Advanced Optical Materials
·
2022
·Vol. 10
·期 20
·2200865
·
IF 10.05
Kai Han,Jiance Jin,Binbin Su,Jianwei Qiao,Zhiguo Xia
Metal clusters with color-tunable radioluminescence have attracted growing attention as X-ray detection materials. However, they are generally less scintillation-efficient due to the coexistence of multiple exciton recombination centers. Herein, two new zero-dimensional copper(I)-based clusters (DIET) 3 Cu 3 X 3 (DIET = 1,3-Diethyl-2-thiourea, X = Cl, Br) are designed, which support the single channel photon emission (Cu cluster centered, CC) to enhance the scintillation performance. Those DIET ligands (L) anchoring with copper(I) ions not only generate direct Cu L bonds, but also form a disorder [Cu 3 X 3 ] cluster, which results in the intense X-ray absorption. (DIET) 3 Cu 3 Br 3 with low halogen electronegativity further weakens halogen-to-ligand charge transfer (XLCT) emission, enabling enhanced quantum efficiency (≈69%) and scintillation performance comparable to commercially available Lu 3 Al 5 O 12 :Ce. Moreover, the flexible thin film counterpart demonstrates legible X-ray imaging with high spatial resolution of 11.71 lp mm −1 . This study provides a feasible design principle to discover new metal cluster-based scintillators and to further expand their radiation detection applications.
研究领域:
材料科学
·
辐射探测
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry C
·
2025
·Vol. 13
·期 7
·3193-3198
·
IF 5.1
Yamei Ding,Mingyu Xie,Ping He,Ziqi Zhao,Huiwen Lin,Li Tao
Wide-bandgap quantum dots (QDs) have recognized as the third generation of low-dimensional semiconductors with reliable optical response, outstanding stability and biocompatibility for long-term biosensing in health care applications, especially in extreme environments. However, the applicable scenarios are limited, because optical switching over a large span from the wide bandgap (deep UV region) to the visible region is challenging due to the stable framework and the high breakdown difficulty. In this work, we adopted a facile protonation/deprotonation treatment process, which is suitable for different biogenic environments, to modulate the one-photon and two-photon fluorescence of wide-bandgap QDs. Two fluorescent centers are coordinative to control one-photon emission from deep blue (410 nm) to yellow (585 nm) emission with a wide large-span modulation, superior to most reports under different acid–base environments. The electron transition between electron-donating amine (–NH2) groups and H+ (–OH) changes the degree of nonradiative transition, narrowing the breadth of the full width at half maximum (FWHM) by 34.4%. Moreover, our QDs exhibit two-photon fluorescence at 710 nm, which have never reported before for wide-bandgap nitrides. It shows pH-independent two-photon fluorescence because of the intrinsic electron–phonon coupling of the π-conjugated structure. This work introduces a simple design strategy to realize fluorescence control over a large span in wide-bandgap nanomaterials, enabling distensible applications in biological health and pH related linear or nonlinear optical fields.
研究领域:
纳米材料
·
生物传感
·
光学
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2015
·
IF 12.881
Fengrui Hu,Huichao Zhang,Chun Sun,Chunyang Yin,Bihu Lv,Chunfeng Zhang,William W. Yu,Xiaoyong Wang,Yu Zhang,Min Xiao
The power conversion efficiency of photovoltaic devices based on semiconductor perovskites has reached ∼20% after just several years of research efforts. With concomitant discoveries of other promising applications in lasers, light-emitting diodes, and photodetectors, it is natural to anticipate what further excitement these exotic perovskites could bring about. Here we report on the observation of single photon emission from single CsPbBr3 perovskite nanocrystals (NCs) synthesized from a facile colloidal approach. Compared with traditional metal-chalcogenide NCs, these CsPbBr3 NCs exhibit nearly 2 orders of magnitude increase in their absorption cross sections at similar emission colors. Moreover, the radiative lifetime of CsPbBr3 NCs is greatly shortened at both room and cryogenic temperatures to favor an extremely fast output of single photons. The above superior optical properties have paved the way toward quantum-light applications of perovskite NCs in various quantum information processing schemes.
