs-TA) to allow a full probe of the excited state cascades for EHDMABA and two of its derivatives in solvents of varied properties. The results provide direct evidence for a nearly solvent independent inner sphere ICT reaction occurring on the sub-picosecond time scale, and an ensuing solvent dictated deactivation of the ICT state. The ICT state in the aprotic solvent acetonitrile decayed solely through the intrinsic intersystem crossing (ISC) to produce a potentially harmful triplet excited state. In the protic solvent, the solvation and formation of ICT-induced solute–solvent hydrogen (H)-bonding opened the originally inaccessible internal conversion (IC) channel of the ICT state, leading to the rapid reformation of the ground state molecule with a unitary efficiency in the aqueous solution. This H-bonding-mediated IC restrained or eliminated the intrinsic ISC, providing a mechanism at the molecular level for the benign dissipation of the electronic excitation. The precise rate of IC was observed to vary with the alkoxy substituent and its efficiency was affected by the H-bonding capacity of the solvent. The findings of this work demonstrate the pivotal role of the microenvironment and the direct participation of solvent molecules through H-bonding in drastically altering the nonradiative dynamics and promoting or inhibiting photostability and photoprotection. This may assist in developing next-generation UV filters and help in improving formulation design for the optimal efficacy of sunscreen products. The pronounced H-bonding-induced fluorescence quenching and variation in the fluorescence wavelength imply that these molecules may also serve as a sensitive fluorescence probe for the H-bonding properties of the microenvironment.
研究领域:
化学
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光生物学
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2016
·
IF 3.858
Huanle Chen,Xiaorong Hu,Enmin Chen,Shan Wu,David Julian McClements,Shilin Liu,Bin Li,Yan Li
Natural aldehydes, such as cinnamaldehyde , can be used to modify the properties of chitosan-based materials by covalent cross-linking the chitosan molecules. Due to the non-polarity and hydrophobicity of cinnamaldehyde, emulsification technique was used to prepare homogeneous cinnamaldehyde-chitosan films. Under optimized conditions, cinnamaldehyde nanoemulsions led to the successful fabrication of uniform and smooth chitosan films. FTIR analysis of the films indicated the formation of chitosan-cinnamaldehyde Schiff base. The cross-linked films strongly absorbed UV–visible light and inhibited the emission of fluorescent light, and may therefore provide good photo-protection. The thickness (26–61 μm) and transparency (clear to turbid) of the chitosan films were modulated by varying the aldehyde/amino group ratio. The mechanical properties and water vapor permeability of the films also depended on the amount of cinnamaldehyde nanoemulsion utilized. Chitosan films showed good antimicrobial activity, but had better antifungal than antibacterial activity.
研究领域:
食品科学
·
材料科学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Dong Wang,Chunrui Wang,Yunfeng Zhang,Wenfei Xun,Dan Chen,Qikuan Cheng,Lu Zhang,Yang Liu,Guigang Li,Suli Wu,Huamin Zhou,Yunming Wang
Restricted by the significant non-radiative losses in the anti-Stokes process of converting low-energy photons to high-energy photons of upconversion materials, their applications necessitate high excitation thresholds in infrared imaging, lasers modulation and photodynamic therapy. Herein, we report an implantable upconversion artificial lens capable of converting infrared into visible light with an ultralow excitation power (0.015 mW cm −2 ), and integrating a self-adaptive photoprotection capability to remedy dim light seeing loss and dazzle blindness. Based on the polymeric dynamic coordination bond microenvironment regulation, the non-radiative vibrations could be suppressed to enhance upconversion luminescence via regulating the surface charge of upconversion nanoparticles in polymers by the stretching and contraction of hydrogen bonds. Furthermore, the integrated lens with indium phthalocyanine could activate a graduated photoprotection in 1 ms; this response speed is 1500 times faster than human pupil constriction and dilation. The lens-implanted rabbits achieved retinal responses under ultralow-power infrared illumination and retinal protection from strong light. The fast and clear imaging capabilities greatly shortened the blind time. This research proposes a strategy to achieve low-threshold upconversion and creates an avenue to establish the link between nonlinear optical nanomaterials and biological engineering, and provides a potential approach for bioimaging, phototherapy and wearable devices.
