National Science Review
·
2023
·Vol. 10
·期 9
·
IF 20.6
Zhou Xiao,Zhao Mei-Huan,Yao Shan-Ming,Dong Hongliang,Wang Yonggang,Chen Bin,Xing Xianran,Li Man-Rong
Chemical stabilization of a high-pressure metastable state is a major challenge for the development of advanced materials. Although chemical pressure (Pchem) can effectively simulate the effect of physical pressure (Pphy), experimental calibration of the pressure passed to local structural motifs, denoted as local chemical pressure (Pchem-Δ) which significantly governs the function of solid materials, remains absent due to the challenge of probing techniques. Here we establish an innovative methodology to experimentally calibrate the Pchem-Δ and build a bridge between Pchem and Pphy via an optical probe strategy. Site-selective Bi3+-traced REVO4 (RE = Y, Gd) is adopted as a prototype to introduce Bi3+ optical probes and on-site sense of the Pchem-Δ experienced by the REO8 motif. The cell compression of RE0.98Bi0.02VO4 under Pphy is chemically simulated by smaller-ion substitution (Sc3+ → RE3+) in RE0.98-xScxBi0.02VO4. The consistent red shift (Δλ) of the emission spectra of Bi3+, which is dominated by locally pressure-induced REO8 dodecahedral variation in RE0.98Bi0.02VO4 (Pphy) and RE0.98-xScxBi0.02VO4 (Pchem-Δ), respectively, is evidence of their similar pressure-dependent local structure evolution. This innovative Δλ-based experimental calibration of Pchem-Δ in the crystal-field dimension portrays the anisotropic transmission of Pchem to the local structure and builds a bridge between Pchem-Δ and Pphy to guide a new perspective for affordable and practical interception of metastable states.
研究领域:
材料科学
·
光学
·
固态化学
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DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2020
·Vol. 22
·期 33
·18711-18721
·
IF 3.43
Linghui Zhang,Guoqiang Peng,Yujiang Wang,Tiejun Li,Dan Wang,Lili Han,Zhipeng Ci
The controllable design and precise modulation of the functional properties of materials based on theoretical calculations has always been the goal of materials researchers. Through the comparative analysis of theoretical calculations and experimental phenomena, physical properties, including optical properties, electrical conductivity, and dielectric properties, can be further comprehended. In this work, on the basis of the first-principles calculations of many inorganic compounds, we selected BaSnSi3O9 (BSSO) as the research focus and found that it contained two cationic sites with completely different electronic characteristics. Among them, the electron density of cations at the Ba site shows obvious localization characteristics, whereas the Sn site shows strong interaction with the surrounding environment. This distinct difference in electronic characteristics is very beneficial to the research and design of materials with functional properties. When functional ions are introduced into Ba sites, the relatively complete independence of these ions will be maintained. That is, if an ion with multiple stable valence states is introduced at the Ba site, it will exhibit the coexistence of multiple valence states. However, if an ion is introduced at the Sn site, this ion will lose its independence and exhibit strong interaction with the surrounding crystal field environment. The rare earth element europium (Eu) with two stable divalent and trivalent valence states in its normal state was chosen as a probe to verify the theoretical predictions in this work. According to the calculation results, when Eu occupied the Ba site, the spectrum simultaneously showed the luminescence of Eu3+ and Eu2+, and had a larger luminescence quenching concentration when the influence of defects was ignored. When Eu occupied the Sn lattice site, it only showed the luminescence of Eu3+, and had a lower luminescence quenching concentration due to the attractive effect that the surrounding O atoms had on the Eu electrons. Our research indicates that the experimental results are consistent with the theoretical predictions. This paper analyzes the important role of Eu optical probes in terms of investigating their physical mechanisms and optical properties in detail. It will provide valuable inspiration for theoretical calculations to guide the design of materials and the modulation of their functional properties.
