Materials Today
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2024
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IF 21.1
Yilin Wang,Ran Wei,Xijing Yang,Jiahao Liang,Xianda Liu,Shengjun Cheng,Shifan Chen,Ziyue Ling,Yujie Xiao,Yuanting Xu,Weifeng Zhao,Changsheng Zhao
Massive loss of proteins is common in patients on long-term blood purification therapy, there is a strong inverse association between the risk of death and serum albumin concentration. Removing toxins and leaving behind albumin is an arduous task in the field of blood purification. Inspired by the dissociation-transportation process of protein-bound toxins in renal tubule, we propose multi-point photodecomposition accompany with adsorption strategy as a novel treatment modality in hemoperfusion. As a proof of concept, bilirubin is chosen as the research object since it is a typical protein-bound toxin that needs to be transported by strong binding to albumin in blood environment. Interestingly, blue light can efficiently break bilirubin into some highly polar water soluble diazo compounds, the decomposed products of bilirubin are water-soluble and loosely bound to albumin. Herein, graphene quantum dots (GQDs) and polymer science are combined in the nanoarchitectonics processes. The “photodecomposition-adsorption” platform is designed by embedding GQDs in poly (diallyldimethylammonium chloride-acrylamide) (poly (DDAC-AAm) hydrogel (PDMG) microspheres. In order to reduce the influence of cationic polymer on blood component, hyaluronic acid (HA) are coated on the surface of the PDMG (PDMG@HA) microspheres by electrostatic interaction. Owing to the luminescence property of GQDs, the PDMG@HA microspheres emit blue light under ultraviolet activation and decompose bilirubin into water soluble diazo compounds, just like numerous “blue bulbs”. The water-soluble bilirubin debris could be dissociated from albumin and adsorbed by “blue bulbs”, which greatly reduce the metabolic burden on the body. In vitro biocompatibility results demonstrate that the PDMG@HA microspheres show lower protein adsorption and blood cell toxicity than the PDMG microspheres. The photodecomposition and adsorption amount of bilirubin is 187.8 mg/g in vitro . In hyperbilirubinemia rabbit hemoperfusion, the “blue bulbs” remove 70.9 % total bilirubin (TBIL) from plasma and defer the liver damage of biliary obstruction. Notably, the bilirubin photodecomposition is persisted to the end of the treatment, and some of the bilirubin debris have been adsorbed by the “blue bulbs”. The strategy combining both photodecomposition and adsorption opens a new route for the treatment of blood-related diseases.
研究领域:
医学
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材料科学
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生物工程
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DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2014
·Vol. 131
·期 22
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IF 1.64
Lanlan Liu,Jinbao Guo,Jie Wei
A fluorescence imaging system is designed based on the photodecomposition of photobase generators embedded in polyvinyl butyral (PVB) matrix. These photobase generators were synthesized with propyl and phenethyl units served as leaving groups, and phthalimido, succinimido, di-2-thienyl ketoximino, and benzophenoneoximino units acted as photosensitive species, respectively. The influences of the two leaving groups and four photosensitive species on the photochemical behavior were investigated in detail. The results demonstrate that the photochemical properties of these photobase generators depend on the photosensitive species other than the leaving groups. And further study shows that succinimido propylcarbamate (SPrC) exhibits the best thermal stability and relatively quick rate of photodecomposition among all the photobase generators. Therefore, a PVB film embedded with SPrC is used as a fluorescence imaging material. The patterned fluorescence image obtained from the fluorescamine-treated irradiated PVB film showed bright green fluorescence, which provides potential application for optical storage or color electronic displays. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 41058.
研究领域:
材料科学
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化学
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光学工程
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DOI
高影响因子
FOOD HYDROCOLLOIDS
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2018
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IF 5.089
Xiaojun Fu,Wusigale,Hao Cheng,Zheng Fang,Li Liang
Proteins have been widely used to prepare effective carriers for the protection of bioactive components. There were rare studies on proteins' change during protection and its impact on the protection, albeit they are important for the choosing of suitable proteins used as carrier materials. Folic acid is a synthetic form of folate but decomposes under ultraviolet irradiation. In this study, improved protection of whey protein isolate (WPI) against the photodecomposition of folic acid was investigated by using fluorescence and HPLC. During the vitamin decomposition, WPI's change was characterized in term of composition, structure, interaction with the vitamin or its decomposition products. Folic acid decomposition photosensitized indirect oxidation of WPI, leading to unfolding, degradation in concurrence with oligomerization . The increase in the absorbance and antioxidant activity contributed to the protein improved protection for folic acid. WPI could thus be a good carrier material for the encapsulation and protection of folic acid.