研究领域:
生物医学工程
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光学材料
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纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Science China-Chemistry
·
2024
·Vol. 67
·期 5
·1653-1663
·
IF 10.4
Yang Zhen,Wang Xianheng,Bai Wanjie,Zou Zikun,Wu Haoxing,Li Yiwen
Manipulating the energy structure of materials represents an efficient way to regulate their light absorption behaviors. For example, constructing donor-acceptor (D-A) structures to increase the polarizability and reduce the energy bandgap of local molecules has been widely used in the field of organic photovoltaics with ordered structures. Remarkably, even in disordered and chaotic systems such as melanin-like polydopamine (PDA), visible and near-infrared light absorption can be significantly improved using this strategy. However, there has been a noticeable dearth of research on the ultraviolet (UV) light absorption regulation of bioinspired polymers with disordered and chaotic architectures by tailoring the D-A microstructures. In this study, a series of benzoheterocyclic molecules with strong electron-donating features screened by molecular simulation calculations were involved in disrupting the D-A structures within PDA. The destruction of D-A structures promoted the increase of the energy band gap and finally boosted the UV absorption of PDA. The resulting PDA nanoparticles with enhanced UV absorption were further employed to fabricate UV shielding composite films to protect the growth of plants from harmful UV radiation. This research may open up new avenues for structural disruption of bioinspired polymers for enhanced photoprotection applications.
研究领域:
材料科学
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生物医学工程
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农业科学
✓ 已验证
产品关联
DOI
高影响因子
Scientific Reports
·
2025
·Vol. 15
·期 1
·44909
·
IF 3.9
Xia Xiuyuan,Zhang Zhenghan,Wang Yizhen,Chen Chen,Wang Yaqi,Luo Yanting,Gao Ying,Hong Weiyong,Ren Chuanpeng
Quercetin and carnosine, natural antioxidants with anti-aging and photoprotective potential, face therapeutic limitations due to poor skin permeability. We engineered EV-QuerCar, a liposomal-based nanoparticles (LPNs) system co-encapsulating both compounds, to enhance transdermal delivery and evaluate its structural and functional efficacy. EV-QuerCar was prepared biomimetically using thermophilic bacterial lipids via ultracentrifugation, thin-film hydration, and high-pressure homogenization. Physicochemical properties, transdermal penetration, cellular uptake, and cytotoxicity were tested in vitro. Molecular docking and qPCR assessed pathway targeting. EV-QuerCar exhibited uniform size (94.70 ± 0.71 nm), high encapsulation efficiency (90.07%), sustained release, and 3.21-fold enhanced transdermal absorption compared to free compounds. Cellular uptake in fibroblasts increased time-dependently (up to 5.48-fold at 4 h). Molecular docking and qPCR confirmed interactions with NRF2 and HES1 targets, significantly upregulating their mRNA levels (2.29- and 3.35-fold, respectively) in UV-exposed human fibroblasts. EV-QuerCar improves skin permeability and antioxidant efficacy, highlighting its cosmeceutical promise.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2023
·Vol. 104
·期 2
·716-726
·
IF 4.1
Jing Wu,Qinglan Li,Chun Cui,Jucai Xu
BACKGROUND The demand for food-based anti-photoaging products is surging because of the rising recognition of health and beauty, as well as enhanced comprehension of the detrimental impact of ultraviolet (UV) radiation. This study aimed to investigate the potential of bioactive peptides derived from bovine elastin, specifically focusing on identifying novel elastase inhibitory peptides and assessing their photoprotective properties using bioinformatics techniques. RESULTS A total of 48 bioactive peptides were screened in bovine elastin hydrolysate (EH) utilizing Peptide Ranker analysis. Three novel elastase inhibitory peptides, GAGQPFPI, FFPGAG and FPGIG (in descending order of activity), exhibited potent inhibitory effects on elastase in vitro , surpassing the inhibitory effect of EH by a factor of 1–2 and reaching significantly lower concentrations (8–15 times lower) than EH. The cumulative inhibitory effect of GAGQPFPI, FFPGAG, and FPGIG reached 91.5%. Further analysis revealed that FFPGAG and FPGIG exhibited mixed inhibition, whereas GAGQPFPI displayed non-competitive inhibition. Molecular simulations showed that these peptides interacted effectively with the elastase active site through hydrogen bonding and hydrophobic interactions. Furthermore, GAGQPFPI, FFPGAG, and FPGIG demonstrated high stability in gastrointestinal digestion, demonstrated transcellular permeability across Caco-2 cell monolayers, and exhibited remarkable photoprotective properties against UVB-irradiated HaCaT cells. CONCLUSION GAGQPFPI showed the most promising potential as a functional food with photoprotective effects against UVB damage and inhibitory properties against elastase. © 2023 Society of Chemical Industry.