研究领域:
材料科学
·
物理化学
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产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
·
IF 3.232
Aiwen Yu,Yitong Zhang,Wanqiang Liu,Jinwei Gao,Lingbo Zhang,Zhi Zeng,Yuhui Zheng
Emissive lanthanide ions are considered as luminescent species or optical probes for the analytes in ambient conditions or even cellular environment. But a variety of factors determine the stability of photo-luminescent signals due to the excitation sources, statistical errors or the selection of solvents. In this way, ratiometric assays effectively circumvent such problem and lead to more sensitive and reliable results. Herein, an organic-inorganic hybrid material has been developed with the europium complex as the core and the terbium species can be attached onto the surface of silica host. As for the evaluation of the internal structure, the terbium complex has been integrated into the hybrid network via weak forces and its sensitizing moiety will be easily attacked by Lewis acid-base interactions. In a different manner, the europium complex has been shielded from perturbation due to the protection of the outside silica shells. Such sharp difference in response to fluoride induces drastic signal changes and the conversion of binding process between fluoride and molecular receptors (boronic group) into readable optical outputs has afforded the lower detection limit for F − as 0.17 μM. In addition, the intracellular uptake and distribution of the hybrid material have been explored.
研究领域:
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Si-Yan Yu,Jing-Jing Qiao,Chun-Pu Mao,Shuai Ying,Li-Hong Zhu,Kai Wang
Nitric oxide plays an important role in the occurrence and development of cardiovascular disease. However, due to the reactive and transient nature of NO, directly detecting its levels is challenging in the clinic, and currently used imaging methods have difficulty imaging NO levels at the living level. In this study, we developed a nitric oxide (NO)-responsive probe (NOP) and its nanoformulation (NanoNOP). NanoNOP exhibited excellent stability, sensitivity, and selectivity toward NO, with enhanced fluorescence and photoacoustic (PA) signals upon NO exposure. In cellular studies, NanoNOP demonstrated strong NO responsiveness in foam cells, a key cell type in cardiovascular disease, with significantly higher photoacoustic and fluorescence signals compared to control macrophages. In vivo studies in mice with acute lung injury (ALI) revealed elevated NO levels in the aortic region, confirmed by ex vivo immunohistochemical analysis showing increased iNOS expression and NO production. NanoNOP also demonstrated excellent biocompatibility, with no significant changes in body weight or organ damage. These findings highlight NanoNOP as a promising tool for studying NO-related pathologies and developing targeted therapeutic strategies.
研究领域:
医学影像学
·
生物化学
·
病理学
✓ 已验证
DOI
PubMed
高影响因子
Analytical Methods
·
2024
·Vol. 16
·期 15
·2301-2310
·
IF 2.7
Yang Cheng,Yuan Liu,Jiguang Li,Yudong Li,Da Lei,Dezhong Li,Xincun Dou
Highly efficient detection of environmental residual potentially toxic species is of concern worldwide as their presence in an excessive amount would greatly endanger the health of human beings as well as environmental sustainability. The solvation effect is a critical factor to be considered for understanding chemical reaction progress as well as the photophysical behaviors of substances and thus is promising for visualized detection of metal ions. Herein, by applying 5-amino-1,10-phenanthroline (APT) as the optical probe, a sensing strategy was proposed based on the solvation effect modulated complexation of APT towards different metal ions to achieve the visualized discrimination of four critical ions (Cu(II), Zn(II), Cd(II), and Al(III)). How the crucial intrinsic properties of the solvent (e.g., polarity, solvent free energy, and electrostatic potential) influenced the complexation and the product emission was clarified, and the detection performances were systematically evaluated with detection limits as low as the nM level and good recognition selectivity. Furthermore, a portable sensing chip was developed with potential for highly efficient analysis in complicated scenes; thus, this strategy offers a new insight into determining multiple metal ions or other critical substances upon solvation manipulation.
研究领域:
分析化学
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Xinyi Yang,Zhenzhen Cai,Dezhong Li,Da Lei,Yushu Li,Guangfa Wang,Jun Zhang,Xincun Dou
Although a set of functional molecules with the D-π-A structure has been explored as optical probes for the detection of target analytes, it remains a great challenge to elaborately design a single probe for distinguishing different analytes by their intrinsic oxidation or reduction capabilities and thus to generate distinct optical responses. Here, a unique TCF-based probe (DMA-CN) containing two unsaturated double bonds in the π-conjugation bridge and TCF with different reaction activities that could be cut off by KMnO4 and NaClO in varying degrees was developed, causing remarkably distinguishable responses for both fluorescence and colorimetric channels to discriminate KMnO4 and NaClO from each other. The fluorescence and colorimetric limits of detection (LODs) of the proposed DMA-CN toward KMnO4 were calculated as 60 and 91 nM, respectively, while those for NaClO were 13.3 and 214 nM, and all the optical signal change can be observed within 1 s with good specificity. Based on the proposed probe design strategy, a well-fabricated test strip was proven to be promising for the rapid, in-field detection and risk management. We expect that the present probe design methodology would provide a powerful strategy for efficient probe exploration, especially for discriminating the substances with similar oxidizing properties.