研究领域:
食品科学
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营养学
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DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
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2017
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IF 3.086
Wusigale,Zheng Fang,Lyulin Hu,Yahui Gao,Juan Li,Li Liang
Folic acid is a synthetic form of the B-group vitamin known as folate and essential for a variety of physiological processes. However, it decomposes under UV irradiation, causing indirect oxidation and structural change of protein. In this study, the protective effect of resveratrol against the photodecomposition of folic acid and its caused protein structural change was investigated by using fluorescence and absorbance spectroscopy, high performance liquid chromatography and ABTS assay . It was found that resveratrol could inhibit the folic acid decomposition and control the decomposition process, depending on the polyphenol concentration and addition time. Transformation of resveratrol was accelerated by photodecomposition of folic acid. Antioxidant activity of resveratrol was important for the protective effect. Moreover, resveratrol could also inhibit the unfolding of beta-lactoglobulin caused by the folic acid decomposition by using circular dichroism .
研究领域:
营养学
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食品科学
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生物化学
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DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2025
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IF 19
Yilin Wang,Xiran Zhou,Xijing Yang,Jiahao Liang,Shifan Chen,Ziyue Ling,Wenjie Wang,Zijian Shao,Xin Song,Ran Wei,Weifeng Zhao,Changsheng Zhao
Separating toxins from albumin is significantly more challenging than simply adsorbing the toxin/protein complex during blood purification. Bilirubin is distinctive among protein-bound toxins because its photodecomposition products are hydrophilic and readily dissociate from albumin. Inspired by phototherapy for neonatal jaundice, an innovative multifunctional adsorbent is proposed and equipped with self-photodecomposition and visual monitoring abilities. Herein, inverse opal beads (IOBs) is developed through strategic nanoarchitectonics. The periodic ordered structure of the IOBs imparts a self-hosted blue light emission property that facilitates the bilirubin photodecomposition. Additionally, the interconnected pores of the IOBs enhance the adsorption of bilirubin photodecomposition products. Moreover, the colors of the IOBs change in response to the amount of adsorbed bilirubin photodecomposition products, allowing for real-time visual monitoring of the adsorption state during hemoperfusion. These features allow the IOBs to effectively compete with albumin for toxin binding. In hyperbilirubinemia rats, the total bilirubin (TBIL) clearance ratios achieved by the IOBs and a commercial adsorbent (BS330) are 45.1% and 29.3%, respectively. Notably, albumin (ALB) concentration decreased by 31.8% after treatment with BS330, whereas no significant change is observed in the IOB-treated group. These results suggest that IOBs hold great potential as a highly promising adsorbent for treating hyperbilirubinemia.
研究领域:
生物医学工程
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材料科学
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DOI
高影响因子
OPTICS AND LASERS IN ENGINEERING
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2019
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IF 4.059
Jiang Li,Wenjun Wang,Xuesong Mei,Aifei Pan,Bin Liu,Jianlei Cui
Microlens arrays were fabricated on polymethyl methacrylate (PMMA) substrate using a microlens array (MLA) with rear-side ps laser swelling in this study. The modified beam energy can ensure the fabricated microlenses are uniform. Using the foci of a microlens array (MLA), approximately 630 microlenses were fabricated with a single series of pulses, which provides greater processing throughput compared to point-to-point direct laser writing . The formation of smooth microlenses is attributed to photolysis of methyl red (MR) and molecular relaxation . The dependence of height and diameter of the microlenses on laser fluence and irradiation time were investigated. The results show that the size of microlenses could be controlled using the appropriate fluence and irradiation time. Finally, an array of mirolenses with high uniformity was fabricated over a large area. The diameter and height of the microlenses were measured to be 55 and 12 µm, respectively.