研究领域:
食品科学
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生物信息学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS LETTERS
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2018
·
IF 2.687
Shujun Chen,Bin Xiang,Yang Zhou,Xuefeng Zou,Xiuzhou Lin
Most of the polymer coatings are directly exposed to sunlight, leading to serious degradation on their surfaces. Functional triazine ultraviolet absorber (FT-UVA) with surface enrichment property was synthesized. The surface enrichment property of FT-UVA in coating surfaces was investigated using X-ray photoelectron spectroscopy (XPS) and attenuated total reflection Fourier-transform infrared spectrometry (ATR-IR). Contact angle measurements suggest that the enrichment of FT-UVAs on coating surface yielded a hydrophobic film. The effective protection of FT-UVA for PVC coating was investigated by artificial accelerated aging test. The calculation of dynamic process was conducted to gain insights into the surface enrichment mechanism of FT-UVA in coating.
研究领域:
材料科学
·
高分子化学
·
表面化学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Ziyong Zhou,Jun Xu,Junliang Lu,Jun Li,Wei Zhang,Kefu Chen
The functional chemicals in conventional personal care products may have negative effects on both human body and the environment, and natural proteins are gaining increasing attention as alternatives to functional chemical. However, due to the poor absorption of proteins on the surface of the hair, it cannot perform their function well. In this study, a protein-based multifunctional complexes, made of keratin and cationic cellulose nanocrystals by opposite charged-induction, were prepared for improving the glossiness and reducing hair thermal-photo damage. By changing the ratio of keratin and cationic cellulose nanocrystals in complexes, the optical properties and oil delivery property were studied. It was found that the protein-based complexes could improve the glossiness of substrate and have synergistic reducing UV transmittance, especially UVB. Besides, the complexes with high ratio of C-CNC were beneficial for the deposition of silicone oil onto hair. And after treated with the complexes or the resulting emulsion, the water evaporation of hair during heat treatment and the hair damage during light radiation were effectively reduced to improve the thermal-photo protection for hair. This study was expected to provide new design for improving adsorption of protein on the substrate and developing protein multifunctional application in personal care.
研究领域:
材料科学
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化妆品科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Chuanfen Pu,Yongxue Luo,Yue Sun,Jie Zhang,Hanwen Cui,Man Li,Qingjie Sun,Wenting Tang
The purpose of this work is to explore the feasibility of water in water ( W /W) emulsion stabilized with liposomes as a water-soluble nutraceutical carrier. A W/W emulsion system composed of xanthan gum (XG) and whey protein isolate (WPI) with different amount (0.2 %, 0.4 %, and 0.6 %) of liposomes as stabilizer was constructed. Fast green staining observation showed that XG was the internal phase and WPI was the continuous phase respectively. Confocal laser scanning microscopy revealed that with the increase of liposomes concentration from 0.4 % to 0.6 %, the interface thickness of the W /W emulsions was approximately twice that of the 0.2 % liposome-stabilized emulsion.The emulsions remained stable under neutral and weakly alkaline conditions. The droplet sizes of the emulsions were little affected by ionic strength. The binding constant (Ka) for XG to riboflavin (12.22) was approximately 5 times that for WPI to riboflavin (2.46), suggesting that riboflavin had a stronger binding affinity for the XG molecule compared to WPI. The fluorescence spectra of riboflavin showed that 0.4 % and 0.6 % liposome stabilized emulsions could effectively retard the photodegradation of riboflavin under ultraviolet irradiation. The successful construction of liposomes stabilized W /W emulsion provides a novel strategy for delivering water-soluble bioactive substances.