研究领域:
分析化学
·
生物传感
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Liting Zhang,Xiaoxin Yan,Ting Jiang,Jie Han,Jianqiang Xiao,Kai Wang,Donglin Hao,Rui Guo,Jianhua Jin
This study introduces Hcy-GST, a new dual-modal optical probe for detecting glutathione S-transferase (GST) activity. The probe combines hemicyanine and rhodamine derivatives, which use fluorescence and photoacoustic (PA) signals, controlled by a photoinduced electron transfer (PET) mechanism. In its original form, the nitro groups in Hcy-GST quench fluorescence, producing weak fluorescence and strong PA signals. When GST replaces the nitro groups with glutathione (GSH), the PET effect is interrupted, leading to fluorescence recovery and reduced PA signals. Hcy-GST shows high sensitivity, with fluorescence and PA signals strongly correlating with GST concentration. It has high selectivity and minimal interference from other substances. In cellular tests, Hcy-GST detected GST inhibition by ethacrynic acid. In vivo studies revealed lower GST activity in obese models, with PA signals increasing after probe injection. Hcy-GST demonstrated excellent stability and low toxicity, showing promise for GST detection in research and diagnostics.
研究领域:
生物化学
·
医学诊断
✓ 已验证
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Jia-Xi Shen,Rui Guo,Miao-Yan Wang,Hai-Liang Zhu,Hao-Xiang Jiang,Han-Bin Cui,Kai Wang
Cardiovascular disease, a chronic and progressive arterial wall disease, is increasingly recognized for its clinical significance. Aminopeptidases N (APN), crucial in the pathophysiological processes of vulnerable plaque, have been linked to endothelial dysfunction, oxidative stress, and plaque formation, thus highlighting their potential as biomarkers for disease progression. However, current detection methods for APN in body fluids and in vivo have limitations, including insufficient sensitivity and specificity, time delays, and the inability to directly reflect enzyme activity in plaques. To address these challenges, we developed an optical probe, HD-APN, for in vivo imaging of aminopeptidases, providing a potential implementation in cardiovascular disease. Our work demonstrated the applicability of HD-APN for specific monitoring of aminopeptidase levels in plaques and serum, shedding light on its potential for further research in cardiovascular disease.
研究领域:
心脏病学
·
分子生物学
·
生物医学工程
·
成像科学
✓ 已验证
DOI
PubMed
高影响因子
TALANTA
·
2020
·
IF 5.339
Qiuju Zhou,Yajun Fang,Jiayu Li,Dan Hong,Panpan Zhu,Shihong Chen,Kejun Tan
In this work, a novel dual-ratiometric optical probe based on europium-doped carbon dots (Eu-CDs) was developed for colorimetric and fluorescent visual sensing dipicolinic acid (DPA), a anthrax biomarker. Eu-CDs with recessive signals were prepared via thermal pyrolysis method. And the magenta appears when Eu-CDs coordinates with Eriochrome Black T (EBT). Based on the ligand displacement strategy, DPA reduces magenta and makes blue appear, which develop ratiometric colorimetric visual detection methods of DPA. Under 270 nm excitation, DPA make the red fluorescence signal of Eu in EBT-CDs@Eu appear, based on the absorbance-energy transfer-emission effect, the ratiometric fluorescent visual detection assay of DPA has been developed. Based above, dual-ratiometric optical probe was designed successfully. The limit of detection (LOD) is 10.6 nM for ratio colorimetric assay . More prominently, naked-eye determination of DPA without instrument is as low as 1.0 μM. Furthermore, its practicability was verified by quantifying the DPA in Bacillus subtilis spores and human urine (with RSD≤2.35%). The sensor shows great superiority in on-site analysis of DPA, especially in limited instruments conditions.
