ACS Biomaterials Science & Engineering
·
2025
·
IF 5.5
Simin Lai,Chenxi Shi,Liting Yuan,Kefeng Li,Xiaojing Wang,Xi Yu,Pengbi Liu,Huan Wang,Lihuan Wang,Hui Yu
Complex wound management remains a significant global challenge, and the development of multifunctional wound dressings that can effectively promote wound healing remains an urgent clinical need. Herein, a kind of multifunctional hydrogel wound dressing that combines bacteriostasis, self-healing capability, growth factor release, electrical stimulation, and photothermal stimulation is developed. This kind of wound dressing is generated by adding protocatechualdehyde (protocatechuic aldehyde (PA)), short core–shell fibers loading with platelet-rich-plasma (platelet-rich plasma fibers), and polydopamine-coated carbon nanotubes (PDA@CNTs) into quaternary ammonium chitosan (QCS) solution to form a shear-reversibly cross-linked QCS/PA/PDA@CNTs-PRP hydrogel. The obtained hydrogels possess impressive properties, including high swelling capacity (445–852%), strong adhesion ability (16.4–36.7 kPa), self-healing ability, injectability, conductivity (0.24–0.46 S/m), and photothermal properties. Notably, under near-infrared irradiation, the hydrogel exhibits a highly efficient bactericidal activity. In vitro experiments demonstrated that the hydrogel exhibits excellent biocompatibility and anti-inflammatory capability as well as its ability to stimulate cell proliferation, migration, and tubule formation. Moreover, the in vivo studies further confirmed that with the additional assistance of near-infrared light and electrical stimulation, the hydrogel further promotes wound epithelization, angiogenesis, and collagen deposition. Consequently, this hydrogel provides a promising therapeutic strategy for complex wound healing.
研究领域:
生物材料学
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医学工程
·
再生医学
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产品关联
DOI
PubMed
高影响因子
MATERIALS RESEARCH BULLETIN
·
2024
·
IF 5.3
Zhigang Wang,Dangli Gao,Chaoyang Jia,Ruipeng Chai,Qing Pang,Xiangyu Zhang,Xiaojun Wang
Long persistent luminescence materials (i.e., electronic capture phosphors) with the tunability on luminescent performance are particularly suitable for information storage and anti-counterfeiting applications. However, traditional electronic capture phosphors face serious challenges in developing multilevel anti-counterfeiting applications using a single phosphor. Here, we developed a series of Eu 3+ , Tb 3+ , Pb 2+ double or triple doped NaGdGeO 4 electronic capture phosphors that exhibit changeable luminescent color in the temporal domain. In addition, the pre-irradiated phosphors also demonstrate the photo/thermo-stimulated luminescence. Based on these excellent optical features, the luminescence patterns are printed by using these phosphors as inks for advanced anti-counterfeiting, which cause anti-counterfeiting more difficult to imitate.
研究领域:
材料科学
·
光学工程
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产品关联
DOI
高影响因子
ACS Nano
·
2024
·
IF 15.8
Xinru Yuan,Jia-Xin Wang,Yunlong Li,Hao Huang,Jiahong Wang,Tongyu Shi,Yuhao Deng,Qiyu Yuan,Rui He,Paul K. Chu,Xue-Feng Yu
Increasing modal variations of stimulus-responsive materials ensure the high capacity and confidentiality of information storage and encryption systems that are crucial to information security. Herein, thermochromic perovskite microcapsules (TPMs) with dual-variable and quadruple-modal reversible properties are designed and prepared on the original oil-in-fluorine (O/F) emulsion system. The TPMs respond to the orthogonal variations of external UV and thermal stimuli in four reversible switchable modes and exhibit excellent thermal, air, and water stability due to the protection of perovskites by the core–shell structure. Benefiting from the high-density information storage TPMs, multiple information encryptions and decryptions are demonstrated. Moreover, a set of devices are assembled for a multilevel information encryption system. By taking advantage of TPMs as a “private key” for decryption, the signal can be identified as the corresponding binary ASCII code and converted to the real message. The results demonstrate a breakthrough in high-density information storage materials as well as a multilevel information encryption system based on switchable quadruple-modal TPMs.
研究领域:
材料科学
·
信息安全
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Likai Hou,Zhongjun Liang,Xu Fan,Jian Yu,Fubing Bao
Many soft coiled actuators are mimic the desirable structures of plant tendril. Here, we present a facile microfluidic spinning method to fabricate self-coiling Janus microfiber actuator with tunable morphology, spontaneous coiling performance and reversible traction property. By adjusting the component of hydrogel Janus fiber in a microfluidic spinning device with theta-shaped channels, tens of hundreds of homogeneous coils can be spontaneously and rapidly generated due to asymmetric contraction upon dehydration process, and three different forms of coiled fibers with various screw diameters are presented. Furthermore, the coiled Janus microfiber with hygroscopic properties possesses a reversible coiling/uncoiling performance under humidity gradients, which can serve as a micro-actuator to lift a certain weight with enough tensile strain and long-range tractive displacement. In addition, local reversible coiling/uncoiling morphing is achieved under water contact and near infrared light optothermal stimulations. As a verification of this coiled microfiber actuator, a smart switch is designed to control different colored LED lights for sensing an ambient moisture content.
