ACS Sensors
·
2025
·
IF 9.1
Ruijie Wu,Ziyihui Wang,Yaoxin Fu,Junfeng Jiang,Yu-Cheng Chen,Tiegen Liu
Hydrogels have emerged as promising sensors for detecting heavy metal ions in fluids and have been extensively developed. However, monitoring of multiple target analytes in Chinese herbs remains challenging due to subtle chemical signals and the complex composition of the extracted solutions. To address these challenges, we developed a hydrogel optofluidic sensor to amplify analyte signals through strong light–matter interactions within the hydrogel. This sensing platform integrates a hydrogel film encapsulated in a whispering-gallery-mode (WGM) microcavity for the detection of heavy metal ions, such as Pb2+ and Hg2+. The 3D cross-linked hydrophilic polymer network facilitates ion penetration from analyte solutions, inducing distinct WGM resonance shifts. The red shift in the spectral wavelength serves as a parameter to quantify the content of heavy metal ions. By modification of the hydrogel with aptamers, the optofluidic sensors achieve high sensitivity and selectivity. Finally, the platform’s performance was demonstrated using Chinese herbs with varying Pb2+ concentrations, highlighting its practical applicability in real-world scenarios. The proposed hydrogel microcavity exhibit a promising method for development of functional hydrogel sensors and healthcare applications.
研究领域:
生物医学工程
·
分析化学
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
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IF 5.401
Yan Wang,Liyuan Zhao,Aojie Xu,Lei Wang,Lingli Zhang,Shuangqiang Liu,Yongjun Liu,Hanyang Li
We report a liquid crystal (LC) microdroplet-based pH sensor and explore its application for detecting enzymatic reactions in penicillinase. Nematic LC 4-cyano-4'-pentylbiphenyl (5CB) microdroplet, doped with 4'-pentyl-biphenyl-4-carboxylic acid (PBA), is produced in phosphate buffer solution (PBS) with a tapered capillary microtube connected to a syringe pump. The PBA-doped 5CB microdroplets exhibit configuration transitions from bipolar to radial as PBS pH values increase from 5.7 to 6.0. These pH-induced changes in optical appearance are experimentally verified and attributed to the deprotonation of PBA at the aqueous/LC interface. We also examine the feasibility of the PBA-doped 5CB microdroplets as optical microcavities of whispering gallery modes (WGMs). Typical WGM lasing emission is observed in micrometer-sized microdroplets under a pulse laser pump. The WGM spectrum from the microdroplet responds to pH variations, reflecting as a spectral redshift as the pH decreases. The PBA-doped 5CB microdroplet can be successfully exploited accordingly for detecting enzymatic reactions in penicillinase. We demonstrate that the detectable shifts in WGM spectra associated with the microdroplet configuration transitions can serve as an indicator of the H + released from the enzymatic reaction.
研究领域:
生物化学
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分析化学
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材料科学
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产品关联
DOI
高影响因子
OPTICS EXPRESS
·
2019
·Vol. 27
·期 24
·35427-35436
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IF 3.561
Rui Duan,Yanzeng Li,Hanyang Li,Hanyang Li,Hanyang Li,Jun Yang,Jun Yang,Jun Yang
A new strategy is reported here to monitor the enzymatic reactions in real time by using whispering gallery mode (WGM) lasing. The optical microcavity is formed via the self-assembly of an ultraviolet (UV)-treated nematic liquid crystal (LC) 4-cyano-4’-pentylbiphenyl (5CB). The single UV-treated 5CB microdroplet serves as both optical resonator and sensing reactor. The microdroplet configuration transitions induced wavelength shift in the WGM lasing spectra can be used as an indicator for the enzymatic reaction. The proposed sensor has a sub-microgram detection limit of urease (∼0.5 µg/ml), which is lower than the detection limit of currently available urease sensor based on LC materials. Our experimental results demonstrate that WGM lasing has unique advantages in the real-time monitoring of enzymatic reactions compared, for instance, with observation of the optical appearance under a polarized optical microscope.
研究领域:
生物传感
·
光学
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产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2023
·
IF 29.4
Linge Xiao,Yanxun Li,Hong Zhang,Gaosheng Huang,Qian Cheng,Shilin Li,Yuan Zhang,Huiqiong Zhou
Semitransparent organic photovoltaics (ST-OPVs), owing to the merits of high power generation, thermal insulation, and aesthetic features, have become a promising candidate for intellectual building- integrated photovoltaic windows. However, the traditional optical evaluation only focuses on the transmission properties and ignores the reflection behaviors. And the lack of quantitative descriptions for array appearance hinders implementation of ST-OPV based large-area modules. To tackle with these issues, an indium tin oxide (ITO)-free optical microcavity architecture into ST-OPVs for achieving high homogeneity in transmittance with controllable reflective appearances through tunning the thickness of individual component layers is introduced. A set of parameters based on optical characteristics of sub-units to provide a quantitative description for the transmittance brightness, transmissive and reflective color purity, and versatility of optical arrays, is further proposed. The optical simulations reveal that reflection modulation from blue to red colors can be realized for devices based on various bulk-heterojunction material systems through regulating the thickness of active layers and antireflection coatings. This work offers a viable design strategy for ST-OPVs toward applications in next-generation smart photovoltaic windows.
研究领域:
材料科学
·
光学工程
·
可再生能源
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
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IF 9.229
Ye Kong,Zhe Zhao,Yunqi Wang,Shuo Yang,Gaoshan Huang,Yang Wang,Chang Liu,Chunyu You,Ji Tan,Chao Wang,Borui Xu,Jizhai Cui,Xuanyong Liu,Yongfeng Mei
Carbon dioxide (CO2) sensing using an optical technique is of great importance in the environment and industrial emission monitoring. However, limited by the poor specific adsorption of gas molecules as well as insufficient coupling efficiency, there is still a long way to go toward realizing a highly sensitive optical CO2 gas sensor. Herein, by combining the advantages of a whispering-gallery-mode microcavity and a metal–organic framework (MOF) film, a porous functional microcavity (PF-MC) was fabricated with the assistance of the atomic layer deposition technique and was applied to CO2 sensing. In this functional composite, the rolled-up microcavity provides the ability to tune the propagation of light waves and the electromagnetic coupling with the surroundings via an evanescent field, while the nanoporous MOF film contributes to the specific adsorption of CO2. The composite demonstrates a high sensitivity of 188 nm RIU–1 (7.4 pm/% with respect to the CO2 concentration) and a low detection limit of ∼5.85 × 10–5 RIU. Furthermore, the PF-MC exhibits great selectivity to CO2 and outstanding reproducibility, which is promising for the next-generation optical gas sensing devices.
研究领域:
材料科学
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光学工程
·
环境监测
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产品关联
DOI
PubMed
高影响因子
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