研究领域:
光学制造
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材料科学
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产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2017
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IF 9.446
Yue Chang,Kai Yu,Chenxi Zhang,Zequn Yang,Yajun Feng,He Hao,Yuanzhi Jiang,Lan-Lan Lou,Wuzong Zhou,Shuangxi Liu
New ternary composites based on three dimensionally ordered macroporous (3DOM) SrTiO 3 (CdS/Au/3DOM-SrTiO 3 ) were prepared and used as photocatalysts in visible light (λ > 420 nm) photocatalytic water splitting for hydrogen evolution. Through optimizing the pore size of 3DOM-SrTiO 3 materials and the loading amounts of Au and CdS , CdS/Au/3DOM-SrTiO 3 (300), templated by 300 nm sized poly(methyl methacrylate) colloids, was found to exhibit a remarkably enhanced photocatalytic hydrogen evolution rate (2.74 mmol/h⋅g), which was 3.2 times as high as that of CdS/Au/C-SrTiO 3 catalyst based on commercial SrTiO 3 . This notably enhanced photocatalytic performance was mainly attributed to the slow photon enhancement effect of 3DOM-SrTiO 3 (300) material, which significantly promoted the light harvesting efficiency of ternary composite for the slow photon region of 3DOM-SrTiO 3 (300) was well matched with the optical absorption band of photocatalyst. Further depositing Pt nanoparticles on CdS/Au/3DOM-SrTiO 3 (300) composite as a co-catalyst, an extraordinarily high hydrogen evolution rate (up to 5.46 mmol/g⋅h) and apparent quantum efficiency (42.2% at 420 nm) were achieved because of the synergistic effect of efficient carrier separation, Au SPR effect, and slow photon effect. Furthermore, these ternary CdS/Au/3DOM-SrTiO 3 composite photocatalysts were very stable and could be easily recycled four times in visible light photocatalytic water splitting experiments without any loss in activity.
研究领域:
材料科学
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能源化学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2016
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IF 5.31
Xiaoyan Liang,Jianhua Cheng,Cao Yang,Shewei Yang
In this study, four photochemical reaction parameters, including the reaction atmosphere, extra inorganic oxidant, inorganic anion and organic matter, were investigated in an aqueous environment to determine their effects on perfluorooctanoic acid (PFOA) photodecomposition. The photochemical defluorination of PFOA was conducted by vacuum ultraviolet light (VUV) using ferric ions as the catalyst. Both direct photolysis and photocatalysis were involved in the reaction. PFOA was completely decomposed by VUV irradiation with and without ferric ions within 72 or 144 h, respectively. There was no significant evidence indicating that the type of atmosphere (oxygen, nitrogen, or air) had any effect on the decomposition results. However, OH radicals generated during the photolysis process profoundly affected the decomposition of PFOA. The introduction of persulfate inhibited the mineralization of PFOA in the VUV/Fe 3+ system. Inorganic anions hindered the defluorination of PFOA in the following order: HCO 3 − > SO 4 2− > NO 3 − ∼ Cl − > ClO 4 − . The adverse effects of organic matter, including volatile organic compounds and dissolved natural organic compounds, were also examined. This study is beneficial to the understanding of the photodecomposition of other similar perfluorinated compounds (PFCs).
研究领域:
环境科学
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化学
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产品关联
DOI
高影响因子
PEST MANAGEMENT SCIENCE
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2024
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IF 3.8
Yiyun Gao,Wenjun Xiao,Chenhua Gu,Sheng Yu,Shengke Li,Aihua Zou
Background Conventional pesticide formulations are often griped about inefficiency due to the low biological uptake after spraying. Controlled release nanopesticides can precisely release pesticides in response to specific stimuli, thereby killing pests and pathogens with the least effective concentration. This study aims to develop nanocapsules-based photo decomposable nanopesticides for efficient pesticide control. Results The target nanopesticides were successfully fabricated by using layer-by-layer assembly of azobenzene grafted hyaluronic acid (Azo-HA) and PolyDADMAC, confirmed by UV–vis, DLS, Zeta potential and TEM measurements. Particle size and Zeta potential of the fabricated nanocapsules were 220 nm and + 46.1 mV, respectively, and the nanocapsules were found to maintain stable for up to 30 days. The optimized drug loading and encapsulation ratio of Imidacloprid (IMI) in IMI/Azo-HA@PolyDADMAC were 21.5% and 91.3%, respectively. Cumulative release of IMI from the nanopesticides was increased from ~50% to ~95% upon UV-light irradiation (365 nm). LC 50 value of the nanopesticides towards Aphis craccivora Koch was decreased from 2.22 mg/L to 0.55 mg/L upon UV-light irradiation. Conclusion The trans to cis transformation of Azo group in HA will decompose IMI/Azo-HA@PolyDADMAC nanopesticides upon UV irradiation, thus facilitated the IMI release, resulting in decreased concentration of pesticides for efficient pesticide control. Our work demonstrated the great potential of light-responsive nanocapsules as controlled release nanocarrier for efficient and eco-friendly pesticide-control in sustainable agriculture. This article is protected by copyright. All rights reserved.