研究领域:
生物医学工程
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软体机器人
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功能高分子材料
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微纳制造
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生物传感器
·
刺激响应材料
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DOI
高影响因子
Chemical Science
·
2017
·Vol. 9
·期 5
·1184-1190
·
IF 8.668
Xiangdan Meng,Wenhao Dai,Kai Zhang,Haifeng Dong,Xueji Zhang
Herein, we design a smart autonomous ATP self-powered strand-displacement cascade amplification (SDCA) system for highly sensitive multiple intracellular miRNA detection. Rationally engineered Y-motif DNA structures are functionalized on mesoporous silica-coated copper sulfide nanoparticles loaded with numerous ATPs (CuS@mSiO2-Y/ATP) through pH stimulus-responsive disulfide bonds. The SDCA system is implemented by endogenous specific miRNA as a trigger and ATP as fuel released from the nanocarrier at acidic pH and photothermal stimuli-responsive CuS. The ATP self-powered SDCA process presents higher sensitivity compared to that without amplification for intracellular miRNA imaging. Two-color simultaneous and sensitive imaging of multiple cancer-related miRNAs in living cells is also confirmed. This enables facile and accurate differentiation between normal cells and different types of cancer cell using intracellular miRNA imaging, which improves the veracity and timeliness for early cancer diagnosis.
研究领域:
纳米技术
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生物医学工程
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分子生物学
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癌症研究
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Ruoyu Liu,Yuning Zhou,Ming Gao,Wenwan Shi,Yuting Zhang,Xiaojiang Liu,Zhongze Gu
Unidirectional liquid transport, a special self-propelled wetting phenomenon observed in natural structures like the Nepenthes pitcher plant peristome, Araucaria leaves, and Crassula muscosa shoots, has inspired scientists to develop various novel microfluidic devices for liquid collection, physical/chemical reactions, and irrigation. Recently, the concept of capillary transistors is proposed to enable a programmable transport area and a significant increase in unidirectional capillary height, which is expected to greatly expand the applications of conventional microfluidic chips. In this work, using black resin as the three-dimensional (3D) printing material, we construct microfluidic chips with capillary transistors for photothermal-responsive unidirectional liquid transport. The transistors consist of asymmetric overhanging structures with connected overhangs, allowing for fast, long-distance, and large-area unidirectional liquid transport, with a unidirectional capillary height exceeding 90.0 mm—more than double the values reported in most previous studies. Furthermore, smart control of capillary height is achieved by applying external photothermal stimuli to the capillary transistors, demonstrating their potential applications in photothermal-responsive unidirectional liquid transport and mixing in 3D space. It is envisioned that additional functions such as liquid patterning, desalination, and biochemical microreactions would be developed by engineering capillary transistors and their responsiveness.
研究领域:
微流控技术
·
材料科学
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生物物理学
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3D打印
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光热工程
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产品关联
DOI
高影响因子
Nano Convergence
·
2022
·Vol. 9
·期 1
·1-13
·
IF 10.038
Liu Jiansheng,Li Jiajia,Zhang Shu,Ding Mengbin,Yu Ningyue,Li Jingchao,Wang Xiuhui,Li Zhaohui
Infrared neural stimulation with the assistance of photothermal transducers holds great promise as a mini-invasive neural modulation modality. Optical nanoparticles with the absorption in the near-infrared (NIR) window have emerged as excellent photothermal transducers due to their good biocompatibility, surface modifiability, and tunable optical absorption. However, poor activation efficiency and limited stimulation depth are main predicaments encountered in the neural stimulation mediated by these nanoparticles. In this study, we prepared a targeted polydopamine (PDA)-coated gold (Au) nanoparticles with specific binding to thermo-sensitive ion channel as nanotransducers for second near-infrared (NIR-II) photo-stimulation of neurons in rats. The targeted Au nanoparticles were constructed via conjugation of anti-TRPV1 antibody with PEGylated PDA-coated Au nanoparticles and thus exhibited potent photothermal performance property in the second NIR (NIR-II) window and converted NIR-II light to heat to rapidly activate Ca2+ influx of neurons in vitro. Furthermore, wireless photothermal stimulation of neurons in living rat successfully evoke excitation in neurons in the targeted brain region as deep as 5 mm beneath cortex. This study thus demonstrates a remote-controlled strategy for neuromodulation using photothermal nanotransducers.
