Polymers
·
2022
·Vol. 14
·期 7
·1370
·
IF 4.967
Xingyu Yuan,Wen Li,Bin Yao,Zhao Li,Deling Kong,Sha Huang,Meifeng Zhu
Bionic grafts hold great promise for directing tissue regeneration. In vascular tissue engineering, although a large number of synthetic grafts have been constructed, these substitutes only partially recapitulated the tri-layered structure of native arteries. Synthetic polymers such as poly(l-lactide-co-ε-caprolactone) (PLCL) possess good biocompatibility, controllable degradation, remarkable processability, and sufficient mechanical strength. These properties of PLCL show great promise for fabricating synthetic vascular substitutes. Here, tri-layered PLCL vascular grafts (TVGs) composed of a smooth inner layer, circumferentially aligned fibrous middle layer, and randomly distributed fibrous outer layer were prepared by sequentially using ink printing, wet spinning, and electrospinning techniques. TVGs possessed kink resistance and sufficient mechanical properties (tensile strength, elastic modulus, suture retention strength, and burst pressure) equivalent to the gold standard conduits of clinical application, i.e., human saphenous veins and human internal mammary arteries. The stratified structure of TVGs exhibited a visible guiding effect on specific vascular cells including enhancing endothelial cell (EC) monolayer formation, favoring vascular smooth muscle cells’ (VSMCs) arrangement and elongation, and facilitating fibroblasts’ proliferation and junction establishment. Our research provides a new avenue for designing synthetic vascular grafts with polymers.Keywords:biomimetic;multilayer structure;smooth surface;aligned microfiber;random microfiber
研究领域:
组织工程
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生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Light-Science & Applications
·
2023
·Vol. 12
·期 1
·1-9
·
IF 19.4
Liu Zhihao,Hu Guangwei,Ye Huapeng,Wei Miaoyang,Guo Zhenghao,Chen Kexu,Liu Chen,Tang Biao,Zhou Guofu
Microlens arrays (MLAs) based on the selective wetting have opened new avenues for developing compact and miniaturized imaging and display techniques with ultrahigh resolution beyond the traditional bulky and volumetric optics. However, the selective wetting lenses explored so far have been constrained by the lack of precisely defined pattern for highly controllable wettability contrast, thus limiting the available droplet curvature and numerical aperture, which is a major challenge towards the practical high-performance MLAs. Here we report a mold-free and self-assembly approach of mass-production of scalable MLAs, which can also have ultrasmooth surface, ultrahigh resolution, and the large tuning range of the curvatures. The selective surface modification based on tunable oxygen plasma can facilitate the precise pattern with adjusted chemical contrast, thus creating large-scale microdroplets array with controlled curvature. The numerical aperture of the MLAs can be up to 0.26 and precisely tuned by adjusting the modification intensity or the droplet dose. The fabricated MLAs have high-quality surface with subnanometer roughness and allow for record-high resolution imaging up to equivalently 10,328 ppi, as we demonstrated. This study shows a cost-effective roadmap for mass-production of high-performance MLAs, which may find applications in the rapid proliferating integral imaging industry and high-resolution display.
研究领域:
光学工程
·
微纳加工
·
表面科学
·
材料科学
·
成像技术
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Minhuan Liu,Fanghui Liu,Xiubin Xu,Danfeng Yu,Ian Wyman,Hui Yang,Jinben Wang,Xu Wu
Antiadhesion performance, stretchability, and transparency are highly desirable properties for materials and devices in numerous applications. However, the existing strategies for imparting materials with antiadhesion performance generally induce rigidity and opacity, and principle is yet to be provided for designing materials that combine these important parameters. Here, we show that four factors including a low surface energy, appropriate cross-linking, availability of a homogeneous and amorphous composite, and a smooth material surface can be used to design an intrinsically stretchable and transparent polymer film with antiadhesion performance against various liquids including water, diiodomethane, hexadecane, cooking oil, and pump oil. The film can be obtained via simply molding a waterborne polymer network at ambient temperature. Furthermore, the film can retain its antiadhesion performance and outstanding transparency even when it is subjected to large mechanical deformations reaching up to 1800%, and its maximal fracture strain exceeds 3000%. These design concepts offer a general platform for achieving multiple material functionalities, and may open new avenues for the surface functionalization of stretchable materials and devices.
研究领域:
高分子材料科学
·
表面功能化
·
柔性电子学
·
生物医学工程
·
纳米材料
·
界面科学
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2019
·
IF 3.45
Weihua Wu,Lingyan Liang,Jingjing Yu,Xi Xiao,Hongliang Zhang,Junhua Gao,Fei Zhuge,Ting-Chang Chang,Linfeng Lan,Hongtao Cao
Dielectrics fabrication on rough substrates, always leading to microstructural defects and detrimental dielectric properties eventually, is a great challenge for academic endeavors in this field. We report here on self-flattening AlO x :Y dielectric thin films processed by a facile aqueous solution method. The obtained AlO x :Y dielectrics are dense, large-area uniform, and amenable to accurate control of film thickness by repeating the deposition cycles. In particular, an atomically smooth surface with a RMS of 0.10 nm was realized for the AlO x :Y film with a thickness of 14.5 nm on Si wafer, yielding a low leakage current density of 7.9 × 10 -8 A cm -2 @2 MV/cm, a dielectric constant of 8.8 @100 Hz, and an attenuated dielectric dispersion property. The interactions between pre-baked YO x underlayer and later-dropped AlO x precursor were comprehensively investigated, in order to understand the film growth mechanism and the origin of self-flattening effect. Fortunately, this self-flattening effect is also applicable to other substrates. A RMS of 0.81 nm was achieved on ITO glasses , and the height distribution profile of the film surface was found to follow symmetric Gaussian distribution. This preparation routine was also examined by device verification in the fully-transparent thin-film transistors. The combination of ease of preparation and attractive physical properties would provide a green-route solution platform for dielectric synthesis, for interface engineering, and for well-performed devices on rough substrates.
研究领域:
材料科学
·
电子学
·
纳米技术
·
薄膜技术
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）