研究领域:
分析化学
·
生物医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Jingtao Huang,Ying Ying Nie,Yu Meng Yang,Xin Ying Long,Yongpeng He,Lei Zhan,Cheng Zhi Huang
Acetylcholinesterase (AChE), one of nature’s most efficient enzymes, plays a crucial role in neural signal transduction and the restoration of tissue homeostasis with implications in the development of neurodegenerative diseases. Conventional methods for detecting AChE mainly rely on its catalytic activity. Herein, we present an approach for AChE detection based on its chiral binding with photoluminescent carbon dots (CDs) with rich chiral cysteine residues (L/D-CDs), synthesized via a general hydrothermal route. Interestingly, L-CDs, despite being synthesized under the same conditions as D-CDs, exhibited a stronger specific binding affinity for AChE than D-CDs through electrostatic interactions, attributed to the amphiphilic nature of AChE, leading to enhanced photoluminescence near the isoelectric point of AChE at 6.50. The enhanced photoluminescence intensity of L-CDs showed a linear correlation with AChE concentrations over the range of 200–4500 mU/mL with a detection limit of 20 mU/mL. Meanwhile, by leveraging the selective recognition of AChE by L-CDs, we applied the probe to distinguish between liver cancer tissues and adjacent nontumor tissues. The results demonstrated that, due to the reduced AChE content in liver cancer tissues, the fluorescence intensity was significantly lower than that in adjacent nontumor tissues. Our findings highlight the potential of CDs rich in chiral residuals as optical probes for biosensing and imaging applications based on biomolecular recognition.
研究领域:
分析化学
·
生物化学
·
纳米技术
·
生物医学工程
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Lin Pang,Tianshi Zhang,Yuan Liu,Dezhong Li,Jiguang Li,Ming Guan,Xincun Dou
Tryptamines , an important family of new psychoactive substances, have attracted special attention from the international community owing to their abuse and corresponding influence on human health and social stabilization. However, realizing the on-site analysis of tryptamines with rapid and precise responses remains a great challenge, especially if these are present in their disguised form. A highly sensitive and specific analytical method was developed herein, driven by a dual noncovalent interaction towards tryptamines. An optical probe was designed to specifically recognize tryptamines via π–π stacking and hydrogen bond effect to produce significant optical responses for both colorimetric and fluorescent modes. The detection limits were calculated as 4.1 nM (fluorescent mode) and 17.2 μM (colorimetric mode), respectively, with an excellent specificity towards 16 interfering substances within 0.6 s. Based on the excellent detection performances of the proposed probe, a portable and operable sensor was developed and demonstrated with the rapid and accurate analysis capability towards the controlled α -methyl-tryptamine in complicated scenarios. We expect the portable sensor equipped with this optical probe would provide a powerful tool for trace tryptamine detection and effective technical support for real-time monitoring of other new psychoactive substances in complicated media.
研究领域:
分析化学
·
药物分析
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2012
·Vol. 129
·期 2
·846-852
·
IF 1.289
Hong Yu Yang,Xiu Mei Zhang,Li Jie Duan,Ming Yao Zhang,Guang Hui Gao,Hui Xuan Zhang
A series of environmental pH-responsive block copolymers PEG-polyurethane with tertiary amine groups in the main chain and free carboxyl groups in the side chain were synthesized, including poly(ethylene glycol) (PEG), 1,4-bis (hydroxyethyl) piperazine, 1,6-diisocyanato hexamethylene, and 2,2-dimethylolpropionic acid. The chemical structure, molecular weight, and pH-dependent capacity of pH-responsive PEG-polyurethane were examined by 1 H-NMR, FTIR, gel permeation chromatography (GPC), and an acid-base titration. Moreover, the fluorescent dye fluorescein isothiocyanate was conjugated with PEG-polyurethane by the similar polymerization method and the obtained polymer was measured by ultraviolet visible spectroscopy (UV-vis) and fluorescent spectroscopy. The results indicated that the pH-responsive PEG-polyurethane showed a pH-buffering phenomenon and fluorescent imaging in a range of pH values. As a result, we demonstrated its potential application for optical imaging; however, it is believed that more applications in the areas of biomedicine will be possible owing to its free carboxyl acid terminal residues in the stimuli-responsive polymer. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
研究领域:
生物材料
·
分子影像学
·
高分子化学
·
纳米医学
·
药物递送
·
生物传感器
·
转化医学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）