SENSORS AND ACTUATORS B-CHEMICAL
·
2015
·
IF 4.097
Huan Yu,Mingtai Sun,Kui Zhang,Houjuan Zhu,Zhengjie Liu,Yajun Zhang,Jun Zhao,Lijun Wu,Zhongping Zhang,Suhua Wang
The intracellular pH value controls many aspects of cell metabolism and is considered as an integral part of many metabolic reactions by maintaining the structure and function of nearly all proteins. Detection of pH fluctuation covering the whole intracellular pH window including both neutral and acidic is essential but challenging and still needs more sensitive pH probes. We have synthesized a new near-infrared fluorescent and colorimetric probe based on cyanine dye, which can be used for monitoring the pH fluctuation. The probe has a good water solubility, excellent photostability, reversibility, low cytotoxicity and exhibits a good performance to detect pH fluctuation in both solution and live cells. Upon incubation with live cells, it responds sensitively to low pH value in cell medium by exhibiting bright red fluorescence. On the contrary, the fluorescence intensity of probe seems to be very weak in neutral cellular environment. The satisfactory results show that the probe was a highly sensitive pH probe in living cells and further demonstrate its promising biological applications.
研究领域:
化学
·
生物学
·
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Yunxiao Zhang,Yingjian Cai,Yuanxiang Zhou,Yuhao Liu,Hao Hu,Tao Lin
Optical measurements can overcome bandwidth limits in space charge detection, achieving high resolution, and rapid measurement. As a key component, the photoelastic properties of sensor core materials determine system accuracy. Therefore, analyzing and designing the core sensor material with high photoelastic sensitivity can contribute to further improving the testing capability of the platform. Epoxy resins are ideal for photoelastic sensors due to their diverse types and pronounced stress-birefringence effects, yet systematic studies on their photoelastic performance remain lacking, which impedes rational material design. This study elucidates molecular structure effects on epoxy resins' photoelastic performance by comparing five types with distinct chain configurations under uniaxial stress and elastic wave conditions. Molecular dynamics simulations reveal that microscopic chain motions govern stress-induced refractive index changes, while structural analyses identify resin suitability for different testing scenarios. Results show E-51 and F-51, with their ether-rich, benzene-ring structures, and long flexible chains, exhibit superior photoelastic performance under uniaxial stress, while DE184, GTE, and TTA21, featuring compact chains with high rotational mobility, are more suitable for high-frequency elastic wave measurements. Based on the analysis results, modification strategies such as adjusting molecular chain size or introducing high molar refractivity groups in appropriate proportions are proposed, which are expected to further improve the photoelastic performance of the materials. This work establishes a theoretical foundation for designing high-performance photoelastic sensors used in space charge optical measurement.
研究领域:
光学测量
·
材料科学
·
高分子物理
·
传感器技术
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产品关联
DOI
高影响因子
APPLIED OPTICS
·
2025
·Vol. 64
·期 8
·2092-2101
·
IF 1.7
Xiaoran Guan,Yitong Li,Jieyu Li,Hao Cheng,Jiaxuan Wang,Hongyu Xing,Wenjiang Ye
Existing polarization state measurement systems often have complex structures and reliance on passive components, which limits their application. Therefore, a polarization state detection method based on an active liquid crystal polarization grating (ALCPG) is proposed in this paper. First, an ALCPG was prepared using a wedged liquid crystal (LC) cell. Next, the diffraction characteristics of the ALCPG are employed to analyze the relationship between the
order energy ratio (
) and the polarization state of the measured light. Finally, the detection of both linearly and arbitrarily polarized laser beams is experimentally verified. The experimental results demonstrate that this proposed method can accurately detect the polarization state of light over a wide wavelength range. For linear polarization detection, the root mean square errors (RMSEs) of
and
under a red laser (
) are 0.807% and 1.218%, respectively; under a green laser (
), they are 1.695% and 1.712%, respectively. For arbitrary polarization detection, the RMSEs of the normalized Stokes parameters (
,
, and
) under a red laser are 0.758%, 0.596%, and 1.657%, respectively; under a green laser, they are 0.369%, 0.804%, and 2.697%, respectively.
研究领域:
光学测量
·
偏振光学
·
液晶光子学
·
光学传感
·
光电子技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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