Wearable blue-green photodetectors have attracted considerable attention in underwater and medical applications. However, semiconductor-based photodetectors generally suffer from inevitable performance deterioration because of elastic modulus mismatch between rigid inorganic materials and polymer matrixes. Besides, most of the photodetectors reported so far can't be used on both sides and the multiple functionalizations can only be realized by stacking different types of devices. Herein, an intrinsically flexible and size-customizable blue-green photodetector has been fabricated based on well-designed composite fabrics with oriented electrospun fibers, consisting of pseudo-stilbene azobenzene-containing cross–linked liquid crystalline polymers (NAzo-CLCP) and piezoelectric poly(vinylidene fluoride-trifluoroethylene) [P(VDF-TrFE)] nanogenerator. Taking advantage of the synergistic effect between liquid crystalline alignment and polymer networks, the NAzo-CLCP devices construct a consecutive and efficient conversion of illuminance – internal stress – electric signal. A responsivity of 233 mV W −1 is achieved in voltage signals and a comparable response time of 0.1 s in current signals compared to the reported wearable semiconductor-based photodetectors. Benefiting from the inherent flexibility and compatibility of the hydrophobic fabrics, the NAzo-CLCP devices exhibit robust stabilities under cyclic irradiations, humidity and temperature variations, and especially slightly dynamic conditions, fulfilling basic requirements for wearable electronics. For practical applications, a photodetector array for light positioning based on blue light and a bracelet for real-time health monitoring based on green light are developed. Profiting from the uniformity of the fabrics and the consistency of detection performance, the integrated bifunction of code transmission and health monitoring over a double-sided one-piece photodetector has been realized for the first time, providing extensive potential for wearable electronics based on the NAzo-CLCP fabrics.
Hui Qiao,Wenxia Zhang,Dongmei Zhang,Wenjun Yan,Jianguo Li,Yingqi Li
The redox homeostasis in tumor cells is an innate defense barrier for reactive oxygen species (ROS)-mediated tumor therapy. Herein, an intratumoral cascade-responsive multifunctional nanodiamond-based platform (NPCD) with a hydrodynamic diameter of 191 ± 5 nm triggering redox dyshomeostasis is fabricated by Cu2+-mediated coordination for polylysinated nanodiamond and doxorubicin (DOX) to achieve cancer-specific diagnosis and therapy. The NPCD nanoplatform enables precise tumor fluorescence localization and chemotherapy through a “turn on” effect due to being specifically activated by GSH to trigger DOX release at a low-pH tumor-specific environment instead of normal cells. Furthermore, NPCD realizes Cu+-based chemodynamic therapy (CDT) and induces GSH depletion by Cu2+ reduction to support CDT. These cause intracellular redox dyshomeostasis, making tumor cells more sensitive to the NPCD nanoparticles. Additionally, NPCD also possesses the intrinsic ability to reverse drug resistance. Of note, NPCD mainly accumulates in the tumor site in 4T1 tumor-bearing mice and enhances the efficacy of therapeutic interventions with negligible side effects. More interestingly, combined with programmed cell death ligand 1 antibody (anti-PD-L1) and imiquimod (R837), NPCD significantly suppresses distant tumor growth, indicating a good immune response. Therefore, this work opens perspectives for the further development of synergistic therapy through a Cu2+-mediated intratumoral cascade reaction.
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