研究领域:
食品科学
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营养保健品
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胶体与界面科学
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生物技术
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2018
·Vol. 28
·期 33
·1802127
·
IF 13.325
Changping Wang,Dong Wang,Tianjiao Dai,Peng Xu,Peilun Wu,Yuan Zou,Peng Yang,Jingjing Hu,Yiwen Li,Yiyun Cheng
Commercial sunscreens usually rely on multiple component formulas against solar irradiation, including UV filters, antioxidants, and nanomaterial matrices. While many efforts are devoted, concern has arisen that the effectiveness and safety issues of most sunscreens are largely limited by their complex formulations, photostability, and toxicity. Inspired by skin pigmentation as primary photoprotective mechanism in human body, novel sunscreen products based on polydopamine (PDA) gels, with a bioinspired protection concept and improved photoprotective capacities, were rationally designed and facilely prepared. The diverse formula of those sunscreen gels can be achieved by the use of PDA nanoparticle, a kind of naturally melanin mimics, to complex/conjugate with different polymers. The resulting PDA sunscreens are bioadhesive, water resistant, and nonskin penetration, yet can be directly removed by towel wiping. They also perform many promising features including superior UV shielding properties, high in vitro and in vivo UV protection efficiencies, nonphototoxicity, and nonirritating nature. These PDA materials in an initial proof-of-concept study were described and it is proposed that this class of bioinspired gels will be useful for incident UV protection where simple, safe, and efficient sunscreens are still highly desirable.
研究领域:
材料科学
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生物医学工程
·
药学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Bio Materials
·
2019
·
IF 0
Lin Xiong,Mengyao Zhao,Yong Fan,Shangfeng Wang,Yanling Yang,Xiaomin Li,Dongyuan Zhao,Fan Zhang
An ultraviolet (UV) filter is the core component of sunscreen and protects skin from various photo damages. Current UV filters are hampered by skin penetration, poor photostability, photocatalytic generation of harmful reactive oxygen species (ROS), and potential environmental risks. In this work, manganese dioxide nanoclusters were developed as an eco-friendly UV filter by a facile two-step synthesis, using colloid silica as support under ambient conditions. These nanoclusters show a better UV-shielding profile than commercial titanium dioxide nanoparticles and capability to scavenge various ROS. They can be easily incorporated by a sunscreen formula and demonstrate an excellent skin photoprotection performance both in vitro and in vivo.
研究领域:
材料科学
·
纳米技术
·
化妆品
·
环境科学
·
皮肤病学
✓ 已验证
产品关联
DOI
PubMed
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 20
·15444
·
IF 5.6
Monika Michalak
Natural ingredients have been used for centuries for skin treatment and care. Interest in the health effects of plants has recently increased due to their safety and applicability in the formulation of pharmaceuticals and cosmetics. Long-known plant materials as well as newly discovered ones are increasingly being used in natural products of plant origin. This review highlights the beneficial effects of plants and plant constituents on the skin, including moisturizing (e.g.,Cannabis sativa,Hydrangea serrata,Pradosia mutisiiandCarthamus tinctorius), anti-aging (e.g.,Aegopodium podagraria,Euphorbia characias,Premna odorataandWarburgia salutaris), antimicrobial (e.g.,Betula pendulaandEpilobium angustifolium), antioxidant (e.g.,Kadsura coccinea,Rosmarinus officinalis,Rubus idaeusandSpatholobus suberectus), anti-inflammatory (e.g.,Antidesma thwaitesianum,Helianthus annuus,Oenanthe javanica,Penthorum chinense,Ranunculus bulumeiandZanthoxylum bungeanum), regenerative (e.g.,Aloe vera,Angelica polymorpha,Digitaria ciliaris,Glycyrrihza glabraandMarantodes pumilum), wound healing (e.g.,Agrimonia eupatoria,Astragalus floccosus,Bursera morelensis,Jatropha neopaucifloraandSapindus mukorossi), photoprotective (e.g.,Astragalus gombiformis,Calea fruticose,Euphorbia characiasandPosoqueria latifolia) and anti-tyrosinase activity (e.g.,Aerva lanata,Bruguiera gymnorhiza,Dodonaea viscosa,Lonicera japonicaandSchisandra chinensis), as well as their role as excipients in cosmetics (coloring (e.g.,Beta vulgaris,Centaurea cyanus,Hibiscus sabdariffaandRubia tinctiorum), protective and aromatic agents (e.g.,Hyssopus officinalis,Melaleuca alternifolia,Pelargonium graveolensandVerbena officinalis)).Keywords:plants;skin;photoprotection;wound healing;anti-aging;anti-tyrosinase;essential oils;colorants;cosmetics;pharmaceutics
研究领域:
植物学
·
药理学
·
化妆品科学
·
皮肤病学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）