研究领域:
材料科学
·
光学
·
量子信息科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
·
2010
·Vol. 15
·期 4
·591-599
·
IF 3.415
Zhu Hua,Huang Liliang,Zhang Yuanqing,Xu Xiaoping,Sun Yanhong,Shen Yu-Mei
To develop technetium- and rhenium-labeled nonsteroidal estrogen imaging agents for estrogen receptor (ER) positive breast tumors, two groups of rhenium and technetium cyclofenil derivatives were synthesized and characterized. The binding affinities of the rhenium complexes for ERs were determined. The tricarbonyl rhenium complex showed the highest binding affinity for ERs (81.2 for ERβ, 16.5 for ERα). Tricarbonyl technetium cyclofenil complexes were obtained in high radiochemical purity and radiochemical yields. The results of studies of their octanol/water partition and in vitro stability are presented. These results demonstrate that these radiolabeled cyclofenil derivatives may be considered as potential breast cancer imaging agents.
研究领域:
医学影像学
·
药物化学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
ACS Nano
·
2013
·
IF 12.062
Yun Sun,Xingjun Zhu,Juanjuan Peng,Fuyou Li
Multimodality imaging overcomes the shortage and incorporates the advantages of different imaging tools. Lanthanide-based nanoprobes are unique and have rich optical, magnetic, radioactive, and X-ray attenuation properties; however, simple doping of different lanthanide cations into one host can result in a material with multifunction but not the optimized properties. In this study, using NaLuF4:Yb,Tm as the core and 4 nm of 153Sm3+-doped NaGdF4 (half-life of 153Sm = 46.3 h) as the shell, we developed a lanthanide-based core–shell nanocomposite as an optimized multimodal imaging probe with enhanced imaging ability. The lifetime of upconversion luminescence (UCL) at 800 nm and relaxation rate (1/T1) were at 1044 μs and 18.15 s–1·mM–1, respectively; however, no significant decrease in the attenuation coefficient was observed, which preserved the excellent X-ray imaging ability. The nanomaterial NaLuF4:Yb,Tm@NaGdF4(153Sm) was confirmed to be effective and applicable for UCL imaging, X-ray computed tomography (CT), magnetic resonance imaging, and single-photon emission computed tomography (SPECT) in vivo. Furthermore, the NaLuF4:Yb,Tm@NaGdF4(153Sm) nanoparticles were applied in tumor angiogenesis analysis by combining multimodality imaging of CT, SPECT, and confocal UCL imaging, which shows its value of multifunctional nanoparticles NaLuF4:Yb,Tm@NaGdF4(153Sm) in tumor angiogenesis imaging.
研究领域:
生物医学工程
·
纳米医学
·
分子影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2024
·
IF 6.6
Ronglin Ma,Chunya Ji,Mengdan Shen,Shujuan Xu,Guojia Fan,Chengcheng Wu,Qiang Yu,Linliang Yin
Background Radionuclides have important roles in clinical tumor radiotherapy as they are used to kill tumor cells or as imaging agents for drug tracing. The application of radionuclides has been developing as an increasing number of nanomaterials are used to deliver radionuclides to tumor areas to kill tumor cells. However, promoting the efficient combination of radionuclides and nanocarriers (NCs), enhancing radionuclide loading efficiency, and avoiding environmental pollution caused by radionuclide overuse are important challenges that hinder their further development.Methods In the present study, a new small molecule compound (3-[[(2S)-2-hydroxy-3-(4-hydroxyphenyl)-1-carbonyl] amino]-alanine, abbreviation: HN, molecular formula: C12H16N2O5) was synthesized as a linker between radionuclide iodine-125 (125I) and NCs to enable a more efficient binding between NCs and radionuclides.Results In vitro evidence indicated that the linker was able to bind 125I with higher efficiency (labeling efficiency >80%) than that of tyrosine, as well as various NCs, such as cellulose nanofibers, metal oxide NCs, and graphene oxide. Single-photon emission computed tomography/computed tomography imaging demonstrated the biological distribution of 125I-labeled NCs in different organs/tissues after administration in mice.Conclusion These results showed an improvement in radionuclide labeling efficiency for nanocarriers and provided an approach for nanocarrier image tracing.