研究领域:
神经科学
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纳米技术
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-17
·
IF 16.6
Fu Shunli,Chang Lili,Liu Shujun,Gao Tong,Sang Xiao,Zhang Zipeng,Mu Weiwei,Liu Xiaoqing,Liang Shuang,Yang Han,Yang Huizhen,Ma Qingping,Liu Yongjun,Zhang Na
Targeting tumour immunosuppressive microenvironment is a crucial strategy in immunotherapy. However, the critical role of the tumour lymph node (LN) immune microenvironment (TLIME) in the tumour immune homoeostasis is often ignored. Here, we present a nanoinducer, NIL-IM-Lip, that remodels the suppressed TLIME via simultaneously mobilizing T and NK cells. The temperature-sensitive NIL-IM-Lip is firstly delivered to tumours, then directed to the LNs following pH-sensitive shedding of NGR motif and MMP2-responsive release of IL-15. IR780 and 1-MT induces immunogenic cell death and suppress regulatory T cells simultaneously during photo-thermal stimulation. We demonstrate that combining NIL-IM-Lip with anti-PD-1 significantly enhances the effectiveness of T and NK cells, leading to greatly suppressed tumour growth in both hot and cold tumour models, with complete response in some instances. Our work thus highlights the critical role of TLIME in immunotherapy and provides proof of principle to combine LN targeting with immune checkpoint blockade in cancer immunotherapy.
研究领域:
癌症免疫疗法
·
纳米技术
·
免疫学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Xin Jin,Chengxiong Wei,Kai Li,Peinan Yin,Chengwei Wu,Wei Zhang
Wound healing is a complex process involving a complicated interplay between numerous cell types and vascular systems. Hyaluronic acid (HA)-based hydrogel facilitates wound healing, and is involved in all processes. However, slow gelation speed and weak adhesion strength limit its ability to form a stable physical barrier quickly. Herein, we propose a HA-based composite hydrogel as the wound dressing based on oxidative coupling reaction. Tannic acid and dopamine-coated carbon particles (DCPs) containing abundant phenolic hydroxyl groups are incorporated into the HA-based hydrogel for increasing the number of crosslinking sites of oxidative coupling of the hydrogel and enhancing adhesion through the formation of covalent bonds and hydrogen bonds between hydrogel and wound sites. The composite hydrogel exhibits short gelation time (<6 s) and high adhesion strength (>8.1 kPa), which are superior to the references and commercial products of its kind. The in vitro experiments demonstrate that the hydrogel has low hemolytic reaction, negligible cytotoxicity, and the ability to promote fibroblast proliferation and migration. The in vivo full-thickness skin defect model experiments demonstrate that the hydrogel can accelerate wound healing under mild photothermal stimulation of DCPs by reducing inflammation, relieving tissue hypoxia, and promoting angiogenesis and epithelialization.
研究领域:
生物材料
·
组织工程
·
伤口愈合
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产品关联
DOI
PubMed
高影响因子
iScience
·
2023
·
IF 5.8
Xu Dong,Xiaoshuang Zhou,Lvzhou Li,Xiaoting Cao,Jiawei Xu,Shengping Dai,Yaoyao Jiang,Qingyue Li,Ningyi Yuan,Jianning Ding
Monodomain liquid crystal elastomers (m-LCEs) exhibit large reversible deformations when subjected to light and heat stimuli. Herein, we developed a new method for the large-scale continuous preparation of m-LCE fibers. These m-LCE fibers exhibit a reversible contraction ratio of 55.6%, breaking strength of 162 MPa (withstanding a load of 1 million times its weight), and maximum output power density of 1250 J/kg, surpassing those of previously reported m-LCEs. These excellent mechanical properties are mainly attributed to the formation of a homogeneous molecular network. Furthermore, the fabrication of m-LCEs with permanent plasticity using m-LCEs with impermanent instability without external intervention was realized by the synergistic effects of the self-restraint of mesogens and the prolonged relaxation process of LCEs. The designed LCE fibers, which are similar to biological muscle fibers and can be easily integrated, exhibit broad application prospects in artificial muscles, soft robots, and micromechanical systems.
研究领域:
材料科学
·
机械工程
·
仿生学
✓ 已验证
DOI
PubMed
高影响因子
Small Methods
·
2023
·
IF 12.4
Shu Yang,Zhijie Chen,Pengzhen Zhuang,Yunkai Tang,Zehao Chen,Fei Wang,Zhengwei Cai,Jie Wei,Wenguo Cui
Current artificial designs of the periosteum focus on osteogenic or angiogenic properties, while ignoring the filling and integration with bone microcracks, which trigger a prolonged excessive inflammatory reaction and lead to failure of bone regeneration. In this study, seamless adhesive biomimetic periosteum patches (HABP/Sr-PLA) were prepared to fill microcracks in defective bone via interfacial self-assembly induced by Sr ions mediated metal-ligand interactions among pamidronate disodium-modified hyaluronic acid (HAPD), black phosphorus (BP), and hydrophilic polylactic acid (PLA). In vitro, HABP/Sr-PLA exhibited excellent self-healing properties, seamlessly filled bone microcracks, and significantly enhanced osteogenesis and angiogenesis. Furthermore, in a rat cranial defect model, HABP/Sr-PLA was demonstrated to significantly promote the formation of blood vessels and new bone under mild 808 nm photothermal stimulation (42.8 °C), and the highest protein expression of CD31 and OPN was five times higher than that of the control group and other groups. Therefore, the proposed seamless microcrack-filled bionic periosteum patch is a promising clinical strategy for promoting bone repair.
研究领域:
生物医学工程
·
材料科学
·
组织工程
·
骨科
✓ 已验证
DOI
PubMed
高影响因子
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