研究领域:
材料科学
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纳米技术
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农药科学
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农业工程
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产品关联
DOI
PubMed
高影响因子
Journal of Physical Chemistry Letters
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2024
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IF 4.8
Zibo Cheng,Yeqin Guan,Hong Wen,Zhao Li,Kaixun Cui,Qijun Pei,Shangshang Wang,Claudio Pistidda,Jianping Guo,Hujun Cao,Ping Chen
Lithium hydride (LiH), a saline hydride with a hydrogen density of 12.6 wt %, is highly thermostable, which hinders its extensive application in hydrogen storage. In this study, we demonstrate a distinct photodecomposition of LiH under ambient conditions. Ultraviolet–visible (UV–vis) illumination induces hydrogen release and creates surface hydrogen vacancies on LiH. The subsequent H– migration enables hydrogen desorption and the accumulation of vacancies at the subsurface, resulting in the generation of metallic Li clusters. Rehydrogenation, on the contrary, can be charged under UV–vis illumination in 1 bar H2. Such phenomena show that the thermodynamic and kinetic limits in the re/dehydrogenation of LiH can be broken under illumination, which allows hydrogen storage over the LiH surface at temperatures ∼600 K lower than those of the corresponding thermal process. This work provides new insights into the interaction of semiconducting hydrides and photons and opens an avenue for the development and optimization of materials for hydrogen storage and related photodriven reactions.
研究领域:
储氢
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材料科学
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表面化学
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光化学
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半导体氢化物
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DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2019
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IF 3.571
Wusigale,Lyulin Hu,Hao Cheng,Yahui Gao,Li Liang
Folic acid, a synthetic form of folate, is a water-soluble vitamin that is essential during periods of rapid cell division and growth. However, it decomposes upon ultraviolet irradiation to form inactive photoproducts. In this study, the protective effect and mechanisms of antioxidants, including cinnamic acids, flavonoids, catechol and its derivatives, stilbenes, p-benzoquinone and its derivatives, isoprenoids, curcumin, oleic acid, and linoleic acid, against folic acid photodecomposition were investigated by using fluorescence and absorbance spectroscopy, high-performance liquid chromatography, and antioxidant assay. It was found that antioxidants could inhibit or delay the folic acid decomposition in varying degrees, among which caffeic acid was the most effective. The increase in its remarkable antioxidant efficiency and absorbance in the UVA region during irradiation contributed to its effective protection. This finding could be useful for the protection of photolabile components in food and other uses.
研究领域:
营养学
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化学
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食品科学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Min Zhang,Muhammad Arif,Yunyuan Dong,Xiaobin Chen,Xiaoheng Liu
In photocatalysis as a “green chemistry” technology, the development of efficient strategies to fabricate high-performance micro-nano photocatalysts with robust solar light utilization to deal with persistent pharmaceutical products in the wastewater system is crucially important. In order to improve the photoelectric activity, interfacial charge transfer, and reduce the recombination rate of photo-generated electron-hole pair, a Z-scheme TiO 2−x @ZnIn 2 S 4 heterojunction was prepared by hydrothermal method . The morphological structure and optical properties of the prepared catalysts were extensively characterized. Experimental results show that the rich of oxygen vacancies in TiO 2−x benefits the formation of local defect energy levels at the bottom of the CB , which can be advantageous to broaden the light absorption range. Likewise, the TiO 2−x @ZnIn 2 S 4 showed 12.4-fold and 7.70-fold higher photocatalytic performance pristine TiO 2−x and ZnIn 2 S 4 towards the degradation of tetracycline hydrochloride (TCH) and nitrofurantoin (NFT) in real water matrix and solution water. Furthermore, the photo-decomposition pathway of NFT was proposed by HPLC-MS, and the Z-scheme electron transfer mechanism in TiO 2−x @ZnIn 2 S 4 heterojunction was proposed and discussed in detail. This work emphasizes a facile method for designing high-efficiency oxygen vacancy mediated titanium-based photocatalysts with excellent photoactivity in environmental remediation.
研究领域:
环境科学
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材料科学
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化学
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光催化
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水处理
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）