研究领域:
放射医学
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纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2018
·
IF 8.806
Hairong Wang,Yu Chao,Jingjing Liu,Wenwen Zhu,Guanglin Wang,Ligeng Xu,Zhuang Liu
Tumor hypoxia is known to be one of critical factors that aggravate the tumor resistance to photodynamic therapy (PDT) in which oxygen is essential for tumor destruction. Herein, catalase , an enzyme to trigger hydrogen peroxide (H 2 O 2 ) decomposition, is modified by in-situ free radical polymerization , using meso-tetra( p -hydroxyphenyl) porphine (THPP) as the cross-linker to enable condensed grafting of short polyethylene glycol (PEG) chains on the protein surface as a permeable brush-like safeguard. The formulated catalase-entrapped nanocapsules (CAT-THPP-PEG) with enhanced enzyme stability can be labeled with 99m Tc 4+ , a radioisotope ion that is chelated by the porphyrin structure of THPP, to allow in vivo single-photon emission computed tomography (SPECT) imaging. It is found that such CAT-THPP-PEG nanoparticles exhibit efficient tumor passive retention after intravenous injection, and are able to greatly relieve tumor hypoxia by triggering the decomposition of tumor endogenous H 2 O 2 into oxygen. With THPP functioning as a photosensitizer , in vivo PDT is further conducted, achieving a remarkable antitumor therapeutic effect. This work presents an enzyme modification strategy by in-situ polymerization with photosensitizer as the cross-linker to develop multifunctional nano-theranostics with strengthened enzymatic stability, efficient tumor passive homing, SPECT imaging capability, enhanced PDT efficacy as well as decreased immunogenicity , promising for clinical translation.
研究领域:
生物医学工程
·
肿瘤学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2025
·
IF 1.6
Su Dongping,Liao Yuhao,Wang Jieru,Liu Ruomeng,Cai Huawei,Yin Xiaojie,Qin Zhi,Zhang Jinsong,Yao Zeen,Li Bo
To evaluate the suitability of 47 Sc for SPECT imaging and therapeutic effect, a fibroblast activation protein (FAP) inhibitor FAPI-46 was used for cancer theranostics in preclinical setting. 47 Sc was successfully produced via thermal neutron irradiation of 46 Ca and then conjugated with FAPI-46, achieving a high radiochemical purity over 98%. In vitro experiments confirmed the FAP mediated specific binding to MG-63 cells for 47 Sc-FAPI-46. Biodistribution and SPECT/CT imaging indicated specific uptake of 47 Sc-FAPI-46 in PANC-2 pancreatic tumors. Therapeutic experiments revealed an effective anti-tumor ability with negligible toxicity of 47 Sc-FAPI-46 in xenografted tumor mice.
研究领域:
核医学
·
放射性药物化学
·
肿瘤学
·
分子成像
·
诊疗一体化
✓ 已验证
DOI
高影响因子
BIOMATERIALS
·
2013
·
IF 7.604
Juanjuan Peng,Yun Sun,Lingzhi Zhao,Yongquan Wu,Wei Feng,Yanhong Gao,Fuyou Li
Nanoparticles that circulate in the bloodstream for a prolonged period of time have important biomedicine applications. However, no example of lanthanide-based nanoparticles having a long-term circulation bloodstream has been reported to date. Herein, we report on difunctional radioactive and upconversion nanoparticles (UCNP) coated with polyphosphoric acid ligand, that is ethylenediamine tetramethylenephosphonic acid (EDTMP), for an application in single-photon emission computed tomography (SPECT) blood pool imaging. The structure, size and zeta-potential of the EDTMP-coated nanoparticles (EDTMP-UCNP) are verified using transmission electron microscopy and dynamic light scattering . Injection of radioisotope samarium-153-labeled EDTMP-UCNP (EDTMP-UCNP: 153 Sm) into mice reveal superior circulation time compared to control nanoparticles coated with citric acid (cit-UCNP: 153 Sm) and 153 Sm complex of EDTMP (EDTMP- 153 Sm). The mechanism for the extended circulation time may be attributed to the adhesion of EDTMP-UCNP on the membrane of red blood cells (RBCs). In vivo toxicity results show no toxicity of EDTMP-UCNP at the dose of 100 mg/kg, validating its safety as an agent for blood pool imaging. Our results provide a new strategy of nanoprobe for a long-term circulation bloodstream by introducing polyphosphoric acid as surface ligand.
