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Nature Communications · 2025 ·Vol. 16 ·期 1 ·1-10 · IF 15.7

Ultralow-threshold upconversion infrared vision via a microsphere-mediated directional photofield

Wang Dong,Cheng Qikuan,Xia Weibang,Tan Yongyao,Yu Kexuan,Zhang Lu,Li Guigang,Liu Rong,Wang Wei,Xu Linjuan,Wu Suli,Liu Yang,Wang Yunming,Zhou Huamin

Constructing micro-/nanostructure-modulated photofields in upconversion devices to absorb low-energy photons and emit high-energy light is revolutionary for bioimaging, lasers, and photovoltaics, with proven capability to boost upconversion luminescence (UCL) by orders of magnitude. However, photoenergy dissipation and inadequate absorption result in excitation thresholds exceeding 1 mW/cm 2 , which exceeds retinal safety limits and hinders wearable upconversion optics. Here, we report the use of upconversion core-shell microsphere-induced infrared field convergence, NaYF 4 :Yb,Er shell-based resonant cavities for multiple reflection-absorption-upconversion and photonic crystal amplifiers to improve UCL intensity three orders of magnitude, and achieve ultralow threshold (0.0025 mW/cm 2 ). The 500 nm upconversion core-shell microspheres generated 1200-fold stronger electric field through concentrated photofield and attained 8-fold infrared absorption with a forward/backward emission ratio of 150. Fabricated upconversion contact lenses significantly improved dark-light imaging clarity and vision restoration in retinal degeneration rabbits. Microsphere-mediated directional upconversion strategy maximizes photoenergy utilization, paving the way for high-performance wearable upconversion devices.

研究领域: 生物医学工程 · 光学材料 · 纳米技术
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Small · 2023 · IF 13.3

Weak Ion-Exchange Based Magnetic Swarm for Targeted Drug Delivery and Chemotherapy

Kai Feng,Wenqi Shen,Ling Chen,Jiang Gong,Thomas Palberg,Jinping Qu,Ran Niu

Swimming microrobots that are actuated by multiple stimuli/fields display various intriguing collective behaviors, ranging from phase separation to clustering and giant number fluctuation; however, it is still chanllenging to achieve multiple responses and functionalities within one colloidal system to emulate high environmental adaptability and improved tasking capability of natural swarms. In this work, a weak ion-exchange based swarm is presented that can self-organize and reconfigure by chemical, light, and magnetic fields, showing living crystal, amorphous glass, liquid, chain, and wheel-like structures. By changing the frequency and strength of the rotating magnetic field, various well-controlled and fast transformations are obtained. Experiments show the high adaptability and functionality of the microrobot swarm in delivering drugs in confined spaces, such as narrow channels with turns or obstacles. The drug-carrying swarm exhibits excellent chemtherapy for Hela and CT26 cells due to the pH-enhanced drug release and locomotion. This reconfigurable microswarm provides a new platform for biomedical and environmental applications.

CAS / MDL: 25316-40-9
研究领域: 生物医学工程 · 纳米医学 · 化学 · 材料科学
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SENSORS AND ACTUATORS B-CHEMICAL · 2023 · IF 8.4

Bio-inspired propeller robot with controllable pitch driven by magnetic and optical coupling field

Wenguang Yang,Zhen Wang,Xiaowen Wang,Yibao Chen,Zhixing Ge,Haibo Yu

The ability of controlled pitch variation can give more forms of motion to the micro-rotor. By combining the photothermal conversion material CNTs with temperature-sensitive hydrogel material, the hydrogel can be driven by light to produce a recoverable and controlled deformation, which is verified by the swimming of a bionic jellyfish. Furthermore, we innovatively apply the variable pitch form of helicopters to the motion of micro-propellers. The magnetic field is used to power the rotation of the micro-rotor robot, and the light illumination provides the pitch variation capability to facilitate the manipulation of the motion behavior of the micro-rotor robot. Driven by a magnetic and optical coupling field, the ascending and descending of micro-propellers carrying objects are achieved. Our design provides a novel idea for the control strategy of micro-robots.

CAS / MDL: 2210-25-5 110-26-9
研究领域: 仿生学 · 微纳米机器人 · 材料科学
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Nano-Micro Letters · 2025 ·Vol. 18 ·期 1 ·58 · IF 36.3

Tunable Optical Metamaterial Enables Steganography, Rewriting, and Multilevel Information Storage

Zheng Jianchen,Zhang Yuzhao,Yu Haibo,Wang Jingang,Guo Hongji,Qiu Ye,Wang Xiaoduo,Feng Yu,Liu Lianqing,Li Wen Jung

Proposed a dynamic grayscale gradient modulation system enabling multi-information analysis and encryption under multi-optical fields, establishing a new paradigm for multi-dimensional encryption of collaborative multispectral information. Developed coumarin-based photo-responsive in situ reconstruction technology and constructed a multi-optical field coupled control system to achieve dynamic configuration of multi-information carriers. Designed and fabricated a micro-dynamic multiple encryption device with integrated functions for information writing, erasing and rewriting, realizing stable information storage and dynamic destruction through micro/nano-optical keys.

研究领域: 光学工程 · 纳米光子学 · 信息科学 · 材料科学 · 密码学 · 微纳制造 · 功能材料 · 光化学
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JOURNAL OF HAZARDOUS MATERIALS · 2025 · IF 11.3

Plasmonic microsphere lens arrays-integrated microfluidic SERS chip for mixed pesticides identification with machine learning

Zhenyong Dong,Feixiang Zheng,Hao Wang,Yukai Liu,Xiao Ren,Feng Lin,Song Zhou,Li Chen,Yan-qing Lu,Guanghui Wang

The use of multiple pesticides in agriculture has caused mixed residues, complicating food safety testing. Surface-enhanced Raman scattering (SERS) offers high sensitivity and fingerprinting capabilities for pesticide detection; however,its application is limited by spot size, uneven sample distribution, spectral analysis challenges in mixed samples, and the lack of integrated automated systems for sample preparation, detection, and analysis. Hence, we developed a SERS microfluidic chip integrated with plasmonic microsphere lens arrays, which integrates optical field-modulated microspheres and plasmonic nanostructures to realise the transition of SERS detection from point-hotspots to uniform area-hotspots, achieving high-sensitivity, high-stability Raman detection under wide-field laser excitation. Moreover, a comprehensive a sample-to-answer total analysis system was established with this chip as the core, incorporating the micro-QuEChERS pretreatment module for efficient extraction of pesticides in complex matrices and the random forest-dual annealing spectral parsing algorithm for mixed spectral analysis. The results indicate that the limits of detection for 2,4-dichlorophenoxyacetic acid, acetamiprid, and thiabendazole were 1.15 nM, 0.63 nM, and 0.69 nM, respectively. The linear ranges were 10⁻⁴–10⁻⁹ M, with R² values of 0.9982, 0.9989, and 0.9996, respectively. Average recoveries ranged from 90.8 % -104.66 %, 89.1 %-107.89 %, and 89.73 %-108.4 %, respectively, with relative standard deviations below 8 %. The algorithm quantified mixed pesticides with mean absolute percentage errors of 4.96 %, 5.35 %, and 7.72 %, respectively. The system showed 3 s detection response and 15-minute analysis time. Thus, the method provides a rapid, on-site solution for detecting mixed pesticides in complex matrices by exceptional optical performance and automated processing functionality.

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