研究领域:
生物医学工程
·
放射医学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2019
·
IF 4.745
Ling Yin,Hao Sun,Meng Zhao,Anna Wang,Shanshan Qiu,Yinjia Gao,Jianan Ding,Shun-Jun Ji,Haibin Shi,Mingyuan Gao
Lymphatic metastasis is an important prognostic indicator for cancer progression. It is therefore considerably meaningful to develop molecularly targeted imaging probes for noninvasive and accurate identification of metastatic lymph nodes (MLNs) at early stages of tumor metastasis. Herein, we report a novel matrix metalloproteinase-2 (MMP-2)-activatable probe constructed with a near-infrared dye (Cy5), a quencher (QSY21), and a tumor-targeting peptide cRGD covalently linked through a radionuclide (125I)-labeled peptide substrate for accurate detection of MLNs. Upon cleavage with activated MMP-2, the above probe emitted MMP-2 concentration-dependent near-infrared fluorescence, which allows sensitive and specific visualization of MLNs via both optical and single-photon emission computed tomography imaging techniques. We thus envision that this probe would serve as a useful tool for studying tumor-induced lymphangiogenesis.
研究领域:
癌症生物学
·
分子影像学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Theranostics
·
2018
·
IF 8.537
Qiufang Liu,Yuyi Qian,Panli Li,Sihang Zhang,Jianjun Liu,Xiaoguang Sun,Michael Fulham,Dagan Feng,Gang Huang,Wei Lu,Shaoli Song
Purpose: Transcatheter hepatic artery embolization therapy is a minimally invasive alternative for treating inoperable liver cancer but recurrence is frequent. Multifunctional agents, however, offer an opportunity for tumor eradication. In this study, we were aim to synthesized poly (lactic-co-glycolic acid) (PLGA) microspheres encapsulating hollow CuS nanoparticles (HCuSNPs) and paclitaxel (PTX) that were then labeled with radioiodine-131 ( 131 I) to produce 131 I-HCuSNPs-MS-PTX. This compound combines the multi-theranostic properties of chemotherapy, radiotherapy and photothermal therapy. In addition, it can also be imaged with single photon emission computed tomography (SPECT) imaging and photoacoustic imaging. Methods: We investigated the value of therapeutic and imaging of 131 I-HCuSNPs-MS-PTX in rats bearing Walker-256 tumor transplanted in the liver. After the intra-arterial (IA) injection of 131 I-HCuSNPs-MS-PTX, 18 F-Fluorodeoxyglucose ( 18 F-FDG) micro-positron emission tomography/computed tomography (micro-PET/CT) imaging was used to monitor the therapeutic effect. PET/CT findings were verified by immunohistochemical analysis. SPECT/CT and photoacoustic imaging were performed to demonstrate the distribution of 131 I-HCuSNPs-MS-PTX in vivo . Results : We found that embolization therapy in combination with chemotherapy, radiotherapy and photothermal therapy offered by 131 I-HCuSNPs-MS-PTX completely ablated the transplanted hepatic tumors at a relatively low dose. In comparison, embolization monotherapy or combination with one or two other therapies had less effective anti-tumor efficacy. The combination of SPECT/CT and photoacoustic imaging effectively confirmed microsphere delivery to the targeted tumors in vivo and guided the near-infrared laser irradiation. Conclusion : Our study suggests that there is a clinical theranostic potential for imaging-guided arterial embolization with 131 I-HCuSNPs-MS-PTX for the treatment of liver tumors.
研究领域:
肿瘤学
·
放射学
·
药理学
·
医学影像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2019
·Vol. 319
·期 3
·1119-1125
·
IF 1.186
Wang Yunhan,Song Hu,Wang Guanquan,Yang Xia,Wang Jing,Wei Hongyuan
In this study, we successfully synthesized polyethylene glycol (PEG) and folic acid (FA) co-functionalized graphene quantum dots (GQDs) to improve the biocompatibility and tumor-targeting ability of GQDs simultaneously, and labeled GQDs–PEG–FA with 131 I for biological behavior evaluation. The in vitro properties, biodistribution and SPECT imaging of 131 I-GQDs–PEG–FA were investigated. The uptake of 131 I-GQDs–PEG–FA at tumor sites can be clearly examined via SPECT imaging, which can ascribe to enhanced permeability and retention effect and active targeting effect of FA to folate receptors. The results indicate that 131 I-GQDs–PEG–FA can be used as a radioactive probe for detection of tumor cells overexpressing folate receptor.
研究领域:
放射学
·
核医学
·
分子影像
·
生物材料
·
癌症研究
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）